{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:51:16Z","timestamp":1786618276332,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["brachyjournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brachytherapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.brachy.2025.11.002","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T22:46:15Z","timestamp":1765493175000},"page":"373-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multicatheter interstitial brachytherapy-delivered APBI as single-fraction treatment in older breast cancer patients: A feasibility retrospective institutional analysis"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8982-7746","authenticated-orcid":false,"given":"Catarina","family":"van der Elzen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-0924","authenticated-orcid":false,"given":"Diana","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5152-2816","authenticated-orcid":false,"given":"Pedro","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8965-274X","authenticated-orcid":false,"given":"Alexandre","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-2078","authenticated-orcid":false,"given":"Sara","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Ma\u00e7\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-4490","authenticated-orcid":false,"given":"Lurdes","family":"Trigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brachy.2025.11.002_bib0001","series-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay","year":"2024"},{"key":"10.1016\/j.brachy.2025.11.002_bib0002","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.annonc.2023.11.016","article-title":"Early breast cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"35","author":"Loibl","year":"2024","journal-title":"Ann Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0003","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1245\/s10434-018-6486-6","article-title":"Eighth edition of the AJCC Cancer Staging Manual: Breast Cancer","volume":"25","author":"Giuliano","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0004","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/s12885-025-13893-8","article-title":"Breast cancer care for the aging population: A focus on age-related disparities in breast cancer treatment","volume":"25","author":"Bertozzi","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.brachy.2025.11.002_bib0005","doi-asserted-by":"crossref","first-page":"506","DOI":"10.21037\/gs.2018.09.01","article-title":"Paradigm shift in the local treatment of breast cancer: Mastectomy to breast conservation surgery","volume":"7","author":"Murugappan","year":"2018","journal-title":"Gland Surg"},{"key":"10.1016\/j.brachy.2025.11.002_bib0006","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3390\/curroncol31030090","article-title":"The role of adjuvant radiotherapy in the treatment of breast cancer","volume":"31","author":"Kol\u00e1\u0159ov\u00e1","year":"2024","journal-title":"Curr Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0007","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1056\/NEJM198107023050102","article-title":"Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast","volume":"305","author":"Veronesi","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1016\/j.brachy.2025.11.002_bib0008","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMoa020989","article-title":"Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer","volume":"347","author":"Veronesi","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.brachy.2025.11.002_bib0009","first-page":"112","article-title":"Omission of postoperative radiation after breast conserving surgery: A progressive paradigm shift towards precision medicine","volume":"21","author":"Franco","year":"2020","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.semradonc.2004.10.002","article-title":"Lessons of studies of breast-conserving therapy with and without whole-breast irradiation for patient selection for partial-breast irradiation","volume":"15","author":"Recht","year":"2005","journal-title":"Semin Radiat Oncol"},{"issue":"Suppl 1","key":"10.1016\/j.brachy.2025.11.002_bib0011","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.21037\/tcr.2019.07.03","article-title":"Accelerated partial breast irradiation in elderly breast cancer patients","volume":"9","author":"Sir\u00e1k","year":"2020","journal-title":"Transl Cancer Res"},{"key":"10.1016\/j.brachy.2025.11.002_bib0012","article-title":"Cosmetic outcome in patients with early stage breast cancer after accelerated partial breast irradiation using intraoperative or external beam radiotherapy","volume":"49","author":"Gunster","year":"2024","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0013","first-page":"820","article-title":"Irradiation in early-stage breast cancer: Conventional whole-breast, accelerated partial-breast, and accelerated whole-breast strategies compared","volume":"26","author":"Mouw","year":"2012","journal-title":"Oncology"},{"key":"10.1016\/j.brachy.2025.11.002_bib0014","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.ijrobp.2020.11.006","article-title":"Breast-conserving surgery followed by partial or whole breast irradiation: Twenty-year results of a phase 3 clinical study","volume":"109","author":"Polg\u00e1r","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2025.11.002_bib0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.adro.2019.09.005","article-title":"Comparison of toxicity and cosmetic outcomes after accelerated partial breast irradiation or whole breast irradiation using 3-dimensional conformal external beam radiation