{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:20:19Z","timestamp":1790616019092,"version":"4.1.0"},"reference-count":137,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["brachyjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brachytherapy"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.brachy.2016.07.005","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T20:13:06Z","timestamp":1473451986000},"page":"44-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["American Brachytherapy Society Task Group Report: Combined external beam irradiation and interstitial brachytherapy for base of tongue tumors and other head and neck sites in the era of new technologies"],"prefix":"10.1016","volume":"16","author":[{"given":"Zolt\u00e1n","family":"Tak\u00e1csi-Nagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Mart\u00ednez-Mongue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Mazeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristopher James","family":"Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis B.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brachy.2016.07.005_bib1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1053\/j.seminoncol.2014.09.015","article-title":"Modern brachytherapy","volume":"41","author":"Lukens","year":"2014","journal-title":"Semin Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib2","first-page":"404","article-title":"Modern head and neck brachytherapy: from radium towards intensity modulated interventional brachytherapy","volume":"6","author":"Kov\u00e1cs","year":"2015","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.radonc.2009.01.005","article-title":"GEC-ESTRO recommendations for brachytherapy for head and neck squamous cell carcinomas","volume":"91","author":"Mazeron","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib4","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0360-3016(01)01567-X","article-title":"The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for head-and-neck carcinoma","volume":"50","author":"Nag","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0360-3016(95)02054-3","article-title":"Pulsed dose rate and fractionated high dose rate brachytherapy: choice of brachytherapy schedules to replace low dose rate treatments","volume":"34","author":"Visser","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0360-3016(01)01561-9","article-title":"Phase III trial of high- vs. low-dose-rate interstitial radiotherapy for early mobile tongue cancer","volume":"51","author":"Inoue","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.brachy.2013.07.001","article-title":"Long-term outcomes with high-dose-rate brachytherapy for the management of base of tongue cancer","volume":"12","author":"Tak\u00e1csi-Nagy","year":"2013","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.ijrobp.2011.09.038","article-title":"High dose-rate versus low dose-rate brachytherapy for lip cancer","volume":"83","author":"Ghadjar","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib9","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1097\/00005537-199912000-00013","article-title":"High-dose-rate brachytherapy for primary carcinomas of the oral cavity and oropharynx","volume":"109","author":"Rudoltz","year":"1999","journal-title":"Laryngoscope"},{"key":"10.1016\/j.brachy.2016.07.005_bib10","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.brachy.2013.05.007","article-title":"From low-dose-rate to high-dose-rate brachytherapy in lip carcinoma: equivalent results but fewer complications","volume":"12","author":"Guinot","year":"2013","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib11","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1002\/cncr.10567","article-title":"Squamous cell carcinoma of the oropharynx","volume":"94","author":"Parsons","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.brachy.2016.07.005_bib12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib13","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/0360-3016(89)90525-7","article-title":"External irradiation plus curietherapy boost in 108 base of tongue carcinomas","volume":"17","author":"Lusinchi","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib14","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0360-3016(88)90003-X","article-title":"Limited external beam and interstitial 192 Iridium irradiation in the treatment of carcinoma of the base of the tongue: a ten year experience","volume":"14","author":"Puthawala","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib15","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/(SICI)1097-0347(199812)20:8<668::AID-HED2>3.0.CO;2-9","article-title":"Long term results of primary radiotherapy with\/without neck dissection for squamous cell cancer of the base of tongue","volume":"20","author":"Harrison","year":"1998","journal-title":"Head and Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0360-3016(88)90353-7","article-title":"Combined external irradiation and interstitial implantation for T1 and T2 epidermoid carcinomas of base of tongue: the Creteil experience (1971-1981)","volume":"15","author":"Crook","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/(SICI)1097-0347(199705)19:3<219::AID-HED10>3.0.CO;2-6","article-title":"The impact of temporary iodine-125 interstitial implant boost in the primary management of squamous cell