{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:54:38Z","timestamp":1788926078069,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006442","name":"Det Sundhedsvidenskabelige Fakultet, K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020584","name":"Region Hovedstadens Psykiatri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R155-2013-16337"],"award-info":[{"award-number":["R155-2013-16337"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.bpsc.2023.12.002","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T17:13:00Z","timestamp":1703351580000},"page":"703-713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Trajectory of Prefrontal GABA Levels in Initially Antipsychotic-Na\u00efve Patients With Psychosis During 2 Years of Treatment and Associations With Striatal Cerebral Blood Flow and Outcome"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-3154","authenticated-orcid":false,"given":"Kirsten Borup","family":"Bojesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egill","family":"Rostrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Korning","family":"Sigvard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.E.","family":"Edden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn Hylsebeck","family":"Ebdrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Glenth\u00f8j","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpsc.2023.12.002_bib1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nrn1648","article-title":"Cortical inhibitory neurons and schizophrenia","volume":"6","author":"Lewis","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bpsc.2023.12.002_bib2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/schbul\/sbx199","article-title":"The circuitry of dopamine system regulation and its disruption in schizophrenia: Insights into treatment and prevention","volume":"45","author":"Grace","year":"2019","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.bpsc.2023.12.002_bib3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41380-021-01297-6","article-title":"Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: A meta-analysis of 1H-magnetic resonance spectroscopy studies","volume":"27","author":"Nakahara","year":"2022","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1001\/jamapsychiatry.2018.3637","article-title":"Assessing brain metabolism with 7-T proton magnetic resonance spectroscopy in patients with first-episode psychosis","volume":"76","author":"Wang","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.biopsych.2020.06.027","article-title":"Associations between cognitive function and levels of glutamatergic metabolites and gamma-aminobutyric acid in antipsychotic-naive patients with schizophrenia or psychosis","volume":"89","author":"Bojesen","year":"2021","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib8","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1017\/S0033291719002277","article-title":"Treatment response after 6 and 26 weeks is related to baseline glutamate and GABA levels in antipsychotic-naive patients with psychosis","volume":"50","author":"Bojesen","year":"2020","journal-title":"Psychol Med"},{"key":"10.1016\/j.bpsc.2023.12.002_bib37","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.biopsych.2017.09.028","article-title":"Prefrontal and striatal gamma-aminobutyric acid levels and the effect of antipsychotic treatment in first-episode psychosis patients","volume":"83","author":"de la Fuente-Sandoval","year":"2018","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib7","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1038\/s41380-023-01969-5","article-title":"Longitudinal changes in brain metabolites in healthy controls and patients with first episode psychosis: A 7-Tesla MRS study","volume":"28","author":"Wang","year":"2023","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.biopsych.2021.08.023","volume":"91","author":"Sigvard","year":"2022","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/schbul\/sbu220","article-title":"Striatal D(2\/3) binding potential values in drug-naive first-episode schizophrenia patients correlate with treatment outcome","volume":"41","author":"Wulff","year":"2015","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.bpsc.2023.12.002_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033291723000144","article-title":"Cerebral blood flow in striatum is increased by partial dopamine agonism in initially antipsychotic-na\u00efve patients with psychosis","volume":"53","author":"Bojesen","year":"2023","journal-title":"Psychol Med"},{"key":"10.1016\/j.bpsc.2023.12.002_bib12","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0006-3223(01)01251-3","article-title":"Dopamine D(2) receptors and their role in atypical antipsychotic action: Still necessary and may even be sufficient","volume":"50","author":"Kapur","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1196\/annals.1300.066","article-title":"Anatomical substrates for glutamate-dopamine interactions: Evidence for specificity of connections and extrasynaptic actions","volume":"1003","author":"Sesack","year":"2003","journal-title":"Ann N Y Acad Sci"},{"issue":"suppl 4","key":"10.1016\/j.bpsc.2023.12.002_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/PL00014183","article-title":"Neurotransmitter interactions in schizophrenia-therapeutic implications","volume":"249","author":"Carlsson","year":"1999","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.bpsc.2023.12.002_bib15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/cercor\/bhj002","article-title":"Properties of excitatory synaptic responses in fast-spiking interneurons and pyramidal cells from monkey and rat prefrontal cortex","volume":"16","author":"Povysheva","year":"2006","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bpsc.2023.12.002_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/syn.20131","article-title":"Cortical GABAergic regulation of dopaminergic responses to psychological stress in the rat dorsolateral striatum","volume":"56","author":"Matsumoto","year":"2005","journal-title":"Synapse"},{"key":"10.1016\/j.bpsc.2023.12.002_bib17","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.bpsgos.2022.05.004","article-title":"Dopamine