{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:59:17Z","timestamp":1792166357474,"version":"4.4.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.braindev.2008.01.003","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T23:49:50Z","timestamp":1204847390000},"page":"483-488","source":"Crossref","is-referenced-by-count":62,"title":["Serial brain imaging analysis of stroke-like episodes in MELAS"],"prefix":"10.1016","volume":"30","author":[{"given":"Hiromichi","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Minato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuo","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Kagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2008.01.003_bib1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ana.410160409","article-title":"Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes: a distinctive clinical syndrome","volume":"16","author":"Pavlakis","year":"1984","journal-title":"Ann Neurol"},{"key":"10.1016\/j.braindev.2008.01.003_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/1567202052773544","article-title":"Pathogenesis of stroke-like episodes in MELAS: analysis of neurovascular cellular mechanisms","volume":"2","author":"Iizuka","year":"2005","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.braindev.2008.01.003_bib3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/BF00688185","article-title":"Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy","volume":"74","author":"Ohama","year":"1987","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.braindev.2008.01.003_bib4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/ana.410250611","article-title":"Vascular involvement in mitochondrial myopathy","volume":"25","author":"Sakuta","year":"1989","journal-title":"Ann Neurol"},{"key":"10.1016\/j.braindev.2008.01.003_bib5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00713541","article-title":"Central nervous system changes in mitochondrial encephalomyopathy: light and electron microscopic study","volume":"83","author":"Mizukami","year":"1992","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.braindev.2008.01.003_bib6","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1212\/01.wnl.0000220197.36849.1e","article-title":"Endothelial dysfunction in MELAS improved by l-arginine supplementation","volume":"66","author":"Koga","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2008.01.003_bib7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00000441-200505000-00008","article-title":"Vascular involvement in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes","volume":"329","author":"Takahashi","year":"2005","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.braindev.2008.01.003_bib8","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1212\/01.WNL.0000151976.60624.01","article-title":"l-Arginine improves the symptoms of strokelike episodes in MELAS","volume":"64","author":"Koga","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2008.01.003_bib9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1055\/s-2007-973500","article-title":"Quantitative proton magnetic resonance spectroscopy of cerebral metabolic disturbances in patients with MELAS","volume":"30","author":"Wilichowski","year":"1999","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.braindev.2008.01.003_bib10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1212\/WNL.55.4.544","article-title":"Cerebral blood flow and glucose metabolism in mitochondrial disorders","volume":"55","author":"Moln\u00e1r","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2008.01.003_bib11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1212\/WNL.59.6.816","article-title":"Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome","volume":"59","author":"Iizuka","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2008.01.003_bib12","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1212\/WNL.53.9.2182","article-title":"Vasogenic edema on MELAS: a serial study with diffusion-weighted MR imaging","volume":"53","author":"Yoneda","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2008.01.003_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/jnnp.69.2.248","article-title":"Can diffusion weighted magnetic resonance imaging help differentiate stroke from stroke-like events in MELAS?","volume":"69","author":"Oppenheim","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.braindev.2008.01.003_bib14","first-page":"269","article-title":"Diffusion-weighted MR imaging in a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes","volume":"22","author":"Yonemura","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.braindev.2008.01.003_bib15","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s00234-003-1029-6","article-title":"Serial diffusion-weighted imaging in a patient with MELAS and presumed cytotoxic oedema","volume":"45","author":"Wang","year":"2003","journal-title":"Neuroradiology"},{"key":"10.1016\/j.braindev.2008.01.003_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jns.2004.11.014","article-title":"Magnetic resonance spectroscopy in patients with MELAS","volume":"229\u2013230","author":"Moller","year":"2005","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.braindev.2008.01.003_bib17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1136\/jnnp.70.5.675","article-title":"Reversible brain dysfunction in MELAS: MEG, and 1H-MRS analysis","volume":"70","author":"Kamada","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.braindev.2008.01.003_bib18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainresprot.2003.08.006","article-title":"Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats","volume":"12","author":"Gerriets","year":"2004","journal-title":"Brain Res Brain Res Protoc"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760408000211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760408000211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T06:56:30Z","timestamp":1546239390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760408000211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0387760408000211"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2008.01.003","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}