carcinoma of the oropharynx","volume":"19","author":"Horwitz","year":"1997","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib18","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/1097-0142(19850301)55:5<941::AID-CNCR2820550505>3.0.CO;2-G","article-title":"192 Ir pharyngoepiglottic fold interstitial implants. The key to successful treatment of base tongue carcinoma by radiation therapy","volume":"55","author":"Goffinet","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/j.brachy.2016.07.005_bib19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0360-3016(03)00597-2","article-title":"Long-term outcomes after external beam irradiation and brachytherapy boost for base-of-tongue cancers","volume":"57","author":"Gibbs","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib20","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hed.20064","article-title":"The National Cancer Data Base report on squamous cell carcinoma of the base of the tongue","volume":"26","author":"Zhen","year":"2004","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.radonc.2011.05.036","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site","volume":"100","author":"Blanchard","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.oraloncology.2011.04.015","article-title":"Superselective arterial cisplatin infusion with concomitant radiation therapy for base of tongue cancer","volume":"47","author":"Kano","year":"2011","journal-title":"Oral Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1470-2045(11)70346-1","article-title":"Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial","volume":"13","author":"Bourhis","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib24","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/hed.23244","article-title":"Intensity-modulated radiotherapy followed by a brachytherapy boost for oropharyngeal cancer","volume":"35","author":"Al-Mamgani","year":"2013","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0194-59989670006-2","article-title":"Role of interstitial brachytherapy in oral and oropharyngeal carcinoma: reflection of a series of 1344 patients treated at the time of initial presentation","volume":"115","author":"Pernot","year":"1996","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.brachy.2016.07.005_bib26","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0360-3016(87)90065-4","article-title":"A retrospective study of three treatment techniques for T1-T2 base of tongue lesions: surgery plus postoperative radiation, external radiation plus interstitial implantation and external radiation alone","volume":"13","author":"Housset","year":"1987","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib27","first-page":"211","article-title":"Brachytherapy and external radiation for carcinoma of the base of tongue: implantation of the primary tumor and cervical adenopathy","volume":"16","author":"Demanes","year":"2000","journal-title":"Int J Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib28","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1097\/00005537-200108000-00009","article-title":"Base-of-tongue cancer: survival, function, and quality of life after external-beam irradiation and brachytherapy","volume":"111","author":"Robertson","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.brachy.2016.07.005_bib29","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/(SICI)1097-0142(19960901)78:5<948::AID-CNCR3>3.0.CO;2-8","article-title":"Excellent functional outcome in patients with squamous cell carcinoma of the base of tongue treated with external irradiation and interstitial Iodine 125 boost","volume":"78","author":"Horwitz","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.brachy.2016.07.005_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brachy.2004.02.001","article-title":"Brachytherapy in the treatment of Stage IV carcinoma of the base of tongue","volume":"3","author":"Cano","year":"2004","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.brachy.2004.09.002","article-title":"A comparison of treatments of squamous cell carcinoma of the base of tongue: surgical resection combined with external radiation therapy, external radiation therapy alone, and external radiation therapy combined with interstitial radiation","volume":"3","author":"Barrett","year":"2004","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hed.20171","article-title":"Definitive radiotherapy with interstitial implant boost for squamous cell carcinoma of the tongue base","volume":"27","author":"Karakoyun-Celik","year":"2005","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brachy.2004.04.002","article-title":"Radical radiotherapy compared with surgery for advanced squamous cell carcinoma of the base of tongue","volume":"3","author":"van de Pol","year":"2004","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib34","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/hed.21111","article-title":"Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy","volume":"31","author":"Cano","year":"2009","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib35","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s00066-004-1238-x","article-title":"Interstitial high-dose-rate brachytherapy in the treatment of base of tongue