{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:30:10Z","timestamp":1761532210889,"version":"build-2065373602"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["brachyjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brachytherapy"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.brachy.2021.09.006","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T02:55:42Z","timestamp":1635476142000},"page":"141-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incorporation of vaginal brachytherapy to external beam radiotherapy in adjuvant therapy for high-risk early-stage cervical cancer: A comparative study"],"prefix":"10.1016","volume":"21","author":[{"given":"Omar M.","family":"Ragab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahil","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6605-6187","authenticated-orcid":false,"given":"David J.","family":"Nusbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-6723","authenticated-orcid":false,"given":"Muneaki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-764X","authenticated-orcid":false,"given":"Laurie L.","family":"Brunette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda D.","family":"Roman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-8701","authenticated-orcid":false,"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brachy.2021.09.006_bib0001","first-page":"7","article-title":"Cancer statistics","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.brachy.2021.09.006_bib0002","unstructured":"Cervical cancer NCCN clinical practice guideline in oncology. Version 1. 2021. Available at: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/cervical.pdf. Accessed June 14, 2021."},{"key":"10.1016\/j.brachy.2021.09.006_bib0003","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/gyno.1999.5387","article-title":"A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study","volume":"73","author":"Sedlis","year":"1999","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0004","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijrobp.2005.10.019","article-title":"A phase III randomized trial of postoperative pelvic irradiation in Stage IB cervical carcinoma with poor prognostic features: Follow-up of a gynecologic oncology group study","volume":"65","author":"Rotman","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2021.09.006_bib0005","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1200\/JCO.2000.18.8.1606","article-title":"Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix","volume":"18","author":"Peters","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0006","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ygyno.2004.11.007","article-title":"Rethinking the use of radiation and chemotherapy after radical hysterectomy: A clinical-pathologic analysis of a Gynecologic Oncology Group\/Southwest Oncology Group\/Radiation Therapy Oncology Group trial","volume":"96","author":"Monk","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0007","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.ijrobp.2006.03.010","article-title":"Influence of margin status and radiation on recurrence after radical hysterectomy in Stage IB cervical cancer","volume":"65","author":"Viswanathan","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2021.09.006_bib0008","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ygyno.2012.10.028","article-title":"The impact of close surgical margins after radical hysterectomy for early-stage cervical cancer","volume":"128","author":"McCann","year":"2013","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0090-8258(90)90038-M","article-title":"Vaginal radiation brachytherapy to reduce central recurrence after radical hysterectomy for cervical carcinoma","volume":"38","author":"Photopulos","year":"1990","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/gyno.1998.5217","article-title":"Postoperative radiotherapy in early stage carcinoma of the uterine cervix: Treatment results and prognostic factors","volume":"72","author":"Yeh","year":"1999","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0011","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13014-015-0495-4","article-title":"Postoperative external beam irradiation with and without brachytherapy in pelvic node-positive IB1-IIA2 cervical cancer patients: A retrospective clinical study","volume":"10","author":"Li","year":"2015","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0012","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.brachy.2019.08.006","article-title":"Vaginal cuff brachytherapy in the adjuvant setting for patients with high-risk early-stage cervical cancer","volume":"18","author":"Mauro","year":"2019","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2021.09.006_bib0013","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/ijgc-2020-001733","article-title":"Role of vaginal brachytherapy boost following adjuvant external beam radiotherapy in cervical cancer: Turkish Society for Radiation Oncology Gynecologic Group Study (TROD 04-002)","volume":"31","author":"Gultekin","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.brachy.2021.09.006_bib0014","doi-asserted-by":"crossref","first-page":"e8384","DOI":"10.1097\/MD.0000000000008384","article-title":"Comparison of chemoradiotherapy with and without brachytherapy as adjuvant therapy after radical surgery in early-stage cervical cancer with poor prognostic factors: An observational study","volume":"96","author":"Lan","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.brachy.2021.09.006_bib0015","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1002\/1097-0142(19951201)76:11<2343::AID-CNCR2820761124>3.0.CO;2-#","article-title":"Completeness of hospital cancer case reporting from the SEER Program of the National Cancer Institute","volume":"76","author":"Zippin","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.brachy.2021.09.006_bib0016","unstructured":"National Cancer Institute. The Surveillance, Epidemiology, and End Results (SEER) Program. 2021. Available at: http:\/\/seer.cancer.gov. Accessed June 14, 2021."},{"key":"10.1016\/j.brachy.2021.09.006_bib0017","unstructured":"National Cancer Registrars Association. Available at: https:\/\/www.ncra-usa.org\/. Accessed June 14, 2021."