{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:40:20Z","timestamp":1790354420967,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["brachyjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brachytherapy"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.brachy.2019.04.004","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T20:34:10Z","timestamp":1557952450000},"page":"530-538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["A machine-learning\u2013based prediction model of fistula formation after interstitial brachytherapy for locally advanced gynecological malignancies"],"prefix":"10.1016","volume":"18","author":[{"given":"Zhen","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hrycushko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brachy.2019.04.004_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ygyno.2016.10.020","article-title":"Long term results from a prospective database on high dose rate (HDR) interstitial brachytherapy for primary cervical carcinoma","volume":"144","author":"Fallon","year":"2017","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2019.04.004_bib2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.brachy.2017.10.004","article-title":"Clinical outcomes using image-guided interstitial brachytherapy for definitive cervical cancer patients with high-risk clinical target volumes greater than 30 cc","volume":"17","author":"Wang","year":"2018","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2019.04.004_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.radonc.2016.05.019","article-title":"Outcomes with image-based interstitial brachytherapy for vaginal cancer","volume":"120","author":"Manuel","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2019.04.004_bib4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.brachy.2006.09.002","article-title":"High-dose-rate interstitial brachytherapy for gynecologic malignancies","volume":"5","author":"Beriwal","year":"2006","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2019.04.004_bib5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.brachy.2017.11.011","article-title":"Image-guided interstitial high-dose-rate brachytherapy for locally recurrent uterine cervical cancer: A single-institution study","volume":"17","author":"Umezawa","year":"2018","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2019.04.004_bib6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.radonc.2017.03.005","article-title":"Three-dimensional-guided perineal-based interstitial brachytherapy in cervical cancer: A systematic review of technique, local control and toxicities","volume":"123","author":"Mendez","year":"2017","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.brachy.2019.04.004_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0360-3016(02)02900-0","article-title":"Long-term results of low-dose-rate interstitial-intracavitary brachytherapy in the treatment of carcinoma of the cervix","volume":"54","author":"Syed","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/gyno.1995.1178","article-title":"Parametrial interstitial brachytherapy for advanced or recurrent pelvic malignancy: The Harvard\/Stanford experience","volume":"58","author":"Hughes-Davies","year":"1995","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2019.04.004_bib9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.brachy.2012.10.005","article-title":"Urethral dosimetry and toxicity with high-dose-rate interstitial brachytherapy for vaginal cancer","volume":"12","author":"Rajagopalan","year":"2013","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2019.04.004_bib10","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.ijrobp.2012.01.085","article-title":"Predictors of toxicity after image-guided high-dose-rate interstitial brachytherapy for gynecologic cancer","volume":"84","author":"Lee","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib12","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative analyses of normal tissue effects in the clinic (QUANTEC): An introduction to the scientific issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0360-3016(91)90172-Z","article-title":"Fitting of normal tissue tolerance data to an analytic function","volume":"21","author":"Burman","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1118\/1.595312","article-title":"Models in radiotherapy: Volume effects","volume":"10","author":"Schultheiss","year":"1983","journal-title":"Med Phys"},{"issue":"2","key":"10.1016\/j.brachy.2019.04.004_bib15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/09553009214552071","article-title":"Tumour and normal tissue responses to fractionated non-uniform dose delivery","volume":"62","author":"K\u00e4llman","year":"1992","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.brachy.2019.04.004_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.radonc.2005.11.014","article-title":"Recommendations from gynaecological (GYN) GEC ESTRO working group (II): Concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy\u20143D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology","volume":"78","author":"P\u00f6tter","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2019.04.004_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brachy.2011.07.002","article-title":"American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: High-dose-rate brachytherapy","volume":"11","author":"Viswanathan","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2019.04.004_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brachy.2011.06.008","article-title":"American Brachytherapy Society consensus guidelines for interstitial brachytherapy for vaginal cancer","volume":"11","author":"Beriwal","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2019.04.004_bib19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ijrobp.2005.12.008","article-title":"Predictors of severe gastrointestinal toxicity after external beam radiotherapy and interstitial brachytherapy for advanced or recurrent gynecologic malignancies","volume":"65","author":"Kasibhatla","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.brachy.2019.04.004_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.canlet.2016.05.033","article-title":"Big data and machine learning in radiation oncology: State of the art and future prospects","volume":"382","author":"Bibault","year":"2016","journal-title":"Cancer Lett"},{"key":"10.1016\/j.brachy.2019.04.004_bib21","series-title":"A training algorithm for optimal margin classifiers","author":"Boser","year":"1992"},{"key":"10.1016\/j.brachy.2019.04.004_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1022627411411","article-title":"Support-vector networks","volume":"20","author":"Cortes","year":"1995","journal-title":"Mach Learn"},{"key":"10.1016\/j.brachy.2019.04.004_bib23","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1118\/1.2776669","article-title":"Investigation of the support vector machine algorithm to predict lung radiation-induced pneumonitis","volume":"34","author":"Chen","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib24","series-title":"Machine learning and applications, 