carcinoma","volume":"180","author":"Tak\u00e1csi-Nagy","year":"2004","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.brachy.2016.07.005_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5114\/jcb.2011.21037","article-title":"Pulsed dose rate brachytherapy as the boost in combination with external beam irradiation in base of tongue cancer. Long-term results from a uniform clinical series","volume":"3","author":"Johansson","year":"2011","journal-title":"J Contemp Brachyther"},{"key":"10.1016\/j.brachy.2016.07.005_bib37","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/1097-0142(197206)29:6<1446::AID-CNCR2820290604>3.0.CO;2-C","article-title":"Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts","volume":"29","author":"Lindberg","year":"1972","journal-title":"Cancer"},{"key":"10.1016\/j.brachy.2016.07.005_bib38","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/(SICI)1097-0347(199912)21:8<751::AID-HED11>3.0.CO;2-4","article-title":"Cancer of the base of the tongue: past and future","volume":"21","author":"Brunin","year":"1999","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib39","first-page":"297","article-title":"Teletherapy versus teletherapy and \u201cboost\u201d brachytherapy in the treatment of base of tongue tumors: 5-year results","volume":"48","author":"Tak\u00e1csi-Nagy","year":"2004","journal-title":"Magy Onkol"},{"key":"10.1016\/j.brachy.2016.07.005_bib40","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/0360-3016(79)90947-7","article-title":"Phillips TL: results of treatment of carcinoma of the base of tongue, the UCSF experience, 1957-1976","volume":"5","author":"Blumberg","year":"1979","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib41","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1259\/0007-1285-62-741-849","article-title":"Squamous cell carcinoma of the base of the tongue: results of treatment in 115 cases","volume":"62","author":"Calais","year":"1989","journal-title":"Br J Radiol"},{"key":"10.1016\/j.brachy.2016.07.005_bib42","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/1097-0142(19910315)67:6<1532::AID-CNCR2820670612>3.0.CO;2-D","article-title":"Results of radiation therapy in carcinoma of the base of the tongue. The Curie Institute experience with about 166 cases","volume":"67","author":"Jaulerry","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.brachy.2016.07.005_bib43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2273.1992.tb01054.x","article-title":"Staging and prognostic factors in carcinoma of the base of the tongue","volume":"17","author":"Mak-Kregar","year":"1992","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"10.1016\/j.brachy.2016.07.005_bib44","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1288\/00005537-199412000-00007","article-title":"External beam irradiation alone or combined with neck dissection for base of tongue carcinoma: an alternative to primary surgery","volume":"104","author":"Hinerman","year":"1994","journal-title":"Laryngoscope"},{"key":"10.1016\/j.brachy.2016.07.005_bib45","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1002\/1097-0142(197606)37:6<2591::AID-CNCR2820370605>3.0.CO;2-7","article-title":"Time, dose, and tumor volume relationships in irradiation of squamous cell carcinoma of the base of the tongue","volume":"37","author":"Spanos","year":"1976","journal-title":"Cancer"},{"key":"10.1016\/j.brachy.2016.07.005_bib46","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0360-3016(83)90059-7","article-title":"Split-course radiation therapy of carcinoma of the base of the tongue: results of a prospective national collaborative trial conducted by the radiation therapy oncology group","volume":"9","author":"Marcial","year":"1983","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib47","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(96)00612-8","article-title":"Complications following definitive irradiation for cancers of the oral cavity and the oropharynx (in a series of 1134 patients)","volume":"37","author":"Pernot","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib48","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s00066-004-9196-x","article-title":"Treatment of oral cavity and oropharyngeal cancer. Indications, technical aspects, and results of interstitial brachytherapy","volume":"180","author":"Strnad","year":"2004","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.brachy.2016.07.005_bib49","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.brachy.2009.11.001","article-title":"Late nodal metastasis in early-stage node-negative oral cavity cancers after successful sole interstitial brachytherapy: an institutional experience of 42 cases in India","volume":"9","author":"Chakrabarti","year":"2010","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/(SICI)1097-0347(199705)19:3<205::AID-HED7>3.0.CO;2-6","article-title":"Depth of invasion as a predictive factor for cervical lymph node metastasis in tongue carcinoma","volume":"19","author":"Fukano","year":"1997","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib51","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/jjco\/hyt108","article-title":"Treatment outcome of high-dose-rate interstitial radiation therapy for patients with stage I and II mobile tongue cancer","volume":"43","author":"Matsumoto","year":"2013","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib52","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/0360-3016(90)90346-L","article-title":"Iridium 