{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:13:50Z","timestamp":1770966830022,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","brachyjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brachytherapy"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.brachy.2024.10.005","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T01:47:32Z","timestamp":1731808052000},"page":"134-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of MRI-based planning in transperineal interstitial brachytherapy for locally advanced cervix tumors: Clinical, dosimetric and toxicity outcomes"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7739-1028","authenticated-orcid":false,"given":"Diana","family":"Guevara Barrera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4415-6563","authenticated-orcid":false,"given":"Silvia","family":"Rodr\u00edguez Villalba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Suso-Mart\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Sanchis-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Perez-Calatayud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-5062","authenticated-orcid":false,"given":"Jose Domingo","family":"Lago Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Bl\u00e1zquez Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Santos Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brachy.2024.10.005_bib0001","series-title":"Global cancer observatory: cancer today","author":"Ferlay","year":"2024"},{"key":"10.1016\/j.brachy.2024.10.005_bib0002","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.radonc.2016.03.020","article-title":"Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: Analysis from the retroEMBRACE study","volume":"120","author":"Fokdal","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2024.10.005_bib0003","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.radonc.2004.12.015","article-title":"Recommendations from Gynecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV","volume":"74","author":"Haie-Meder","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2024.10.005_bib0004","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.radonc.2005.11.014","article-title":"Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology","volume":"78","author":"P\u00f6tter","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2024.10.005_bib0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brachy.2011.07.003","article-title":"American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part I: General principles","volume":"11","author":"Viswanathan","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0006","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brachy.2011.07.002","article-title":"American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: high-dose-rate brachytherapy","volume":"11","author":"Viswanathan","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0007","unstructured":"International Study on MRI-Guided Brachytherapy in Locally Advanced Cervical Cancer. Medical university of vienna. The EMBRACE Collaborative Group, Vienna. Available from: https:\/\/www.embracestudy.dk. Accessed February 3, 2024."},{"key":"10.1016\/j.brachy.2024.10.005_bib0008","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.ijrobp.2004.04.032","article-title":"Proposed guidelines for image-based intracavitary brachytherapy for cervical carcinoma: report from image-guided brachytherapy working group","volume":"60","author":"Nag","year":"2004","journal-title":"Int. J. Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2024.10.005_bib0009","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S1470-2045(20)30753-1","article-title":"MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study","volume":"22","author":"P\u00f6tter","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.brachy.2024.10.005_bib0010","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.radonc.2010.06.004","article-title":"Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group: considerations and pitfalls in commissioning and applicator reconstruction in 3D image-based treatment planning of cervix cancer brachytherapy","volume":"96","author":"Hellebust","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2024.10.005_bib0011","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.radonc.2011.12.024","article-title":"Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): Basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy","volume":"103","author":"Dimopoulos","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2024.10.005_bib0012","first-page":"2","article-title":"89: Prescribing, recording, and reporting brachytherapy for cancer of the cervix","volume":"13","year":"2016","journal-title":"J. ICRU"},{"key":"10.1016\/j.brachy.2024.10.005_bib0013","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3390\/cancers14051257","article-title":"3D-image-guided multi-catheter interstitial brachytherapy for bulky and high-risk stage IIB\u2013IVB cervical cancer","volume":"14","author":"Kokabu","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.brachy.2024.10.005_bib0014","doi-asserted-by":"crossref","first-page":"598","DOI":"10.5732\/cjc.011.10452","article-title":"Dose-volume parameters and clinical outcome of CT-guided free-hand high-dose-rate interstitial brachytherapy for cervical cancer","volume":"31","author":"Wang","year":"2012","journal-title":"Chin J Cancer"},{"key":"10.1016\/j.brachy.2024.10.005_bib0015","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1007\/s12094-022-03016-1","article-title":"Recommendations of the spanish brachytherapy group of the Spanish society of radiation oncology and the spanish society of medical physics for interstitial high-dose-rate brachytherapy for gynaecologic malignancies","volume":"25","author":"Guti\u00e9rrez Migu\u00e9lez","year":"2023","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.brachy.2024.10.005_bib0016","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0360-3016(84)90016-6","article-title":"A