{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:51:11Z","timestamp":1786985471221,"version":"build-2736575974"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008240","name":"Fonds de recherche du Quebec Societe et culture","doi-asserted-by":"publisher","award":["2002-RS-79238"],"award-info":[{"award-number":["2002-RS-79238"]}],"id":[{"id":"10.13039\/100008240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008240","name":"Fonds de recherche du Quebec Societe et culture","doi-asserted-by":"publisher","award":["2009-RG-124779"],"award-info":[{"award-number":["2009-RG-124779"]}],"id":[{"id":"10.13039\/100008240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-453327"],"award-info":[{"award-number":["MOP-453327"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-97910"],"award-info":[{"award-number":["MOP-97910"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-133537"],"award-info":[{"award-number":["MOP-133537"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-44072"],"award-info":[{"award-number":["MOP-44072"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000155","name":"Social Sciences and Humanities Research Council of Canada","doi-asserted-by":"publisher","award":["410-99-1048"],"award-info":[{"award-number":["410-99-1048"]}],"id":[{"id":"10.13039\/501100000155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000155","name":"Social Sciences and Humanities Research Council of Canada","doi-asserted-by":"publisher","award":["839-2000-1008"],"award-info":[{"award-number":["839-2000-1008"]}],"id":[{"id":"10.13039\/501100000155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000008","name":"Health Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024890","name":"Institut de la statistique du Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de recherche du Quebec Sante","doi-asserted-by":"publisher","award":["981055"],"award-info":[{"award-number":["981055"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de recherche du Quebec Sante","doi-asserted-by":"publisher","award":["35282"],"award-info":[{"award-number":["35282"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de recherche du Quebec Sante","doi-asserted-by":"publisher","award":["991027"],"award-info":[{"award-number":["991027"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000023","name":"Government of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biological Psychiatry Global Open Science"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bpsgos.2026.100734","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:59:19Z","timestamp":1776409159000},"page":"100734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry"],"prefix":"10.1016","volume":"6","author":[{"given":"Maja","family":"Nikolic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2203-5509","authenticated-orcid":false,"given":"Charlotte B.","family":"Caswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Palacio","family":"Prada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisha","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia M.L.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Jaworska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7077-1340","authenticated-orcid":false,"given":"Natalie","family":"Castellanos-Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Vitaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Brendgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Parent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Boivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7944-0647","authenticated-orcid":false,"given":"Sylvana","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3359-6202","authenticated-orcid":false,"given":"Jean R.","family":"S\u00e9guin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1243-2252","authenticated-orcid":false,"given":"Marco","family":"Leyton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpsgos.2026.100734_bib1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1037\/abn0000258","article-title":"The Hierarchical Taxonomy of Psychopathology (HiTOP): A dimensional alternative to traditional nosologies","volume":"126","author":"Kotov","year":"2017","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/jamapsychiatry.2024.0215","article-title":"A dynamical systems view of psychiatric disorders-theory: A review","volume":"81","author":"Scheffer","year":"2024","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12916-020-01561-6","article-title":"Mechanisms linking childhood trauma exposure and psychopathology: A transdiagnostic model of risk and resilience","volume":"18","author":"McLaughlin","year":"2020","journal-title":"BMC Med"},{"key":"10.1016\/j.bpsgos.2026.100734_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1176\/appi.ajp.2019.19010020","article-title":"The devastating clinical consequences of child abuse and neglect: Increased disease vulnerability and poor treatment response in mood disorders","volume":"177","author":"Lippard","year":"2020","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpsychires.2012.08.006","article-title":"Early life trauma predicts self-reported levels of depressive and anxiety symptoms in nonclinical community adults: Relative contributions of early life stressor types and adult trauma exposure","volume":"47","author":"Chu","year":"2013","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.bpsgos.2026.100734_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1176\/appi.ajp.20220174","article-title":"Childhood maltreatment and mental health problems: A systematic review and meta-analysis of quasi-experimental studies","volume":"180","author":"Baldwin","year":"2023","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S0954579421000821","article-title":"Beyond