{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:31:50Z","timestamp":1777260710638,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","bestpracticeobgyn.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Obstetrics & Gynaecology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.bpobgyn.2016.06.003","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T05:22:37Z","timestamp":1467782557000},"page":"97-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Long term follow-up concerning safety and efficacy of novel adhesion prophylactic agent for laparoscopic myomectomy in the prospective randomized ADBEE study"],"prefix":"10.1016","volume":"35","author":[{"given":"Cristina","family":"Cezar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garri","family":"Tchartchian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Korell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Senshu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya Sophie","family":"De Wilde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Larbig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudy Leon","family":"De Wilde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpobgyn.2016.06.003_bib1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bpobgyn.2015.11.004","article-title":"How to avoid risks for patients in minimal-access trials: avoiding complications in clinical first-in-human studies by example of the ADBEE study","volume":"35","author":"Cezar","year":"2015","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"3","key":"10.1016\/j.bpobgyn.2016.06.003_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10397-007-0338-x","article-title":"Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position","volume":"4","author":"De Wilde","year":"2007","journal-title":"Gynecological Surgery"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib3","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1471-0528.2000.tb11083.x","article-title":"The impact of adhesions on hospital readmissions over ten years after 8489 open gynaecological operations: an assessment from the Surgical and Clinical Adhesions Research Study","volume":"107","author":"Lower","year":"2000","journal-title":"Br J Obstet Gynaecol"},{"issue":"8","key":"10.1016\/j.bpobgyn.2016.06.003_bib4","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/humrep\/deh321","article-title":"Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients","volume":"19","author":"Lower","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib5","first-page":"185","article-title":"Adhesion in gynecology. Complication, cost and prevention. A review","volume":"14","author":"Baakdah","year":"2005","journal-title":"Surg Technol"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib6","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/BF02234701","article-title":"Postoperative adhesions: ten-year follow-up of 12,584 patients undergoing lower abdominal surgery","volume":"44","author":"Parker","year":"2001","journal-title":"Dis Colon Rectum"},{"issue":"10","key":"10.1016\/j.bpobgyn.2016.06.003_bib7","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s11605-010-1189-8","article-title":"The incidence and risk factors of post-laparotomy adhesive small bowel obstruction","volume":"14","author":"Barmparas","year":"2010","journal-title":"J\u00a0Gastrointest Surg"},{"issue":"1\u20132","key":"10.1016\/j.bpobgyn.2016.06.003_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.rigapp.2006.02.001","article-title":"Postoperative adhesions and their prevention","volume":"6","author":"Trew","year":"2006","journal-title":"Rev Gynaecol Perinatal Pract"},{"issue":"6","key":"10.1016\/j.bpobgyn.2016.06.003_bib9","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.fertnstert.2004.07.948","article-title":"Adhesions in patients with chronic pelvic pain: a role for adhesiolysis?","volume":"82","author":"Hammoud","year":"2004","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.bpobgyn.2016.06.003_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/09513590802549858","article-title":"Chronic pelvic pain in women: etiology, pathogenesis and diagnostic approach","volume":"25","author":"Vercellini","year":"2009","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"10.1016\/j.bpobgyn.2016.06.003_bib11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/bjs.5634","article-title":"Long-term follow-up and cost analysis following surgery for small bowel obstruction caused by intra-abdominal adhesions","volume":"94","author":"Tingstedt","year":"2007","journal-title":"Br J Surg"},{"issue":"4","key":"10.1016\/j.bpobgyn.2016.06.003_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10397-007-0333-2","article-title":"Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position. Part 2\u2014steps to reduce adhesions","volume":"4","author":"De Wilde","year":"2007","journal-title":"Gynecological Surgery"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00404-014-3312-7","article-title":"Consensus recommendation on adhesions (version 2014)","volume":"290","author":"De Wilde","year":"2014","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib14","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/S0002-9378(13)90479-8","article-title":"Adhesions after extensive gynecologic surgery: clinical significance, etiology, and prevention","volume":"170","author":"Monk","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib15","first-page":"56","article-title":"Pathogenesis and prevention \u2013 panel discussion and summary","volume":"163","author":"Holmdahl","year":"1997","journal-title":"Eur J Surg"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10397-012-0762-4","article-title":"Adhesions after abdominal, pelvic and intra-uterine surgery and their prevention","volume":"9","author":"Wallwiener","year":"2012","journal-title":"Gynecol Surg"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib17","first-page":"598","article-title":"Adhesion prevention in gynaecological surgery","volume":"243","author":"Robertson","year":"2010","journal-title":"SOGC Clinical Practice Guideline, JOGC"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1553350610379869","article-title":"Adhesion prevention and reduction: current status and future recommendations of a multinational interdisciplinary consensus conference","volume":"17","author":"Diamond","year":"2010","journal-title":"Surg Innov"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib19","doi-asserted-by":"crossref","DOI":"10.1007\/s00404-015-3804-0","article-title":"Predicting formation of adhesions after gynaecological surgery - development of a risk score","author":"Lundorff","year":"2015","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"10.1016\/j.bpobgyn.2016.06.003_bib20","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00404-011-2097-1","article-title":"A\u00a0review of the problematic adhesion prophylaxis in gynaecological surgery","volume":"285","author":"Hirschelmann","year":"2012","journal-title":"Arch Gynecol Obstet"},{"issue":"Suppl. 