{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:22:47Z","timestamp":1740176567560,"version":"3.37.3"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001034","name":"Australian Liver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","award":["2013\u201307434","2019\u201301138"],"award-info":[{"award-number":["2013\u201307434","2019\u201301138"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["213674\/Z\/18\/Z"],"award-info":[{"award-number":["213674\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016670","name":"Region \u00d6sterg\u00f6tland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.bpsc.2023.12.001","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T03:39:06Z","timestamp":1703302746000},"page":"437-446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contributions of Polygenic Risk and Disease Status to Gray Matter Abnormalities in Major Depression"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1107-5644","authenticated-orcid":false,"given":"Robin","family":"K\u00e4mpe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth R.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"\u00d6stman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Heilig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Paul","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpsc.2023.12.001_bib1","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1176\/appi.ajp.161.11.1957","article-title":"Hippocampal volume and depression: A meta-analysis of MRI studies","volume":"161","author":"Videbech","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/mp.2008.57","article-title":"Amygdala volume in major depressive disorder: A meta-analysis of magnetic resonance imaging studies","volume":"13","author":"Hamilton","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neubiorev.2021.07.002","article-title":"Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis","volume":"129","author":"Serra-Blasco","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bpsc.2023.12.001_bib4","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1176\/appi.ajp.2019.19050560","article-title":"Multimodal abnormalities of brain structure and function in major depressive disorder: A\u00a0meta-analysis of neuroimaging studies","volume":"177","author":"Gray","year":"2020","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib5","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/mp.2016.60","article-title":"Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group","volume":"22","author":"Schmaal","year":"2017","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.pnpbp.2018.08.008","article-title":"Cortical thickness in major depressive disorder: A systematic review and meta-analysis","volume":"88","author":"Suh","year":"2019","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41386-019-0563-9","article-title":"Meta-analysis of cortical thickness abnormalities in medication-free patients with major depressive disorder","volume":"45","author":"Li","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsc.2023.12.001_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1001\/archgenpsychiatry.2009.202","article-title":"Decreased hippocampal volume in healthy girls at risk of depression","volume":"67","author":"Chen","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bpsgos.2022.05.008","article-title":"Specificity of psychiatric polygenic risk scores and their effects on associated risk phenotypes","volume":"3","author":"Rodrigue","year":"2023","journal-title":"Biol Psychiatry Glob Open Sci"},{"key":"10.1016\/j.bpsc.2023.12.001_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2019.07.065","article-title":"State-independent and -dependent structural alterations in limbic-cortical regions in patients with current and remitted depression","volume":"258","author":"Xiong","year":"2019","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.bpsc.2023.12.001_bib11","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/mp.2015.69","article-title":"Subcortical brain alterations in major depressive disorder: Findings from the ENIGMA Major Depressive Disorder working group","volume":"21","author":"Schmaal","year":"2016","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib12","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/s41380-020-01002-z","article-title":"Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders","volume":"26","author":"Radonji\u0107","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib13","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1038\/s41380-022-01687-4","article-title":"Reduced hippocampal gray matter volume is\u00a0a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders","volume":"27","author":"Brosch","year":"2022","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41593-018-0326-7","article-title":"Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions","volume":"22","author":"Howard","year":"2019","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bpsc.2023.12.001_bib15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/nimg.1995.1032","article-title":"A\u00a0voxel-based method for the statistical analysis of gray and white matter density applied to schizophrenia","volume":"2","author":"Wright","year":"1995","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2023.12.001_bib16","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry\u2014The methods","volume":"11","author":"Ashburner","year":"2000","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2023.12.001_bib17","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.neuroimage.2008.01.003","article-title":"Ten simple rules for reporting voxel-based morphometry studies","volume":"40","author":"Ridgway","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2023.12.001_bib18","first-page":"1","article-title":"MatchIt: Nonparametric preprocessing for parametric causal inference","volume":"42","author":"Ho","year":"2011","journal-title":"J\u00a0Stat Softw"},{"key":"10.1016\/j.bpsc.2023.12.001_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.bpsc.2023.12.001_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A\u00a0voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2023.12.001_bib21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.bpsc.2023.12.001_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12883-015-0274-8","article-title":"Disparate voxel based morphometry (VBM) results between SPM and FSL softwares in ALS patients with frontotemporal dementia: Which VBM results to consider?","volume":"15","author":"Rajagopalan","year":"2015","journal-title":"BMC Neurol"},{"key":"10.1016\/j.bpsc.2023.12.001_bib23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.neuroimage.2009.06.043","article-title":"A\u00a0comparison between voxel-based cortical thickness and voxel-based morphometry in normal aging","volume":"48","author":"Hutton","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2023.12.001_bib24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2023.12.001_bib25","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/s12311-020-01157-z","article-title":"Abnormal cerebellar volume in patients with remitted major depression with persistent cognitive deficits","volume":"19","author":"Depping","year":"2020","journal-title":"Cerebellum"},{"key":"10.1016\/j.bpsc.2023.12.001_bib26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12888-018-1761-4","article-title":"Bayesian alternatives for common null-hypothesis significance tests in psychiatry: A non-technical guide using JASP","volume":"18","author":"Quintana","year":"2018","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib27","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41593-020-0660-4","article-title":"Using Bayes factor hypothesis testing in neuroscience to establish evidence of absence","volume":"23","author":"Keysers","year":"2020","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bpsc.2023.12.001_bib28","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1152\/jn.00339.2011","article-title":"The organization of the human cerebellum estimated by intrinsic functional connectivity","volume":"106","author":"Buckner","year":"2011","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.bpsc.2023.12.001_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133402","article-title":"Surface-based display of volume-averaged cerebellar imaging data","volume":"10","author":"Diedrichsen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bpsc.2023.12.001_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2018.04.004","article-title":"Human adult neurogenesis: Evidence and remaining questions","volume":"23","author":"Kempermann","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bpsc.2023.12.001_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.576444","article-title":"Beyond the hippocampus and the SVZ: Adult neurogenesis throughout the brain","volume":"14","author":"Jurkowski","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.bpsc.2023.12.001_bib32","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jpsychires.2009.08.011","article-title":"Anterior cingulate pyramidal neurons display altered dendritic branching in depressed suicides","volume":"44","author":"Hercher","year":"2010","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.bpsc.2023.12.001_bib33","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.biopsych.2003.11.006","article-title":"Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes","volume":"55","author":"Hamidi","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib34","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nm.4386","article-title":"Sex-specific transcriptional signatures in human depression","volume":"23","author":"Labont\u00e9","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.bpsc.2023.12.001_bib35","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41588-019-0379-x","article-title":"Clinical use of current polygenic risk scores may exacerbate health disparities","volume":"51","author":"Martin","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2023.12.001_bib36","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0006-3223(02)01404-X","article-title":"Low glial numbers in the amygdala in major depressive disorder","volume":"52","author":"Bowley","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.001_bib37","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ng.3367","article-title":"A\u00a0gene-based association method for mapping traits using reference transcriptome data","volume":"47","author":"Gamazon","year":"2015","journal-title":"Nat Genet"}],"container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902223003385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902223003385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T22:57:32Z","timestamp":1729119452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451902223003385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S2451902223003385"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsc.2023.12.001","relation":{},"ISSN":["2451-9022"],"issn-type":[{"type":"print","value":"2451-9022"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contributions of Polygenic Risk and Disease Status to Gray Matter Abnormalities in Major Depression","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsc.2023.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2023 Published by Elsevier Inc on behalf of Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}