{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:52:50Z","timestamp":1790808770718,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer&apos;s Association","doi-asserted-by":"publisher","award":["AARGD-16-443384"],"award-info":[{"award-number":["AARGD-16-443384"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence nationale de la recherche","doi-asserted-by":"publisher","award":["ANR-10-COHO-05"],"award-info":[{"award-number":["ANR-10-COHO-05"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence nationale de la recherche","doi-asserted-by":"publisher","award":["ANR-18-RHUS-0002"],"award-info":[{"award-number":["ANR-18-RHUS-0002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009453","name":"Fondation Claude Pompidou","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006251","name":"Universit\u00e9 de Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS017950"],"award-info":[{"award-number":["R01 NS017950"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG059727"],"award-info":[{"award-number":["R01AG059727"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DIC202161236446"],"award-info":[{"award-number":["DIC202161236446"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["754517"],"award-info":[{"award-number":["754517"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["643417"],"award-info":[{"award-number":["643417"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["667375"],"award-info":[{"award-number":["667375"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["640643"],"award-info":[{"award-number":["640643"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG0101029"],"award-info":[{"award-number":["P30 AG0101029"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG054076"],"award-info":[{"award-number":["R01AG054076"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG059725"],"award-info":[{"award-number":["R01AG059725"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG049505"],"award-info":[{"award-number":["U01AG049505"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG049607"],"award-info":[{"award-number":["R01AG049607"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG052409"],"award-info":[{"award-number":["U01AG052409"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG059421"],"award-info":[{"award-number":["R01AG059421"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG031287"],"award-info":[{"award-number":["R01AG031287"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201500001I"],"award-info":[{"award-number":["HHSN268201500001I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-25195"],"award-info":[{"award-number":["N01-HC-25195"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92019D00031"],"award-info":[{"award-number":["75N92019D00031"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007161","name":"Boston University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013340","name":"Institute Pasteur De Lille","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008018","name":"Mutuelle G\u00e9n\u00e9rale de l&apos;Education Nationale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.bpsc.2021.10.011","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T15:50:33Z","timestamp":1635177033000},"page":"616-628","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes"],"prefix":"10.1016","volume":"7","author":[{"given":"Quentin","family":"Le Grand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia L.","family":"Satizabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muralidharan","family":"Sargurupremraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniket","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aicha","family":"Soumar\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Crivello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Macalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baljeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa S.","family":"Beiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Paus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lathrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hieab H.H.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Bis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Tzourio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Mazoyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Debette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpsc.2021.10.011_bib1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrn1919","article-title":"The role of the basal ganglia in habit formation","volume":"7","author":"Yin","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bpsc.2021.10.011_bib2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/jnr.23709","article-title":"Functional neuroanatomy of amygdalohippocampal interconnections and their role in learning and memory: Amygdalohippocampal Interconnections","volume":"95","author":"McDonald","year":"2017","journal-title":"J\u00a0Neurosci Res"},{"key":"10.1016\/j.bpsc.2021.10.011_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev-neuro-071013-013924","article-title":"Basal ganglia circuits for reward value\u2013guided behavior","volume":"37","author":"Hikosaka","year":"2014","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.bpsc.2021.10.011_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.neuro.051508.135256","article-title":"Emotion, cognition, and mental state representation in amygdala and prefrontal cortex","volume":"33","author":"Salzman","year":"2010","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.bpsc.2021.10.011_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-psych-010213-115159","article-title":"The nucleus accumbens: An interface between cognition, emotion, and action","volume":"66","author":"Floresco","year":"2015","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.bpsc.2021.10.011_bib6","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/hbm.25320","article-title":"Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years","volume":"43","author":"Dima","year":"2022","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.bpsc.2021.10.011_bib7","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1038\/s41598-019-39809-8","article-title":"Lifespan changes of the human brain in Alzheimer\u2019s disease","volume":"9","author":"Coup\u00e9","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.bpsc.2021.10.011_bib8","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1093\/brain\/awn278","article-title":"Strongly