{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:36:29Z","timestamp":1774611389016,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.bpobgyn.2019.02.007","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T12:14:38Z","timestamp":1551788078000},"page":"142-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Fetal stem cell transplantation and gene therapy"],"prefix":"10.1016","volume":"58","author":[{"given":"Rachel","family":"Sagar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"G\u00f6therstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna L.","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Westgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bpobgyn.2019.02.007_bib1","doi-asserted-by":"crossref","first-page":"F264","DOI":"10.1136\/archdischild-2016-311790","article-title":"Birth weight trends in England and Wales (1986-2012): babies are getting heavier","volume":"103","author":"Ghosh","year":"2018","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"7","key":"10.1016\/j.bpobgyn.2019.02.007_bib2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.nucmedbio.2011.03.008","article-title":"In\u00a0vivo tracking of 111 In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis","volume":"38","author":"Gholamrezanezhad","year":"2011","journal-title":"Nucl Med Biol"},{"issue":"2","key":"10.1016\/j.bpobgyn.2019.02.007_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/scd.2014.0265","article-title":"Treatment of severe chronic graft-versus-host disease with decidual stromal cells and tracing with (111)indium radiolabeling","volume":"24","author":"Erkers","year":"2015","journal-title":"Stem Cell Dev"},{"issue":"5","key":"10.1016\/j.bpobgyn.2019.02.007_bib4","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1182\/blood.V99.5.1870","article-title":"Brief report Allogenic fetal liver cells have a distinct competitive engraftment advantage over adult bone marrow cells when infused into fetal as compared with adult severe combined immunodeficient recipients","volume":"99","author":"Taylor","year":"2016","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bpobgyn.2019.02.007_bib5","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1182\/blood-2002-01-0016","article-title":"Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion","volume":"100","author":"Hayashi","year":"2002","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bpobgyn.2019.02.007_bib6","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/uog.17319","article-title":"Complications of intrauterine intravascular blood transfusion: lessons learned after 1678 procedures","volume":"50","author":"Zwiers","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5411","key":"10.1016\/j.bpobgyn.2019.02.007_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bpobgyn.2019.02.007_bib8","first-page":"151","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"18","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"8","key":"10.1016\/j.bpobgyn.2019.02.007_bib9","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/stem.103","article-title":"A\u00a0Regenerative effects of transplanted mesenchymal stem cells in fracture healing","volume":"27","author":"Granero-Molt\u00f3","year":"2009","journal-title":"Stem Cell"},{"issue":"5","key":"10.1016\/j.bpobgyn.2019.02.007_bib10","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/jcb.20886","article-title":"Mesenchymal stem cells as trophic mediators","volume":"98","author":"Caplan","year":"2006","journal-title":"J\u00a0Cell Biochem"},{"issue":"1","key":"10.1016\/j.bpobgyn.2019.02.007_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2011.06.008","article-title":"The MSC: an injury drugstore","volume":"9","author":"Caplan","year":"2011","journal-title":"Cell stem cell"},{"issue":"1","key":"10.1016\/j.bpobgyn.2019.02.007_bib12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ajog.2003.07.022","article-title":"Immunologic properties of human fetal mesenchymal stem cells","volume":"190","author":"G\u00f6therstr\u00f6m","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.bpobgyn.2019.02.007_bib13","first-page":"557","article-title":"Ex\u00a0vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use","volume":"16","author":"Lazarus","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.bpobgyn.2019.02.007_bib14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3727\/096368915X689622","article-title":"Review clinical trials with mesenchymal stem cells: an update","volume":"25","author":"Squillaro","year":"2016","journal-title":"Cell Transplant"},{"issue":"10","key":"10.1016\/j.bpobgyn.2019.02.007_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047559","article-title":"Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials","volume":"7","author":"Lalu","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bpobgyn.2019.02.007_bib16","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3109\/14653249.2010.507330","article-title":"Defining the risks of mesenchymal