{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T21:40:43Z","timestamp":1788730843259,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.bpsc.2024.05.012","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T19:53:27Z","timestamp":1718308407000},"page":"975-985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early Cortical Microstructural Changes in Aging Are Linked to Vulnerability to Alzheimer\u2019s Disease Pathology"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-9024","authenticated-orcid":false,"given":"Rongxiang","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol E.","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Hauger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders M.","family":"Dale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Dorros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa T.","family":"Eyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Fennema-Notestine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Donald J.","family":"Hagler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Panizzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia K.","family":"Puckett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McKenna E.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Elman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Kremen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpsc.2024.05.012_bib1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: A prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.bpsc.2024.05.012_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.bpsc.2024.05.012_bib3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1212\/WNL.0000000000002923","article-title":"A\/T\/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers","volume":"87","author":"Jack","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.bpsc.2024.05.012_bib4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bpsc.2024.05.012_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13195-015-0132-3","article-title":"Diffusion imaging changes in grey matter in Alzheimer\u2019s disease: A potential marker of early neurodegeneration","volume":"7","author":"Weston","year":"2015","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.bpsc.2024.05.012_bib6","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1093\/cercor\/bhz286","article-title":"Cortical microstructural alterations in mild cognitive impairment and Alzheimer\u2019s disease dementia","volume":"30","author":"Vogt","year":"2020","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bpsc.2024.05.012_bib7","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/brain\/awac343","article-title":"Measures of cortical microstructure are linked to amyloid pathology in Alzheimer\u2019s disease","volume":"146","author":"Spotorno","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.bpsc.2024.05.012_bib8","doi-asserted-by":"crossref","first-page":"7813","DOI":"10.1038\/s41380-021-01290-z","article-title":"Association of cortical microstructure with amyloid-beta and tau: Impact on cognitive decline, neurodegeneration, and clinical progression in older adults","volume":"26","author":"Rodriguez-Vieitez","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2024.05.012_bib9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13195-020-00679-2","article-title":"Measuring cortical mean diffusivity to assess early microstructural cortical change in presymptomatic familial Alzheimer\u2019s disease","volume":"12","author":"Weston","year":"2020","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.bpsc.2024.05.012_bib10","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab167","article-title":"12-year prediction of mild cognitive impairment aided by Alzheimer\u2019s brain signatures at mean age 56","volume":"3","author":"Williams","year":"2021","journal-title":"Brain Commun"},{"key":"10.1016\/j.bpsc.2024.05.012_bib11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s43856-023-00324-7","article-title":"Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid","volume":"3","author":"Gagliardi","year":"2023","journal-title":"Commun Med (Lond)"},{"key":"10.1016\/j.bpsc.2024.05.012_bib12","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/brain\/awad428","article-title":"Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer\u2019s disease","volume":"147","author":"Spotorno","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.bpsc.2024.05.012_bib13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cortex.2017.09.018","article-title":"Tau, amyloid, and cascading network failure across the Alzheimer\u2019s disease spectrum","volume":"97","author":"Jones","year":"2017","journal-title":"Cortex"},{"key":"10.1016\/j.bpsc.2024.05.012_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41467-019-14159-1","article-title":"Functional brain architecture is associated with the rate of tau accumulation in Alzheimer\u2019s disease","volume":"11","author":"Franzmeier","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.bpsc.2024.05.012_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc8693","article-title":"Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of Alzheimer\u2019s disease","volume":"14","author":"Therriault","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bpsc.2024.05.012_bib16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41582-021-00529-1","article-title":"The human connectome in Alzheimer disease\u2014relationship to biomarkers and genetics","volume":"17","author":"Yu","year":"2021","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.bpsc.2024.05.012_bib17","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1038\/s41467-019-10217-w","article-title":"Abeta-induced vulnerability propagates via the brain\u2019s default mode network","volume":"10","author":"Pascoal","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.bpsc.2024.05.012_bib18","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41593-022-01186-3","article-title":"Mapping neurotransmitter systems to the structural and functional organization of the human neocortex","volume":"25","author":"Hansen","year":"2022","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bpsc.2024.05.012_bib19","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1038\/s41467-022-32420-y","article-title":"Local