{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:05:17Z","timestamp":1789077917353,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100015279","name":"Osaka Foundation for Promotion of Fundamental Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015279","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["brainanddevelopment.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.braindev.2014.12.004","type":"journal-article","created":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T17:04:39Z","timestamp":1419613479000},"page":"790-796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Carnitine deficiency: Risk factors and incidence in children with epilepsy"],"prefix":"10.1016","volume":"37","author":[{"given":"Mitsumasa","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Takehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Iwano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozue","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiya","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Wakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2014.12.004_b0005","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1203\/00006450-199711000-00005","article-title":"Deficient muscle carnitine transport in primary carnitine deficiency","volume":"42","author":"Pons","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1016\/j.braindev.2014.12.004_b0010","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1096\/fasebj.6.15.1464372","article-title":"Carnitine function and requirements during the life cycle","volume":"6","author":"Rebouche","year":"1992","journal-title":"FASEB J"},{"key":"10.1016\/j.braindev.2014.12.004_b0015","first-page":"134","article-title":"Primary and secondary disorders of carnitine metabolism","volume":"5","author":"De Vivo","year":"1990","journal-title":"Int Pediatr"},{"key":"10.1016\/j.braindev.2014.12.004_b0020","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/088307389801301104","article-title":"Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital","volume":"13","author":"Castro-Gago","year":"1998","journal-title":"J Child Neurol"},{"key":"10.1016\/j.braindev.2014.12.004_b0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1248\/bpb.20.91","article-title":"Reduction in blood free carnitine levels in association with changes in sodium valproate (VPA) disposition in epileptic patients treated with VPA and other anti-epileptic drugs","volume":"20","author":"Hiraoka","year":"1997","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.braindev.2014.12.004_b0030","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s005990050060","article-title":"Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs","volume":"29","author":"Verrotti","year":"1999","journal-title":"Int J Clin Lab Res"},{"key":"10.1016\/j.braindev.2014.12.004_b0035","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1177\/0883073895010002S05","article-title":"Carnitine deficiency in epilepsy: risk factors and treatment","volume":"10","author":"Coulter","year":"1995","journal-title":"J Child Neurol"},{"key":"10.1016\/j.braindev.2014.12.004_b0040","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/clinchem\/40.5.817","article-title":"Carnitine determination by an enzymatic cycling method with carnitine dehydrogenase","volume":"40","author":"Takahashi","year":"1994","journal-title":"Clin Chem"},{"key":"10.1016\/j.braindev.2014.12.004_b0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1469-8749.1997.tb07414.x","article-title":"Development and reliability of a system to classify gross motor function in children with cerebral palsy","volume":"39","author":"Palisano","year":"1997","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.braindev.2014.12.004_b0050","first-page":"127","article-title":"Classifying cerebral palsy","volume":"25","author":"Graham","year":"2005","journal-title":"J Pediatr Orthop"},{"key":"10.1016\/j.braindev.2014.12.004_b0055","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5551\/jat.10.321","article-title":"A case of severe hyperlipidemia caused by long-term tube feedings","volume":"10","author":"Tanaka","year":"2003","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.braindev.2014.12.004_b0060","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0022-3476(05)80931-X","article-title":"Carnitine deficiency caused by valproic acid","volume":"120","author":"Castro-Gago","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.braindev.2014.12.004_b0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/088307389100600102","article-title":"Carnitine, valproate, and toxicity","volume":"6","author":"Coulter","year":"1991","journal-title":"J Child Neurol"},{"key":"10.1016\/j.braindev.2014.12.004_b0070","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.braindev.2010.12.003","article-title":"Evaluation of valproate effects on acylcarnitine in epileptic children by LC\u2013MS\/MS","volume":"33","author":"Nakajima","year":"2011","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2014.12.004_b0075","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0009-9120(01)00272-7","article-title":"Characterization of plasma acylcarnitines in patients under valproate monotherapy using ESI-MS\/MS","volume":"34","author":"Silva","year":"2001","journal-title":"Clin Biochem"},{"key":"10.1016\/j.braindev.2014.12.004_b0080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1528-1167.2006.00833.x","article-title":"Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS\/MS","volume":"48","author":"Werner","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2014.12.004_b0085","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/rcm.2905","article-title":"Simultaneous quantification of acylcarnitine isomers containing dicarboxylic acylcarnitines in human serum and urine by high-performance liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"21","author":"Maeda","year":"2007","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.braindev.2014.12.004_b0090","first-page":"999","article-title":"The effect of valproic acid on plasma carnitine levels","volume":"145","author":"Opala","year":"1991","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.braindev.2014.12.004_b0095","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.braindev.2014.03.012","article-title":"Carnitine in severely disabled patients: relation to anthropometric, biochemical variables, and nutritional intake","volume":"37","author":"Takeda","year":"2015","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2014.12.004_b0100","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.eplepsyres.2009.04.002","article-title":"The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status","volume":"86","author":"Hamed","year":"2009","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.braindev.2014.12.004_b0105","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1528-1157.1990.tb05387.x","article-title":"Valproate, carnitine metabolism, and biochemical indicators of liver function. Collaborative Group for the study of epilepsy","volume":"31","author":"Beghi","year":"1990","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2014.12.004_b0110","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1528-1157.1998.tb01315.x","article-title":"l-carnitine supplementation in childhood epilepsy: current perspectives","volume":"39","author":"De Vivo","year":"1998","journal-title":"Epilepsia"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760414002897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760414002897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T11:46:56Z","timestamp":1598615216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760414002897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0387760414002897"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2014.12.004","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carnitine deficiency: Risk factors and incidence in children with epilepsy","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2014.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}