{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:38:09Z","timestamp":1792528689837,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019771","name":"European Union's Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020098","name":"Innovative Medicines Initiative 2 Joint Undertaking","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Netherlands Organisation for Scientific Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bpsc.2026.10.003","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:17:27Z","timestamp":1792451847000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validating gene-brain-behavior associations in autism: A replication study"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5385-4745","authenticated-orcid":false,"given":"Dongyue","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-4460","authenticated-orcid":false,"given":"Ting","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Oldehinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Mennes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1452-0600","authenticated-orcid":false,"given":"Natalie J.","family":"Forde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Dell\u2019Acqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-1144","authenticated-orcid":false,"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Ecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary J.","family":"Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bourgeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Charman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Loth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan G.M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8288-7757","authenticated-orcid":false,"given":"Jan K.","family":"Buitelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumana","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ambrosino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Auyeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Baron-Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Baumeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"B\u00f6lte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bourgeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bours","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Brandeis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Brogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"de Bruijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan K.","family":"Buitelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhismadev","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Charman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ineke","family":"Cornelissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Crawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Dell\u2019Acqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Dumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Durston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Ecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Faulkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Frouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Garc\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goyard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Ham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Hipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary J.","family":"Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.H.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prantik","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Chuan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier Liogier","family":"D\u2019ardhuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Loth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Lythgoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Mandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Marquand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Mennes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meyer-Lindenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Moessnang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan G.M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"O\u2019Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Oldehinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Oranje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gahan","family":"Pandina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio M.","family":"Persico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rausch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber N.V.","family":"Ruigrok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Sabet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"San J\u00f3se C\u00e1ceres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Simonoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will","family":"Spooren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Tillmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Toro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Tost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Waldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve C.R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Wooldridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Ilioska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel P.","family":"Zwiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpsc.2026.10.003_bib1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013): Diagnostic and Statistical Manual of Mental Disorders: DSM-5TM, 5th Ed. Arlington, VA, US: American Psychiatric Publishing, Inc., pp xliv, 947.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"10.1016\/j.bpsc.2026.10.003_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-019-0138-4","article-title":"Autism spectrum disorder","volume":"6","author":"Lord","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.bpsc.2026.10.003_bib3","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s41593-023-01259-x","article-title":"Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder","volume":"26","author":"Buch","year":"2023","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bpsc.2026.10.003_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopsych.2022.12.018","article-title":"Connectome-wide Mega-analysis Reveals Robust Patterns of Atypical Functional Connectivity in Autism","volume":"94","author":"Ilioska","year":"2023","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41398-020-01057-0","article-title":"Fractionating autism based on neuroanatomical normative modeling","volume":"10","author":"Zabihi","year":"2020","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neubiorev.2016.06.013","article-title":"Genetic heterogeneity in autism: From single gene to a pathway perspective","volume":"68","author":"An","year":"2016","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.bpsc.2026.10.003_bib7","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/s41588-025-02224-z","article-title":"Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs","volume":"57","author":"Litman","year":"2025","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2026.10.003_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2021.102033","article-title":"Validation strategies for subtypes in psychiatry: A