{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:42:27Z","timestamp":1784691747468,"version":"3.55.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","brainanddevelopment.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.braindev.2018.01.001","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T20:32:41Z","timestamp":1517517161000},"page":"415-420","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of everolimus in patients younger than 12\u202fmonths with congenital subependymal giant cell astrocytoma"],"prefix":"10.1016","volume":"40","author":[{"given":"Ichiro","family":"Kuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Kawawaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Ehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritsugu","family":"Kunihiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Matsusaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2018.01.001_b0005","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0140-6736(12)61134-9","article-title":"Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial","volume":"381","author":"Franz","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.braindev.2018.01.001_b0010","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s00381-014-2555-8","article-title":"Congenital subependymal giant cell astrocytomas in patients with tuberous sclerosis complex","volume":"30","author":"Kotulska","year":"2014","journal-title":"Childs Nerv Syst"},{"issue":"49","key":"10.1016\/j.braindev.2018.01.001_b0015","first-page":"243","article-title":"Tuberous sclerosis complex diagnostic criteria update: recommendations of the Iinternational Tuberous Sclerosis Complex Consensus Conference","volume":"2013","author":"Northrup","year":"2012","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.braindev.2018.01.001_b0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jpeds.2016.01.027","article-title":"Safety of everolimus in patients younger than 3\u202fyears of age: results from EXIST-1, a randomized Controlled Clinical Trial","volume":"172","author":"J\u00f3\u017awiak","year":"2016","journal-title":"J Pediatr"},{"key":"10.1016\/j.braindev.2018.01.001_b0025","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1177\/0883073814544703","article-title":"Everolimus treatment for an early infantile subependymal giant cell astrocytoma with tuberous sclerosis complex","volume":"30","author":"Fukumura","year":"2015","journal-title":"J Child Neurol"},{"key":"10.1016\/j.braindev.2018.01.001_b0030","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.pediatrneurol.2015.01.004","article-title":"Use of mTOR inhibitor everolimus in three neonates for treatment of tumors associated with tuberous sclerosis complex","volume":"52","author":"Goyer","year":"2015","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.braindev.2018.01.001_b0035","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.pediatrneurol.2013.12.004","article-title":"Surgical treatment of subependymal giant cell astrocytoma in tuberous sclerosis complex patients","volume":"50","author":"Kotulska","year":"2014","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.braindev.2018.01.001_b0040","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/S0140-6736(16)31419-2","article-title":"Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study","volume":"388","author":"French","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.braindev.2018.01.001_b0045","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.1038\/ncomms7842","article-title":"Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex","volume":"6","author":"Sugiura","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.braindev.2018.01.001_b0050","first-page":"72","article-title":"Rapid enlargement of cardiac rhabdomyoma during corticotropin therapy for infantile spasms","volume":"13","author":"Hishitani","year":"1997","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.braindev.2018.01.001_b0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/08880018.2012.734896","article-title":"Cardiac rhabdomyomas associated with tuberous sclerosis complex in 11 children: presentation to outcome","volume":"30","author":"Kocaba\u015f","year":"2013","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.braindev.2018.01.001_b0060","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2147\/TCRM.S138576","article-title":"Clinical patterns and outcomes of status epilepticus in patients with tuberous sclerosis complex","volume":"13","author":"Shehata","year":"2017","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.braindev.2018.01.001_b0065","first-page":"129","article-title":"Everolimus for the treatment of subependymal giant cell astrocytoma probably causing seizure aggravation in a child with tuberous sclerosis complex: a case report","volume":"45","author":"Wiemer-Kruel","year":"2014","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.braindev.2018.01.001_b0070","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/ejhg.2015.47","article-title":"Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2","volume":"23","author":"Kwiatkowski","year":"2015","journal-title":"Eur J Hum Genet"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760418300056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760418300056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T14:47:52Z","timestamp":1529938072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760418300056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0387760418300056"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2018.01.001","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of everolimus in patients younger than 12\u202fmonths with congenital subependymal giant cell astrocytoma","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2018.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}