reduced volumes of putamen and thalamus in Alzheimer\u2019s disease: An MRI study","volume":"131","author":"de Jong","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.bpsc.2021.10.011_bib9","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1093\/brain\/awv211","article-title":"Baseline and longitudinal grey matter changes in newly diagnosed Parkinson\u2019s disease: ICICLE-PD study","volume":"138","author":"Mak","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.bpsc.2021.10.011_bib10","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/mds.25904","article-title":"Apathy in Parkinson\u2019s disease is associated with nucleus accumbens atrophy: A magnetic resonance imaging shape analysis","volume":"29","author":"Carriere","year":"2014","journal-title":"Mov Disord"},{"key":"10.1016\/j.bpsc.2021.10.011_bib11","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3233\/JAD-141230","article-title":"More atrophy of deep gray matter structures in frontotemporal dementia compared to Alzheimer\u2019s disease","volume":"44","author":"M\u00f6ller","year":"2015","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.bpsc.2021.10.011_bib12","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1212\/WNL.0000000000004680","article-title":"Caudate nucleus as a component of networks controlling behavior","volume":"89","author":"Graff-Radford","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.bpsc.2021.10.011_bib13","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1136\/jnnp-2018-320157","article-title":"Clinical implications of early caudate dysfunction in Parkinson\u2019s disease","volume":"90","author":"Pasquini","year":"2019","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.bpsc.2021.10.011_bib14","first-page":"1020","article-title":"Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders","volume":"3","author":"Luo","year":"2019","journal-title":"World J Psychiatry Ment Health Res"},{"key":"10.1016\/j.bpsc.2021.10.011_bib15","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/s41588-019-0511-y","article-title":"Genetic architecture of subcortical brain structures in 38,851 individuals","volume":"51","author":"Satizabal","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib16","doi-asserted-by":"crossref","first-page":"19006","DOI":"10.1073\/pnas.1313735110","article-title":"Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging","volume":"110","author":"Glahn","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bpsc.2021.10.011_bib17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrg1578","article-title":"Gene\u2013environment interactions in human diseases","volume":"6","author":"Hunter","year":"2005","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib18","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.neuron.2013.12.003","article-title":"Biomarker modeling of Alzheimer\u2019s disease","volume":"80","author":"Jack","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.bpsc.2021.10.011_bib19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature14101","article-title":"Common genetic variants influence human subcortical brain structures","volume":"520","author":"Hibar","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bpsc.2021.10.011_bib20","doi-asserted-by":"crossref","first-page":"13624","DOI":"10.1038\/ncomms13624","article-title":"Novel genetic loci associated with hippocampal volume","volume":"8","author":"Hibar","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.bpsc.2021.10.011_bib21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/ng.2237","article-title":"Common variants at 12q14 and 12q24 are associated with hippocampal volume","volume":"44","author":"Bis","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.biopsych.2016.02.033","article-title":"Multimodal brain imaging reveals structural differences in Alzheimer\u2019s disease polygenic risk carriers: A study in healthy young adults","volume":"81","author":"Foley","year":"2017","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.10.011_bib23","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1002\/hbm.23672","article-title":"Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group: Heritability Estimates of Brain Changes","volume":"38","author":"Brouwer","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.bpsc.2021.10.011_bib24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s11682-014-9296-x","article-title":"Heritable changes in regional cortical thickness with age","volume":"8","author":"Chouinard-Decorte","year":"2014","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.bpsc.2021.10.011_bib25","doi-asserted-by":"crossref","first-page":"116450","DOI":"10.1016\/j.neuroimage.2019.116450","article-title":"Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan","volume":"208","author":"Pomponio","year":"2020","journal-title":"NeuroImage"},{"key":"10.1016\/j.bpsc.2021.10.011_bib26","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009089","article-title":"Association of screen time with self-perceived attention problems and hyperactivity levels in French students: A cross-sectional study","volume":"6","author":"Montagni","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.bpsc.2021.10.011_bib27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000072920","article-title":"Vascular factors and risk of dementia: Design of the three-city study and baseline characteristics of the study population","volume":"22","year":"2003","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.bpsc.2021.10.011_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00234-007-0312-3","article-title":"An automated procedure for the assessment of white matter hyperintensities by multispectral (T1, T2, PD) MRI and an evaluation of its between-centre reproducibility based on two large community databases","volume":"50","author":"Maillard","year":"2008","journal-title":"Neuroradiology"},{"key":"10.1016\/j.bpsc.2021.10.011_bib29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: A tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib30","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"Almasy","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib32","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/ng.2876","article-title":"Advantages and pitfalls in the application of mixed-model association