orchids and dandelions: Susceptibility to environmental influences is not bimodal","volume":"35","author":"Zhang","year":"2023","journal-title":"Dev Psychopathol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/mp.2012.35","article-title":"A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology","volume":"18","author":"Bogdan","year":"2013","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1037\/0021-843X.111.3.411","article-title":"Etiologic connections among substance dependence, antisocial behavior, and personality: Modeling the externalizing spectrum","volume":"111","author":"Krueger","year":"2002","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib10","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/archpsyc.56.10.921","article-title":"The structure of common mental disorders","volume":"56","author":"Krueger","year":"1999","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib11","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00127-010-0297-9","article-title":"Developmental trajectories of child to adolescent externalizing behavior and adult DSM-IV disorder: Results of a 24-year longitudinal study","volume":"46","author":"Reef","year":"2011","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.tics.2016.04.002","article-title":"Reward processing and risk for depression across development","volume":"20","author":"Luking","year":"2016","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.bpsgos.2026.100734_bib13","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1176\/appi.ajp.160.6.1078","article-title":"Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder","volume":"160","author":"Tarter","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib14","first-page":"535","volume":"xv","author":"Zuckerman","year":"1999"},{"key":"10.1016\/j.bpsgos.2026.100734_bib15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.neuron.2014.12.055","article-title":"A neural biomarker of psychological vulnerability to future life stress","volume":"85","author":"Swartz","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.bpsgos.2026.100734_bib16","doi-asserted-by":"crossref","first-page":"14120","DOI":"10.1073\/pnas.0903183106","article-title":"Human vulnerability to stress depends on amygdala\u2019s predisposition and hippocampal plasticity","volume":"106","author":"Admon","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bpsgos.2026.100734_bib17","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/s41386-021-01187-z","article-title":"A three-factor model of common early onset psychiatric disorders: Temperament, adversity, and dopamine","volume":"47","author":"Iqbal","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsgos.2026.100734_bib18","article-title":"A novel diathesis-stress model of comorbid early onset psychiatric disorders","author":"Caswell","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.bpsgos.2026.100734_bib19","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1038\/npp.2011.99","article-title":"Identifying neurobiological phenotypes associated with alcohol use disorder severity","volume":"36","author":"Claus","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsgos.2026.100734_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1369-1600.2012.00464.x","article-title":"Functional neuroimaging studies of alcohol cue reactivity: A quantitative meta-analysis and systematic review","volume":"18","author":"Schacht","year":"2013","journal-title":"Addict Biol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib21","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/add.12437","article-title":"Functional magnetic resonance imaging (fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students","volume":"109","author":"Dager","year":"2014","journal-title":"Addiction"},{"key":"10.1016\/j.bpsgos.2026.100734_bib22","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s11682-017-9757-0","article-title":"Prospective changes in neural alcohol cue reactivity in at-risk adolescents","volume":"12","author":"Nguyen-Louie","year":"2018","journal-title":"Brain Imaging Behav"},{"issue":"suppl 1","key":"10.1016\/j.bpsgos.2026.100734_bib23","first-page":"E161","article-title":"Influence of alcohol use and family history of alcoholism on neural response to alcohol cues in college drinkers","volume":"37","author":"Dager","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.bpsgos.2026.100734_bib24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroimage.2009.11.076","article-title":"Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers","volume":"50","author":"Kareken","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.bpsgos.2026.100734_bib25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/acer.15511","article-title":"A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography","volume":"49","author":"Nikolic","year":"2025","journal-title":"Alcohol Clin Exp Res (Hoboken)"},{"key":"10.1016\/j.bpsgos.2026.100734_bib26","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41386-020-0662-7","article-title":"Extra-striatal D2\/3 receptor availability in youth at risk for addiction","volume":"45","author":"Jaworska","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsgos.2026.100734_bib27","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1038\/s41386-020-0708-x","article-title":"mGlu5 receptor availability in youth at risk for addictions: Effects of vulnerability traits and cannabis use","volume":"45","author":"Cox","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsgos.2026.100734_bib28","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1037\/h0037058","article-title":"A