{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:42:29Z","timestamp":1791258149237,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.braindev.2013.10.004","type":"journal-article","created":{"date-parts":[[2013,10,27]],"date-time":"2013-10-27T03:45:56Z","timestamp":1382845556000},"page":"676-681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Early clinical features and diagnosis of Dravet syndrome in 138 Chinese patients with SCN1A mutations"],"prefix":"10.1016","volume":"36","author":[{"given":"Xiaojing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiru","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2013.10.004_b0005","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1046\/j.1528-1157.2001.10401.x","article-title":"International League Against Epilepsy (ILAE). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE task force on classification and terminology","volume":"42","author":"Engel","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2013.10.004_b0010","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.0013-9580.2004.15103.x","article-title":"Mutations of neuronal voltage-gated Na+ channel alpha 1 subunit gene SCN1A in core severe myoclonic epilepsy in infancy (SMEI) and in borderline SMEI (SMEB)","volume":"45","author":"Fukuma","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2013.10.004_b0015","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1212\/01.wnl.0000237322.04338.2b","article-title":"A new molecular mechanism for severe myoclonic epilepsy of infancy: exonic deletions in SCN1A","volume":"67","author":"Mulley","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2013.10.004_b0020","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.seizure.2010.01.007","article-title":"Unusual consequences of status epilepticus in Dravet syndrome","volume":"19","author":"Chipaux","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.braindev.2013.10.004_b0025","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/0883073807300294","article-title":"Dravet syndrome (severe myoclonic epilepsy in infancy): a retrospective study of 16 patients","volume":"22","author":"Korff","year":"2007","journal-title":"J Child Neurol"},{"key":"10.1016\/j.braindev.2013.10.004_b0030","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/01.wnl.0000265222.24102.db","article-title":"An open-label trial of levetiracetam in severe myoclonic epilepsy of infancy","volume":"69","author":"Striano","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2013.10.004_b0035","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1474-4422(04)00808-7","article-title":"Fever, genes and epilepsy","volume":"3","author":"Baulac","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.braindev.2013.10.004_b0040","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/jhg.2010.39","article-title":"Analysis of SCN1A mutation and parental origin in patients with Dravet syndrome","volume":"55","author":"Sun","year":"2010","journal-title":"J Hum Genet"},{"key":"10.1016\/j.braindev.2013.10.004_b0045","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.braindev.2013.10.004_b0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0006-291X(02)00617-4","article-title":"Significant correlation of the SCN1A mutations and severe myoclonic epilepsy in infancy","volume":"295","author":"Ohmori","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.braindev.2013.10.004_b0055","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJM198702263160901","article-title":"Factors prognostic of unprovoked seizures after febrile convulsions","volume":"316","author":"Annegers","year":"1987","journal-title":"N Engl J Med"},{"issue":"Suppl. 2","key":"10.1016\/j.braindev.2013.10.004_b0060","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1528-1157.1994.tb05932.x","article-title":"The prevalence and incidence of convulsive disorders in children","volume":"35","author":"Hauser","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2013.10.004_b0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-3016.1991.tb00699.x","article-title":"Prevalence of febrile seizures in Dutch schoolchildren","volume":"5","author":"Offringa","year":"1991","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.braindev.2013.10.004_b0070","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1528-1157.1996.tb00003.x","article-title":"Complex febrile seizures","volume":"37","author":"Berg","year":"1996","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2013.10.004_b0075","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1528-1157.1993.tb00433.x","article-title":"International league against epilepsy guidelines for epidemiologic studies on epilepsy","volume":"34","author":"Commission on Epidemiology and Prognosis","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2013.10.004_b0080","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/bmj.303.6814.1373","article-title":"Risk of epilepsy after febrile convulsions: a national cohort study","volume":"303","author":"Verity","year":"1991","journal-title":"BMJ"},{"key":"10.1016\/j.braindev.2013.10.004_b0085","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1212\/WNL.47.2.562","article-title":"Unprovoked seizures in children with febrile seizures: short-term