multiple-site perineal applicator (MUPIT) for treatment of prostatic, anorectal and gynecologic malignancies","volume":"10","author":"Martinez","year":"1984","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2024.10.005_bib0017","first-page":"1","article-title":"Transperineal interstitial intracavitary \u201cSyed-Neblett\u201d applicator in the treatment of carcinoma of the uterine cervix","volume":"2","author":"Syed","year":"1986","journal-title":"Endocuriether Hypertherm"},{"key":"10.1016\/j.brachy.2024.10.005_bib0018","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5114\/jcb.2015.54051","article-title":"A new template for MRI-based intracavitary\/interstitial gynecologic brachytherapy: design and clinical implementation","volume":"7","author":"Rodriguez Villalba","year":"2015","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0019","doi-asserted-by":"crossref","first-page":"472","DOI":"10.5114\/jcb.2017.70710","article-title":"Pre-plan technique feasibility in multi-interstitial\/endocavitary perineal gynecological brachytherapy","volume":"9","author":"Rodriguez Villalba","year":"2017","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0020","doi-asserted-by":"crossref","first-page":"407","DOI":"10.5114\/jcb.2015.55340","article-title":"A practical MRI-based reconstruction method for a new endocavitary and interstitial gynaecological template","volume":"7","author":"Richart Sancho","year":"2015","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0021","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.rpor.2018.06.005","article-title":"Review of strategies for MRI based reconstruction of endocavitary and interstitial applicators in brachytherapy of cervical cancer","volume":"23","author":"Richart Sancho","year":"2018","journal-title":"Rep Pract Oncol Radiother"},{"key":"10.1016\/j.brachy.2024.10.005_bib0022","first-page":"29","article-title":"Consideraciones pr\u00e1cticas en la implementaci\u00f3n de la Resonancia Magn\u00e9tica en la planificaci\u00f3n en braquiterapia ginecol\u00f3gica de c\u00e9rvix","volume":"19","author":"Perez-Calatayud","year":"2018","journal-title":"Informe del Grupo de Trabajo de Braquiterapia de la Sociedad Espa\u00f1ola de F\u00edsica M\u00e9dica. Rev Fis Med"},{"key":"10.1016\/j.brachy.2024.10.005_bib0023","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5114\/jcb.2017.65290","article-title":"A method to incorporate interstitial components into the TPS gynecologic rigid applicator library","volume":"9","author":"Otal","year":"2017","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0024","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.3390\/cancers14143467","article-title":"Review on treatment planning systems for cervix brachytherapy (interventional radiotherapy): some desirable and convenient practical aspects to be implemented from radiation oncologist and medical physics perspectives","volume":"14","author":"Otal","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.brachy.2024.10.005_bib0025","unstructured":"National Comprehensive Cancer Network. Cervical Cancer (Version 3.2024). https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/cervical.pdf. Accessed August 1, 2024"},{"key":"10.1016\/j.brachy.2024.10.005_bib0026","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) Version 5. Published: November 27. US department of health and human services, National Institutes of Health, National Cancer Institute. Washington, D.C."},{"key":"10.1016\/j.brachy.2024.10.005_bib0027","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.brachy.2020.04.010","article-title":"Outcomes of freehand interstitial brachytherapy in advanced gynecologic malignancies","volume":"19","author":"Bajwa","year":"2020","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0028","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/curroncol31010004","article-title":"High-dose-rate three-dimensional image-guided adaptive brachytherapy (3d igabt) for locally advanced cervical cancer (LACC): a narrative review on imaging modality and clinical evidence","volume":"31","author":"Wang","year":"2024","journal-title":"Curr Oncol"},{"key":"10.1016\/j.brachy.2024.10.005_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brachy.2014.07.006","article-title":"Preliminary results of MRI-assisted high dose rate interstitial brachytherapy for uterine cervical cancer","volume":"14","author":"Yoshida","year":"2015","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.5114\/jcb.2021.110347","article-title":"A single-institution review of image-guided brachytherapy for vaginal malignancies using customized molded applicators and interstitial needles","volume":"13","author":"Flower","year":"2021","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0031","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijrobp.2022.05.027","article-title":"Applying 3D-printed templates in high-dose-rate brachytherapy for cervix cancer: simplified needle insertion for optimized dosimetry","volume":"114","author":"Marar","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2024.10.005_bib0032","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5114\/jcb.2023.132695","article-title":"Dosimetry and plan parameters study of three-dimensional-printed template-based intra-cavitary\/interstitial interpolation technology using computed tomography-guided high-dose-rate brachytherapy in locally advanced cervical cancer","volume":"15","author":"Liu","year":"2023","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0033","doi-asserted-by":"crossref","first-page":"405","DOI":"10.5114\/jcb.2023.134170","article-title":"Clinical implementation of three-dimensional standardized template-guided brachytherapy for patients with locally advanced cervical cancer","volume":"15","author":"Tu","year":"2023","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0034","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1538-4721(03)00133-8","article-title":"Image fusion of CT and MRI data enables