{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:38:17Z","timestamp":1783471097072,"version":"3.55.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.braindev.2008.01.011","type":"journal-article","created":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T11:03:02Z","timestamp":1205233382000},"page":"579-583","source":"Crossref","is-referenced-by-count":27,"title":["MR spectroscopy of the brain in Leigh syndrome"],"prefix":"10.1016","volume":"30","author":[{"given":"P.E.","family":"Sijens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.P.A.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"R\u00f6diger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.J.","family":"van Spronsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Oudkerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Rodenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Lunsing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2008.01.011_bib1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1136\/jnnp.14.3.216","article-title":"Subacute necrotizing encephalomyelopathy in an infant","volume":"14","author":"Leigh","year":"1951","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.braindev.2008.01.011_bib2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0022-3476(05)81650-6","article-title":"Complex I (reduced nicotinamide-adenine dinucleotide-coenzyme Q reductase) deficiency in two patients with probable Leigh syndrome","volume":"116","author":"Fujii","year":"1990","journal-title":"J Pediatr"},{"key":"10.1016\/j.braindev.2008.01.011_bib3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1469-8749.1993.tb11728.x","article-title":"Proton spectroscopy in five patients with Leigh\u2019s disease and mitochondrial enzyme deficiency","volume":"35","author":"Kr\u00e4geloh-Mann","year":"1993","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.braindev.2008.01.011_bib4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/ana.410290219","article-title":"Regional variation in brain lactate in Leigh syndrome by localized 1H magnetic resonance spectroscopy","volume":"29","author":"Detre","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.braindev.2008.01.011_bib5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0387-7604(98)00095-3","article-title":"Proton magnetic resonance spectroscopy to study the metabolic changes in the brain of a patient with Leigh syndrome","volume":"21","author":"Takahashi","year":"1999","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2008.01.011_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-510X(96)00248-1","article-title":"Dichloroacetate treatment in Leigh syndrome caused by mitochondrial DNA mutation","volume":"145","author":"Takanashi","year":"1997","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.braindev.2008.01.011_bib7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/mrm.1910370214","article-title":"1H chemical shift imaging reveals loss of brain tumor choline signal after administration of Gd-contrast","volume":"37","author":"Sijens","year":"1997","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.braindev.2008.01.011_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1522-2594(199907)42:1<24::AID-MRM5>3.0.CO;2-3","article-title":"1H chemical shift imaging of the human brain at age 60\u201390 years reveals metabolic differences between women and men","volume":"42","author":"Sijens","year":"1999","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.braindev.2008.01.011_bib9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jocn.2004.02.024","article-title":"Functional imaging of a large demyelinating lesion","volume":"12","author":"Padma","year":"2005","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.braindev.2008.01.011_bib10","first-page":"1502","article-title":"Leigh syndrome: serial MR imaging and clinical follow-up","volume":"21","author":"Arii","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"issue":"Suppl. 2","key":"10.1016\/j.braindev.2008.01.011_bib11","first-page":"S121","article-title":"Proton MR spectroscopy to assess axonal damage in multiple sclerosis and other white matter disorders","volume":"6","author":"Stefano","year":"2000","journal-title":"J Neurovirol"},{"key":"10.1016\/j.braindev.2008.01.011_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00330-005-2839-1","article-title":"1H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings","volume":"16","author":"Sijens","year":"2006","journal-title":"Eur Radiol"},{"key":"10.1016\/j.braindev.2008.01.011_bib13","first-page":"1958","article-title":"Proton MR spectroscopy of mitochondrial diseases: analysis of brain metabolic abnormalities and their possible diagnostic relevance","volume":"24","author":"Bianchi","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.braindev.2008.01.011_bib14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.2214\/AJR.05.0180","article-title":"Chronic progressive external ophthalmoplegia: MR spectroscopy and MR diffusion studies in the brain","volume":"187","author":"Heidenreich","year":"2006","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.braindev.2008.01.011_bib15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jns.2004.11.014","article-title":"Magnetic resonance spectroscopy in patients with MELAS","volume":"229\u2013230","author":"M\u00f6ller","year":"2005","journal-title":"J Neurol Sci"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760408000302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760408000302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T23:50:55Z","timestamp":1546213855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760408000302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0387760408000302"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2008.01.011","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}