{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:32:31Z","timestamp":1790260351623,"version":"4.1.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","brainanddevelopment.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.braindev.2015.07.002","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T14:52:21Z","timestamp":1437663141000},"page":"128-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Dramatic effect of levetiracetam in early-onset epileptic encephalopathy due to STXBP1 mutation"],"prefix":"10.1016","volume":"38","author":[{"given":"Robertino","family":"Dilena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Striano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Traverso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Viri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Cristofori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tadini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Zara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2015.07.002_b0005","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/ng.150","article-title":"De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy","volume":"40","author":"Saitsu","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.braindev.2015.07.002_b0010","doi-asserted-by":"crossref","first-page":"18332","DOI":"10.1073\/pnas.0608507103","article-title":"Munc 18-1 expression levels control synapse recovery by regulation readily releasable pool size","volume":"103","author":"Toonen","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.braindev.2015.07.002_b0015","doi-asserted-by":"crossref","first-page":"9861","DOI":"10.1073\/pnas.0308208101","article-title":"The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam","volume":"101","author":"Lynch","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.braindev.2015.07.002_b0020","first-page":"64","article-title":"Successful treatment with levetiracetam in a case of Ohtahara syndrome caused by STXBP1 mutation (in Japanese)","volume":"45","author":"Yamashita","year":"2013","journal-title":"No To Hattatsu"},{"key":"10.1016\/j.braindev.2015.07.002_b0025","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.neuro.26.041002.131412","article-title":"The synaptic vesicle cycle","volume":"27","author":"Sudhof","year":"2004","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.braindev.2015.07.002_b0030","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.287.5454.864","article-title":"Synaptic assembly of the brain in the absence of neurotransmitter secretion","volume":"287","author":"Verhage","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.braindev.2015.07.002_b0035","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/j.eplepsyres.2006.02.008","article-title":"A new paradigm for West syndrome based on molecular and cell biology","volume":"70","author":"Kato","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.braindev.2015.07.002_b0040","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0883073813506936","article-title":"A novel mutation in STXBP1 gene in a child with epileptic encephalopathy and an atypical electroclinical pattern","volume":"29","author":"Romaniello","year":"2014","journal-title":"J Child Neurol"},{"key":"10.1016\/j.braindev.2015.07.002_b0045","doi-asserted-by":"crossref","first-page":"e29560","DOI":"10.1371\/journal.pone.0029560","article-title":"Levetiracetam reverses synaptic deficits produced by overexpression of SV2A","volume":"6","author":"Nowack","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.braindev.2015.07.002_b0050","doi-asserted-by":"crossref","first-page":"10535","DOI":"10.1074\/jbc.M114.631341","article-title":"Synaptotagmin-1 is an antagonist for Munc18-1 in SNARE zippering","volume":"290","author":"Lou","year":"2015","journal-title":"J Biol Chem"}],"updated-by":[{"DOI":"10.1016\/j.braindev.2023.11.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000}}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760415001333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760415001333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T10:36:05Z","timestamp":1704796565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760415001333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0387760415001333"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2015.07.002","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.braindev.2023.11.006","asserted-by":"object"}]},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dramatic effect of levetiracetam in early-onset epileptic encephalopathy due to STXBP1 mutation","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2015.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}