therapy","volume":"5","author":"Yadav","year":"2019","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0016","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s12094-021-02664-z","article-title":"Comparison between accelerated partial breast irradiation with multicatheter interstitial brachytherapy and whole breast irradiation, in clinical practice","volume":"24","author":"Gardu\u00f1o-S\u00e1nchez","year":"2022","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0017","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/COC.0000000000000945","article-title":"Accelerated partial breast irradiation: An opportunity for therapeutic de-escalation","volume":"46","author":"Shah","year":"2023","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0018","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ejca.2014.12.013","article-title":"Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial","volume":"51","author":"Livi","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.brachy.2025.11.002_bib0019","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(17)31145-5","article-title":"Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial","volume":"390","author":"Coles","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.brachy.2025.11.002_bib0020","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jamcollsurg.2009.02.066","article-title":"Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO)","volume":"209","author":"Smith","year":"2009","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.brachy.2025.11.002_bib0021","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.radonc.2010.01.014","volume":"94","author":"Polg\u00e1r","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0022","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.brachy.2022.07.004","article-title":"Partial breast irradiation: An updated consensus statement from the American brachytherapy society","volume":"21","author":"Anderson","year":"2022","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.11.002_bib0023","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0140-6736(15)00471-7","volume":"387","author":"Strnad","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.brachy.2025.11.002_bib0024","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2178469","article-title":"Age is not a limiting factor in interventional radiotherapy (Brachytherapy) for patients with localized cancer","volume":"2018","author":"Lancellotta","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.brachy.2025.11.002_bib0025","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0360-3016(95)02167-1","article-title":"The influence of older age on breast cancer treatment decisions and outcome","volume":"34","author":"Merchant","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2025.11.002_bib0026","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.radonc.2015.03.002","article-title":"Clinical outcomes of prospectively treated 140 women with early stage breast cancer using accelerated partial breast irradiation with 3 dimensional computerized tomography based brachytherapy","volume":"115","author":"Budrukkar","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0027","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/jnci\/93.17.1344","article-title":"Relationship of distance from a radiotherapy facility and initial breast cancer treatment","volume":"93","author":"Nattinger","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.brachy.2025.11.002_bib0028","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13014-018-1119-6","article-title":"Single fraction of accelerated partial breast irradiation in the elderly: Early clinical outcome","volume":"13","author":"Kinj","year":"2018","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0029","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00066-020-01613-z","article-title":"DEGRO practical guideline for partial-breast irradiation","volume":"196","author":"Strnad","year":"2020","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0030","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.prro.2023.11.001","article-title":"Partial breast irradiation for patients with early-stage invasive breast cancer or ductal carcinoma In situ: An ASTRO clinical practice guideline","volume":"14","author":"Shaitelman","year":"2024","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0031","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.radonc.2018.04.009","article-title":"ESTRO-ACROP guideline: Interstitial multi-catheter breast brachytherapy as accelerated partial breast irradiation alone or as boost - GEC-ESTRO Breast Cancer Working Group practical recommendations","volume":"128","author":"Strnad","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0032","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.radonc.2015.12.006","article-title":"Recommendations from GEC ESTRO Breast Cancer Working Group (II): Target definition and target delineation for accelerated or boost partial breast irradiation using multicatheter interstitial brachytherapy after breast conserving open cavity surgery","volume":"118","author":"Major","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0033","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.radonc.2015.06.010","article-title":"Recommendations from GEC ESTRO Breast Cancer Working Group (I): Target definition and target delineation for accelerated or boost partial Breast irradiation using multicatheter interstitial brachytherapy after breast conserving closed cavity surgery","volume":"115","author":"Strnad","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0034","first-page":"125","article-title":"Biological equivalency of high single doses used in intraoperative irradiation","volume":"77","author":"Dutreix","year":"1990","journal-title":"Bull Cancer Radiother"},{"key":"10.1016\/j.brachy.2025.11.002_bib0035","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0167-8140(97)00162-X","article-title":"The linear-quadratic transformation of dose-volume histograms in fractionated radiotherapy","volume":"46","author":"Wheldon","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0036","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brachy.2019.10.007","article-title":"Accelerated partial breast irradiation in the elderly: 5-year results of the single fraction elderly breast irradiation (SiFEBI) phase I\/II trial","volume":"19","author":"Hannoun-L\u00e9vi","year":"2020","journal-title":"Brachytherapy"},{"key":"10.1016\/j.brachy.2025.11.002_bib0037","unstructured":"Common terminology criteria for adverse events (CTCAE) version 5.0. National Cancer Institute (NCI) United States, 2017."