{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:28:00Z","timestamp":1762522080944,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GV0615"],"award-info":[{"award-number":["01GV0615"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004937","name":"Bundesministerium f\u00fcr Bildung und Forschung Dienststelle Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018934","name":"University of Greifswald","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018934","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PA 2737\/1-1"],"award-info":[{"award-number":["PA 2737\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.bpsc.2021.11.005","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T20:52:32Z","timestamp":1637614352000},"page":"397-405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Defensive Mobilization During Anticipation of Symptom Provocation: Association With Panic Pathology"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3595-1258","authenticated-orcid":false,"given":"Christoph","family":"Benke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela G.","family":"Alius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons O.","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane A.","family":"Pan\u00e9-Farr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2013","series-title":"Diagnostic and Statistical Manual of Mental Disorders","key":"10.1016\/j.bpsc.2021.11.005_bib1"},{"key":"10.1016\/j.bpsc.2021.11.005_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1037\/0033-295X.108.1.4","article-title":"A\u00a0modern learning theory perspective on the etiology of panic disorder","volume":"108","author":"Bouton","year":"2001","journal-title":"Psychol Rev"},{"key":"10.1016\/j.bpsc.2021.11.005_bib3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/psyp.12553","article-title":"Panic disorder with agoraphobia from a behavioral neuroscience perspective: Applying the research principles formulated by the Research Domain Criteria (RDoC) initiative","volume":"53","author":"Hamm","year":"2016","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2021.11.005_bib4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1101\/lm.039180.115","article-title":"Neurobehavioral perspectives on the distinction between fear and anxiety","volume":"22","author":"Perusini","year":"2015","journal-title":"Learn Mem"},{"key":"10.1016\/j.bpsc.2021.11.005_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/npp.2009.109","article-title":"Phasic vs sustained fear in rats and humans: Role of the extended amygdala in fear vs anxiety","volume":"35","author":"Davis","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsc.2021.11.005_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/wps.20087","article-title":"The RDoC framework: Facilitating transition from ICD\/DSM to dimensional approaches that integrate neuroscience and psychopathology","volume":"13","author":"Cuthbert","year":"2014","journal-title":"World Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.005_bib7","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1017\/S0033291717001192","article-title":"Distinct phasic and sustained brain responses and connectivity of amygdala and bed nucleus of the stria terminalis during threat anticipation in panic disorder","volume":"47","author":"Brinkmann","year":"2017","journal-title":"Psychol Med"},{"key":"10.1016\/j.bpsc.2021.11.005_bib8","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1176\/appi.ajp.2007.07101581","article-title":"Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder","volume":"165","author":"Grillon","year":"2008","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.005_bib9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/2167702616666507","article-title":"Impact of panic on psychophysiological and neural reactivity to unpredictable threat in depression and anxiety","volume":"5","author":"Lieberman","year":"2017","journal-title":"Clin Psychol Sci"},{"key":"10.1016\/j.bpsc.2021.11.005_bib10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.biopsych.2011.03.005","article-title":"Aversive imagery in panic disorder: Agoraphobia severity, comorbidity, and defensive physiology","volume":"70","author":"McTeague","year":"2011","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.005_bib11","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1037\/0003-066X.61.8.741","article-title":"Neural systems involved in fear and anxiety measured with fear-potentiated startle","volume":"61","author":"Davis","year":"2006","journal-title":"Am Psychol"},{"key":"10.1016\/j.bpsc.2021.11.005_bib12","series-title":"International Encyclopedia of the Social & Behavioral Sciences","first-page":"860","article-title":"Fear-potentiated startle","author":"Hamm","year":"2015"},{"key":"10.1016\/j.bpsc.2021.11.005_bib13","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.biopsych.2019.07.028","article-title":"The neurofunctional basis of affective startle modulation in humans: Evidence from combined facial electromyography and functional magnetic resonance imaging","volume":"87","author":"Kuhn","year":"2020","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.005_bib14","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.brat.2008.07.002","article-title":"Anticipation of interoceptive threat in highly anxiety sensitive persons","volume":"46","author":"Melzig","year":"2008","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.bpsc.2021.11.005_bib15","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1469-8986.2007.00560.x","article-title":"Startle reflex modulation and autonomic responding during anxious apprehension in panic disorder patients","volume":"44","author":"Melzig","year":"2007","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2021.11.005_bib16","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1469-8986.1991.tb01999.x","article-title":"Fear-potentiated startle in humans: Effects of anticipatory anxiety on the acoustic blink reflex","volume":"28","author":"Grillon","year":"1991","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2021.11.005_bib17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0006-3223(94)90040-X","article-title":"Baseline and fear-potentiated startle in panic disorder patients","volume":"35","author":"Grillon","year":"1994","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.005_bib18","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1469-8986.1993.tb02055.x","article-title":"Measuring the time course of anticipatory anxiety using the fear-potentiated startle reflex","volume":"30","author":"Grillon","year":"1993","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2021.11.005_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1037\/abn0000233","article-title":"Startle potentiation to uncertain threat as a psychophysiological indicator of fear-based psychopathology: An examination across multiple internalizing disorders","volume":"126","author":"Gorka","year":"2017","journal-title":"J\u00a0Abnorm Psychol"},{"key":"10.1016\/j.bpsc.2021.11.005_bib20","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1037\/a0030747","article-title":"A\u00a0psychophysiological investigation of threat and reward sensitivity in individuals with panic