{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:44:39Z","timestamp":1791931479900,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bpobgyn.2026.102771","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T22:44:51Z","timestamp":1787438691000},"page":"102771","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["First trimester ultrasound"],"prefix":"10.1016","volume":"109","author":[{"given":"Shreyasi","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-7670","authenticated-orcid":false,"given":"Asma","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6831","key":"10.1016\/j.bpobgyn.2026.102771_bib1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/bmj.304.6831.867","article-title":"Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy","volume":"304","author":"Nicolaides","year":"1992","journal-title":"Br Med J"},{"issue":"3","key":"10.1016\/j.bpobgyn.2026.102771_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000324320","article-title":"Turning the Pyramid of prenatal care","volume":"29","author":"Nicolaides","year":"2011","journal-title":"Fetal Diagn Ther"},{"issue":"3","key":"10.1016\/j.bpobgyn.2026.102771_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/uog.26100","article-title":"Cost\u2010effectiveness of ultrasound before non\u2010invasive prenatal screening for fetal aneuploidy","volume":"61","author":"Battarbee","year":"2023","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2026.102771_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejogrb.2020.11.036","article-title":"Outcome of cesarean scar pregnancy according to gestational age at diagnosis: a systematic review and meta-analysis","volume":"258","author":"Timor-Tritsch","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"10.1016\/j.bpobgyn.2026.102771_bib5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/uog.21939","article-title":"Value of first\u2010trimester ultrasound in prediction of third\u2010trimester sonographic stage of placenta accreta spectrum disorder and surgical outcome","volume":"55","author":"Cal\u00ed","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.bpobgyn.2026.102771_bib6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/uog.12342","article-title":"ISUOG Practice guidelines: performance of first\u2010trimester fetal ultrasound scan","volume":"41","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.bpobgyn.2026.102771_bib7","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/uog.17283","article-title":"Accuracy of first\u2010trimester combined test in screening for trisomies 21, 18 and 13","volume":"49","author":"Santorum","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.bpobgyn.2026.102771_bib8","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1097\/AOG.0000000000000015","article-title":"Accuracy of ultrasonography at 11\u201314 weeks of gestation for detection of fetal structural anomalies","volume":"122","author":"Rossi","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.bpobgyn.2026.102771_bib9","article-title":"AIUM\u2013ACR\u2013ACOG\u2013SMFM\u2013SRU practice parameter for the performance of standard diagnostic Obstetric Ultrasound examinations","volume":"37","year":"2018","journal-title":"J Ultrasound Med"},{"issue":"6","key":"10.1016\/j.bpobgyn.2026.102771_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/uog.23610","article-title":"ISUOG statement on the safe use of Doppler for fetal ultrasound examination in the first 13 + 6 weeks of pregnancy (updated)","volume":"57","author":"Salvesen","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.bpobgyn.2026.102771_bib11","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/uog.6410","article-title":"Fetal nuchal translucency thickness evaluation in the overweight and obese gravida","volume":"33","author":"Thornburg","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bpobgyn.2026.102771_bib12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1097\/AOG.0b013e3181a1d2f5","article-title":"Effect of maternal obesity on the ultrasound detection of anomalous fetuses","volume":"113","author":"Dashe","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bpobgyn.2026.102771_bib13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/14767058.2019.1618825","article-title":"Does transvaginal ultrasound at 13\u201315 weeks improve anatomic survey completion rates in obese gravidas?","volume":"34","author":"Toscano","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.bpobgyn.2026.102771_bib14","series-title":"Obstetric ultrasound imaging in the Obese patient","author":"Chung","year":"2023"},{"issue":"1","key":"10.1016\/j.bpobgyn.2026.102771_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/uog.26106","article-title":"ISUOG Practice Guidelines (updated): performance of 11\u201314\u2010week ultrasound scan","volume":"61","author":"Bilardo","year":"2023","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bpobgyn.2026.102771_bib17","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1097\/AOG.0000000000002899","article-title":"ACOG practice bulletin no. 200: early pregnancy loss","volume":"132","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.bpobgyn.2026.102771_bib18","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1046\/j.1469-0705.2000.00292.x","article-title":"Fetal heart rate in chromosomally abnormal fetuses","volume":"16","author":"Liao","year":"2000","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bpobgyn.2026.102771_bib19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1469-0705.1999.14050311.x","article-title":"First\u2010trimester fetal heart block: a marker for cardiac