{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:25:08Z","timestamp":1790511908659,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23 MH123931-01A1"],"award-info":[{"award-number":["K23 MH123931-01A1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006942","name":"Medical University of South Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010647","name":"Canadian Thoracic Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bpsc.2022.07.010","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T22:19:26Z","timestamp":1659997166000},"page":"712-719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Coping in the Clinic: Effects of Clinically Elevated Anxiety on Dynamic Neurophysiological Mechanisms of Escape\/Avoidance Preparation"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0040-0939","authenticated-orcid":false,"given":"Christopher T.","family":"Sege","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle L.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Fleischmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"McTeague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpsc.2022.07.010_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10879-006-9008-y","article-title":"Emotional processing theory (EPT) and exposure therapy for PTSD","volume":"36","author":"Rauch","year":"2006","journal-title":"J\u00a0Contemp Psychother"},{"key":"10.1016\/j.bpsc.2022.07.010_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neubiorev.2018.03.015","article-title":"The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research","volume":"88","author":"Pittig","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bpsc.2022.07.010_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brat.2017.04.009","article-title":"Treatment of avoidance behavior as an adjunct to exposure therapy: Insights from modern learning theory","volume":"96","author":"Treanor","year":"2017","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.bpsc.2022.07.010_bib4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1037\/tra0000484","article-title":"Predicting treatment dropout among veterans receiving prolonged exposure therapy","volume":"12","author":"Eftekhari","year":"2020","journal-title":"Psychol Trauma"},{"key":"10.1016\/j.bpsc.2022.07.010_bib5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.brat.2017.04.009","article-title":"Treatment of avoidance behavior as an adjunct to exposure therapy: Insights from modern learning theory","volume":"96","author":"Treanor","year":"2017","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.bpsc.2022.07.010_bib6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/psyp.12553","article-title":"Panic disorder with agoraphobia from a behavioral neuroscience perspective: Applying the research principles formulated by the Research Domain Criteria (RDoC) initiative","volume":"53","author":"Hamm","year":"2016","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2022.07.010_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/mp.2016.166","article-title":"The birth, death and resurrection of avoidance: A reconceptualization of a troubled paradigm","volume":"22","author":"LeDoux","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2022.07.010_bib8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0149-7634(96)00061-9","article-title":"Opposing roles of the amygdala and dorsolateral periaqueductal gray in fear-potentiated startle","volume":"21","author":"Walker","year":"1997","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bpsc.2022.07.010_bib9","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/s41593-018-0222-1","article-title":"Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli","volume":"21","author":"Menegas","year":"2018","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bpsc.2022.07.010_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3758\/LB.38.1.50","article-title":"Two-factor theory, the actor-critic model, and conditioned avoidance","volume":"38","author":"Maia","year":"2010","journal-title":"Learn Behav"},{"key":"10.1016\/j.bpsc.2022.07.010_bib11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/psyp.12842","article-title":"Escaping aversive exposure","volume":"54","author":"Sege","year":"2017","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2022.07.010_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.brat.2018.03.002","article-title":"Avoidance and escape: Defensive reactivity and trait anxiety","volume":"104","author":"Sege","year":"2018","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.bpsc.2022.07.010_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(06)56001-7","article-title":"Emotion, motivation, and the brain: Reflex foundations in animal and human research","volume":"156","author":"Lang","year":"2006","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.bpsc.2022.07.010_bib14","series-title":"An Introduction to the Event-Related Potential Technique","author":"Luck","year":"2014"},{"key":"10.1016\/j.bpsc.2022.07.010_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0301-0511(94)90048-5","article-title":"Motor and non-motor aspects of slow brain potentials","volume":"38","author":"Van Boxtel","year":"1994","journal-title":"Biol Psychol"},{"key":"10.1016\/j.bpsc.2022.07.010_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0167-8760(01)00179-9","article-title":"Wait and see","volume":"43","author":"Brunia","year":"2001","journal-title":"Int J Psychophysiol"},{"key":"10.1016\/j.bpsc.2022.07.010_bib17","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ejp.990","article-title":"Measuring expectation of pain: Contingent negative variation in placebo and nocebo effects","volume":"21","author":"Piedimonte","year":"2017","journal-title":"Eur J Pain"},{"key":"10.1016\/j.bpsc.2022.07.010_bib18","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/psyp.12786","article-title":"Perceived control increases the reward positivity and stimulus preceding negativity","volume":"54","author":"M\u00fchlberger","year":"2017","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2022.07.010_bib19","series-title":"Manual for the State-Trait Anxiety Inventory","author":"Spielberger","year":"1983"},{"key":"10.1016\/j.bpsc.2022.07.010_bib20","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41398-019-0508-4","article-title":"Trait anxiety on effort allocation to monetary incentives: A behavioral and high-density EEG study","volume":"9","author":"Berchio","year":"2019","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.bpsc.2022.07.010_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pscychresns.2019.06.007","article-title":"Disruption of volitional control in obsessive\u2013compulsive disorder: Evidence from the bereitschaftspotential","volume":"290","author":"Takashima","year":"2019","journal-title":"Psychiatry Res Neuroimaging"},{"key":"10.1016\/j.bpsc.2022.07.010_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neuroscience.2016.06.013","article-title":"Impact of anxiety on prefrontal cortex encoding of cognitive flexibility","volume":"345","author":"Park","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.bpsc.2022.07.010_bib23","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.actpsy.2007.11.007","article-title":"The relevance of recent