192 implantation of T1 and T2 carcinomas of the mobile tongue","volume":"19","author":"Mazeron","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib53","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1186\/2193-1801-3-590","article-title":"Role of high dose rate interstitial brachytherapy in early and locally advanced squamous cell carcinoma of buccal mucosa","volume":"3","author":"Vedasoundaram","year":"2014","journal-title":"Springerplus"},{"key":"10.1016\/j.brachy.2016.07.005_bib54","first-page":"1","article-title":"Le carcinome epidermoide de la face interne de joue: \u00e0 propos de 748 malades","volume":"6","author":"Gerbaulet","year":"1985","journal-title":"J Eur Radiother"},{"key":"10.1016\/j.brachy.2016.07.005_bib55","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1748-717X-5-116","article-title":"Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older","volume":"5","author":"Yamazaki","year":"2010","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brachy.2009.10.003","article-title":"Efficacy of high-dose-rate interstitial brachytherapy in patients with oral tongue carcinoma","volume":"9","author":"Guinot","year":"2010","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib57","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0360-3016(98)00041-8","article-title":"High dose rate versus low dose rate interstitial radiotherapy for carcinoma of the floor of mouth","volume":"41","author":"Inoue","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib58","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1269\/jrr.11025","article-title":"Low-dose-rate interstitial brachytherapy preserves good quality of life in buccal mucosa cancer patients","volume":"52","author":"Tayier","year":"2011","journal-title":"J Radiat Res"},{"key":"10.1016\/j.brachy.2016.07.005_bib59","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/0360-3016(81)90151-6","article-title":"Analysis of time-dose factors in squamous cell carcinoma of the oral tongue and floor of mouth treated with radiation therapy alone","volume":"7","author":"Mendenhall","year":"1981","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib60","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0167-8140(92)80125-3","article-title":"Iridium-192 brachytherapy in the management of 147 T2N0 oral tongue carcinomas treated with irradiation alone: comparison of two treatment techniques","volume":"23","author":"Pernot","year":"1992","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib61","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/0360-3016(90)90299-Y","article-title":"Primary radiotherapy in the treatment of stage I and II oral tongue cancers: importance of the proportion of therapy delivered with interstitial therapy","volume":"18","author":"Wendt","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib62","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.oraloncology.2004.12.012","article-title":"Treatment results of stage I oral tongue cancer with definitive radiotherapy","volume":"41","author":"Ichimiya","year":"2005","journal-title":"Oral Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib63","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0360-3016(01)02761-4","article-title":"Brachytherapy for T1-T2 floor-of-the-mouth cancers: the Gustave-Roussy Institute experience","volume":"52","author":"Marsiglia","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib64","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ijrobp.2003.11.032","article-title":"Brachytherapy versus surgery in carcinoma of tonsillar fossa and\/or soft palate: late adverse sequelae and performance status: can we be more selective and obtain better tissue sparing?","volume":"59","author":"Levendag","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib65","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0360-3016(93)90235-N","article-title":"Place of Iridium 192 implantation in definitive irradiation of faucial arch squamous cell carcinomas","volume":"27","author":"Mazeron","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib66","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0360-3016(94)90309-3","article-title":"Influence of tumoral, radiobiological, and general factors on local control and survival of a series of 361 tumors of the velotonsillar area treated by exclusive irradiation (external beam irradiation+brachytherapy or\u00a0brachytherapy alone)","volume":"30","author":"Pernot","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib67","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0167-8140(97)00119-9","article-title":"Treatment duration as a prognostic factor for local control and survival in epidermoid carcinomas of the tonsillar region treated by combined external beam irradiation and brachytherapy","volume":"45","author":"Hoffstetter","year":"1997","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib68","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0360-3016(94)90161-9","article-title":"Iridium-192 interstitial implant and external beam radiation therapy in the management of squamous cell carcinomas of the tonsil and soft palate","volume":"28","author":"Behar","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib69","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0360-3016(97)00046-1","article-title":"Fractionated high-dose-rate