behavior rating scale for the preschool child","volume":"10","author":"Behar","year":"1974","journal-title":"Dev Psychol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/016502549201500204","article-title":"A prosocial scale for the preschool behaviour questionnaire: Concurrent and predictive correlates","volume":"15","author":"Tremblay","year":"1992","journal-title":"Int J Behav Dev"},{"key":"10.1016\/j.bpsgos.2026.100734_bib30","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/0706743720982429","volume":"66","author":"Cox","year":"2021","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1521\/pedi.1995.9.2.83","article-title":"The structured clinical interview for DSM-III-R personality disorders (SCID-II). Part I: Description","volume":"9","author":"First","year":"1995","journal-title":"J Pers Disord"},{"key":"10.1016\/j.bpsgos.2026.100734_bib32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1037\/a0030992","article-title":"Reliability of the Timeline followback for cocaine, cannabis, and cigarette use","volume":"28","author":"Robinson","year":"2014","journal-title":"Psychol Addict Behav"},{"key":"10.1016\/j.bpsgos.2026.100734_bib33","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1360-0443.1993.tb02093.x","article-title":"Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption\u2014II","volume":"88","author":"Saunders","year":"1993","journal-title":"Addiction"},{"key":"10.1016\/j.bpsgos.2026.100734_bib34","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1176\/ajp.151.8.1132","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","volume":"151","author":"Bernstein","year":"1994","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib35","series-title":"An Introduction to the Bootstrap","author":"Efron","year":"1994"},{"key":"10.1016\/j.bpsgos.2026.100734_bib36","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/00401706.1962.10490038","article-title":"Transformation of the independent variables","volume":"4","author":"Box","year":"1962","journal-title":"Technometrics"},{"key":"10.1016\/j.bpsgos.2026.100734_bib37","series-title":"Wiley Series in Probability and Statistics)","article-title":"Applied logistic regression","author":"Hosmer","year":"2013"},{"key":"10.1016\/j.bpsgos.2026.100734_bib38","series-title":"Applied Multiple Regression\/Correlation Analysis for the Behavioral Sciences","author":"Cohen","year":"2003"},{"key":"10.1016\/j.bpsgos.2026.100734_bib39","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/acer.12815","article-title":"Converging patterns of alcohol use and related outcomes among females and males in the United States, 2002 to 2012","volume":"39","author":"White","year":"2015","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.bpsgos.2026.100734_bib40","doi-asserted-by":"crossref","first-page":"01","DOI":"10.35946\/arcr.v40.2.01","article-title":"Gender differences in the epidemiology of alcohol use and related harms in the United States","volume":"40","author":"White","year":"2020","journal-title":"Alcohol Res"},{"key":"10.1016\/j.bpsgos.2026.100734_bib41","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1001\/archpsyc.60.7.727","article-title":"Neural response to alcohol stimuli in adolescents with alcohol use disorder","volume":"60","author":"Tapert","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.addbeh.2003.07.003","article-title":"fMRI BOLD response to alcohol stimuli in alcohol dependent young women","volume":"29","author":"Tapert","year":"2004","journal-title":"Addict Behav"},{"key":"10.1016\/j.bpsgos.2026.100734_bib43","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/sj.npp.1301513","article-title":"Exposure to the taste of alcohol elicits activation of the mesocorticolimbic neurocircuitry","volume":"33","author":"Filbey","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsgos.2026.100734_bib44","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1001\/jamapsychiatry.2023.5483","article-title":"Parameter space and potential for biomarker development in 25 years of fMRI drug cue reactivity: A systematic review","volume":"81","author":"Sangchooli","year":"2024","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bpsgos.2026.100734_bib45","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0166-2236(03)00233-9","article-title":"Parsing reward","volume":"26","author":"Berridge","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.bpsgos.2026.100734_bib46","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","article-title":"Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats","volume":"85","author":"Di Chiara","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bpsgos.2026.100734_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-psych-122414-033457","article-title":"Drug addiction: Updating actions to habits to compulsions ten years on","volume":"67","author":"Everitt","year":"2016","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib48","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0959-4388(96)80079-1","article-title":"Neurobiology of addiction","volume":"6","author":"Wise","year":"1996","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib49","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrn3119","article-title":"Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications","volume":"12","author":"Goldstein","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bpsgos.2026.100734_bib50","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/cercor\/10.3.318","article-title":"Addiction, a disease of compulsion and drive: Involvement of the orbitofrontal