methods","volume":"46","author":"Yang","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/sj.hdy.6800717","article-title":"Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix","volume":"95","author":"Li","year":"2005","journal-title":"Heredity"},{"key":"10.1016\/j.bpsc.2021.10.011_bib35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib37","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature10523","article-title":"Spatio-temporal transcriptome of the human brain","volume":"478","author":"Kang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bpsc.2021.10.011_bib38","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41588-020-00776-w","article-title":"Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer\u2019s disease risk genes","volume":"53","author":"Schwartzentruber","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib39","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: A meta-analysis of genome-wide association studies","volume":"18","author":"Nalls","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.bpsc.2021.10.011_bib40","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1038\/s41467-018-04362-x","article-title":"Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function","volume":"9","author":"Davies","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.bpsc.2021.10.011_bib41","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41467-017-02317-2","article-title":"Causal associations between risk factors and common diseases inferred from GWAS summary data","volume":"9","author":"Zhu","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.bpsc.2021.10.011_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2013.10.003","article-title":"The heritability of volumes of brain structures and its relationship to age: A review of twin and family studies","volume":"13","author":"Batouli","year":"2014","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.bpsc.2021.10.011_bib43","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hbm.20403","article-title":"Structural brain magnetic resonance imaging of pediatric twins","volume":"28","author":"Giedd","year":"2007","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.bpsc.2021.10.011_bib44","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/hbm.25292","article-title":"Genetic scores for adult subcortical volumes associate with subcortical volumes during infancy and childhood","volume":"42","author":"Lamballais","year":"2021","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.bpsc.2021.10.011_bib45","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature25739","article-title":"A\u00a0molecular atlas of cell types and zonation in the brain vasculature","volume":"554","author":"Vanlandewijck","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bpsc.2021.10.011_bib46","doi-asserted-by":"crossref","first-page":"180160","DOI":"10.1038\/sdata.2018.160","article-title":"Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types","volume":"5","author":"He","year":"2018","journal-title":"Sci Data"},{"key":"10.1016\/j.bpsc.2021.10.011_bib47","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0092-8674(01)00586-4","article-title":"The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation","volume":"107","author":"Davis","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bpsc.2021.10.011_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005679","article-title":"A\u00a0comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain complex deficiencies","volume":"12","author":"Kohda","year":"2016","journal-title":"PLoS Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1086\/510559","article-title":"Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu","volume":"80","author":"Valente","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.bpsc.2021.10.011_bib50","doi-asserted-by":"crossref","first-page":"1765.e7","DOI":"10.1016\/j.neurobiolaging.2014.12.028","article-title":"Association of Alzheimer disease GWAS loci with MRI-markers of brain aging","volume":"36","author":"Chauhan","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bpsc.2021.10.011_bib51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2015.12.023","article-title":"The effect of increased genetic risk for Alzheimer\u2019s disease on hippocampal and amygdala volume","volume":"40","author":"Lupton","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bpsc.2021.10.011_bib52","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41398-018-0221-8","article-title":"The genetic risk of Alzheimer\u2019s disease beyond APOE \u03b54: Systematic review of Alzheimer\u2019s genetic risk scores","volume":"8","author":"Stocker","year":"2018","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.bpsc.2021.10.011_bib53","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1212\/WNL.0000000000002922","article-title":"Polygenic risk of Alzheimer disease is associated with early- and late-life processes","volume":"87","author":"Mormino","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.bpsc.2021.10.011_bib54","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3233\/JAD-191233","article-title":"From polygenic scores to precision medicine in Alzheimer\u2019s disease: A systematic review","volume":"74","author":"Harrison","year":"2020","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.bpsc.2021.10.011_bib55","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1176\/appi.ajp.2017.17050529","article-title":"Polygenic risk score for Alzheimer\u2019s disease: Implications for memory performance and hippocampal volumes in early life","volume":"175","author":"Axelrud","year":"2018","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bpsc.2021.10.011_bib56","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neurobiolaging.2010.01.014","article-title":"Fractional anisotropy of water diffusion in cerebral white matter across the lifespan","volume":"33","author":"Kochunov","year":"2012","journal-title":"Neurobiol Aging"}],"container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245190222100286X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245190222100286X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:33:24Z","timestamp":1778888004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245190222100286X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S245190222100286X"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsc.2021.10.011","relation":{},"ISSN":["2451-9022"],"issn-type":[{"value":"2451-9022","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsc.2021.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc on behalf of Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}