{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:15:36Z","timestamp":1780528536887,"version":"3.54.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","brachyjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brachytherapy"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.brachy.2025.02.005","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T06:24:55Z","timestamp":1742711095000},"page":"389-394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gastrointestinal and genitourinary toxicity following high dose rate vaginal cuff brachytherapy for endometrial cancer"],"prefix":"10.1016","volume":"24","author":[{"given":"Niki","family":"Tselepidakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5103-4807","authenticated-orcid":false,"given":"Ruyun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Horton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9517-7481","authenticated-orcid":false,"given":"Wendy","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einsley Marie","family":"Janowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brachy.2025.02.005_bib0001","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.brachy.2025.02.005_bib0002","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0140-6736(09)62163-2","article-title":"Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial","volume":"375","author":"Nout","year":"2010","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.brachy.2025.02.005_bib0003","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brachy.2015.09.012","article-title":"Vaginal brachytherapy for postoperative endometrial cancer: 2014 Survey of the American Brachytherapy Society","volume":"15","author":"Harkenrider","year":"2016","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.02.005_bib0004","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brachy.2011.08.005","article-title":"American Brachytherapy Society consensus guidelines for adjuvant vaginal cuff brachytherapy after hysterectomy","volume":"11","author":"Small","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.02.005_bib0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.prro.2022.09.002","article-title":"Radiation Therapy for endometrial cancer: an American Society for Radiation Oncology clinical Practice Guideline","volume":"13","author":"Harkenrider","year":"2023","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.02.005_bib0006","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.brachy.2013.09.007","article-title":"Evaluating adjacent organ radiation doses from postoperative intracavitary vaginal vault brachytherapy for endometrial cancer","volume":"13","author":"Caon","year":"2014","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.02.005_bib0007","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.brachy.2013.12.002","article-title":"Body mass index, dose to organs at risk during vaginal brachytherapy, and the role of three-dimensional CT-based treatment planning","volume":"13","author":"Boyle","year":"2014","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.02.005_bib0008","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.ijrobp.2011.08.023","article-title":"Image-based 3D treatment planning for vaginal cylinder brachytherapy: dosimetric effects of bladder filling on organs at risk","volume":"83","author":"Hung","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2025.02.005_bib0009","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.brachy.2015.02.391","article-title":"Dosimetric analysis of rectal filling on rectal doses during vaginal cuff brachytherapy","volume":"14","author":"Sabater","year":"2015","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.02.005_bib0010","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.brachy.2014.06.001","article-title":"Three-dimensional treatment planning for vaginal cuff brachytherapy: dosimetric effects on organs at risk according to patients position","volume":"13","author":"Iat\u00ec","year":"2014","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.02.005_bib0011","doi-asserted-by":"crossref","first-page":"230","DOI":"10.5114\/jcb.2017.68171","article-title":"Effects of vaginal cylinder position on dose distribution in patients with endometrial carcinoma in treatment of vaginal cuff brachytherapy","volume":"9","author":"Ozdemir","year":"2017","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.brachy.2025.02.005_bib0012","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejogrb.2024.04.040","article-title":"Intermediate-risk endometrial cancer treated with adjuvant brachytherapy using single dosimetric planning: long-term outcome and toxicity assessment","volume":"298","author":"Cordoba","year":"2024","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.brachy.2025.02.005_bib0013","article-title":"Toxicity and efficacy after adjuvant vaginal brachytherapy using 30 gy in 6 fractions for stages I and II endometrial cancer","volume":"6","author":"Arden","year":"2021","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.02.005_bib0014","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brachy.2011.07.003","article-title":"American Brachytherapy Society Cervical Cancer Recommendations Committee, American Brachytherapy Society. American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part I: general principles","volume":"11","author":"Viswanathan","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.02.005_bib0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brachy.2011.07.002","article-title":"American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: high-dose-rate brachytherapy","volume":"11","author":"Viswanathan","year":"2012","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.02.005_bib0016","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/ijgc-2021-002456","article-title":"Vaginal cuff brachytherapy for endometrial cancer: a review of major clinical trials with a focus on fractionation","volume":"32","author":"Parsons","year":"2022","journal-title":"Int J Gynecol Cancer Off J Int Gynecol Cancer Soc"},{"key":"10.1016\/j.brachy.2025.02.005_bib0017","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ijrobp.2023.03.071","article-title":"Dosimetric evaluation of organs at risk from SAVE protocol","volume":"117","author":"Kunz","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2025.02.005_bib0018","unstructured":"Romano K. A randomized Phase III trial of two standard dose fractionation regimes for adjuvant vaginal brachytherapy in early stage endometrial cancer. Clinicaltrials.Gov; 2024. Accessed November 20, 2024. https:\/\/clinicaltrials.gov\/study\/NCT03785288."},{"key":"10.1016\/j.brachy.2025.02.005_bib0019","unstructured":"University of Utah. Short course adjuvant vaginal cuff brachytherapy (VCB) in early endometrial cancer compared to standard of care (SAVE). Clinicaltrials.Gov; 2024. Accessed November 21, 2024. https:\/\/clinicaltrials.gov\/study\/NCT03422198."},{"key":"10.1016\/j.brachy.2025.02.005_bib0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.prro.2012.12.005","article-title":"Single or multi-channel vaginal cuff high-dose-rate brachytherapy: is replanning necessary prior to each fraction?","volume":"4","author":"Zhou","year":"2014","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.02.005_bib0021","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.brachy.2010.10.005","article-title":"Viswanathan AN. Should the organs at risk be contoured in vaginal cuff brachytherapy?","volume":"10","author":"Holloway","year":"2011","journal-title":"Brachytherapy"}],"container-title":["Brachytherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472125000352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472125000352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T23:53:30Z","timestamp":1745279610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538472125000352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1538472125000352"],"URL":"https:\/\/doi.org\/10.1016\/j.brachy.2025.02.005","relation":{},"ISSN":["1538-4721"],"issn-type":[{"value":"1538-4721","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastrointestinal and genitourinary toxicity following high dose rate vaginal cuff brachytherapy for endometrial cancer","name":"articletitle","label":"Article Title"},{"value":"Brachytherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brachy.2025.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Brachytherapy Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}