2","key":"10.1016\/j.bpobgyn.2016.06.003_bib21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1463-1318.2007.01342.x","article-title":"Adhesions and colorectal surgery \u2013 call for action","volume":"9","author":"Parker","year":"2007","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.pog.2010.07.004","article-title":"Las adherencias abdominales postoperatorias y su prevenci\u00f3n en cirug\u00eda ginecol\u00f3gica. Documento de consenso del Grupo de Trabajo sobre las Adherencias de la secci\u00f3n de endoscopia de la SEGO","author":"Perez-Medina","year":"2010","journal-title":"Progresos de Obstetricia y Ginecologia"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib23","first-page":"47","article-title":"Aderenze addominali postoperatorie e loro prevenzione in chirurgia ginecologica Documento di consenso di una \u201ctask force\u201d di ginecologi italiani sulle aderenze","volume":"63","author":"Mais","year":"2011","journal-title":"Minerva Ginecologica"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bpobgyn.2015.10.010","article-title":"Adhesions are the major cause of complications in operative gynaecology","volume":"35","author":"Herrmann","year":"2015","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.gmit.2014.02.001","article-title":"Laparoscopic myomectomy \u2013 the gold standard","author":"Herrmann","year":"2014","journal-title":"Gynecol Minimal Inv Ther"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib26","series-title":"Revised as of April 1993","first-page":"146","author":"FDA, Food and Drug Administration; 21 CFR 800-1299 (Food and Drugs)","year":"1993"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000084513","article-title":"Effect of fibroids on fertility in patients undergoing assisted reproduction. A structured literature review","volume":"59","author":"Benecke","year":"2005","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib28","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1093\/humrep\/13.8.2102","article-title":"Second look after laparoscopic myomectomy","volume":"13","author":"Dubuisson","year":"1998","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.bpobgyn.2016.06.003_bib29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejogrb.2009.03.009","article-title":"Laparoscopic versus open myomectomy-a meta-analysis of randomized controlled trials","volume":"145","author":"Jin","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"10.1016\/j.bpobgyn.2016.06.003_bib30","first-page":"137","article-title":"Fertility following myomectomy","volume":"48","author":"Kasum","year":"2009","journal-title":"Acta Clin Croat"},{"issue":"4","key":"10.1016\/j.bpobgyn.2016.06.003_bib31","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S1074-3804(05)60516-6","article-title":"Evaluation of adhesion formation after laparoscopic myomectomy by systematic second-look microlaparoscopy","volume":"9","author":"Takeuchi","year":"2002","journal-title":"J\u00a0Am Assoc Gynecol Laparosc"},{"issue":"8","key":"10.1016\/j.bpobgyn.2016.06.003_bib32","first-page":"571","article-title":"Adhesion-prevention effects of fibrin sealants after laparoscopic myomectomy as determined by second-look laparoscopy: a prospective, randomized, controlled study","volume":"50","author":"Takeuchi","year":"2005","journal-title":"J\u00a0Reprod Med"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0020-7292(95)02644-4","article-title":"\u201cLaparoscopy for adhesion prevention following myomectomy","volume":"53","author":"Ugur","year":"1996","journal-title":"Int J Gynecol Obstet"},{"issue":"2","key":"10.1016\/j.bpobgyn.2016.06.003_bib34","first-page":"CD000475","article-title":"Barrier agents for adhesion prevention after gynaecological surgery","author":"Ahmad","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"8","key":"10.1016\/j.bpobgyn.2016.06.003_bib35","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1093\/humrep\/der135","article-title":"\u201cGynaecological endoscopic evaluation of 4% icodextrin solution: a European, multicentre, double-blind, randomized study of the efficacy and safety of Adept in the reduction of de noce adhesions after laparoscopic gynaecological surgery","volume":"26","author":"Trew","year":"2011","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.bpobgyn.2016.06.003_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10397-013-0824-2","article-title":"A\u00a0European survey on awareness of post-surgical adhesions among gynaecological surgeons","volume":"11","author":"Wallwiener","year":"2014","journal-title":"Gynecological Surgery"},{"key":"10.1016\/j.bpobgyn.2016.06.003_bib37","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00404-010-1504-3","article-title":"Patients' awareness of postoperative adhesions: results from a multi centre study and online survey","volume":"283","author":"Kraemer","year":"2011","journal-title":"Arch Gynecol Obstet"}],"container-title":["Best Practice & Research Clinical Obstetrics & Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693416300396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693416300396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T13:58:55Z","timestamp":1536587935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693416300396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":37,"alternative-id":["S1521693416300396"],"URL":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2016.06.003","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long term follow-up concerning safety and efficacy of novel adhesion prophylactic agent for laparoscopic myomectomy in the prospective randomized ADBEE study","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Obstetrics & Gynaecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2016.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}