and pulsed-dose-rate brachytherapy: first clinical experience in squamous cell carcinoma of the tonsillar fossa and soft palate","volume":"38","author":"Levendag","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib70","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.ijrobp.2003.12.015","article-title":"High-dose-rate interstitial brachytherapy for oropharyngeal carcinoma: results of 83 lesions in 82 patients","volume":"59","author":"Nose","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib71","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0360-3016(92)90740-9","article-title":"Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure","volume":"23","author":"Lee","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib72","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/0360-3016(94)90306-9","article-title":"The effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx: an analysis of 1301 patients","volume":"30","author":"Kwong","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib73","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11864-013-0261-5","article-title":"Current treatment options for local residual nasopharyngeal carcinoma","volume":"14","author":"Stoker","year":"2013","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib74","doi-asserted-by":"crossref","first-page":"e90048","DOI":"10.1371\/journal.pone.0090048","article-title":"Endoscope-guided interstitial intensity modulated brachytherapy and intracavitary brachytherapy as boost radiation for primary early T stage nasopharyngeal carcinoma","volume":"9","author":"Wan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.brachy.2016.07.005_bib75","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0360-3016(99)00326-0","article-title":"Intracavitary brachytherapy significantly enhances local control of early T-stage nasopharyngeal carcinoma: the existence of a dose-tumor-control relationship above conventional tumoricidal dose","volume":"46","author":"Teo","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib76","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0360-3016(00)00520-4","article-title":"Brachytherapy for primary and recurrent nasopharyngeal carcinoma: 20 years' experience at Long Beach Memorial","volume":"47","author":"Syed","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib77","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0167-8140(02)00008-7","article-title":"High-dose, high-precision treatment options for boosting cancer of the nasopharynx","volume":"63","author":"Levendag","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib78","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0360-3016(96)00416-6","article-title":"The role of brachytherapy in early-stage nasopharyngeal carcinoma","volume":"36","author":"Chang","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib79","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0360-3016(01)01818-1","article-title":"Adjuvant high-dose-rate brachytherapy after external beam radiotherapy in nasopharyngeal carcinoma","volume":"52","author":"\u00d6zyar","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib80","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ijrobp.2007.06.078","article-title":"High-dose-rate intracavitary brachytherapy boost for early T stage nasopharyngeal carcinoma","volume":"70","author":"Leung","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib81","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1748-717X-9-67","article-title":"Brachytherapy boost in loco-regionally advanced nasopharyngeal carcinoma: a prospective randomized trial of the International Atomic Energy Agency","volume":"9","author":"Rosenblatt","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib82","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00000421-199102000-00002","article-title":"Improved local control of nasopharyngeal carcinoma after intracavitary brachytherapy boost","volume":"14","author":"Wang","year":"1991","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib83","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/hed.10377","article-title":"Postoperative brachytherapy alone and combined postoperative radiotherapy and brachytherapy boost for squamous cell carcinoma of the oral cavity, with positive or close margins","volume":"26","author":"Lapeyre","year":"2004","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib84","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/PL00002416","article-title":"Interstitial brachytherapy with Ir-192 low-dose-rate in the treatment of primary and recurrent cancer of the oral cavity and oropharynx. Review of 318 patients treated between 1985 and 1997","volume":"177","author":"Grabenbauer","year":"2001","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.brachy.2016.07.005_bib85","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.brachy.2013.07.002","article-title":"Interstitial pulsed-dose-rate brachytherapy for head and neck cancer\u2013single-institution long-term results of 385 patients","volume":"12","author":"Strnad","year":"2013","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib86","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.brachy.2014.05.015","article-title":"Volume of high-dose regions and likelihood of locoregional control after perioperative high-dose-rate brachytherapy: do hotter implants