molecular and global connectomic contributions to cross-disorder cortical abnormalities","volume":"13","author":"Hansen","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.bpsc.2024.05.012_bib20","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.conb.2006.09.002","article-title":"The role of acetylcholine in learning and memory","volume":"16","author":"Hasselmo","year":"2006","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.bpsc.2024.05.012_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(02)00272-3","article-title":"Glutamate receptor function in learning and memory","volume":"140","author":"Riedel","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.bpsc.2024.05.012_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuropharm.2010.02.010","article-title":"Neurochemical basis for symptomatic treatment of Alzheimer\u2019s disease","volume":"59","author":"Francis","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bpsc.2024.05.012_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.55782\/ane-2004-1495","article-title":"Alzheimer\u2019s disease and acetylcholine receptors","volume":"64","author":"Kihara","year":"2004","journal-title":"Acta Neurobiol Exp (Warsz)"},{"key":"10.1016\/j.bpsc.2024.05.012_bib24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuropharm.2014.11.018","article-title":"Role of the nicotinic acetylcholine receptor in Alzheimer\u2019s disease pathology and treatment","volume":"96","author":"Lombardo","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bpsc.2024.05.012_bib25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/cns.12095","article-title":"Amyloid \u03b2, glutamate, excitotoxicity in Alzheimer\u2019s disease: Are we on the right track?","volume":"19","author":"Esposito","year":"2013","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.bpsc.2024.05.012_bib26","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/j.neuron.2021.06.016","article-title":"Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology","volume":"109","author":"Sydnor","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.bpsc.2024.05.012_bib27","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/cercor\/bhn232","article-title":"High consistency of regional cortical thinning in aging across multiple samples","volume":"19","author":"Fjell","year":"2009","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bpsc.2024.05.012_bib28","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10548-011-0198-6","article-title":"Age-related changes in the thickness of cortical zones in humans","volume":"24","author":"McGinnis","year":"2011","journal-title":"Brain Topogr"},{"key":"10.1016\/j.bpsc.2024.05.012_bib29","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/brain\/awab294","article-title":"Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer\u2019s disease","volume":"145","author":"Strom","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.bpsc.2024.05.012_bib30","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/s41592-022-01625-w","article-title":"neuromaps: Structural and functional interpretation of brain maps","volume":"19","author":"Markello","year":"2022","journal-title":"Nat Methods"},{"key":"10.1016\/j.bpsc.2024.05.012_bib31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroimage.2016.11.032","article-title":"Genetic and environmental influences on cortical mean diffusivity","volume":"146","author":"Elman","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2024.05.012_bib32","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1017\/thg.2019.125","article-title":"Current status of the Vietnam Era Twin Study of Aging (VETSA)","volume":"22","author":"Kremen","year":"2019","journal-title":"Twin Res Hum Genet"},{"key":"10.1016\/j.bpsc.2024.05.012_bib33","first-page":"1","article-title":"Health characteristics of adults aged 55 years and over: United States, 2004-2007","volume":"8","author":"Schoenborn","year":"2009","journal-title":"Natl Health Stat Report"},{"key":"10.1016\/j.bpsc.2024.05.012_bib34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/HYPERTENSIONAHA.115.05336","article-title":"Hypertension-related alterations in white matter microstructure detectable in middle age","volume":"66","author":"McEvoy","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.bpsc.2024.05.012_bib35","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/hbm.23502","article-title":"Heritability of white matter microstructure in late middle age: A twin study of tract-based fractional anisotropy and absolute diffusivity indices","volume":"38","author":"Vuoksimaa","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.bpsc.2024.05.012_bib36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroimage.2016.07.026","article-title":"Imaging of cerebral \u03b14\u03b22\u2217 nicotinic acetylcholine receptors with (-)-[(18)F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain","volume":"141","author":"Hillmer","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2024.05.012_bib37","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2967\/jnumed.120.246967","article-title":"First-in-human assessment of (11)C-LSN3172176, an M1 muscarinic acetylcholine receptor PET radiotracer","volume":"62","author":"Naganawa","year":"2021","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.bpsc.2024.05.012_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd1327","article-title":"Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer\u2019s disease","volume":"6","author":"Franzmeier","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.bpsc.2024.05.012_bib39","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","article-title":"Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer","year":"2018","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bpsc.2024.05.012_bib40","series-title":"Wechsler Memory Scale (WMS-III)","author":"Wechsler","year":"1997"},{"key":"10.1016\/j.bpsc.2024.05.012_bib41","series-title":"California Verbal Learning Test (CVLT-2)","author":"Delis","year":"2000"},{"key":"10.1016\/j.bpsc.2024.05.012_bib42","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1037\/a0035962","article-title":"Genetic