improved target volume definition in 3D-brachytherapy treatment planning","volume":"2","author":"Krempien","year":"2003","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0035","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ijrobp.2006.12.021","article-title":"Computed tomography versus magnetic resonance imaging-based contouring in cervical cancer brachytherapy: results of a prospective trial and preliminary guidelines for standardized contours","volume":"68","author":"Viswanathan","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2024.10.005_bib0036","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ijrobp.2014.06.005","article-title":"Comparison and consensus guidelines for delineation of clinical target volume for CT\u2013 and MRI-based brachytherapy in locally advanced cervical cancer","volume":"90","author":"Viswanathan","year":"2014","journal-title":"Int J Radiat Oncology Biol Phys"},{"key":"10.1016\/j.brachy.2024.10.005_bib0037","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.brachy.2006.09.002","article-title":"High dose rate interstitial brachytherapy for gynecologic malignancies","volume":"5","author":"Beriwal","year":"2006","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0038","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.brachy.2013.09.009","article-title":"Template-based high-dose-rate interstitial brachytherapy in gynecologic cancers: a single institutional experience","volume":"13","author":"Mahantshetty","year":"2014","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0039","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.brachy.2019.02.008","article-title":"Compendium of fractionation choices for gynecologic HDR brachytherapy - An American brachytherapy society task group report","volume":"18","author":"Albuquerque","year":"2019","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0040","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.brachy.2021.01.004","volume":"20","author":"Sood","year":"2021","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0041","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ijrobp.2012.05.033","article-title":"Outcomes of high-dose-rate interstitial brachytherapy in the treatment of locally advanced cervical cancer: long-term results","volume":"85","author":"Pinn-Bingham","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2024.10.005_bib0042","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.brachy.2008.12.002","article-title":"High-dose-rate interstitial brachytherapy for previously untreated cervical carcinoma","volume":"8","author":"Isohashi","year":"2009","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0043","doi-asserted-by":"crossref","first-page":"399","DOI":"10.5114\/jcb.2023.134169","article-title":"Clinical outcomes of single application multi-fractionated CT-guided interstitial high-dose-rate brachytherapy for locally advanced cervical cancer: A multi-institution initial experience","volume":"15","author":"Yap","year":"2023","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0044","first-page":"194","article-title":"Dosimetric predictors of local control and complications in gynecologic transperineal implant patients: The medical college of wisconsin experience","volume":"2","author":"Zeitlin","year":"2022","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0045","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ygyno.2017.03.004","article-title":"Comparison of outcomes for MR-guided versus CT-guided high-dose-rate interstitial brachytherapy in women with locally advanced carcinoma of the cervix","volume":"145","author":"Kamran","year":"2017","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.brachy.2024.10.005_bib0046","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brachy.2019.10.003","article-title":"Long-term effectiveness and safety of image-based, transperineal combined intracavitary and interstitial brachytherapy in treatment of locally advanced cervical cancer","volume":"19","author":"Tiwari","year":"2020","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0047","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.brachy.2012.02.007","article-title":"High-dose-rate interstitial computed tomography-based brachytherapy for the treatment of cervical cancer: early results","volume":"11","author":"Kannan","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2024.10.005_bib0048","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1269\/jrr.10189","article-title":"High-dose-rate interstitial brachytherapy with computed tomography-based treatment planning for patients with locally advanced uterine cervical carcinoma","volume":"52","author":"Saitoh","year":"2011","journal-title":"J Radiat Res"},{"key":"10.1016\/j.brachy.2024.10.005_bib0049","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brachy.2023.09.005","article-title":"Image-guided preplanning workflow for high-dose-rate interstitial brachytherapy for gynecological malignancies","volume":"23","author":"Huang","year":"2024","journal-title":"Brachytherapy"}],"container-title":["Brachytherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472124004045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472124004045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T12:13:56Z","timestamp":1737634436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538472124004045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1538472124004045"],"URL":"https:\/\/doi.org\/10.1016\/j.brachy.2024.10.005","relation":{},"ISSN":["1538-4721"],"issn-type":[{"value":"1538-4721","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of MRI-based planning in transperineal interstitial brachytherapy for locally advanced cervix tumors: Clinical, dosimetric and toxicity outcomes","name":"articletitle","label":"Article Title"},{"value":"Brachytherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brachy.2024.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Brachytherapy Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}