{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:38:41Z","timestamp":1782297521250,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003958","name":"Dutch Technology Foundation STW","doi-asserted-by":"crossref","award":["06069"],"award-info":[{"award-number":["06069"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["brachyjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brachytherapy"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.brachy.2012.08.001","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T14:30:19Z","timestamp":1348065019000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Microbrachytherapy using holmium-166 acetylacetonate microspheres: A pilot study in a spontaneous cancer animal model"],"prefix":"10.1016","volume":"12","author":[{"given":"Wouter","family":"Bult","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten A.D.","family":"Vente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Vandermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Gielen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Seevinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred D.","family":"van het Schip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J.G.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard C.","family":"Krijger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathelijne","family":"Peremans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes F.W.","family":"Nijsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brachy.2012.08.001_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.gastro.2009.09.006","article-title":"Radioembolization for hepatocellular carcinoma using Yttrium-90 microspheres: A comprehensive report of long-term outcomes","volume":"138","author":"Salem","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.brachy.2012.08.001_bib2","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.ijrobp.2008.10.005","article-title":"Treatment parameters and outcome in 680 treatments of internal radiation with resin 90Y-microspheres for unresectable hepatic tumors","volume":"74","author":"Kennedy","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2012.08.001_bib3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1001\/archsurg.142.7.675","article-title":"Yttrium 90 microsphere selective internal radiation treatment of hepatic colorectal metastases","volume":"142","author":"Gulec","year":"2007","journal-title":"Arch Surg"},{"key":"10.1016\/j.brachy.2012.08.001_bib4","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s00330-009-1613-1","article-title":"Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: Technical aspects studies in a large animal model","volume":"20","author":"Vente","year":"2010","journal-title":"Eur Radiol"},{"key":"10.1016\/j.brachy.2012.08.001_bib5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s002590050440","article-title":"Holmium-166 poly lactic acid microspheres applicable for intra-arterial radionuclide therapy of hepatic malignancies: Effects of preparation and neutron activation techniques","volume":"26","author":"Nijsen","year":"1999","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.brachy.2012.08.001_bib6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1018908600711","article-title":"Poly(L-lactic acid) microspheres containing neutron-activatable holmium-165: A study of the physical characteristics of microspheres before and after irradiation in a nuclear reactor","volume":"9","author":"Mumper","year":"1992","journal-title":"Pharm Res"},{"key":"10.1016\/j.brachy.2012.08.001_bib7","first-page":"2139","article-title":"Neutron-activated homium-166-poly(L-lactic acid) microspheres: A potential agent for the internal radiation therapy of hepatic tumors","volume":"32","author":"Mumper","year":"1991","journal-title":"J Nucl Med"},{"key":"10.1016\/j.brachy.2012.08.001_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2174\/187152007780618153","article-title":"Factors affecting the sensitivity and detection limits of MRI, CT, and SPECT for multimodal diagnostic and therapeutic agents","volume":"7","author":"Seevinck","year":"2007","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.brachy.2012.08.001_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1756-9966-29-70","article-title":"Holmium-166 radioembolization for the treatment of patients with liver metastases: Design of the phase I HEPAR trial","volume":"29","author":"Smits","year":"2010","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.brachy.2012.08.001_bib10","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<980::AID-CNCR28>3.0.CO;2-H","article-title":"An early phase II study of intratumoral P-32 chromic phosphate injection therapy for patients with refractory solid tumors and solitary metastases","volume":"85","author":"Firusian","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.brachy.2012.08.001_bib11","first-page":"958","article-title":"Ultrasound-guided internal radiotherapy using yttrium-90-glass microspheres for liver malignancies","volume":"37","author":"Tian","year":"1996","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.brachy.2012.08.001_bib12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1158\/1078-0432.CCR-05-1730","article-title":"Long-term clinical outcome of phase IIb clinical trial of percutaneous injection with holmium-166\/chitosan complex (Milican) for the treatment of small hepatocellular carcinoma","volume":"12","author":"Kim","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.brachy.2012.08.001_bib13","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s11095-009-9848-8","article-title":"Microspheres with ultrahigh holmium content for radioablation of malignancies","volume":"26","author":"Bult","year":"2009","journal-title":"Pharm Res"},{"key":"10.1016\/j.brachy.2012.08.001_bib14","unstructured":"Bult W. Holmium microparticles for intratumoral radioablation [Ph.D. thesis]. The Netherlands: Utrecht University; 2010. ISBN 978-90-393-5458-1."},{"key":"10.1016\/j.brachy.2012.08.001_bib15","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10544-009-9291-y","article-title":"Neutron activation of holmium poly(L-lactic acid) microspheres for hepatic arterial radio-embolization: A validation study","volume":"11","author":"Vente","year":"2009","journal-title":"Biomed Microdevices"},{"key":"10.1016\/j.brachy.2012.08.001_bib16","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s00259-008-0747-8","article-title":"Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(L-lactic acid) microspheres in healthy pigs","volume":"35","author":"Vente","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.brachy.2012.08.001_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11060-004-2352-4","article-title":"Brachytherapy for brain tumors","volume":"73","author":"Vitaz","year":"2005","journal-title":"J Neurooncol"},{"key":"10.1016\/j.brachy.2012.08.001_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.brachy.2009.03.191","article-title":"Interstitial brachytherapy as boost for locally advanced T4 head-and-neck cancer","volume":"8","author":"Do","year":"2009","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2012.08.001_bib19","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1088\/0031-9155\/51\/19\/004","article-title":"Hybrid scatter correction applied to quantitative holmium-166 SPECT","volume":"51","author":"de Wit","year":"2006","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.brachy.2012.08.001_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jmri.20479","article-title":"Fully MR-guided hepatic artery catheterization for selective drug delivery: A feasibility study in pigs","volume":"23","author":"Seppenwoolde","year":"2006","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.brachy.2012.08.001_bib21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ijrobp.2009.09.026","article-title":"Local response and impact on survival after local ablation of liver metastases from colorectal carcinoma by computed tomography-guided high-dose-rate brachytherapy","volume":"78","author":"Ricke","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2012.08.001_bib22","series-title":"Physical Pharmacy","author":"Martin","year":"1993"},{"key":"10.1016\/j.brachy.2012.08.001_bib23","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s11095-010-0226-3","article-title":"Holmium nanoparticles: Preparation and in\u00a0vitro characterization of a new device for radioablation of solid malignancies","volume":"27","author":"Bult","year":"2010","journal-title":"Pharm Res"},{"key":"10.1016\/j.brachy.2012.08.001_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00004032-195907000-00001","article-title":"Metabolic characteristics within a chemical family","volume":"2","author":"Durbin","year":"1960","journal-title":"Health Phys"}],"container-title":["Brachytherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472112001924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472112001924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:06:51Z","timestamp":1761530811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538472112001924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S1538472112001924"],"URL":"https:\/\/doi.org\/10.1016\/j.brachy.2012.08.001","relation":{},"ISSN":["1538-4721"],"issn-type":[{"value":"1538-4721","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbrachytherapy using holmium-166 acetylacetonate microspheres: A pilot study in a spontaneous cancer animal model","name":"articletitle","label":"Article Title"},{"value":"Brachytherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brachy.2012.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}