outcome","volume":"47","author":"Berg","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2013.10.004_b0090","first-page":"11","article-title":"Treatment of children with simple febrile seizures: the AAP practice parameter","volume":"23","author":"Baumann","year":"2000","journal-title":"Am Acad Pediatr"},{"key":"10.1016\/j.braindev.2013.10.004_b0095","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0920-1211(02)00083-9","article-title":"Childhood febrile convulsions\u2013which factors determine the subsequent epilepsy syndrome? A retrospective study","volume":"50","author":"Trinka","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.braindev.2013.10.004_b0100","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/adc.2003.028449","article-title":"Febrile seizures: an update","volume":"89","author":"Waruiru","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.braindev.2013.10.004_b0105","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.pediatrneurol.2011.08.001","article-title":"When should clinicians order genetic testing for Dravet syndrome?","volume":"45","author":"Fountain-Capal","year":"2011","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.braindev.2013.10.004_b0110","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1528-1167.2007.01475.x","article-title":"A screening test for the prediction of Dravet syndrome before one year of age","volume":"49","author":"Hattori","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2013.10.004_b0115","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.braindev.2009.09.014","article-title":"Dravet syndrome: early clinical manifestations and cognitive outcome in 37 Italian patients","volume":"32","author":"Ragona","year":"2010","journal-title":"Brain Dev"},{"issue":"Suppl 1","key":"10.1016\/j.braindev.2013.10.004_b0120","doi-asserted-by":"crossref","first-page":"S231","DOI":"10.1016\/j.eplepsyres.2005.11.026","article-title":"Dravet syndrome: a study of 53 patients","volume":"70","author":"Caraballo","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.braindev.2013.10.004_b0125","first-page":"620","article-title":"Severe myoclonic epilepsy in childhood. Epidemiologic analytical study","volume":"30","author":"Nieto-Barrera","year":"2000","journal-title":"Rev Neurol"},{"key":"10.1016\/j.braindev.2013.10.004_b0130","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S1474-4422(06)70446-X","article-title":"De-novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy: a retrospective study","volume":"5","author":"Berkovic","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.braindev.2013.10.004_b0135","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S1474-4422(10)70107-1","article-title":"Effects of vaccination on onset and outcome of Dravet syndrome: a retrospective study","volume":"9","author":"McIntosh","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.braindev.2013.10.004_b0140","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMoa003077","article-title":"Centers for disease control and prevention vaccine safety datalink working group. The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine","volume":"345","author":"Barlow","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.braindev.2013.10.004_b0145","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0140-6736(95)90471-9","article-title":"A new method for active surveillance of adverse events from diphtheria\/tetanus\/pertussis and measles\/mumps\/rubella vaccines","volume":"345","author":"Farrington","year":"1995","journal-title":"Lancet"},{"issue":"Suppl 3","key":"10.1016\/j.braindev.2013.10.004_b0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1528-1167.2011.03032.x","article-title":"Vaccinations and febrile seizures","volume":"52","author":"Cendes","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2013.10.004_b0155","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0920-1211(03)00084-6","article-title":"Navl. 1channels with mutations of severe myoclonic epilepsy in infancy display attenuated currents","volume":"54","author":"Sugawara","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.braindev.2013.10.004_b0160","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.seizure.2010.10.027","article-title":"Antiepileptic drug therapy the story so far","volume":"19","author":"Brodie","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.braindev.2013.10.004_b0165","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1111\/j.1528-1167.2005.05705.x","article-title":"Ketogenic diet in patients with Dravet syndrome","volume":"46","author":"Caraballo","year":"2005","journal-title":"Epilepsia"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760413002945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760413002945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T09:20:35Z","timestamp":1539249635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760413002945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0387760413002945"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2013.10.004","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early clinical features and diagnosis of Dravet syndrome in 138 Chinese patients with SCN1A mutations","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2013.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}