{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:04:02Z","timestamp":1778774642090,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["42\/FA020000\/685"],"award-info":[{"award-number":["42\/FA020000\/685"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["41\/FA020000\/FFB140317"],"award-info":[{"award-number":["41\/FA020000\/FFB140317"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.bpsc.2021.11.010","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T10:27:08Z","timestamp":1638181628000},"page":"607-615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantification of Metabotropic Glutamate Receptor 5 Availability With Both [11C]ABP688\u00a0and [18F]FPEB Positron Emission Tomography in the Sapap3 Knockout Mouse Model for Obsessive-Compulsive\u2013like Behavior"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3918-608X","authenticated-orcid":false,"given":"Dorien","family":"Glorie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Verhaeghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stef","family":"De Lombaerde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Stroobants","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Staelens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpsc.2021.11.010_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biopsych.2017.08.025","article-title":"Metabotropic glutamatergic receptor 5 and stress disorders: Knowledge gained from receptor imaging studies","volume":"84","author":"Esterlis","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.010_bib2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00259-015-3301-5","article-title":"Metabotropic glutamate receptor 5\u2014A promising target in drug development and neuroimaging","volume":"43","author":"Pillai","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.bpsc.2021.11.010_bib3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/mp.2008.94","article-title":"The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication","volume":"15","author":"Ruscio","year":"2010","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.010_bib4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0140-6736(09)60240-3","article-title":"Obsessive-compulsive disorder","volume":"374","author":"Abramowitz","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.bpsc.2021.11.010_bib5","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"10.1016\/j.bpsc.2021.11.010_bib6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archgenpsychiatry.2010.122","article-title":"Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder","volume":"67","author":"Denys","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.010_bib7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.pharmthera.2011.09.006","article-title":"Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, pathophysiology, and treatment","volume":"132","author":"Pittenger","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bpsc.2021.11.010_bib8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.pbb.2011.10.007","article-title":"The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder","volume":"100","author":"Wu","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bpsc.2021.11.010_bib9","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/mp.2017.154","article-title":"Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis","volume":"23","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.010_bib10","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/npp.2015.26","article-title":"Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice","volume":"40","author":"Aida","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsc.2021.11.010_bib11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnbeh.2020.00057","article-title":"Astrocytic glutamate Transporter 1 (GLT1) deficiency reduces anxiety- and depression-like behaviors in mice","volume":"14","author":"Jia","year":"2020","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.bpsc.2021.11.010_bib12","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature06104","article-title":"Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice","volume":"448","author":"Welch","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bpsc.2021.11.010_bib13","doi-asserted-by":"crossref","first-page":"32155","DOI":"10.1073\/pnas.2008456117","article-title":"Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors","volume":"117","author":"Zhang","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bpsc.2021.11.010_bib14","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s41386-018-0302-7","article-title":"Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression","volume":"44","author":"Delgado-Acevedo","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsc.2021.11.010_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","article-title":"Metabotropic glutamate receptors: Physiology, pharmacology, and disease","volume":"50","author":"Niswender","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bpsc.2021.11.010_bib16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.biopsych.2016.04.023","article-title":"Increased metabotropic glutamate receptor 5 signaling underlies obsessive-compulsive disorder-like behavioral and striatal circuit abnormalities in mice","volume":"80","author":"Ade","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.010_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1176\/appi.ajp.2020.20111601","article-title":"Harmonizing the neurobiology and treatment of obsessive-compulsive disorder","volume":"178","author":"Goodman","year":"2021","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.010_bib18","first-page":"695","article-title":"Investigational and experimental drugs to treat obsessive-compulsive disorder","volume":"12","author":"Grassi","year":"2020","journal-title":"J\u00a0Exp Pharmacol"},{"key":"10.1016\/j.bpsc.2021.11.010_bib19","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s12325-016-0468-5","article-title":"Mavoglurant augmentation in OCD patients resistant to selective