{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:18:29Z","timestamp":1791209909801,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["brachyjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brachytherapy"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.brachy.2008.11.010","type":"journal-article","created":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T08:57:03Z","timestamp":1234515423000},"page":"210-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Transperineal injection of hyaluronic acid in the anterior perirectal fat to decrease rectal toxicity from radiation delivered with low-dose-rate brachytherapy for prostate cancer patients"],"prefix":"10.1016","volume":"8","author":[{"given":"Pedro J.","family":"Prada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herminio","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Men\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Llaneza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Santamarta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro P\u00e9rez","family":"Ricarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brachy.2008.11.010_bib1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/jama.280.11.969","article-title":"Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer","volume":"280","author":"D\u00b4Amico","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.brachy.2008.11.010_bib2","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.radonc.2003.12.011","article-title":"Monotherapy for stage T1-T2 prostate cancer: Radical prostatectomy, external beam radiotherapy, or permanent seed implantation","volume":"71","author":"Potters","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2008.11.010_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brachy.2004.12.001","article-title":"103Pb brachytherapy versus radical prostatectomy in patients with clinically localized prostate cancer: 12-Year experience from a single group practice","volume":"4","author":"Sharkey","year":"2005","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2008.11.010_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0167-8140(00)00306-6","article-title":"ESTRO\/EAU\/EORTC recommendations on permanent seed implantation for localized prostate cancer","volume":"57","author":"Ash","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2008.11.010_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.brachy.2005.05.002","article-title":"Variability of prostate brachytherapy preimplant dosimetry: A multi-institutional analysis","volume":"5","author":"Merrick","year":"2005","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2008.11.010_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0360-3016(00)00632-5","article-title":"Rectal complications associated with transperineal interstitial brachytherapy for prostate cancer","volume":"48","author":"Daphna","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib7","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0360-3016(98)00486-6","article-title":"Rectal dosimetric analysis following prostate brachytherapy","volume":"43","author":"Merrick","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0360-3016(98)00080-7","article-title":"Clinical course of rectal bleeding following I-125 prostate brachytherapy","volume":"41","author":"Hu","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0360-3016(94)00599-G","article-title":"Dosimetry guidelines to minimize urethral and rectal morbidity following transperineal I-125 prostate brachytherapy","volume":"32","author":"Wallner","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib10","first-page":"113","article-title":"Transperineal ultrasound-guided implantation of the prostate: Morbidity and complications","volume":"137","author":"Blasko","year":"1991","journal-title":"Scand J\u00a0Urol Nephrol Suppl"},{"key":"10.1016\/j.brachy.2008.11.010_bib11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1200\/JCO.1996.14.2.449","article-title":"Tumor control and morbidity following transperineal I-125 implantation for stage T1\/T2 prostatic carcinoma","volume":"14","author":"Wallner","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.brachy.2008.11.010_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijrobp.2007.02.034","article-title":"Transperineal injection of hyaluronic acid in the anterior peri-rectal fat to decease rectal toxicity from radiation delivered with intensity modulated brachytherapy or EBRT for prostate cancer patients","volume":"69","author":"Prada","year":"2007","journal-title":"Int J Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib13","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0360-3016(97)00949-8","article-title":"Clinical impact of implementing the recommendations of AAPM Task Group 43 on permanent prostate brachytherapy using 125I. American Association of Physicists in Medicine","volume":"40","author":"Bice","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib14","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1136\/ard.57.11.637","article-title":"Intra-articular hyaluronan treatment for osteoarthritis","volume":"57","author":"George","year":"1998","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.brachy.2008.11.010_bib15","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0149-2918(00)80010-7","article-title":"The role of elastoviscosity in the efficacy of viscosupplementation for osteoarthritis of the knee: A comparison of Hyalan G-F20 and a lower molecular weight hyaluronan","volume":"21","author":"Wobig","year":"1999","journal-title":"Clin Ther"},{"key":"10.1016\/j.brachy.2008.11.010_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0167-8140(99)00173-5","article-title":"Endoscopic scoring of late rectal mucosal damage after conformal radiotherapy for prostatic carcinoma","volume":"54","author":"Wachter","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2008.11.010_bib17","first-page":"191","volume":"91","author":"Crespi","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.brachy.2008.11.010_bib18","unstructured":"SPSS Inc. Headquarters. Chicago, IL. V15. 2008."},{"key":"10.1016\/j.brachy.2008.11.010_bib19","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF02716584","article-title":"High dose brachytherapy (real time) in patients with intermediate or high risk prostate cancer: Technical description and preliminary experience","volume":"7","author":"Prada","year":"2005","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.brachy.2008.11.010_bib20","first-page":"1299","article-title":"External beam radiotherapy dose-response of prostate cancer","volume":"15","author":"Pollack","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib21","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1200\/JCO.2000.18.23.3904","article-title":"Preliminary results of a randomized radiotherapy dose escalation study comparing 70 Gy to 78 Gy for prostate cancer","volume":"18","author":"Pollack","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.brachy.2008.11.010_bib22","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0360-3016(99)00498-8","article-title":"Dose selection for prostate cancer patients based on dose comparison and dose response studies","volume":"46","author":"Hanks","year":"2000","journal-title":"Int J Radiot Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0360-3016(97)00301-5","article-title":"Rectal bleeding after conformal 3D treatment of prostate cancer: Time to occurrence, response to treatment and duration of morbidity","volume":"39","author":"Teshima","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000016873","article-title":"Pathophysiology and therapy of chronic radiation-induced injury to the colon","volume":"16","author":"Donner","year":"1998","journal-title":"Dig Dis"},{"key":"10.1016\/j.brachy.2008.11.010_bib25","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ijrobp.2005.08.042","article-title":"Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: Use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors","volume":"64","author":"Shah","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0360-3016(01)01442-0","article-title":"Defining the risk of developing grade 2 proctitis following iodine 125 prostate brachytherapy using a rectal dose-volume histogram analysis","volume":"50","author":"Snyder","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib27","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0360-3016(02)03934-2","article-title":"Probability of late rectal morbidity in iodine 125 prostate brachytherapy","volume":"55","author":"Waterman","year":"2003","journal-title":"Int J Radait Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2008.11.010_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.radonc.2004.01.020","article-title":"Results of permanent prostate brachytherapy, 13 years of experience at a single institution","volume":"71","author":"Battermann","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2008.11.010_bib29","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0022-5347(01)66985-4","article-title":"Prostate specific antigen based disease control following ultrasound guided iodine-125 implantation for state Tl\/T2 prostatic carcinoma","volume":"154","author":"Blasko","year":"1995","journal-title":"J Urol"},{"key":"10.1016\/j.brachy.2008.11.010_bib30","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/S0360-3016(03)00739-9","article-title":"Ten-year biochemical control relapse-free survival after external beam irradiation and brachytherapy for localized prostatic cancer: The Seattle experience","volume":"57","author":"Sylvester","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Brachytherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472108006818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472108006818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:04:49Z","timestamp":1761530689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538472108006818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S1538472108006818"],"URL":"https:\/\/doi.org\/10.1016\/j.brachy.2008.11.010","relation":{},"ISSN":["1538-4721"],"issn-type":[{"value":"1538-4721","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transperineal injection of hyaluronic acid in the anterior perirectal fat to decrease rectal toxicity from radiation delivered with low-dose-rate brachytherapy for prostate cancer patients","name":"articletitle","label":"Article Title"},{"value":"Brachytherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brachy.2008.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}