Synthesis Capacity and GABA and Glutamate Levels Separate Antipsychotic-Na\u00efve Patients With First-Episode Psychosis From Healthy Control Subjects in a Multimodal Prediction Model","volume":"3","author":"Sigvard","year":"2022","journal-title":"Biological Psychiatry Global Open Science"},{"key":"10.1016\/j.bpsc.2023.12.002_bib18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archpsyc.1990.01810180089012","article-title":"Scan. Schedules for clinical assessment in neuropsychiatry","volume":"47","author":"Wing","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.bpsc.2023.12.002_bib20","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/sj.npp.1301325","article-title":"Defining \u2018response\u2019 in antipsychotic drug trials: Recommendations for the use of scale-derived cutoffs","volume":"32","author":"Leucht","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsc.2023.12.002_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0033-3182(95)71666-8","article-title":"Global assessment of functioning: A modified scale","volume":"36","author":"Hall","year":"1995","journal-title":"Psycosomatics"},{"key":"10.1016\/j.bpsc.2023.12.002_bib22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fpsyt.2018.00022","article-title":"Glutamate levels and resting cerebral blood flow in anterior cingulate cortex are associated at rest and immediately following infusion of S-ketamine in healthy volunteers","volume":"9","author":"Bojesen","year":"2018","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/(SICI)1099-1492(199810)11:6<266::AID-NBM530>3.0.CO;2-J","article-title":"Simultaneous in\u00a0vivo spectral editing and water suppression","volume":"11","author":"Mescher","year":"1998","journal-title":"NMR Biomed"},{"key":"10.1016\/j.bpsc.2023.12.002_bib24","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/jmri.24478","article-title":"Gannet: A batch-processing tool for the quantitative analysis of gamma-aminobutyric acid-edited MR spectroscopy spectra","volume":"40","author":"Edden","year":"2014","journal-title":"J\u00a0Magn Reson Imaging"},{"key":"10.1016\/j.bpsc.2023.12.002_bib25","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/mrm.21790","article-title":"Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields","volume":"60","author":"Dai","year":"2008","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.bpsc.2023.12.002_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15622975.2020.1731925","article-title":"Frontal GABA in schizophrenia: A meta-analysis of 1H-MRS studies","volume":"22","author":"Kumar","year":"2021","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib27","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1523\/JNEUROSCI.4439-05.2006","article-title":"Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats","volume":"26","author":"Mallet","year":"2006","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.bpsc.2023.12.002_bib28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/brain\/116.2.433","article-title":"Electrophysiology of dopamine-denervated striatal neurons. Implications for Parkinson\u2019s disease","volume":"116","author":"Calabresi","year":"1993","journal-title":"Brain"},{"key":"10.1016\/j.bpsc.2023.12.002_bib29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.semcdb.2021.02.008","article-title":"Developmental regulation of excitatory-inhibitory synaptic balance in the prefrontal cortex during adolescence","volume":"118","author":"Caballero","year":"2021","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.bpsc.2023.12.002_bib30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neubiorev.2021.11.010","article-title":"Frontal neural metabolite changes in schizophrenia and their association with cognitive control: A systematic review","volume":"132","author":"Dixon","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bpsc.2023.12.002_bib31","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.biopsych.2022.06.017","article-title":"Integrating the neurodevelopmental and dopamine hypotheses of schizophrenia and the role of cortical excitation-inhibition balance","volume":"92","author":"Howes","year":"2022","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mcna.2021.08.012","article-title":"Benzodiazepines and related sedatives","volume":"106","author":"Peng","year":"2022","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.bpsc.2023.12.002_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pscychresns.2014.05.009","article-title":"Zolpidem increases GABA in depressed volunteers maintained on SSRIs","volume":"224","author":"Licata","year":"2014","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.bpsc.2023.12.002_bib34","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1038\/npp.2014.79","article-title":"Neuropharmacological and neurobiological relevance of in\u00a0vivo 1H-MRS of GABA and glutamate for preclinical drug discovery in mental disorders","volume":"39","author":"Waschkies","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsc.2023.12.002_bib35","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1038\/npp.2012.142","article-title":"The impact of gabapentin administration on brain GABA and glutamate concentrations: A 7T 1H-MRS study","volume":"37","author":"Cai","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsc.2023.12.002_bib36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3109\/15622975.2012.696143","article-title":"World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance","volume":"13","author":"Hasan","year":"2012","journal-title":"World J Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib38","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/archgenpsychiatry.2011.1519","article-title":"Elevated prefrontal cortex gamma-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in\u00a0vivo with proton magnetic resonance spectroscopy","volume":"69","author":"Kegeles","year":"2012","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib39","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.pnpbp.2007.10.017","article-title":"Treatment