},{"key":"10.1016\/j.brachy.2025.11.002_bib0038","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0360-3016(79)90729-6","article-title":"Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast","volume":"5","author":"Harris","year":"1979","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.brachy.2025.11.002_bib0039","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jgo.2021.04.009","article-title":"Quality of life and comprehensive geriatric assessment (CGA) in older adults receiving accelerated partial breast irradiation (APBI) using a single fraction of Multi-Catheter Interstitial high-dose rate brachytherapy (MIB). The SiFEBI phase I\/II trial","volume":"12","author":"Boulahssass","year":"2021","journal-title":"J Geriatr Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0040","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13014-018-1119-6","article-title":"Single fraction of accelerated partial breast irradiation in the elderly: Early clinical outcome","volume":"13","author":"Kinj","year":"2018","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0041","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1093\/annonc\/mdu104","article-title":"Review of current best practice and priorities for research in radiation oncology for elderly patients with cancer: The International Society of Geriatric Oncology (SIOG) task force","volume":"25","author":"Kunkler","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0042","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.3390\/cancers15174343","article-title":"Whole breast irradiation in comparison to endocrine therapy in early stage breast cancer-A direct and network meta-analysis of published randomized trials","volume":"15","author":"Haussmann","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.brachy.2025.11.002_bib0043","first-page":"1","article-title":"Endocrine therapy with accelerated partial breast irradiation or exclusive ultra-accelerated partial breast irradiation for women aged \u2265 60 years with early-stage breast cancer (EPOPE): The rationale for a GEC-ESTRO randomized phase III-controlled trial","volume":"29","author":"Hannoun-Levi","year":"2021","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0044","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jgo.2020.07.013","volume":"12","author":"Meattini","year":"2021","journal-title":"J Geriatr Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0045","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.1245\/s10434-023-13897-3","article-title":"Risk-adapted intraoperative radiation therapy (IORT) for breast cancer: A novel analysis","volume":"30","author":"Silverstein","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.759903","article-title":"Comparison of the oncological efficacy between intraoperative radiotherapy with whole-breast irradiation for early breast cancer: A meta-analysis","volume":"11","author":"He","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0047","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3389\/fonc.2018.00545","article-title":"A prospective analysis of quality of life and toxicity outcomes in treating early breast cancer with breast conservation therapy and intraoperative radiation therapy","volume":"8","author":"Sosin","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0048","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.788213","article-title":"Targeted intraoperative radiotherapy (TARGIT-IORT) for early-stage invasive breast cancer: A single institution experience","volume":"12","author":"Brown","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.brachy.2025.11.002_bib0049","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13014-023-02299-0","article-title":"Experience with intraoperative radiation therapy in an urban cancer center","volume":"18","author":"Andraos","year":"2023","journal-title":"Radiat Oncol"}],"container-title":["Brachytherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472125003575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538472125003575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:41:07Z","timestamp":1772109667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538472125003575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1538472125003575"],"URL":"https:\/\/doi.org\/10.1016\/j.brachy.2025.11.002","relation":{},"ISSN":["1538-4721"],"issn-type":[{"value":"1538-4721","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multicatheter interstitial brachytherapy-delivered APBI as single-fraction treatment in older breast cancer patients: A feasibility retrospective institutional analysis","name":"articletitle","label":"Article Title"},{"value":"Brachytherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brachy.2025.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Brachytherapy Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}