2008. ICMLA'08. Seventh International Conference on","article-title":"Nonlinear kernel-based approaches for predicting normal tissue toxicities","author":"El Naqa","year":"2008"},{"key":"10.1016\/j.brachy.2019.04.004_bib25","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1109\/78.650102","article-title":"Comparing support vector machines with Gaussian kernels to radial basis function classifiers","volume":"45","author":"Scholkopf","year":"1997","journal-title":"IEEE Trans Image Process"},{"key":"10.1016\/j.brachy.2019.04.004_bib26","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.ijrobp.2012.10.017","article-title":"Spatial-temporal [18F] FDG-PET features for predicting pathologic response of esophageal cancer to neoadjuvant chemoradiation therapy","volume":"85","author":"Tan","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib27","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1088\/0031-9155\/60\/13\/5123","article-title":"Staging of cervical cancer based on tumor heterogeneity characterized by texture features on 18F-FDG PET images","volume":"60","author":"Mu","year":"2015","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.brachy.2019.04.004_bib28","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1088\/0031-9155\/60\/14\/5471","article-title":"A radiomics model from joint FDG-PET and MRI texture features for the prediction of lung metastases in soft-tissue sarcomas of the extremities","volume":"60","author":"Valli\u00e8res","year":"2015","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.brachy.2019.04.004_bib29","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1088\/1361-6560\/aa6ae5","article-title":"Multi-objective radiomics model for predicting distant failure in lung SBRT","volume":"62","author":"Zhou","year":"2017","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.brachy.2019.04.004_bib30","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/0167-8655(94)90127-9","article-title":"Floating search methods in feature selection","volume":"15","author":"Pudil","year":"1994","journal-title":"Pattern Recognit Lett"},{"key":"10.1016\/j.brachy.2019.04.004_bib31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1613\/jair.953","article-title":"SMOTE: Synthetic minority over-sampling technique","volume":"16","author":"Chawla","year":"2002","journal-title":"J Artif Intell Res"},{"key":"10.1016\/j.brachy.2019.04.004_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0360-3016(98)00401-5","article-title":"Patterns of radiotherapy practice for patients with squamous carcinoma of the uterine cervix: Patterns of care study","volume":"43","author":"Eifel","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/sim.4780030207","article-title":"Regression modelling strategies for improved prognostic prediction","volume":"3","author":"Harrell","year":"1984","journal-title":"Stat Med"},{"key":"10.1016\/j.brachy.2019.04.004_bib34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat Med"},{"key":"10.1016\/j.brachy.2019.04.004_bib35","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ygyno.2007.04.030","article-title":"Vesicovaginal fistula formation in patients with Stage IVA cervical carcinoma","volume":"106","author":"Moore","year":"2007","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2019.04.004_bib36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ygyno.2008.02.021","article-title":"Vesicovaginal fistula formation in patients with Stage IVA cervical carcinoma","volume":"109","author":"Mahajan","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2019.04.004_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1507-1367(04)71008-1","article-title":"Rectovaginal fistula risk doses in patients with cervical cancer","volume":"9","author":"Lebioda","year":"2004","journal-title":"Rep Pract Oncol Radiother"},{"key":"10.1016\/j.brachy.2019.04.004_bib38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ijrobp.2009.11.002","article-title":"Dose\u2013volume histogram parameters and late side effects in magnetic resonance image\u2013guided adaptive cervical cancer brachytherapy","volume":"79","author":"Georg","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib39","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/IGC.0b013e3181d224c8","article-title":"Can we predict vesicovaginal or rectovaginal fistula formation in patients with stage IVA cervical cancer?","volume":"20","author":"Biewenga","year":"2010","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.brachy.2019.04.004_bib40","doi-asserted-by":"crossref","first-page":"9299","DOI":"10.18632\/oncotarget.24271","article-title":"Locally advanced cervical cancer with bladder invasion: Clinical outcomes and predictive factors for vesicovaginal fistulae","volume":"9","author":"Sun","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.brachy.2019.04.004_bib41","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ygyno.2014.02.005","article-title":"Impact of post-radiation biopsies on development of fistulae in patients with cervical cancer","volume":"133","author":"Feddock","year":"2014","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2019.04.004_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1748-717X-9-31","article-title":"Vaginal tolerance of CT based image-guided high-dose rate interstitial brachytherapy for gynecological malignancies","volume":"9","author":"Murakami","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.brachy.2019.04.004_bib43","doi-asserted-by":"crossref","first-page":"46349","DOI":"10.1038\/srep46349","article-title":"Radiomics-based prognosis analysis for non-small cell lung cancer","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.brachy.2019.04.004_bib44","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/mp.12820","article-title":"Radiomics analysis of pulmonary nodules in low-dose CT for early detection of lung cancer","volume":"45","author":"Choi","year":"2018","journal-title":"Med Phys"},{"key":"10.1016\/j.brachy.2019.04.004_bib45","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.radonc.2016.04.029","article-title":"Predicting distant failure in early stage NSCLC treated with SBRT using clinical parameters","volume":"119","author":"Zhou","year":"2016","journal-title":"Radiother Oncol"}],"container-title":["Brachytherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472118307633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472118307633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:14:58Z","timestamp":1761531298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538472118307633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1538472118307633"],"URL":"https:\/\/doi.org\/10.1016\/j.brachy.2019.04.004","relation":{},"ISSN":["1538-4721"],"issn-type":[{"value":"1538-4721","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A machine-learning\u2013based prediction model of fistula formation after interstitial brachytherapy for locally advanced gynecological malignancies","name":"articletitle","label":"Article Title"},{"value":"Brachytherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brachy.2019.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}