stromal cell therapy","volume":"12","author":"Prockop","year":"2010","journal-title":"Cytotherapy"},{"issue":"10","key":"10.1016\/j.bpobgyn.2019.02.007_bib17","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.earlhumdev.2009.08.005","article-title":"Stem cells and the frontiers of neonatology","volume":"85","author":"Lanfranchi","year":"2009","journal-title":"Early Hum Dev"},{"issue":"11","key":"10.1016\/j.bpobgyn.2019.02.007_bib18","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1097\/01.TP.0000159029.48678.93","article-title":"Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta","volume":"79","author":"Le Blanc","year":"2005","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.bpobgyn.2019.02.007_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.5966\/sctm.2013-0090","article-title":"Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience","volume":"3","author":"G\u00f6therstr\u00f6m","year":"2014","journal-title":"Stem Cells Transl Med"},{"issue":"12","key":"10.1016\/j.bpobgyn.2019.02.007_bib20","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1634\/stemcells.2007-0466","article-title":"Distribution of single-cell expanded marrow derived progenitors in a developing mouse model of osteogenesis imperfecta following systemic transplantation","volume":"25","author":"Li","year":"2007","journal-title":"Stem Cell"},{"issue":"2","key":"10.1016\/j.bpobgyn.2019.02.007_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1182\/blood-2008-12-195859","article-title":"In utero transplantation of adult bone marrow decreases perinatal lethality and rescues the bone phenotype in the knockin murine model for classical, dominant osteogenesis imperfecta","volume":"114","author":"Panaroni","year":"2009","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bpobgyn.2019.02.007_bib22","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1182\/blood-2007-08-105809","article-title":"Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice","volume":"111","author":"Guillot","year":"2008","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bpobgyn.2019.02.007_bib23","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1182\/blood-2010-05-287565","article-title":"Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties","volume":"117","author":"Vanleene","year":"2011","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bpobgyn.2019.02.007_bib24","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1182\/blood-2011-12-400085","article-title":"Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms","volume":"120","author":"Otsuru","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bpobgyn.2019.02.007_bib25","doi-asserted-by":"crossref","first-page":"39656","DOI":"10.1038\/srep39656","article-title":"Counteracting bone fragility with human amniotic mesenchymal stem cells","volume":"6","author":"Ranzoni","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.bpobgyn.2019.02.007_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/ten.teb.2011.0488","article-title":"Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvements","volume":"18","author":"Doorn","year":"2012","journal-title":"Tissue Eng B Rev"},{"issue":"1","key":"10.1016\/j.bpobgyn.2019.02.007_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13287-018-0791-7","article-title":"Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine","volume":"9","author":"Keshtkar","year":"2018","journal-title":"Stem Cell Res Ther"},{"issue":"9","key":"10.1016\/j.bpobgyn.2019.02.007_bib28","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1182\/blood-2008-08-078220","article-title":"The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases","volume":"112","author":"Weissman","year":"2008","journal-title":"Blood"},{"issue":"8651","key":"10.1016\/j.bpobgyn.2019.02.007_bib29","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(89)92819-5","article-title":"In-utero transplantation of stem cells in bare lymphocyte syndrome","volume":"333","author":"Touraine","year":"1989","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.bpobgyn.2019.02.007_bib30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000077957","article-title":"Reappraisal of in utero stem cell transplantation based on long-term results","volume":"19","author":"Touraine","year":"2004","journal-title":"Fetal Diagn Ther"},{"issue":"24","key":"10.1016\/j.bpobgyn.2019.02.007_bib31","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1056\/NEJM199612123352404","article-title":"Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow","volume":"335","author":"Flake","year":"1996","journal-title":"N\u00a0Engl J Med"},{"issue":"9040","key":"10.1016\/j.bpobgyn.2019.02.007_bib32","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/S0140-6736(96)09392-0","article-title":"In-utero transplantation of parental CD34 haematopoietic progenitor cells in a patient with X-linked severe combined immunodeficiency (SCIDXI)","volume":"348","author":"Wengler","year":"1996","journal-title":"Lancet (London, England)"},{"issue":"4","key":"10.1016\/j.bpobgyn.2019.02.007_bib33","first-page":"450","article-title":"Reconstitution of T-cell compartment after in utero stem cell transplantation: analysis of T-cell repertoire and thymic output","volume":"89","author":"Pirovano","year":"2004","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.bpobgyn.2019.02.007_bib34","first-page":"515","article-title":"In utero stem cell therapy","volume":"37","author":"Diukman","year":"1992","journal-title":"J\u00a0Reprod Med"},{"issue":"2","key":"10.1016\/j.bpobgyn.2019.02.007_bib35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1067\/mob.2002.123602","article-title":"Prenatal T-cell reconstitution after in utero transplantation with fetal liver cells in a patient with X-linked severe combined immunodeficiency","volume":"187","author":"Westgren","year":"2002","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bpobgyn.2019.02.007_bib36","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1055\/s-2006-952156","article-title":"In utero stem cell transplantation","volume":"24","author":"Westgren","year":"2006","journal-title":"Semin Reprod Med"},{"issue":"7","key":"10.1016\/j.bpobgyn.2019.02.007_bib37","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1182\/blood.V94.7.2179.419k43_2179_2191","article-title":"In utero hematopoietic stem cell transplantation: ontogenic opportunities and biologic barriers","volume":"94","author":"Flake","year":"1999","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.bpobgyn.2019.02.007_bib38","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1182\/blood.V86.12.4681.bloodjournal86124681","article-title":"Induction of tolerance in nondefective mice after in-utero transplantation of major histocompatibility complex-mismatched fetal hematopoietic stem-cells","volume":"86","author":"Carrier","year":"1995","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bpobgyn.2019.02.007_bib39","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1067\/mlc.2000.108942","article-title":"Microchimerism does not induce tolerance after in utero transplantation and may lead to the development of alloreactivity","volume":"136","author":"Carrier","year":"2000","journal-title":"J\u00a0Lab Clin Med"},{"key":"10.1016\/j.bpobgyn.2019.02.007_bib40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bpobgyn.2015.08.006","article-title":"In utero stem cell transplantation and gene therapy: recent progress and the potential for clinical application","volume":"31","author":"McClain","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"9","key":"10.1016\/j.bpobgyn.2019.02.007_bib41","first-page":"2590","article-title":"Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice","volume":"119","author":"Merianos","year":"2009","journal-title":"J\u00a0Clin Investig"},{"key":"10.1016\/j.bpobgyn.2019.02.007_bib42","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3727\/096368910X543402","article-title":"Autologous transplantation of amniotic fluid-derived mesenchymal stem cells into sheep fetuses","volume":"20","author":"Shaw","year":"2011","journal-title":"Cell Transplant"},{"key":"10.1016\/j.bpobgyn.2019.02.007_bib43","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/stem.1839","article-title":"Sheep CD34+ amniotic fluid cells have hematopoietic potential and engraft after autologous in utero transplantation","volume":"33","author":"Shaw","year":"2015","journal-title":"Stem Cell"},{"key":"10.1016\/j.bpobgyn.2019.02.007_bib44","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fphar.2014.00270","article-title":"In utero therapy for congenital disorders using amniotic fluid stem cells","volume":"5","author":"Ramachandra","year":"2014","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.bpobgyn.2019.02.007_bib45","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/s41591-018-0106-7","article-title":"Fetal gene therapy for neurodegenerative disease of infants","volume":"24","author":"Massaro","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.bpobgyn.2019.02.007_bib46","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/d41586-018-06756-9","article-title":"Clear up this stem-cell mess","volume":"561","author":"Sipp","year":"2018","journal-title":"Nature"}],"container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693418302438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693418302438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:10:30Z","timestamp":1761498630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693418302438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":46,"alternative-id":["S1521693418302438"],"URL":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2019.02.007","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fetal stem cell transplantation and gene therapy","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Obstetrics & Gynaecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2019.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}