systematic review of research on autism spectrum disorder","volume":"87","author":"Agelink Van Rentergem","year":"2021","journal-title":"Clinical Psychology Review"},{"key":"10.1016\/j.bpsc.2026.10.003_bib9","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/s41380-018-0321-0","article-title":"Big data approaches to decomposing heterogeneity across the autism spectrum","volume":"24","author":"Lombardo","year":"2019","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib10","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/hbm.24400","article-title":"Parsing brain structural heterogeneity in males with autism spectrum disorder reveals distinct clinical subtypes","volume":"40","author":"Chen","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.bpsc.2026.10.003_bib11","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1093\/cercor\/bhac156","article-title":"A convergent structure\u2013function substrate of cognitive imbalances in autism","volume":"33","author":"Hong","year":"2023","journal-title":"Cerebral Cortex"},{"key":"10.1016\/j.bpsc.2026.10.003_bib12","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.biopsych.2022.01.011","article-title":"Mapping the Heterogeneous Brain Structural Phenotype of Autism Spectrum Disorder Using the Normative Model","volume":"91","author":"Shan","year":"2022","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41588-019-0344-8","article-title":"Identification of common genetic risk variants for autism spectrum disorder","volume":"51","author":"Grove","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpsc.2026.10.003_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41525-024-00411-1","article-title":"Genomic analysis of 116 autism families strengthens known risk genes and highlights promising candidates","volume":"9","author":"Viggiano","year":"2024","journal-title":"npj Genom Med"},{"key":"10.1016\/j.bpsc.2026.10.003_bib15","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1038\/s41380-025-02927-z","article-title":"Polygenic scores for autism are associated with reduced neurite density in adults and children from the general population","volume":"30","author":"Gu","year":"2025","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41398-025-03252-3","article-title":"Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connectome project","volume":"15","author":"Le","year":"2025","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41398-025-03253-2","article-title":"Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project","volume":"15","author":"Le","year":"2025","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-024-00632-2","article-title":"Molecular architecture of the altered cortical complexity in autism","volume":"16","author":"Mamat","year":"2025","journal-title":"Molecular Autism"},{"key":"10.1016\/j.bpsc.2026.10.003_bib19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00787-024-02476-w","article-title":"Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles","volume":"34","author":"Shan","year":"2025","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib20","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.biopsych.2021.12.004","article-title":"Alterations in Connectome Dynamics in Autism Spectrum Disorder: A Harmonized Mega- and Meta-analysis Study Using the Autism Brain Imaging Data Exchange Dataset","volume":"91","author":"Xie","year":"2022","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s44220-023-00195-w","article-title":"Symptom dimensions of resting-state electroencephalographic functional connectivity in autism","volume":"2","author":"Tong","year":"2024","journal-title":"Nat Mental Health"},{"key":"10.1016\/j.bpsc.2026.10.003_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s44271-024-00063-y","article-title":"Limited generalizability of multivariate brain-based dimensions of child psychiatric symptoms","volume":"2","author":"Xu","year":"2024","journal-title":"Commun Psychol"},{"key":"10.1016\/j.bpsc.2026.10.003_bib23","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.20479","article-title":"Dementia Subtypes Defined Through Neuropsychiatric Symptom\u2013Associated Brain Connectivity Patterns","volume":"7","author":"Zhao","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.bpsc.2026.10.003_bib24","article-title":"Resting-state connectivity biomarkers define neurophysiological subtypes of depression","volume":"23","author":"Drysdale","year":"2017","journal-title":"nature medicine"},{"key":"10.1016\/j.bpsc.2026.10.003_bib25","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1038\/s41467-018-05317-y","article-title":"Linked dimensions of psychopathology and connectivity in functional brain networks","volume":"9","author":"Xia","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.bpsc.2026.10.003_bib26","article-title":"Evaluating the evidence for biotypes of depression: Methodological replication and extension of","volume":"22","author":"Dinga","year":"2019","journal-title":"NeuroImage: Clinical"},{"key":"10.1016\/j.bpsc.2026.10.003_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13229-017-0145-9","article-title":"The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation","volume":"8","author":"Charman","year":"2017","journal-title":"Molecular Autism"},{"key":"10.1016\/j.bpsc.2026.10.003_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13229-017-0146-8","article-title":"The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders","volume":"8","author":"Loth","year":"2017","journal-title":"Molecular Autism"},{"key":"10.1016\/j.bpsc.2026.10.003_bib29","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10803-008-0674-3","article-title":"Standardizing ADOS Scores for a Measure of Severity in Autism Spectrum Disorders","volume":"39","author":"Gotham","year":"2009","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.bpsc.2026.10.003_bib30","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1007\/s10803-014-2080-3","article-title":"The Autism Diagnostic Observation Schedule, Module 4: Revised Algorithm and Standardized Severity Scores","volume":"44","author":"Hus","year":"2014","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.bpsc.2026.10.003_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12874-022-01656-z","article-title":"Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: the case of the EU-AIMS Longitudinal European Autism Project","volume":"22","author":"Llera","year":"2022","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.bpsc.2026.10.003_bib32","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.neuron.2011.09.006","article-title":"Functional Network Organization of the Human Brain","volume":"72","author":"Power","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.bpsc.2026.10.003_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/01621459.1989.10478752","article-title":"Regularized Discriminant Analysis","volume":"84","author":"Friedman","year":"1989","journal-title":"Journal of the American Statistical Association"},{"key":"10.1016\/j.bpsc.2026.10.003_bib34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/1471-2105-12-483","article-title":"Supervised Regularized Canonical Correlation Analysis: integrating histologic and proteomic measurements for predicting biochemical recurrence following prostate