{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:39:08Z","timestamp":1775615948051,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UH2HL132368"],"award-info":[{"award-number":["UH2HL132368"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry Global Open Science"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bpsgos.2022.03.012","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T17:05:11Z","timestamp":1649178311000},"page":"430-442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mediating Effects of Neural Targets on Depression, Weight, and Anxiety Outcomes of an Integrated Collaborative Care Intervention: The ENGAGE-2 Mechanistic Pilot Randomized Clinical Trial"],"prefix":"10.1016","volume":"3","author":[{"given":"Nan","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusola A.","family":"Ajilore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Venditti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip W.","family":"Lavori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben S.","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark B.","family":"Snowden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy E.","family":"Wittels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina R.","family":"Ronneberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Stetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amruta","family":"Barve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushanth","family":"Dosala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa L.","family":"Eckley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea N.","family":"Goldstein-Piekarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa G.","family":"Rosas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kannampallil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Zulueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trisha","family":"Suppes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpsgos.2022.03.012_bib1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/jama.2016.10486","article-title":"A\u00a0public health perspective on mental and medical comorbidity","volume":"316","author":"Walker","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib2","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.19686","article-title":"Prevalence of depression symptoms in US adults before and during the COVID-19 pandemic","volume":"3","author":"Ettman","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.orcp.2020.05.004","article-title":"Self-quarantine and weight gain related risk factors during the COVID-19 pandemic","volume":"14","author":"Zeigler","year":"2020","journal-title":"Obes Res Clin Pract"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib4","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.15585\/mmwr.mm6932a1","article-title":"Mental health, substance use, and suicidal ideation during the COVID-19 pandemic \u2014 United States, June 24\u201330, 2020","volume":"69","author":"Czeisler","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jad.2020.08.001","article-title":"Impact of COVID-19 pandemic on mental health in the general population: A systematic review","volume":"277","author":"Xiong","year":"2020","journal-title":"J\u00a0Affect Disord"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib6","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1037\/0003-066X.44.9.1175","article-title":"Human agency in social cognitive theory","volume":"44","author":"Bandura","year":"1989","journal-title":"Am Psychol"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib7","series-title":"Problem-Solving Therapy: A Social Competence Approach to Clinical Interventions","author":"D\u2019Zurilla","year":"1986"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/jama.2019.0557","article-title":"Effect of integrated behavioral weight loss treatment and problem-solving therapy on body mass index and depressive symptoms among patients with obesity and depression: The RAINBOW randomized clinical trial","volume":"321","author":"Ma","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11892-022-01458-z","article-title":"Integrated behavioral interventions for adults with comorbid obesity and depression: A systematic review","volume":"22","author":"Lv","year":"2022","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brat.2017.07.002","article-title":"The NIH Science of Behavior Change Program: Transforming the science through a focus on mechanisms of change","volume":"101","author":"Nielsen","year":"2018","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brat.2017.09.012","article-title":"The ENGAGE study: Integrating neuroimaging, virtual reality and smartphone sensing to understand self-regulation for managing depression and obesity in a precision medicine model","volume":"101","author":"Williams","year":"2018","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib12","doi-asserted-by":"crossref","first-page":"103387","DOI":"10.1016\/j.ebiom.2021.103387","article-title":"Early changes in neural circuit function engaged by negative emotion and modified by behavioural intervention are associated with depression and problem-solving outcomes: A report from the ENGAGE randomized controlled trial","volume":"67","author":"Goldstein-Piekarski","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib13","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1093\/ajcn\/nqab280","article-title":"Problem-solving therapy-induced amygdala engagement mediates lifestyle behavior change in obesity with comorbid depression: A randomized proof-of-mechanism trial","volume":"114","author":"Lv","year":"2021","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib14","doi-asserted-by":"crossref","first-page":"106072","DOI":"10.1016\/j.cct.2020.106072","article-title":"The ENGAGE-2 study: Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomes in a randomized controlled trial (Phase 2)","volume":"95","author":"Lv","year":"2020","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib15","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.2196\/jmir.2392","article-title":"An easily accessible Web-based minimization random allocation system for clinical trials","volume":"15","author":"Xiao","year":"2013","journal-title":"J\u00a0Med Internet Res"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib16","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0197-2456(02)00242-8","article-title":"The method of minimization for allocation to clinical trials. A review","volume":"23","author":"Scott","year":"2002","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib17","series-title":"Clinical Trials: Design, Conduct, and Analysis","author":"Meinert","year":"1986"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib18","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1001\/jama.291.13.1569","article-title":"Community-integrated home-based depression treatment in older adults: A randomized controlled trial","volume":"291","author":"Ciechanowski","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.yebeh.2010.06.003","article-title":"PEARLS depression treatment for individuals with epilepsy: A randomized controlled trial","volume":"19","author":"Ciechanowski","year":"2010","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.amepre.2009.07.020","article-title":"Translating the Diabetes Prevention Program: A comprehensive model for prevention training and program delivery","volume":"37","author":"Kramer","year":"2009","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib21","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1001\/archpsyc.1978.01770340039003","article-title":"Psychiatric screening in a medical clinic. An evaluation of a self-report inventory","volume":"35","author":"Glass","year":"1978","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1192\/bjp.129.1.61","article-title":"A\u00a0comparison of two psychiatric screening tests","volume":"129","author":"Goldberg","year":"1976","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib23","series-title":"PhenX Toolkit, ver 4.2","year":"2011"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib24","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A\u00a0brief measure for assessing generalized anxiety