{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:20:42Z","timestamp":1791411642940,"version":"4.3.3"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010817","name":"Stiftelsen Kronprinsessan Margaretas Arbetsnamnd For Synskadade","doi-asserted-by":"publisher","award":["157"],"award-info":[{"award-number":["157"]}],"id":[{"id":"10.13039\/100010817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["20 0798 Fk"],"award-info":[{"award-number":["20 0798 Fk"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001725","name":"Kungliga Vetenskapsakademien","doi-asserted-by":"publisher","award":["ME2019-0036"],"award-info":[{"award-number":["ME2019-0036"]}],"id":[{"id":"10.13039\/501100001725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2020-013333"],"award-info":[{"award-number":["2020-013333"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2020-02517"],"award-info":[{"award-number":["2020-02517"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2019-01900"],"award-info":[{"award-number":["2019-01900"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Region Stockholm","doi-asserted-by":"publisher","award":["20200356"],"award-info":[{"award-number":["20200356"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010810","name":"Ogonfonden","doi-asserted-by":"publisher","award":["2021-04-28"],"award-info":[{"award-number":["2021-04-28"]}],"id":[{"id":"10.13039\/100010810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018666","name":"Carmen and Bertil Regn\u00e9r&apos;s Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["SLS 934014"],"award-info":[{"award-number":["SLS 934014"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["brachyjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brachytherapy"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.brachy.2021.05.162","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T02:44:48Z","timestamp":1625885088000},"page":"1245-1256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Long-term outcomes after enucleation or plaque brachytherapy of choroidal melanomas touching the optic disc"],"prefix":"10.1016","volume":"20","author":[{"given":"Maria","family":"Fili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-4335","authenticated-orcid":false,"given":"Melvin","family":"Astrahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-8911","authenticated-orcid":false,"given":"Gustav","family":"St\u00e5lhammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brachy.2021.05.162_bib0001","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archopht.124.12.1684","article-title":"The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. twelve-year mortality rates and prognostic factors: COMS report No. 28","volume":"124","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0002","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/archophthalmol.2009.208","article-title":"Metastasis of uveal melanoma millimeter-by-millimeter in 8033 consecutive eyes","volume":"127","author":"Shields","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0003","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0360-3016(88)90362-8","article-title":"Dosimetric calculations and measurements of gold plaque ophthalmic irradiators using iridium-192 and iodine-125 seeds","volume":"15","author":"Luxton","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2021.05.162_bib0004","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.brachy.2014.05.018","article-title":"Monte Carlo dosimetry of the eye plaque design used at the St. Erik Eye Hospital for (125)I brachytherapy","volume":"13","author":"Karlsson","year":"2014","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2021.05.162_bib0005","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1088\/1361-6560\/aa5696","article-title":"Monte carlo simulation of ruthenium eye plaques with geant4: influence of multiple scattering algorithms, the spectrum and the geometry on depth dose profiles","volume":"62","author":"Sommer","year":"2017","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0006","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0161-6420(02)01277-0","article-title":"The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: IV. Local treatment failure and enucleation in the first 5 years after brachytherapy. COMS report no. 19","volume":"109","author":"Jampol","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0007","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1136\/bjophthalmol-2014-305055","article-title":"High dose rate and low dose rate ruthenium brachytherapy for uveal melanoma. No association with ocular outcome","volume":"98","author":"Fili","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0008","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/bjophthalmol-2018-313419","article-title":"Ruthenium-106 versus iodine-125 plaque brachytherapy of 571 choroidal melanomas with a thickness of >\/=5.5 mm","volume":"104","author":"Fili","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0009","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0161-6420(89)32806-5","article-title":"Reasons for enucleation after plaque radiotherapy for posterior uveal melanoma. Clinical findings","volume":"96","author":"Shields","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0010","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000479558","article-title":"Dose distributions and treatment margins in ocular brachytherapy with 106Ru eye plaques","volume":"4","author":"Stockel","year":"2018","journal-title":"Ocul Oncol Pathol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0011","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ophtha.2010.06.007","article-title":"Plaque radiotherapy for juxtapapillary choroidal melanoma: tumor control in 650 consecutive cases","volume":"118","author":"Sagoo","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0012","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1001\/jamaophthalmol.2014.111","article-title":"Plaque radiotherapy for juxtapapillary choroidal melanoma: treatment complications and visual outcomes in 650 consecutive cases","volume":"132","author":"Sagoo","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0013","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archopht.1995.01100030071024","article-title":"Transpupillary