{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:37:12Z","timestamp":1776400632818,"version":"3.51.2"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006190","name":"National High Technology Research and Development Program","doi-asserted-by":"publisher","award":["2011AA020113"],"award-info":[{"award-number":["2011AA020113"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010218","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["2013SK5070"],"award-info":[{"award-number":["2013SK5070"]}],"id":[{"id":"10.13039\/501100010218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["brainanddevelopment.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.braindev.2018.08.007","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T22:48:55Z","timestamp":1535755735000},"page":"173-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of human umbilical cord blood CD34+ cell transplantation in neonatal hypoxic-ischemia rat model"],"prefix":"10.1016","volume":"41","author":[{"given":"Yan","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YiZhong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LaMei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2018.08.007_b0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1203\/PDR.0b013e3181bf594b","article-title":"Mesenchymal stem-cell transplantation for hypoxic-ischemic brain injury in neonatal rat model","volume":"67","author":"Lee","year":"2010","journal-title":"Pediatr Res"},{"key":"10.1016\/j.braindev.2018.08.007_b0010","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1161\/STROKEAHA.111.000719","article-title":"Human umbilical vein endothelial cells protect against hypoxic-ischemic damage in neonatal brain via stromal cell-derived factor 1\/C-X-C chemokine receptor type 4","volume":"44","author":"Wu","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.braindev.2018.08.007_b0015","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1007\/s12035-016-0030-0","article-title":"The role of stem cells in the treatment of cerebral palsy: a review","volume":"54","author":"Kiasatdolatabadi","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.braindev.2018.08.007_b0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00381-013-2304-4","article-title":"Stem cells for brain repair in neonatal hypoxia-ischemia","volume":"30","author":"Chicha","year":"2014","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.braindev.2018.08.007_b0025","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1056\/NEJM198910263211707","article-title":"Hematopoietic reconstitution in a patient with Fanconi\u2019s anemia by means of umbilical-cord blood from an HLA-identical sibling","volume":"321","author":"Gluckman","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.braindev.2018.08.007_b0030","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/scd.2005.14.595","article-title":"Anti-inflammatory effects of human cord blood cells in a rat model of stroke","volume":"14","author":"Vendrame","year":"2005","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.braindev.2018.08.007_b0035","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1089\/neu.2008.0725","article-title":"Neuronal apoptosis is inhibited by cord blood stem cells after spinal cord injury","volume":"26","author":"Dasari","year":"2009","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.braindev.2018.08.007_b0040","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/scd.2009.0049","article-title":"Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum","volume":"19","author":"Pimentel-Coelho","year":"2010","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.braindev.2018.08.007_b0045","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aanat.2012.09.003","article-title":"Changes in Interleukin-1 alpha serum levels after transplantation of umbilical cord blood cells in a model of perinatal hypoxic-ischemic brain damage","volume":"195","author":"Rosenkranz","year":"2013","journal-title":"Ann Anat"},{"key":"10.1016\/j.braindev.2018.08.007_b0050","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.brainres.2013.04.038","article-title":"Umbilical cord blood cells regulate endogenous neural stem cell proliferation via hedgehog signaling in hypoxic ischemic neonatal rats","volume":"1518","author":"Wang","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.braindev.2018.08.007_b0055","first-page":"581","article-title":"Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized","volume":"31","author":"Min","year":"2013","journal-title":"Placebo-Controlled Trial Stem Cells"},{"key":"10.1016\/j.braindev.2018.08.007_b0060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2014.01.018","article-title":"Effects of intravenous administration of umbilical cord blood CD34+ cells in a mouse model of neonatal stroke","volume":"263","author":"Tsuji","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.braindev.2018.08.007_b0065","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1172\/JCI200420622","article-title":"Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesisin a mouse model","volume":"114","author":"Taguchi","year":"2004","journal-title":"J Clin Investig"},{"key":"10.1016\/j.braindev.2018.08.007_b0070","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/scd.2009.0049","article-title":"Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum","volume":"19","author":"Pimentel-Coelho","year":"2010","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.braindev.2018.08.007_b0075","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1523\/JNEUROSCI.15-07-05372.1995","article-title":"Elevated body swing test: a new behavioral parameter for rats with 6-hydroxydopamine-induced hemiparkinsonism","volume":"15","author":"Borlongan","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.braindev.2018.08.007_b0080","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.molmed.2017.07.003","article-title":"HSC niche biology and HSC expansion Ex Vivo","volume":"23","author":"Kumar","year":"2017","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.braindev.2018.08.007_b0085","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/ana.22670","article-title":"Cell therapy for neonatal hypoxia-ischemia and cerebral palsy","volume":"71","author":"Bennet","year":"2012","journal-title":"Ann Neurol"},{"key":"10.1016\/j.braindev.2018.08.007_b0090","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fncel.2017.00078","article-title":"Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges","volume":"11","author":"Millar","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.braindev.2018.08.007_b0095","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1161\/hs1101.098367","article-title":"Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.braindev.2018.08.007_b0100","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1074\/jbc.M111.296434","article-title":"Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction","volume":"287","author":"Rowe","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.braindev.2018.08.007_b0105","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1517\/14712598.2011.557060","article-title":"Update on stem cell therapy for cerebral palsy","volume":"11","author":"Carroll","year":"2011","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.braindev.2018.08.007_b0110","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3233\/JPD-130214","article-title":"Recovery of neurological functions in non-human primate model of Parkinson's disease by transplantation of encapsulated neonatal porcine choroid plexus cells","volume":"3","author":"Luo","year":"2013","journal-title":"J Parkinsons Dis"},{"key":"10.1016\/j.braindev.2018.08.007_b0115","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1161\/01.STR.0000141680.49960.d7","article-title":"Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke","volume":"35","author":"Borlongan","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.braindev.2018.08.007_b0120","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1582-4934.2008.00671.x","article-title":"Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts","volume":"14","author":"Yasuhara","year":"2010","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.braindev.2018.08.007_b0125","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1161\/STROKEAHA.107.504175","article-title":"Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines","volume":"39","author":"Nijboer","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.braindev.2018.08.007_b0130","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.nbd.2010.01.016","article-title":"NF-kappaB inhibition after neonatal cerebral hypoxia-ischemia improves long-term motor and cognitive outcome in rats","volume":"38","author":"van der Kooij","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.braindev.2018.08.007_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2016.03.017","article-title":"Heterogeneous astrocytes: active players in CNS","volume":"125","author":"Hu","year":"2016","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.braindev.2018.08.007_b0140","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.trsl.2016.04.003","article-title":"Transplantation of hematopoietic stem cells: intra-arterial versus intravenous administration impacts stroke outcomes in a murine model","volume":"176","author":"Kasahara","year":"2016","journal-title":"Transl Res"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038776041830425X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038776041830425X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:47:47Z","timestamp":1759952867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S038776041830425X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S038776041830425X"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2018.08.007","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of human umbilical cord blood CD34+ cell transplantation in neonatal hypoxic-ischemia rat model","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2018.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}