anomaly","volume":"14","author":"Baschat","year":"1999","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bpobgyn.2026.102771_bib20","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1097\/AOG.0000000000002046","article-title":"Committee opinion no 700: methods for estimating the due date","volume":"129","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.bpobgyn.2026.102771_bib21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/uog.20272","article-title":"ISUOG Practice Guidelines: ultrasound assessment of fetal biometry and growth","volume":"53","author":"Salomon","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.bpobgyn.2026.102771_bib22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/uog.15821","article-title":"ISUOG Practice guidelines: role of ultrasound in twin pregnancy","volume":"47","author":"Khalil","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.bpobgyn.2026.102771_bib23","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/uog.24888","article-title":"ISUOG Practice Guidelines (updated): performance of the routine mid\u2010trimester fetal ultrasound scan","volume":"59","author":"Salomon","year":"2022","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.bpobgyn.2026.102771_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/uog.27538","article-title":"ISUOG Practice guidelines: performance of third\u2010trimester obstetric ultrasound scan","volume":"63","author":"Khalil","year":"2024","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.bpobgyn.2026.102771_bib25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/uog.23690","article-title":"Crown\u2013rump length measurement error: impact on assessment of growth","volume":"58","author":"Gadsb\u00f8ll","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.bpobgyn.2026.102771_bib26","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/uog.13448","article-title":"International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown\u2013rump length in the first trimester of pregnancy","volume":"44","author":"Papageorghiou","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bpobgyn.2026.102771_bib27","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/1471-0528.12478","article-title":"Pregnancy dating by fetal crown\u2013rump length: a systematic review of charts","volume":"121","author":"Napolitano","year":"2014","journal-title":"Br J Obstet Gynaecol"},{"issue":"10","key":"10.1016\/j.bpobgyn.2026.102771_bib28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/OGX.0000000000000490","article-title":"First-trimester crown-rump length and risk of chromosomal aberrations\u2014A systematic review and meta-analysis","volume":"72","author":"Sagi-Dain","year":"2017","journal-title":"Obstet Gynecol Surv"},{"issue":"4","key":"10.1016\/j.bpobgyn.2026.102771_bib29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/uog.17246","article-title":"Systematic review of first\u2010trimester ultrasound screening for detection of fetal structural anomalies and factors that affect screening performance","volume":"50","author":"Karim","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.bpobgyn.2026.102771_bib30","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/uog.20844","article-title":"Diagnosis of fetal non\u2010chromosomal abnormalities on routine ultrasound examination at 11\u201313 weeks' gestation","volume":"54","author":"Syngelaki","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.bpobgyn.2026.102771_bib31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/pd.2642","article-title":"Challenges in the diagnosis of fetal non\u2010chromosomal abnormalities at 11\u201313 weeks","volume":"31","author":"Syngelaki","year":"2011","journal-title":"Prenat Diagn"},{"issue":"1","key":"10.1016\/j.bpobgyn.2026.102771_bib32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jum.70044","article-title":"A practical approach to incorporating the detailed first trimester ultrasound examination into clinical practice","volume":"45","author":"Abu\u2010Rustum","year":"2026","journal-title":"J Ultrasound Med"},{"issue":"4","key":"10.1016\/j.bpobgyn.2026.102771_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/uog.17487","article-title":"Effectiveness of 12\u201313\u2010week scan for early diagnosis of fetal congenital anomalies in the cell\u2010free DNA era","volume":"51","author":"Kenkhuis","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.bpobgyn.2026.102771_bib34","doi-asserted-by":"crossref","first-page":"396.e1","DOI":"10.1016\/j.ajog.2020.10.037","article-title":"Routine first-trimester ultrasound screening using a standardized anatomical protocol","volume":"224","author":"Liao","year":"2021","journal-title":"Am J Obstet Gynecol"},{"issue":"25","key":"10.1016\/j.bpobgyn.2026.102771_bib35","doi-asserted-by":"crossref","first-page":"8691","DOI":"10.1080\/14767058.2021.1998442","article-title":"Feasibility and learning curve of performing first trimester fetal anatomy screening among operators with varying experience using the protocol of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG)","volume":"35","author":"Sripilaipong","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"5","key":"10.1016\/j.bpobgyn.2026.102771_bib36","doi-asserted-by":"crossref","first-page":"695","DOI":"10.7863\/jum.2011.30.5.695","article-title":"Learning curve and factors influencing the feasibility of performing fetal echocardiography at the time of the first-trimester Scan","volume":"30","author":"Abu-Rustum","year":"2011","journal-title":"J Ultrasound Med"},{"issue":"12","key":"10.1016\/j.bpobgyn.2026.102771_bib37","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1002\/jum.16310","article-title":"Cleft lip and cleft palate","volume":"42","author":"Tonni","year":"2023","journal-title":"J Ultrasound