disorder: The GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib25","doi-asserted-by":"crossref","first-page":"100014","DOI":"10.1016\/j.psycom.2021.100014","article-title":"Treatment of anxiety symptoms in patients receiving rTMS for treatment resistant depression","volume":"2","author":"Tuinstra","year":"2022","journal-title":"Psychiatry Res Commun"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib26","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.biopsych.2021.06.024","article-title":"Mapping neural circuit biotypes to symptoms and behavioral dimensions of depression and anxiety","volume":"91","author":"Goldstein-Piekarski","year":"2022","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/da.22556","article-title":"Defining biotypes for depression and anxiety based on large-scale circuit dysfunction: A theoretical review of the evidence and future directions for clinical translation","volume":"34","author":"Williams","year":"2017","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib28","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S2215-0366(15)00579-9","article-title":"Precision psychiatry: A neural circuit taxonomy for depression and anxiety","volume":"3","author":"Williams","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib29","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/archpsyc.59.10.877","article-title":"Mediators and moderators of treatment effects in randomized clinical trials","volume":"59","author":"Kraemer","year":"2002","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib30","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1001\/jamapsychiatry.2019.1965","article-title":"Is it time to ban the P value?","volume":"76","author":"Kraemer","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1056\/NEJMe1906559","article-title":"New guidelines for statistical reporting in the Journal","volume":"381","author":"Harrington","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib32","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann Statist"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib33","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1056\/NEJMoa1003955","article-title":"Collaborative care for patients with\u00a0depression and chronic illnesses","volume":"363","author":"Katon","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib34","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cct.2010.03.009","article-title":"Integrating depression and chronic disease care among patients with diabetes and\/or coronary heart disease: The design of the TEAMcare study","volume":"31","author":"Katon","year":"2010","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib35","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/oby.23066","article-title":"The impact of COVID-19 stay-at-home orders on health behaviors in adults","volume":"29","author":"Flanagan","year":"2021","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib36","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.2536","article-title":"Body weight changes during pandemic-related shelter-in-place in a longitudinal cohort study","volume":"4","author":"Lin","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib37","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/osp4.442","article-title":"Weight-related lifestyle behaviours and the COVID-19 crisis: An online survey study of UK adults during social lockdown","volume":"6","author":"Robinson","year":"2020","journal-title":"Obes Sci Pract"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib38","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.3390\/nu12072016","article-title":"Changes in weight and nutritional habits in adults with obesity during the \u201clockdown\u201d period caused by the COVID-19 virus emergency","volume":"12","author":"Pellegrini","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib39","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41386-019-0407-7","article-title":"Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: A randomized trial","volume":"44","author":"Gorka","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib40","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1017\/S0033291720000410","article-title":"A\u00a0mechanistic model for individualised treatment of anxiety disorders based on predictive neural biomarkers","volume":"50","author":"Brehl","year":"2020","journal-title":"Psychol Med"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib41","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/da.22541","article-title":"Comorbid anxiety increases cognitive control activation in major depressive disorder","volume":"33","author":"Crane","year":"2016","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib42","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s40473-014-0018-x","article-title":"Current neural and behavioral dimensional constructs across mood disorders","volume":"1","author":"Langenecker","year":"2014","journal-title":"Curr Behav Neurosci Rep"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib43","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1001\/jamapsychiatry.2020.0114","article-title":"A\u00a0framework for advancing precision medicine in clinical trials for mental disorders [published correction appears in JAMA Psychiatry 2020; 77:768]","volume":"77","author":"Lenze","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib44","doi-asserted-by":"crossref","first-page":"E97","DOI":"10.1503\/jpn.200042","article-title":"Precision clinical trials: A framework for getting to precision medicine for neurobehavioural disorders","volume":"46","author":"Lenze","year":"2021","journal-title":"J\u00a0Psychiatry Neurosci"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12888-018-1989-z","article-title":"A\u00a0systematic literature review of the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) in non-treatment resistant patients with major depressive disorder","volume":"19","author":"Voigt","year":"2019","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1284","article-title":"Transcranial magnetic stimulation in anxiety and trauma-related disorders: A systematic review and meta-analysis","volume":"9","author":"Cirillo","year":"2019","journal-title":"Brain Behav"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib47","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/s41386-019-0401-0","article-title":"Neural predictors of treatment response to brain stimulation and psychological therapy in depression: A double-blind randomized controlled trial","volume":"44","author":"Nord","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib48","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s41386-020-00935-x","article-title":"Distinct trajectories of response to prefrontal tDCS in major depression: Results from a 3-arm randomized controlled trial","volume":"46","author":"Goerigk","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsgos.2022.03.012_bib49","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/brainsci9040082","article-title":"Noninvasive brain stimulation and psychotherapy in anxiety and depressive disorders: A viewpoint","volume":"9","author":"Chalah","year":"2019","journal-title":"Brain Sci"}],"container-title":["Biological Psychiatry Global Open Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667174322000519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667174322000519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:52:33Z","timestamp":1762642353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667174322000519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S2667174322000519"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsgos.2022.03.012","relation":{},"ISSN":["2667-1743"],"issn-type":[{"value":"2667-1743","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mediating Effects of Neural Targets on Depression, Weight, and Anxiety Outcomes of an Integrated Collaborative Care Intervention: The ENGAGE-2 Mechanistic Pilot Randomized Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry Global Open Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsgos.2022.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of the Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}]}}