},{"key":"10.1016\/j.brachy.2021.09.006_bib0018","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/ijc.30793","article-title":"Comparison of adjuvant therapy for node-positive clinical stage IB-IIB cervical cancer: Systemic chemotherapy versus pelvic irradiation","volume":"141","author":"Matsuo","year":"2017","journal-title":"Int J Cancer"},{"key":"10.1016\/j.brachy.2021.09.006_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2019.10.010","article-title":"Populational trends and outcomes of postoperative radiotherapy for high-risk early-stage cervical cancer with lymph node metastasis: concurrent chemo-radiotherapy versus radiotherapy alone","volume":"222","author":"Matsuo","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0020","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1200\/JCO.2003.94.023","article-title":"The surveillance, epidemiology, and end-results program database as a resource for conducting descriptive epidemiologic and clinical studies","volume":"21","author":"Harlan","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0021","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ygyno.2014.11.010","article-title":"Significance of lymph node ratio in defining risk category in node-positive early stage cervical cancer","volume":"136","author":"Fleming","year":"2015","journal-title":"Gynecol Oncol"},{"year":"2009","series-title":"Gynecologic oncology group surgical procedures manual","author":"Whitney","key":"10.1016\/j.brachy.2021.09.006_bib0022"},{"key":"10.1016\/j.brachy.2021.09.006_bib0023","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/ije\/dyw040","article-title":"Outcome modelling strategies in epidemiology: Traditional methods and basic alternatives","volume":"45","author":"Greenland","year":"2016","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0024","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1002\/sim.6607","article-title":"Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies","volume":"34","author":"Austin","year":"2015","journal-title":"Stat Med"},{"issue":"7","key":"10.1016\/j.brachy.2021.09.006_bib0025","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1136\/ijgc-2021-002655","article-title":"Utilization and outcomes of adjuvant systemic chemotherapy alone in high risk, early stage cervical cancer in the United States","volume":"31","author":"Matsuo","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.brachy.2021.09.006_bib0026","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1161\/CIRCULATIONAHA.115.017719","article-title":"Introduction to the analysis of survival data in the presence of competing risks","volume":"133","author":"Austin","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.brachy.2021.09.006_bib0027","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.brachy.2021.09.006_bib0028","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/jamasurg.2021.0528","article-title":"STROBE reporting guidelines for observational studies","volume":"156","author":"Ghaferi","year":"2021","journal-title":"JAMA Surg"},{"key":"10.1016\/j.brachy.2021.09.006_bib0029","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3857\/roj.2018.00087","article-title":"Adjuvant external beam radiation and brachytherapy for vaginal resection margin positive cervical cancer","volume":"36","author":"Kim","year":"2018","journal-title":"Radiat Oncol J"},{"key":"10.1016\/j.brachy.2021.09.006_bib0030","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ijrobp.2018.05.076","article-title":"Survival benefit of adjuvant brachytherapy after hysterectomy with positive surgical margins in cervical cancer","volume":"102","author":"Li","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"10.1016\/j.brachy.2021.09.006_bib0031","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jjco\/hyab035","article-title":"Adjuvant radiotherapy for cervical cancer in South Korea: A radiation oncology survey of the Korean Radiation Oncology Group (KROG 20-06)","volume":"51","author":"Kim","year":"2021","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0032","doi-asserted-by":"crossref","first-page":"S474","DOI":"10.1016\/j.ijrobp.2014.05.1474","article-title":"The addition of brachytherapy to adjuvant external beam radiation improves survival in cervical cancer patients following surgery","volume":"90","author":"Felder","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2021.09.006_bib0033","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1016\/j.brachy.2016.04.183","article-title":"Addition of brachytherapy to adjuvant external beam radiation in patients with cervical cancer","volume":"15","author":"Leachman","year":"2016","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2021.09.006_bib0034","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ygyno.2020.09.015","article-title":"The ASTRO clinical practice guidelines in cervical cancer: optimizing radiation therapy for improved outcomes","volume":"159","author":"Chino","year":"2020","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0035","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1056\/NEJMoa1806395","article-title":"Minimally invasive versus abdominal radical hysterectomy for cervical cancer","volume":"379","author":"Ramirez","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.brachy.2021.09.006_bib0036","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.canrad.2020.10.001","article-title":"Evaluation of adjuvant vaginal vault brachytherapy in early stage cervical cancer patients","volume":"24","author":"Bronsart","year":"2020","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.brachy.2021.09.006_bib0037","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brachy.2012.04.007","article-title":"Interstitial preoperative high-dose-rate brachytherapy for early stage cervical cancer: dose-volume histogram parameters, pathologic response and early clinical outcome","volume":"12","author":"Hannoun-Levi","year":"2013","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2021.09.006_bib0038","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1056\/NEJMc2035819","article-title":"Effect of a randomized, controlled trial on surgery for cervical cancer","volume":"384","author":"Lewicki","year":"2021","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.brachy.2021.09.006_bib0039","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ygyno.2021.05.005","article-title":"Decreasing utilization of minimally invasive hysterectomy for cervical cancer in the United States","volume":"162","author":"Matsuo","year":"2021","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2021.09.006_bib0040","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1097\/AOG.0000000000003280","article-title":"Association of radical hysterectomy surgical volume and survival for early-stage cervical cancer","volume":"133","author":"Matsuo","year":"2019","journal-title":"Obstet Gynecol"}],"container-title":["Brachytherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472121004864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472121004864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:17:10Z","timestamp":1761531430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538472121004864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1538472121004864"],"URL":"https:\/\/doi.org\/10.1016\/j.brachy.2021.09.006","relation":{},"ISSN":["1538-4721"],"issn-type":[{"type":"print","value":"1538-4721"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incorporation of vaginal brachytherapy to external beam radiotherapy in adjuvant therapy for high-risk early-stage cervical cancer: A comparative study","name":"articletitle","label":"Article Title"},{"value":"Brachytherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brachy.2021.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}