Med"},{"issue":"1","key":"10.1016\/j.bpobgyn.2026.102771_bib38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ajog.2004.03.090","article-title":"Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities","volume":"191","author":"Nicolaides","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"8821","key":"10.1016\/j.bpobgyn.2026.102771_bib39","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/0140-6736(92)92240-G","article-title":"Ultrasonographically detectable markers of fetal chromosomal abnormalities","volume":"340","author":"Nicolaides","year":"1992","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.bpobgyn.2026.102771_bib40","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/(SICI)1097-0223(199709)17:9<821::AID-PD154>3.0.CO;2-5","article-title":"Combining ultrasound and biochemistry in first-trimester screening for Down's syndrome","volume":"17","author":"Wald","year":"1997","journal-title":"Prenat Diagn"},{"issue":"4","key":"10.1016\/j.bpobgyn.2026.102771_bib41","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.ajog.2004.12.093","article-title":"Increased nuchal translucency with normal karyotype","volume":"192","author":"Souka","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.bpobgyn.2026.102771_bib42","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1186\/s12884-025-07863-y","article-title":"Intelligent quality assessment of ultrasound images for fetal nuchal translucency measurement during the first trimester of pregnancy based on deep learning models","volume":"25","author":"Liu","year":"2025","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"10.1016\/j.bpobgyn.2026.102771_bib43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/pd.2637","article-title":"Screening for fetal aneuploidies at 11 to 13 weeks","volume":"31","author":"Nicolaides","year":"2011","journal-title":"Prenat Diagn"},{"issue":"1","key":"10.1016\/j.bpobgyn.2026.102771_bib44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ajog.2005.12.057","article-title":"Nasal bone in first-trimester screening for trisomy 21","volume":"195","author":"Cicero","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"9294","key":"10.1016\/j.bpobgyn.2026.102771_bib45","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0140-6736(01)06709-5","article-title":"Absence of nasal bone in fetuses with trisomy 21 at 11\u201314 weeks of gestation: an observational study","volume":"358","author":"Cicero","year":"2001","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bpobgyn.2026.102771_bib46","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/uog.992","article-title":"Likelihood ratio for trisomy 21 in fetuses with absent nasal bone at the 11\u201314\u2010week scan","volume":"23","author":"Cicero","year":"2004","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.bpobgyn.2026.102771_bib47","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/uog.6318","article-title":"Fetal nasal bone in screening for trisomies 21, 18 and 13 and Turner syndrome at 11\u201313 weeks of gestation","volume":"33","author":"Kagan","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"8","key":"10.1016\/j.bpobgyn.2026.102771_bib48","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3390\/medicina61081391","article-title":"Feasibility of Ductus Venosus doppler screening during first trimester ultrasound: prospective multicenter study","volume":"61","author":"Joinau-Zoulovits","year":"2025","journal-title":"Medicina (B Aires)"},{"issue":"7","key":"10.1016\/j.bpobgyn.2026.102771_bib49","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/pd.5065","article-title":"First\u2010trimester ultrasound screening for trisomy 21 based on maternal age, fetal nuchal translucency, and different methods of ductus venosus assessment","volume":"37","author":"Wagner","year":"2017","journal-title":"Prenat Diagn"},{"issue":"6","key":"10.1016\/j.bpobgyn.2026.102771_bib50","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/uog.7706","article-title":"Ductus venosus pulsatility index measurement reduces the false\u2010positive rate in first\u2010trimester screening","volume":"36","author":"Timmerman","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bpobgyn.2026.102771_bib51","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/uog.6330","article-title":"Ductus venosus doppler in screening for trisomies 21, 18 and 13 and Turner syndrome at 11\u201313 weeks of gestation","volume":"33","author":"Maiz","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bpobgyn.2026.102771_bib52","doi-asserted-by":"crossref","DOI":"10.1515\/jpm-2014-0058","article-title":"First trimester tricuspid regurgitation and fetal abnormalities","volume":"43","author":"Wiechec","year":"2015","journal-title":"J Perinat Med"},{"issue":"4","key":"10.1016\/j.bpobgyn.2026.102771_bib53","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/uog.24828","article-title":"First\u2010trimester ultrasound diagnostic features of placenta accreta spectrum in low\u2010implantation pregnancy","volume":"59","author":"Abinader","year":"2022","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693426000714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693426000714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:45:40Z","timestamp":1791927940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693426000714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":52,"alternative-id":["S1521693426000714"],"URL":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2026.102771","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First trimester ultrasound","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Obstetrics & Gynaecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2026.102771","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102771"}}