surgery","volume":"12","author":"Golugula","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.bpsc.2026.10.003_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-024-02954-4","article-title":"Multivariate brain-behaviour associations in psychiatric disorders","volume":"14","author":"Vieira","year":"2024","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1023\/A:1024068626366","article-title":"Inference for the Generalization Error","volume":"52","author":"Nadeau","year":"2003","journal-title":"Machine Learning"},{"key":"10.1016\/j.bpsc.2026.10.003_bib37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1109\/TPAMI.1979.4766909","article-title":"A Cluster Separation Measure","volume":"PAMI-1","author":"Davies","year":"1979","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"10.1016\/j.bpsc.2026.10.003_bib38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/biom.12111","article-title":"An evaluation of independent component analyses with an application to resting\u2010state fMRI","volume":"70","author":"Risk","year":"2014","journal-title":"Biometrics"},{"key":"10.1016\/j.bpsc.2026.10.003_bib39","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society: Series B (Methodological)"},{"key":"10.1016\/j.bpsc.2026.10.003_bib40","article-title":"Variational Mixture Models with Gamma or inverse-Gamma components","author":"Llera","year":"2016","journal-title":"arXiv"},{"key":"10.1016\/j.bpsc.2026.10.003_bib41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41398-021-01284-z","article-title":"Task-generic and task-specific connectivity modulations in the ADHD brain: an integrated analysis across multiple tasks","volume":"11","author":"Chauvin","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib42","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An anatomically comprehensive atlas of the adult human brain transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bpsc.2026.10.003_bib43","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3390\/cimb47090721","article-title":"Neurodevelopmental Impact of Maternal Immune Activation and Autoimmune Disorders, Environmental Toxicants and Folate Metabolism on Autism Spectrum Disorder","volume":"47","author":"Ayoub","year":"2025","journal-title":"CIMB"},{"key":"10.1016\/j.bpsc.2026.10.003_bib44","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1177\/1362361319890793","article-title":"Prevalence of physical and mental health conditions in Medicare-enrolled, autistic older adults","volume":"24","author":"Hand","year":"2020","journal-title":"Autism"},{"key":"10.1016\/j.bpsc.2026.10.003_bib45","first-page":"76","article-title":"Thalamocortical Dysconnectivity in Autism Spectrum Disorder: An Analysis of the Autism Brain Imaging Data Exchange","volume":"2","author":"Woodward","year":"2017","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"10.1016\/j.bpsc.2026.10.003_bib46","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s11682-024-00858-x","article-title":"Intrinsic network abnormalities in children with autism spectrum disorder: an independent component analysis","volume":"18","author":"Yoon","year":"2024","journal-title":"Brain Imaging and Behavior"},{"key":"10.1016\/j.bpsc.2026.10.003_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s11689-025-09613-9","article-title":"Functional connectivity between the visual and salience networks and autistic social features at school-age","volume":"17","author":"Girault","year":"2025","journal-title":"J Neurodevelop Disord"},{"key":"10.1016\/j.bpsc.2026.10.003_bib48","first-page":"476","article-title":"The Default Mode Network in Autism","volume":"2","author":"Padmanabhan","year":"2017","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"10.1016\/j.bpsc.2026.10.003_bib49","first-page":"359","article-title":"Default Mode Network Functional Connectivity As a Transdiagnostic Biomarker of Cognitive Function","volume":"10","author":"Tripathi","year":"2025","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"10.1016\/j.bpsc.2026.10.003_bib50","first-page":"260","article-title":"Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project","volume":"4","author":"Oldehinkel","year":"2019","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"10.1016\/j.bpsc.2026.10.003_bib51","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaf067","article-title":"Cortico-hippocampal networks underpin verbal memory encoding in temporal lobe epilepsy","volume":"7","author":"Fiore","year":"2025","journal-title":"Brain Communications"},{"key":"10.1016\/j.bpsc.2026.10.003_bib52","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bandc.2005.12.015","article-title":"Brain activation during semantic processing in autism spectrum disorders via functional magnetic resonance imaging","volume":"61","author":"Harris","year":"2006","journal-title":"Brain and Cognition"},{"key":"10.1016\/j.bpsc.2026.10.003_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/aur.70076","article-title":"The Role of the Brain\u2019s Pragmatic Language Network in Reading Comprehension in Autistic Children","author":"Valles\u2010Capetillo","year":"2025","journal-title":"Autism Research aur"},{"key":"10.1016\/j.bpsc.2026.10.003_bib54","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13229-025-00640-w","article-title":"Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism","volume":"16","author":"Wagner","year":"2025","journal-title":"Molecular Autism"},{"key":"10.1016\/j.bpsc.2026.10.003_bib55","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/aur.2239","article-title":"Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder","volume":"13","author":"Xu","year":"2020","journal-title":"Autism Research"},{"key":"10.1016\/j.bpsc.2026.10.003_bib56","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/s41586-025-09542-6","article-title":"Polygenic and developmental profiles of autism differ by age at diagnosis","volume":"646","author":"Zhang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.bpsc.2026.10.003_bib57","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.biopsych.2020.10.018","article-title":"Shared and Anxiety-Specific Pediatric Psychopathology Dimensions Manifest Distributed Neural Correlates","volume":"89","author":"Linke","year":"2021","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.bpsc.2026.10.003_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41593-026-02359-0","article-title":"The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders","author":"Cao","year":"2026","journal-title":"Nat Neurosci"}],"container-title":["Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902226003083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451902226003083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:39:16Z","timestamp":1792525156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451902226003083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":58,"alternative-id":["S2451902226003083"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsc.2026.10.003","relation":{},"ISSN":["2451-9022"],"issn-type":[{"value":"2451-9022","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validating gene-brain-behavior associations in autism: A replication study","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsc.2026.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc on behalf of Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}