cortex","volume":"10","author":"Volkow","year":"2000","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bpsgos.2026.100734_bib51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/35077500","article-title":"Primate anterior cingulate cortex: Where motor control, drive and cognition interface","volume":"2","author":"Paus","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bpsgos.2026.100734_bib52","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/npp.2009.110","article-title":"Neurocircuitry of addiction","volume":"35","author":"Koob","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpsgos.2026.100734_bib53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/nyas.12415","article-title":"The insula: A critical neural substrate for craving and drug seeking under conflict and risk","volume":"1316","author":"Naqvi","year":"2014","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bpsgos.2026.100734_bib54","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3174\/ajnr.A2355","article-title":"Using high-resolution MR imaging at 7T to evaluate the anatomy of the midbrain dopaminergic system","volume":"32","author":"Eapen","year":"2011","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib55","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1542\/peds.2007-3412","article-title":"Adverse childhood experiences predict earlier age of drinking onset: Results from a representative US sample of current or former drinkers","volume":"122","author":"Rothman","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.bpsgos.2026.100734_bib56","doi-asserted-by":"crossref","first-page":"444.e1","DOI":"10.1016\/j.jadohealth.2005.06.006","article-title":"Adverse childhood experiences and the association with ever using alcohol and initiating alcohol use during adolescence","volume":"38","author":"Dube","year":"2006","journal-title":"J Adolesc Health"},{"key":"10.1016\/j.bpsgos.2026.100734_bib57","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1037\/abn0000193","article-title":"The structure of psychopathology in adolescence and its common personality and cognitive correlates","volume":"125","author":"Castellanos-Ryan","year":"2016","journal-title":"J Abnorm Psychol"},{"issue":"suppl 1","key":"10.1016\/j.bpsgos.2026.100734_bib58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1360-0443.2008.02174.x","article-title":"Childhood and adolescent predictors of heavy drinking and alcohol use disorders in early adulthood: A longitudinal developmental analysis","volume":"103","author":"Englund","year":"2008","journal-title":"Addiction"},{"key":"10.1016\/j.bpsgos.2026.100734_bib59","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1037\/0021-843X.116.4.645","article-title":"Linking antisocial behavior, substance use, and personality: An integrative quantitative model of the adult externalizing spectrum","volume":"116","author":"Krueger","year":"2007","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib60","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s10802-014-9867-8","article-title":"Do childhood externalizing disorders predict adult depression? A meta-analysis","volume":"42","author":"Loth","year":"2014","journal-title":"J Abnorm Child Psychol"},{"key":"10.1016\/j.bpsgos.2026.100734_bib61","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.dr.2016.03.003","article-title":"The interaction between temperament and the family environment in adolescent substance use and externalizing behaviors: Support for diathesis-stress or differential susceptibility?","volume":"40","author":"Rioux","year":"2016","journal-title":"Dev Rev"},{"key":"10.1016\/j.bpsgos.2026.100734_bib62","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1177\/0093854819826213","article-title":"The effects of adverse childhood experiences on internalizing versus externalizing outcomes","volume":"46","author":"Muniz","year":"2019","journal-title":"Crim Justice Behav"},{"key":"10.1016\/j.bpsgos.2026.100734_bib63","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-0438","article-title":"Long-term cognitive, psychological, and health outcomes associated with child abuse and neglect","volume":"146","author":"Strathearn","year":"2020","journal-title":"Pediatrics"},{"key":"10.1016\/j.bpsgos.2026.100734_bib64","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.40018","article-title":"Adverse life experiences and brain function: A meta-analysis of functional magnetic resonance imaging findings","volume":"6","author":"Hosseini-Kamkar","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.bpsgos.2026.100734_bib65","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1111\/adb.12445","article-title":"Emotional, physical and sexual abuse are associated with a heightened limbic response to cocaine cues","volume":"22","author":"Regier","year":"2017","journal-title":"Addict Biol"}],"container-title":["Biological Psychiatry Global Open Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667174326000479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667174326000479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:40:02Z","timestamp":1783100402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667174326000479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2667174326000479"],"URL":"https:\/\/doi.org\/10.1016\/j.bpsgos.2026.100734","relation":{},"ISSN":["2667-1743"],"issn-type":[{"value":"2667-1743","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry","name":"articletitle","label":"Article Title"},{"value":"Biological Psychiatry Global Open Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpsgos.2026.100734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 THE AUTHORS. Published by Elsevier Inc on behalf of the Society of Biological Psychiatry.","name":"copyright","label":"Copyright"}],"article-number":"100734"}}