with haloperidol and diazepam alters GABAA receptor density in the rat brain","volume":"32","author":"McLeod","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib40","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.euroneuro.2020.10.004","article-title":"Region-specific and dose-specific effects of chronic haloperidol exposure on [3H]-flumazenil and [3H]-Ro15-4513 GABAA receptor binding sites in the rat brain","volume":"41","author":"Peris-Yague","year":"2020","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.bpsc.2023.12.002_bib41","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1021\/pr800892u","article-title":"Analyzing the effects of psychotropic drugs on metabolite profiles in rat brain using 1H NMR spectroscopy","volume":"8","author":"McLoughlin","year":"2009","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.bpsc.2023.12.002_bib42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yhbeh.2018.04.002","article-title":"Rapid effects of ovarian hormones in dorsal striatum and nucleus accumbens","volume":"104","author":"Yoest","year":"2018","journal-title":"Horm Behav"},{"key":"10.1016\/j.bpsc.2023.12.002_bib43","doi-asserted-by":"crossref","first-page":"9130","DOI":"10.1073\/pnas.1300454110","article-title":"Perineuronal nets protect fast-spiking interneurons against oxidative stress","volume":"110","author":"Cabungcal","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bpsc.2023.12.002_bib44","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00429-013-0508-8","article-title":"Differential regulation of parvalbumin and calretinin interneurons in the prefrontal cortex during adolescence","volume":"219","author":"Caballero","year":"2014","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.bpsc.2023.12.002_bib45","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1038\/s41386-017-0004-6","article-title":"Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis","volume":"43","author":"Modinos","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsc.2023.12.002_bib46","doi-asserted-by":"crossref","first-page":"pyw067","DOI":"10.1093\/ijnp\/pyw067","article-title":"Baseline perfusion alterations due to acute application of quetiapine and pramipexole in healthy adults","volume":"19","author":"Michels","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.bpsc.2023.12.002_bib47","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/hbm.23844","article-title":"An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers","volume":"39","author":"Hawkins","year":"2018","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.bpsc.2023.12.002_bib48","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/j.1476-5381.2010.01161.x","article-title":"Effects on resting cerebral blood flow and functional connectivity induced by metoclopramide: A perfusion MRI study in healthy volunteers","volume":"163","author":"Fern\u00e1ndez-Seara","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bpsc.2023.12.002_bib49","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.neuroimage.2003.08.007","article-title":"Systemic sulpiride modulates striatal blood flow: Relationships to spatial working memory and planning","volume":"20","author":"Mehta","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2023.12.002_bib50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00213-013-3091-z","article-title":"Effects of amisulpride on human resting cerebral perfusion","volume":"229","author":"Viviani","year":"2013","journal-title":"Psychopharmacol (Berl)"},{"key":"10.1016\/j.bpsc.2023.12.002_bib51","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0006-3223(02)01421-X","article-title":"The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: A comparison between the neuroleptic-naive and medicated states","volume":"52","author":"Corson","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib52","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1600-0447.1998.tb10029.x","article-title":"Regional cerebral blood flow in first-episode schizophrenia patients before and after antipsychotic drug treatment. Scottish Schizophrenia Research Group","volume":"97","year":"1998","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.bpsc.2023.12.002_bib53","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0165-0173(99)00049-1","article-title":"Gating of information flow within the limbic system and the pathophysiology of schizophrenia","volume":"31","author":"Grace","year":"2000","journal-title":"Brain Res Brain Res Rev"},{"issue":"suppl 1","key":"10.1016\/j.bpsc.2023.12.002_bib54","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1055\/s-2006-931483","article-title":"The neurochemical circuitry of schizophrenia","volume":"39","author":"Carlsson","year":"2006","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.bpsc.2023.12.002_bib55","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/(SICI)1098-2396(19990615)32:4<288::AID-SYN5>3.0.CO;2-U","article-title":"Effects of medial prefrontal cortical injections of GABA receptor agonists and antagonists on the local and nucleus accumbens dopamine responses to stress","volume":"32","author":"Doherty","year":"1999","journal-title":"Synapse"}],"container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902223003397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902223003397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T17:05:28Z","timestamp":1720026328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451902223003397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2451902223003397"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsc.2023.12.002","relation":{},"ISSN":["2451-9022"],"issn-type":[{"value":"2451-9022","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Trajectory of Prefrontal GABA Levels in Initially Antipsychotic-Na\u00efve Patients With Psychosis During 2 Years of Treatment and Associations With Striatal Cerebral Blood Flow and Outcome","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsc.2023.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Society of Biological Psychiatry. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}