serotonin reuptake inhibitors: A proof-of-concept, randomized, placebo-controlled, phase 2 study","volume":"34","author":"Rutrick","year":"2017","journal-title":"Adv Ther"},{"key":"10.1016\/j.bpsc.2021.11.010_bib20","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1080\/14656566.2018.1528230","article-title":"Current and up-and-coming pharmacotherapy for obsessive-compulsive disorder in adults","volume":"19","author":"Grassi","year":"2018","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.bpsc.2021.11.010_bib21","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.3390\/molecules25204749","article-title":"A\u00a0review of molecular imaging of glutamate receptors","volume":"25","author":"Kim","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bpsc.2021.11.010_bib22","first-page":"698","article-title":"Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5","volume":"47","author":"Ametamey","year":"2006","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.bpsc.2021.11.010_bib23","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/syn.20445","article-title":"Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5","volume":"61","author":"Wang","year":"2007","journal-title":"Synapse"},{"key":"10.1016\/j.bpsc.2021.11.010_bib24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41398-020-01152-2","article-title":"Study of influence of the glutamatergic concentration of [18F]FPEB binding to metabotropic glutamate receptor subtype 5 with N-acetylcysteine challenge in rats and SRM\/PET study in human healthy volunteers","volume":"11","author":"Dupont","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.010_bib25","series-title":"FPEB and ABP688 Cannot Accesss Internalized MGluR5 Receptors. mGluR5 Workshop","author":"Lin","year":"2015"},{"key":"10.1016\/j.bpsc.2021.11.010_bib26","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.2967\/jnumed.115.162636","article-title":"Preclinical evaluation and quantification of 18F-FPEB as a radioligand for PET imaging of the metabotropic glutamate receptor 5","volume":"56","author":"De Laat","year":"2015","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.bpsc.2021.11.010_bib27","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3389\/fneur.2018.00516","article-title":"Noninvasive relative quantification of [11C]ABP688 PET imaging in mice versus an input function measured over an arteriovenous shunt","volume":"9","author":"Verhaeghe","year":"2018","journal-title":"Front Neurol"},{"key":"10.1016\/j.bpsc.2021.11.010_bib28","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.nucmedbio.2007.07.009","article-title":"Species differences in mGluR5 binding sites in mammalian central nervous system determined using in\u00a0vitro binding with [18F]F-PEB","volume":"34","author":"Patel","year":"2007","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.bpsc.2021.11.010_bib29","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1017\/S1461145714000716","article-title":"Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder","volume":"17","author":"Akkus","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.bpsc.2021.11.010_bib30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/npp.2014.245","article-title":"Relationship between in\u00a0vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in\u00a0vitro binding profiles","volume":"40","author":"Rook","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsc.2021.11.010_bib31","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s00259-010-1723-7","article-title":"In\u00a0vivo positron emission tomography imaging with [11C]ABP688: Binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons","volume":"38","author":"Delorenzo","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.bpsc.2021.11.010_bib32","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/jcbfm.2010.65","article-title":"In\u00a0vivo and in\u00a0vitro validation of reference tissue models for the mGluR (5) ligand [11C]ABP688","volume":"30","author":"Elmenhorst","year":"2010","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.bpsc.2021.11.010_bib33","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1177\/0271678X16673646","article-title":"In\u00a0vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB","volume":"37","author":"DeLorenzo","year":"2017","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.bpsc.2021.11.010_bib34","doi-asserted-by":"crossref","first-page":"108160","DOI":"10.1016\/j.neuropharm.2020.108160","article-title":"Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [11C]ABP688 PET study","volume":"177","author":"Glorie","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bpsc.2021.11.010_bib35","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/ejn.12510","article-title":"Synaptic basis of social dysfunction: A focus on postsynaptic proteins linking group-I mGluRs with AMPARs and NMDARs","volume":"39","author":"O\u2019Connor","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.bpsc.2021.11.010_bib36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/cne.20060","article-title":"Differential mRNA expression and protein localization of the SAP90\/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse","volume":"472","author":"Welch","year":"2004","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1016\/j.bpsc.2021.11.010_bib37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s002590050211","article-title":"Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals","volume":"25","author":"Hume","year":"1998","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.bpsc.2021.11.010_bib38","doi-asserted-by":"crossref","DOI":"10.1088\/2057-1976\/ab8c13","article-title":"Validation of a spatially variant resolution model for small animal brain PET studies","volume":"6","author":"Miranda","year":"2020","journal-title":"Biomed Phys Eng Express"},{"key":"10.1016\/j.bpsc.2021.11.010_bib39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuroimage.2010.06.067","article-title":"Waxholm Space: An image-based reference for coordinating mouse brain