work better?","volume":"13","author":"Mart\u00ednez-Mongue","year":"2014","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib87","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1016\/j.ijrobp.2011.03.026","article-title":"Determinants of complications and outcome in high-risk squamous cell head-and-neck cancer treated with perioperative high-dose rate brachytherapy (PHDRB)","volume":"81","author":"Mart\u00ednez-Mongue","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib88","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.ijrobp.2009.12.023","article-title":"Interaction of\u00a02-Gy equivalent dose and margin status in perioperative high-dose-rate brachytherapy","volume":"79","author":"Mart\u00ednez-Mongue","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib89","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.brachy.2013.10.009","article-title":"Perioperative image-adapted brachytherapy for the treatment of paranasal sinus and nasal cavity malignancies","volume":"13","author":"Teudt","year":"2014","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib90","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/hed.23007","article-title":"Intraoperative high-dose-rate radiotherapy in the management of locoregionally recurrent head and neck cancer","volume":"35","author":"Scala","year":"2013","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib91","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.brachy.2013.01.165","article-title":"High-dose-rate intraoperative brachytherapy and radical surgical resection in the management of recurrent head-and-neck cancer","volume":"12","author":"Teckie","year":"2013","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib92","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.brachy.2005.06.002","article-title":"Intraoperative single fraction high-dose-rate brachytherapy for head and neck cancers","volume":"4","author":"Nag","year":"2005","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib93","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1200\/JCO.2004.08.021","article-title":"Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma","volume":"22","author":"Denis","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib94","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/hed.21360","article-title":"Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue","volume":"32","author":"Pederson","year":"2010","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib95","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1200\/JCO.1998.16.4.1310","article-title":"Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099","volume":"16","author":"Al-Sarraf","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib96","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1200\/JCO.2008.18.1545","article-title":"Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma","volume":"27","author":"Hui","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib97","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1538-4721(02)00056-9","article-title":"Pulsed-dose rate brachytherapy with concomitant chemotherapy and interstitial hyperthermia in patients with recurrent head-and-neck cancer","volume":"1","author":"Geiger","year":"2002","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib98","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00066-014-0809-8","article-title":"Reirradiation for recurrent head and neck cancer with salvage interstitial pulsed-dose-rate brachytherapy: long-term results","volume":"191","author":"Strnad","year":"2015","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.brachy.2016.07.005_bib99","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/s00268-003-7105-6","article-title":"Salivary gland sparing and improved target irradiation by conformal and intensity modulated irradiation of head and neck cancer","volume":"27","author":"Eisbruch","year":"2003","journal-title":"World J Surg"},{"key":"10.1016\/j.brachy.2016.07.005_bib100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.radonc.2011.12.010","article-title":"Intensity-modulated radiotherapy in head and neck cancer: results of the prospective study GORTEC 2004-03","volume":"103","author":"Toledano","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib101","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib102","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/cncr.28372","article-title":"Improved survival using intensity-modulated radiation therapy in head and neck cancers: a SEER-Medicare analysis","volume":"120","author":"Beadle","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.brachy.2016.07.005_bib103","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.ijrobp.2007.04.083","article-title":"Can IMRT or brachytherapy reduce dysphagia associated with chemoradiotherapy of head and neck cancer? the Michigan and Rotterdam experiences","volume":"69","author":"Eisbruch","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib104","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.radonc.2007.07.009","article-title":"Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship","volume":"85","author":"Levendag","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brachy.2004.10.002","article-title":"Point: brachytherapy versus intensity-modulated radiation therapy in the management of base of