developments in classical conditioning to understanding the etiology and maintenance of anxiety disorders","volume":"127","author":"Mineka","year":"2008","journal-title":"Acta Psychol (Amst)"},{"key":"10.1016\/j.bpsc.2022.07.010_bib24","volume":"vol. 10","author":"Beck","year":"1996"},{"key":"10.1016\/j.bpsc.2022.07.010_bib25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2190\/5DCP-25BV-U1G9-9G7C","article-title":"The emotional impact of end-stage renal disease: Importance of patients\u2019 perception of intrusiveness and control","volume":"13","author":"Devins","year":"1983","journal-title":"Int J Psychiatric Med"},{"key":"10.1016\/j.bpsc.2022.07.010_bib26","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J\u00a0Clin Psychol"},{"key":"10.1016\/j.bpsc.2022.07.010_bib27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jneumeth.2009.12.009","article-title":"The ERP PCA Toolkit: An open source program for advanced statistical analysis of event-related potential data","volume":"187","author":"Dien","year":"2010","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.bpsc.2022.07.010_bib28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/87565641.2012.697503","article-title":"Applying principal components analysis to event-related potentials: A tutorial","volume":"37","author":"Dien","year":"2012","journal-title":"Dev Neuropsychol"},{"key":"10.1016\/j.bpsc.2022.07.010_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-8986.1997.tb02409.x","article-title":"Probe P3 and blinks: Two measures of affective startle modulation","volume":"34","author":"Schupp","year":"1997","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2022.07.010_bib30","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1469-8986.1987.tb00320.x","article-title":"Editorial policy on analyses of variance with repeated measures","volume":"24","author":"Jennings","year":"1987","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2022.07.010_bib31","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/1469-8986.3540470","article-title":"Testing treatment effects in repeated measures designs: An update for psychophysiological researchers","volume":"35","author":"Keselman","year":"1998","journal-title":"Psychophysiology"},{"key":"10.1016\/j.bpsc.2022.07.010_bib32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.biopsycho.2010.12.013","article-title":"The neural correlates of cognitive effort in anxiety: Effects on processing efficiency","volume":"86","author":"Ansari","year":"2011","journal-title":"Biol Psychol"},{"key":"10.1016\/j.bpsc.2022.07.010_bib33","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1037\/a0033531","article-title":"The neural correlates of impaired attentional control in social anxiety: An ERP study of inhibition and shifting","volume":"13","author":"Judah","year":"2013","journal-title":"Emotion"},{"key":"10.1016\/j.bpsc.2022.07.010_bib34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bandc.2015.01.002","article-title":"Anticipatory processes under academic stress: An ERP study","volume":"94","author":"Duan","year":"2015","journal-title":"Brain Cogn"},{"key":"10.1016\/j.bpsc.2022.07.010_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brat.2017.03.005","article-title":"Enhanced action tendencies in obsessive\u2013compulsive disorder: An ERP study","volume":"93","author":"Dayan","year":"2017","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.bpsc.2022.07.010_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsycho.2021.108144","article-title":"Trait anxiety modulates the temporal dynamics of Stroop task switching: An ERP study","volume":"163","author":"Wu","year":"2021","journal-title":"Biol Psychol"},{"key":"10.1016\/j.bpsc.2022.07.010_bib37","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1037\/1528-3542.1.3.276","article-title":"Emotion and motivation I: Defensive and appetitive reactions in picture processing","volume":"1","author":"Bradley","year":"2001","journal-title":"Emotion"},{"key":"10.1016\/j.bpsc.2022.07.010_bib38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/da.21891","article-title":"The anxiety spectrum and the reflex physiology of defense: From circumscribed fear to broad distress","volume":"29","author":"McTeague","year":"2012","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.bpsc.2022.07.010_bib39","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1037\/0003-066X.61.8.741","article-title":"Neural systems involved in fear and anxiety measured with fear-potentiated startle","volume":"61","author":"Davis","year":"2006","journal-title":"Am Psychol"},{"key":"10.1016\/j.bpsc.2022.07.010_bib40","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.biopsych.2019.07.028","article-title":"The neurofunctional basis of affective startle modulation in humans: Evidence from combined facial electromyography and functional magnetic resonance imaging","volume":"87","author":"Kuhn","year":"2020","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2022.07.010_bib41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1101\/lm.1676610","article-title":"The role of amygdala nuclei in the expression of auditory signaled two-way active avoidance in rats","volume":"17","author":"Choi","year":"2010","journal-title":"Learn Mem"},{"key":"10.1016\/j.bpsc.2022.07.010_bib42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1207\/s15327558ijbm0401_6","article-title":"You want to measure coping but your protocol\u2019s too long: Consider the brief COPE","volume":"4","author":"Carver","year":"1997","journal-title":"Int J Behav Med"},{"key":"10.1016\/j.bpsc.2022.07.010_bib43","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.biopsych.2014.02.014","article-title":"Ventromedial prefrontal cortex is critical for the regulation of amygdala activity in humans","volume":"77","author":"Motzkin","year":"2015","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2022.07.010_bib44","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.cell.2018.09.028","article-title":"The basolateral amygdala is essential for rapid escape: A human and rodent study","volume":"175","author":"Terburg","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bpsc.2022.07.010_bib45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.biopsycho.2005.11.004","article-title":"The strong situation: A potential impediment to studying the psychobiology and pharmacology of anxiety disorders","volume":"72","author":"Lissek","year":"2006","journal-title":"Biol Psychol"}],"container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902222001835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902222001835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:21:37Z","timestamp":1762521697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451902222001835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S2451902222001835"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsc.2022.07.010","relation":{},"ISSN":["2451-9022"],"issn-type":[{"value":"2451-9022","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coping in the Clinic: Effects of Clinically Elevated Anxiety on Dynamic Neurophysiological Mechanisms of Escape\/Avoidance Preparation","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsc.2022.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}