research","volume":"53","author":"Johnson","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2021.11.010_bib40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/nimg.1996.0066","article-title":"Simplified reference tissue model for PET receptor studies","volume":"4","author":"Lammertsma","year":"1996","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2021.11.010_bib41","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1097\/01.WCB.0000033967.83623.34","article-title":"Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging","volume":"22","author":"Wu","year":"2002","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.bpsc.2021.11.010_bib42","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1177\/0271678X19886316","article-title":"Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET","volume":"40","author":"Holmes","year":"2020","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.bpsc.2021.11.010_bib43","first-page":"390","article-title":"Evaluation of 11C-ABP688 and 18F-FPEB for imaging mGluR5 receptors in the human brain","volume":"52","author":"Kuwabara","year":"2011","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.bpsc.2021.11.010_bib44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/syn.20147","article-title":"Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers","volume":"56","author":"Hamill","year":"2005","journal-title":"Synapse"},{"key":"10.1016\/j.bpsc.2021.11.010_bib45","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/35082096","article-title":"Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer","volume":"411","author":"Ango","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bpsc.2021.11.010_bib46","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/sj.jcbfm.9600493","article-title":"Consensus nomenclature for in\u00a0vivo imaging of reversibly binding radioligands","volume":"27","author":"Innis","year":"2007","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.bpsc.2021.11.010_bib47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbrc.2012.09.040","article-title":"Constitutive internalization and recycling of metabotropic glutamate receptor 5 (mGluR5)","volume":"427","author":"Trivedi","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bpsc.2021.11.010_bib48","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.biopsych.2014.06.024","article-title":"In\u00a0vivo ketamine-induced changes in [11C]ABP688 binding to metabotropic glutamate receptor subtype 5","volume":"77","author":"Delorenzo","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.010_bib49","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/mp.2017.58","article-title":"Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: An [11C]ABP688 and PET imaging study in depression","volume":"23","author":"Esterlis","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2021.11.010_bib50","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.2967\/jnumed.113.121608","article-title":"N-acetylcysteine-and MK-801-induced changes in glutamate levels do not affect in\u00a0vivo binding of metabotropic glutamate 5 receptor radioligand 11C-ABP688 in rat brain","volume":"54","author":"Wyckhuys","year":"2013","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.bpsc.2021.11.010_bib51","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.nucmedbio.2010.04.107","article-title":"Evaluation of a bolus\/infusion protocol for 11C-ABP688, a PET tracer for mGluR5","volume":"37","author":"Burger","year":"2010","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.bpsc.2021.11.010_bib52","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1007\/s00259-015-3094-6","article-title":"Test\u2013retest reproducibility of the metabotropic glutamate receptor 5 ligand [18F]FPEB with bolus plus constant infusion in humans","volume":"42","author":"Park","year":"2015","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.bpsc.2021.11.010_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/syn.22041","article-title":"Test\u2013retest variability of [11C]ABP688 estimates of metabotropic glutamate receptor subtype 5 availability in humans","volume":"72","author":"Smart","year":"2018","journal-title":"Synapse"},{"key":"10.1016\/j.bpsc.2021.11.010_bib54","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2967\/jnumed.112.107995","article-title":"18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: A first-in-human study of radiochemical safety, biokinetics, and radiation dosimetry","volume":"54","author":"Wong","year":"2013","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.bpsc.2021.11.010_bib55","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/syn.21890","article-title":"Kinetic modeling and long-term test-retest reproducibility of the mGluR5 PET tracer 18F-FPEB in human brain","volume":"70","author":"Leurquin-Sterk","year":"2016","journal-title":"Synapse"},{"key":"10.1016\/j.bpsc.2021.11.010_bib56","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/syn.21542","article-title":"Test-retest stability of cerebral mGluR 5 quantification using [11C]ABP688 and positron emission tomography in rats","volume":"66","author":"Elmenhorst","year":"2012","journal-title":"Synapse"}],"container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902221003232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902221003232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:18:29Z","timestamp":1762521509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451902221003232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S2451902221003232"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsc.2021.11.010","relation":{},"ISSN":["2451-9022"],"issn-type":[{"value":"2451-9022","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification of Metabotropic Glutamate Receptor 5 Availability With Both [11C]ABP688\u00a0and [18F]FPEB Positron Emission Tomography in the Sapap3 Knockout Mouse Model for Obsessive-Compulsive\u2013like Behavior","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsc.2021.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}