disorder and\/or major depressive disorder","volume":"122","author":"Shankman","year":"2013","journal-title":"J\u00a0Abnorm Psychol"},{"year":"2002","series-title":"Anxiety and Its Disorders. The Nature and Treatment of Anxiety and Panic","author":"Barlow","key":"10.1016\/j.bpsc.2021.11.005_bib21"},{"key":"10.1016\/j.bpsc.2021.11.005_bib22","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuroimage.2012.03.019","article-title":"Brain activation during anticipation of interoceptive threat","volume":"61","author":"Holtz","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2021.11.005_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1037\/0003-066X.61.1.10","article-title":"A\u00a0contemporary learning theory perspective on the etiology of anxiety disorders: It\u2019s not what you thought it was","volume":"61","author":"Mineka","year":"2006","journal-title":"Am Psychol"},{"year":"2011","series-title":"DIPS. Diagnostisches Interview bei psychischen St\u00f6rungen; f\u00fcr DSM-IV-TR; Handbuch, Interviewleitfaden, Protokollbogen; mit CD-ROM","author":"Schneider","key":"10.1016\/j.bpsc.2021.11.005_bib24"},{"year":"1997","series-title":"Instruktionsmanual zur Durchf\u00fchrung von DIA-X-Interviews","author":"Wittchen","key":"10.1016\/j.bpsc.2021.11.005_bib25"},{"key":"10.1016\/j.bpsc.2021.11.005_bib26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1469-8986.2010.01150.x","article-title":"Interoceptive threat leads to defensive mobilization in highly anxiety sensitive persons","volume":"48","author":"Melzig","year":"2011","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2021.11.005_bib27","first-page":"726","article-title":"Stimulus control and data acquisition for IBM PCs and compatibles","volume":"24","author":"Cook","year":"1987","journal-title":"Psychophysiology"},{"year":"1991","series-title":"Multiple Regression: Testing and Interpreting Interactions","author":"Aiken","key":"10.1016\/j.bpsc.2021.11.005_bib28"},{"key":"10.1016\/j.bpsc.2021.11.005_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jbtep.2015.10.009","article-title":"Origins and outlook\u00a0of\u00a0interoceptive exposure","volume":"53","author":"Boettcher","year":"2016","journal-title":"J\u00a0Behav Ther Exp Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.005_bib30","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.brat.2013.06.006","article-title":"Maximizing the efficacy of interoceptive exposure by optimizing inhibitory learning: A randomized controlled trial","volume":"51","author":"Deacon","year":"2013","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.bpsc.2021.11.005_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S003329171000036X","article-title":"Emotion-modulated startle in anxiety disorders is blunted by co-morbid depressive episodes","volume":"41","author":"Taylor-Clift","year":"2011","journal-title":"Psychol Med"},{"key":"10.1016\/j.bpsc.2021.11.005_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070969","article-title":"Major depression is not associated with blunting of aversive responses; evidence for enhanced anxious anticipation","volume":"8","author":"Grillon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bpsc.2021.11.005_bib33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.drugalcdep.2017.08.023","article-title":"Preliminary evidence that reactivity to uncertain threat is an endophenotype for alcohol use disorder","volume":"180","author":"Gorka","year":"2017","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.bpsc.2021.11.005_bib34","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.drugalcdep.2013.02.003","article-title":"Startle response to unpredictable threat in comorbid panic disorder and alcohol dependence","volume":"132","author":"Gorka","year":"2013","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.bpsc.2021.11.005_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12774","article-title":"Behavioral and neural sensitivity to uncertain threat in individuals with alcohol use disorder: Associations with drinking behaviors and motives","volume":"25","author":"Gorka","year":"2020","journal-title":"Addict Biol"},{"key":"10.1016\/j.bpsc.2021.11.005_bib36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0887-6185(95)00032-1","article-title":"Effects of anxiety sensitivity and perceived control on emotional responding to caffeine challenge","volume":"10","author":"Telch","year":"1996","journal-title":"J\u00a0Anxiety Disord"},{"key":"10.1016\/j.bpsc.2021.11.005_bib37","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jbtep.2010.03.008","article-title":"Effects of threat context and cardiac sensitivity on fear\u00a0responding to a 35% CO2 challenge: A test of the context-sensitivity panic vulnerability model","volume":"41","author":"Telch","year":"2010","journal-title":"J\u00a0Behav Ther Exp Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.005_bib38","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.janxdis.2011.02.005","article-title":"Unexpected arousal, anxiety sensitivity, and their interaction on CO2-induced panic: Further evidence for the context-sensitivity vulnerability model","volume":"25","author":"Telch","year":"2011","journal-title":"J\u00a0Anxiety Disord"},{"key":"10.1016\/j.bpsc.2021.11.005_bib39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0005-7894(05)80283-7","article-title":"Role of fear of fear and safety information in moderating the effects of voluntary hyperventilation","volume":"25","author":"Schmidt","year":"1994","journal-title":"Behav Ther"},{"key":"10.1016\/j.bpsc.2021.11.005_bib40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/archpsyc.1989.01810020059010","article-title":"The influence of an illusion of control on panic attacks induced via inhalation of 5.5% carbon dioxide-enriched air","volume":"46","author":"Sanderson","year":"1989","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.005_bib41","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0005-7967(90)90158-F","article-title":"A\u00a0descriptive report of features of initial unexpected panic attacks in minimal and extensive avoiders","volume":"28","author":"Craske","year":"1990","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.bpsc.2021.11.005_bib42","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1037\/0003-066X.55.11.1247","article-title":"Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory","volume":"55","author":"Barlow","year":"2000","journal-title":"Am Psychol"}],"container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902221003189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902221003189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:20:59Z","timestamp":1762521659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451902221003189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S2451902221003189"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsc.2021.11.005","relation":{},"ISSN":["2451-9022"],"issn-type":[{"type":"print","value":"2451-9022"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defensive Mobilization During Anticipation of Symptom Provocation: Association With Panic Pathology","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsc.2021.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}