thermotherapy in choroidal melanomas","volume":"113","author":"Oosterhuis","year":"1995","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0014","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s00417-012-1962-3","article-title":"Eccentric ruthenium plaque radiotherapy of posterior choroidal melanoma","volume":"250","author":"Russo","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0015","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ophtha.2011.08.017","article-title":"A five-year study of slotted eye plaque radiation therapy for choroidal melanoma: near, touching, or surrounding the optic nerve","volume":"119","author":"Finger","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0016","first-page":"519","article-title":"Primary photodynamic therapy with verteporfin for small pigmented posterior pole choroidal melanoma","volume":"31","author":"Fabian","year":"2017"},{"key":"10.1016\/j.brachy.2021.05.162_bib0017","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ophtha.2014.09.029","article-title":"Primary transpupillary thermotherapy for choroidal melanoma in 391 cases: importance of risk factors in tumor control","volume":"122","author":"Mashayekhi","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0018","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ophtha.2004.11.038","article-title":"Ruthenium brachytherapy for uveal melanoma, 1979-2003: survival and functional outcomes in the Swedish population","volume":"112","author":"Bergman","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0019","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1259\/bjr\/76813976","article-title":"Dosimetric comparison of 106Ru and 125I plaques for treatment of shallow (<or=5 mm) choroidal melanoma lesions","volume":"81","author":"Wilkinson","year":"2008","journal-title":"Br J Radiol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0020","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.brachy.2014.04.002","article-title":"(106)Ru plaque brachytherapy for uveal melanoma: factors associated with local tumor recurrence","volume":"13","author":"Barker","year":"2014","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2021.05.162_bib0021","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000497186","article-title":"No gender differences in long-term survival after brachytherapy of 1,541 patients with uveal melanoma","volume":"5","author":"Stalhammar","year":"2019","journal-title":"Ocul Oncol Pathol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0022","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1001\/archophthalmol.2011.228","article-title":"Proton irradiation for peripapillary and parapapillary melanomas","volume":"129","author":"Lane","year":"2011","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0023","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.ajo.2014.02.032","article-title":"Proton beam therapy of parapapillary choroidal melanoma","volume":"157","author":"Riechardt","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.brachy.2021.05.162_bib0024","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0161-6420(99)90456-6","article-title":"Comparison of episcleral plaque and proton beam radiation therapy for the treatment of choroidal melanoma","volume":"106","author":"Wilson","year":"1999","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0025","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0161-6420(01)00902-2","article-title":"Primary transpupillary thermotherapy for small choroidal melanoma in 256 consecutive cases: outcomes and limitations","volume":"109","author":"Shields","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0026","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/S0161-6420(03)00858-3","article-title":"Transpupillary thermotherapy versus plaque radiotherapy for suspected choroidal melanomas","volume":"110","author":"Harbour","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0027","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/S0161-6420(98)91121-6","article-title":"A comparison of cause-specific melanoma mortality and all-cause mortality in survival analyses after radiation treatment for uveal melanoma","volume":"105","author":"Kroll","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.brachy.2021.05.162_bib0028","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/sj.eye.6702911","article-title":"Posterior uveal melanoma treated with I-125 brachytherapy or primary enucleation","volume":"22","author":"Krohn","year":"2008","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.brachy.2021.05.162_bib0029","doi-asserted-by":"crossref","first-page":"11297","DOI":"10.1038\/s41598-020-68232-7","article-title":"Forty-year prognosis after plaque brachytherapy of uveal melanoma","volume":"10","author":"Stalhammar","year":"2020","journal-title":"Sci Rep."},{"key":"10.1016\/j.brachy.2021.05.162_bib0030","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ophtha.2015.09.014","article-title":"Local recurrence significantly increases the risk of metastatic uveal melanoma","volume":"123","author":"Simpson","year":"2016","journal-title":"Ophthalmology"}],"updated-by":[{"DOI":"10.1016\/j.brachy.2022.06.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000}}],"container-title":["Brachytherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472121004311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472121004311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:26:54Z","timestamp":1778617614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538472121004311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1538472121004311"],"URL":"https:\/\/doi.org\/10.1016\/j.brachy.2021.05.162","relation":{},"ISSN":["1538-4721"],"issn-type":[{"value":"1538-4721","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term outcomes after enucleation or plaque brachytherapy of choroidal melanomas touching the optic disc","name":"articletitle","label":"Article Title"},{"value":"Brachytherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brachy.2021.05.162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of American Brachytherapy Society.","name":"copyright","label":"Copyright"}]}}