complexity of episodic memory: A twin approach to studies of aging","volume":"29","author":"Kremen","year":"2014","journal-title":"Psychol Aging"},{"key":"10.1016\/j.bpsc.2024.05.012_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119807","article-title":"BrainStat: A toolbox for brain-wide statistics and multimodal feature associations","volume":"266","author":"Lariviere","year":"2023","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2024.05.012_bib44","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.neuroimage.2018.05.070","article-title":"On testing for spatial correspondence between maps of human brain structure and function","volume":"178","author":"Alexander-Bloch","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsc.2024.05.012_bib45","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrn2194","article-title":"Tau-mediated neurodegeneration in Alzheimer\u2019s disease and related disorders","volume":"8","author":"Ballatore","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bpsc.2024.05.012_bib46","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.bpsc.2024.05.012_bib47","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: A Meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.bpsc.2024.05.012_bib48","article-title":"Prospective longitudinal atrophy in Alzheimer\u2019s disease correlates with the intensity and topography of baseline tau-PET","volume":"12","author":"La","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bpsc.2024.05.012_bib49","doi-asserted-by":"crossref","first-page":"e601","DOI":"10.1212\/WNL.0000000000006875","article-title":"Associations between tau, A\u03b2, and cortical thickness with cognition in Alzheimer disease","volume":"92","author":"Ossenkoppele","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.bpsc.2024.05.012_bib50","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","article-title":"Association of amyloid and tau with cognition in preclinical Alzheimer disease: A longitudinal study","volume":"76","author":"Hanseeuw","year":"2019","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.bpsc.2024.05.012_bib51","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jalz.2017.09.013","article-title":"Cortical microstructural changes along the Alzheimer\u2019s disease continuum","volume":"14","author":"Montal","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bpsc.2024.05.012_bib52","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3233\/JAD-2010-100678","article-title":"Increased cortical thickness and caudate volume precede atrophy in PSEN1 mutation carriers","volume":"22","author":"Fortea","year":"2010","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.bpsc.2024.05.012_bib53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neurobiolaging.2023.05.004","article-title":"Higher cortical thickness\/volume in Alzheimer\u2019s-related regions: Protective factor or risk factor?","volume":"129","author":"Williams","year":"2023","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bpsc.2024.05.012_bib54","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1017\/S1092852900014164","article-title":"The interplay of neurotransmitters in Alzheimer\u2019s disease","volume":"10","author":"Francis","year":"2005","journal-title":"CNS Spectr"},{"key":"10.1016\/j.bpsc.2024.05.012_bib55","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1093\/brain\/awab375","article-title":"Personalized brain models identify neurotransmitter receptor changes in Alzheimer\u2019s disease","volume":"145","author":"Khan","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.bpsc.2024.05.012_bib56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnins.2019.00043","article-title":"The role of NMDA receptors in Alzheimer\u2019s disease","volume":"13","author":"Liu","year":"2019","journal-title":"Front Neurosci"},{"key":"10.1016\/j.bpsc.2024.05.012_bib57","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fnins.2015.00215","article-title":"Therapeutic potential of mGluR5 targeting in Alzheimer\u2019s disease","volume":"9","author":"Kumar","year":"2015","journal-title":"Front Neurosci"},{"key":"10.1016\/j.bpsc.2024.05.012_bib58","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pharmtox-021821-091747","article-title":"Noncanonical metabotropic glutamate receptor 5 signaling in Alzheimer\u2019s disease","volume":"62","author":"Abd-Elrahman","year":"2022","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bpsc.2024.05.012_bib59","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12264-013-1406-z","article-title":"M1 muscarinic acetylcholine receptor in Alzheimer\u2019s disease","volume":"30","author":"Jiang","year":"2014","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.bpsc.2024.05.012_bib60","doi-asserted-by":"crossref","DOI":"10.1042\/NS20210004","article-title":"Targeting the M1 muscarinic acetylcholine receptor in Alzheimer\u2019s disease","volume":"6","author":"Dwomoh","year":"2022","journal-title":"Neuronal Signal"},{"key":"10.1016\/j.bpsc.2024.05.012_bib61","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1111\/bph.15750","article-title":"A\u00a0positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe\/PSEN1\u0394E9 mice","volume":"179","author":"Abd-Elrahman","year":"2022","journal-title":"Br J Pharmacol"}],"container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902224001587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902224001587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T01:20:41Z","timestamp":1728091241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451902224001587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S2451902224001587"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsc.2024.05.012","relation":{},"ISSN":["2451-9022"],"issn-type":[{"value":"2451-9022","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Cortical Microstructural Changes in Aging Are Linked to Vulnerability to Alzheimer\u2019s Disease Pathology","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsc.2024.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Society of Biological Psychiatry. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}