{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:09:00Z","timestamp":1759972140752,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["brainanddevelopment.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.braindev.2007.08.007","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T10:56:04Z","timestamp":1191322564000},"page":"238-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of l-arginine on synaptosomal mitochondrial function"],"prefix":"10.1016","volume":"30","author":[{"given":"Koji","family":"Hirata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Akita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Povalko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Yatsuga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyojiro","family":"Matsuishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutoshi","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2007.08.007_bib1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ana.410160409","article-title":"Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome","volume":"16","author":"Pavlakis","year":"1984","journal-title":"Ann Neurol"},{"key":"10.1016\/j.braindev.2007.08.007_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1212\/WNL.58.5.827","article-title":"Effects of l-arginine on the acute phase of strokes in three patients with MELAS","volume":"58","author":"Koga","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2007.08.007_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.braindev.2004.01.006","article-title":"Beneficial effect of l-arginine for stroke-like episode in MELAS","volume":"26","author":"Kubota","year":"2004","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2007.08.007_bib4","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1212\/01.WNL.0000151976.60624.01","article-title":"l-arginine improves the symptoms of strokelike episodes in MELAS","volume":"64","author":"Koga","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2007.08.007_bib5","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1212\/01.wnl.0000220197.36849.1e","article-title":"Endothelial dysfunction in MELAS was improved by l-arginine supplementation","volume":"66","author":"Koga","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2007.08.007_bib6","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1046\/j.1471-4159.1994.63062108.x","article-title":"Inhibitory effects of nitric oxide on the uptake of [3H]dopamine and [3H] glutamate by striatal synaptosomes","volume":"63","author":"Lonart","year":"1994","journal-title":"J Neurochem"},{"key":"10.1016\/j.braindev.2007.08.007_bib7","first-page":"359","article-title":"Nutritional support for wound healing","volume":"8","author":"MacKay","year":"2003","journal-title":"Altern Med Rev"},{"key":"10.1016\/j.braindev.2007.08.007_bib8","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1016\/S0021-9258(17)40523-0","article-title":"Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes","volume":"252","author":"Krueger","year":"1977","journal-title":"J Biol Chem"},{"key":"10.1016\/j.braindev.2007.08.007_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0006-8993(78)90636-4","article-title":"Evaluation of glutamate as a hippocampal neurotransmitter: glutamate uptake and release from synaptosomes","volume":"142","author":"Sandoval","year":"1978","journal-title":"Brain Res"},{"key":"10.1016\/j.braindev.2007.08.007_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(02)00105-2","article-title":"Prolonged depolarization of rat cerebral synaptosomes leads to an increase in vesicular glutamate content","volume":"322","author":"Bole","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.braindev.2007.08.007_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(79)55003-4","article-title":"Overview\u2013preparation and properties of mitochrondria from different sources","volume":"55","author":"Nedergaard","year":"1979","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.braindev.2007.08.007_bib12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/oxfordjournals.jbchem.a128334","article-title":"On the isolation of mitochondria with high respiratory control from rat brain","volume":"59","author":"Ozawa","year":"1966","journal-title":"J Biochem (Tokyo)"},{"key":"10.1016\/j.braindev.2007.08.007_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0091-679X(01)65006-4","article-title":"Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues","volume":"65","author":"Birch-Machin","year":"2001","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.braindev.2007.08.007_bib14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(96)64044-0","article-title":"Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines","volume":"264","author":"Trounce","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.braindev.2007.08.007_bib15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1085\/jgp.95.4.591","article-title":"Relationships between the neuronal sodium\/potassium pump and energy metabolism. Effects of K+, Na+, and adenosine triphosphate in isolated brain synaptosomes","volume":"95","author":"Erecinska","year":"1990","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.braindev.2007.08.007_bib16","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1042\/bst0060993","article-title":"Isocitrate dehydrogenase and malate dehydrogenase in synaptic and non-synaptic rat brain mitochondria: a comparison of their kinetic constants","volume":"6","author":"Lai","year":"1978","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.braindev.2007.08.007_bib17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1046\/j.1471-4159.2001.00060.x","article-title":"Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson\u2019s disease","volume":"76","author":"Chinopoulos","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.braindev.2007.08.007_bib18","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0006-2952(02)00910-3","article-title":"Mitochondrial toxin inhibition of [3H]dopamine uptake into rat striatal synaptosomes","volume":"63","author":"Maragos","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.braindev.2007.08.007_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bj1860021","article-title":"Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ","volume":"186","author":"Scott","year":"1980","journal-title":"Biochem J"},{"key":"10.1016\/j.braindev.2007.08.007_bib20","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1471-4159.1984.tb12719.x","article-title":"Arginine metabolism in mouse brain synaptosomes","volume":"42","author":"Johnson","year":"1984","journal-title":"J Neurochem"},{"key":"10.1016\/j.braindev.2007.08.007_bib21","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1046\/j.1471-4159.1997.69062421.x","article-title":"Uptake of agmatine into rat brain synaptosomes: possible role of cation channels","volume":"69","author":"Sastre","year":"1997","journal-title":"J Neurochem"},{"key":"10.1016\/j.braindev.2007.08.007_bib22","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s001250050690","article-title":"Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1","volume":"40","author":"Weinhaus","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.braindev.2007.08.007_bib23","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0306-4522(03)00210-0","article-title":"Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus","volume":"119","author":"Liu","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.braindev.2007.08.007_bib24","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1097\/00001756-199707070-00052","article-title":"Glutamate uptake is inhibited by l-arginine in mitochondria isolated from rat cerebrum","volume":"8","author":"Dolinska","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.braindev.2007.08.007_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(94)90546-0","article-title":"Amino acids differentially inhibit the l-[3H]arginine transport and nitric oxide synthase in rat brain synaptosomes","volume":"181","author":"Lopes","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.braindev.2007.08.007_bib26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0006-8993(98)00064-X","article-title":"Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion","volume":"790","author":"Almeida","year":"1998","journal-title":"Brain Res"},{"year":"1995","series-title":"The metabolic basis of inherited disease","author":"Scriver","key":"10.1016\/j.braindev.2007.08.007_bib27"},{"key":"10.1016\/j.braindev.2007.08.007_bib28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jns.2004.11.026","article-title":"Hypocitrullinemia in patients with MELAS: an insight into the \u201cMELAS paradox\u201d","volume":"229\u2013230","author":"Naini","year":"2005","journal-title":"J Neurol Sci"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760407002033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760407002033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:46:21Z","timestamp":1759952781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760407002033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0387760407002033"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2007.08.007","relation":{},"ISSN":["0387-7604"],"issn-type":[{"type":"print","value":"0387-7604"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of l-arginine on synaptosomal mitochondrial function","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2007.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}