tongue cancers","volume":"4","author":"Hu","year":"2005","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib106","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1586\/era.11.110","article-title":"Emerging applications of stereotactic body radiation therapy for head and neck cancer","volume":"11","author":"Siddiqui","year":"2011","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.brachy.2016.07.005_bib107","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.rpor.2013.09.009","article-title":"Extracranial stereotactic body radiotherapy. Review of main SBRT features and indications in primary tumors","volume":"18","author":"Rubio","year":"2013","journal-title":"Rep Pract Oncol Radiother"},{"key":"10.1016\/j.brachy.2016.07.005_bib108","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1055\/s-0034-1368166","article-title":"Transoral robotic reconstructive surgery","volume":"28","author":"Selber","year":"2014","journal-title":"Semin Plast Surg"},{"key":"10.1016\/j.brachy.2016.07.005_bib109","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1093\/annonc\/mdq210","article-title":"p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters","volume":"21","author":"Fischer","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib110","first-page":"649","article-title":"High p16 expression predicts a positive response to chemoradiotherapy in stage IVa\/b head and neck squamous cell carcinoma","volume":"12","author":"Chen","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.brachy.2016.07.005_bib111","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.ijrobp.2010.04.031","article-title":"Intensity-modulated radiotherapy for oral cavity squamous cell carcinoma: patterns of failure and predictors of local control","volume":"80","author":"Daly","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib112","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.brachy.2009.05.006","article-title":"Acquisition of equal or\u00a0better planning results with interstitial brachytherapy when compared with intensity-modulated radiotherapy in tongue cancers","volume":"9","author":"Sresty","year":"2010","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib113","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1002\/hed.23245","article-title":"Intensity-modulated radiation therapy as primary treatment for oropharyngeal squamous cell carcinoma","volume":"35","author":"May","year":"2013","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib114","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/lary.21144","article-title":"Intensity-modulated radiotherapy for oropharyngeal squamous cell carcinoma","volume":"120","author":"Mendenhall","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.brachy.2016.07.005_bib115","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.ijrobp.2012.08.004","article-title":"Patterns of disease recurrence following treatment of oropharyngeal cancer with intensity modulated radiation therapy","volume":"85","author":"Garden","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib116","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.ijrobp.2009.04.006","article-title":"Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: clinical outcomes and patterns of failure","volume":"76","author":"Daly","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib117","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.ijrobp.2008.02.061","article-title":"Treatment techniques and site considerations regarding dysphagia-related quality of life in cancer of the oropharynx and nasopharynx","volume":"72","author":"Teguh","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib118","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hed.20760","article-title":"Trismus in patients with oropharyngeal cancer: relationship with dose in structures of mastication apparatus","volume":"30","author":"Teguh","year":"2008","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib119","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.radonc.2012.12.014","article-title":"A prospective evaluation of patient-reported quality-of-life after (chemo)radiation for oropharyngeal cancer: which patients are at risk of significant quality-of-life deterioration?","volume":"106","author":"Al-Mamgani","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib120","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/cam4.364","article-title":"Clinical outcomes associated with evolving treatment modalities and radiation techniques for base-of-tongue carcinoma: thirty years of institutional experience","volume":"4","author":"Chen","year":"2015","journal-title":"Cancer Med"},{"key":"10.1016\/j.brachy.2016.07.005_bib121","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijrobp.2004.02.059","article-title":"Three-dimensional conformal radiotherapy versus intracavitary brachytherapy for salvage treatment of locally persistent nasopharyngeal carcinoma","volume":"60","author":"Zheng","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib122","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/hed.20093","article-title":"Effectiveness of brachytherapy and fractionated stereotactic radiotherapy boost for persistent nasopharyngeal carcinoma","volume":"26","author":"Yau","year":"2004","journal-title":"Head Neck"},{"key":"10.1016\/j.brachy.2016.07.005_bib123","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.canrad.2014.03.013","article-title":"Stereotactic irradiation in head and neck cancers","volume":"18","author":"Benha\u00efm","year":"2014","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.brachy.2016.07.005_bib124","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brachy.2012.06.001","article-title":"Local control in advanced cancer of the nasopharynx: is a boost dose by endocavitary brachytherapy of prognostic significance?","volume":"12","author":"Levendag","year":"2013","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib125","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ijrobp.2007.10.027","article-title":"Excellent local control with stereotactic radiotherapy boost after external beam radiotherapy in patients with nasopharyngeal carcinoma","volume":"71","author":"Hara","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib126","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0360-3016(01)02719-5","article-title":"Role of endocavitary brachytherapy with or without chemotherapy in cancer of the nasopharynx","volume":"52","author":"Levendag","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib127","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1748-717X-7-85","article-title":"Long-term outcome and toxicity of hypofractionated stereotactic body radiotherapy as a boost treatment for head and neck cancer: the importance of boost volume assessment","volume":"7","author":"Lee","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib128","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1016\/j.brachy.2015.02.376","article-title":"Dosimetric and economic comparison of interstitial high-dose-rate brachytherapy to stereotactic body radiation therapy for liver lesions","volume":"14","author":"Hrycushko","year":"2015","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2016.07.005_bib129","first-page":"1089","article-title":"Osteoradionecrosis in cancer patients: the evidence base for treatment-dependent frequency, current management strategies, and future studies","volume":"18","author":"Peterson","year":"2010","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.brachy.2016.07.005_bib130","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.radonc.2005.09.007","article-title":"Cancer in the oropharynx: cost calculation of different treatment modalities for controlled primaries, relapses and grade III\/IV complications","volume":"77","author":"Nijdam","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib131","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-8140(03)00055-0","article-title":"Results of low- and high-dose rate interstitial brachytherapy for T3 mobile tongue cancer","volume":"68","author":"Kakimoto","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2016.07.005_bib132","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0360-3016(97)00732-3","article-title":"A conformal index (COIN) to evaluate implant quality and dose specification in brachytherapy","volume":"40","author":"Baltas","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib133","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1118\/1.596152","article-title":"A dose homogeneity index for evaluating Ir-192 interstitial breast implants","volume":"15","author":"Wu","year":"1988","journal-title":"Med Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib134","series-title":"Brachytherapy from radium to optimization","first-page":"300","article-title":"Evaluation and optimization of interstitial brachytherapy dose distributions","author":"Meertens","year":"1994"},{"key":"10.1016\/j.brachy.2016.07.005_bib135","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0360-3016(93)90971-W","article-title":"Concept of dose nonuniformity in interstitial brachytherapy","volume":"26","author":"Saw","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2016.07.005_bib136","series-title":"Practical handbook of brachytherapy","first-page":"166","year":"2014"},{"key":"10.1016\/j.brachy.2016.07.005_bib137","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0360-3016(94)90553-3","article-title":"The study of tumoral, radiobiological, and general health factors that influence results and complications in a series of 448 oral tongue carcinomas treated exclusively by irradiation","volume":"29","author":"Pernot","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Brachytherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472116305116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472116305116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:12:18Z","timestamp":1761531138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538472116305116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":137,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S1538472116305116"],"URL":"https:\/\/doi.org\/10.1016\/j.brachy.2016.07.005","relation":{},"ISSN":["1538-4721"],"issn-type":[{"value":"1538-4721","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"American Brachytherapy Society Task Group Report: Combined external beam irradiation and interstitial brachytherapy for base of tongue tumors and other head and neck sites in the era of new technologies","name":"articletitle","label":"Article Title"},{"value":"Brachytherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brachy.2016.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}