{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:48:31Z","timestamp":1770706111898,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["brainanddevelopment.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.braindev.2019.02.011","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T20:20:53Z","timestamp":1551471653000},"page":"531-537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Clinical time course of pediatric acute disseminated encephalomyelitis"],"prefix":"10.1016","volume":"41","author":[{"given":"Masahiro","family":"Nishiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Tomioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisaku","family":"Toyoshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Oyazato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Takami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kandai","family":"Nozu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-8948","authenticated-orcid":false,"given":"Ichiro","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumoto","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2019.02.011_b0005","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1177\/1352458513484547","article-title":"International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions","volume":"19","author":"Krupp","year":"2013","journal-title":"Mult Scler"},{"key":"10.1016\/j.braindev.2019.02.011_b0010","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1177\/0883073812455104","article-title":"Acute disseminated encephalomyelitis","volume":"27","author":"Alper","year":"2012","journal-title":"J Child Neurol"},{"key":"10.1016\/j.braindev.2019.02.011_b0015","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1212\/01.wnl.0000259404.51352.7f","article-title":"Acute disseminated encephalomyelitis","volume":"68","author":"Tenembaum","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2019.02.011_b0020","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1212\/WNL.59.8.1224","article-title":"Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients","volume":"59","author":"Tenembaum","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2019.02.011_b0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/0883073812465013","article-title":"Acute disseminated encephalomyelitis: the time until diagnosis and its subsequent course in children","volume":"29","author":"Omata","year":"2014","journal-title":"J Child Neurol"},{"key":"10.1016\/j.braindev.2019.02.011_b0030","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1542\/peds.2004-2038","article-title":"Acute disseminated encephalomyelitis in children: discordant neurologic and neuroimaging abnormalities and response to plasmapheresis","volume":"116","author":"Khurana","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.braindev.2019.02.011_b0035","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1212\/WNL.0000000000000101","article-title":"Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders","volume":"82","author":"Sato","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2019.02.011_b0040","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.braindev.2009.10.006","article-title":"Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture","volume":"32","author":"Torisu","year":"2010","journal-title":"Japan. Brain Dev"},{"key":"10.1016\/j.braindev.2019.02.011_b0045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-0032-1309309","article-title":"Acute disseminated encephalomyelitis in children: a single institution experience of 28 patients","volume":"43","author":"Hung","year":"2012","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.braindev.2019.02.011_b0050","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1212\/WNL.0000000000002723","article-title":"Acute disseminated encephalomyelitis in 228 patients: a retrospective, multicenter US study","volume":"86","author":"Koelman","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2019.02.011_b0055","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1212\/WNL.0000000000003318","article-title":"A nationwide survey of pediatric acquired demyelinating syndromes in Japan","volume":"87","author":"Yamaguchi","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2019.02.011_b0060","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jpeds.2003.10.056","article-title":"First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disability","volume":"144","author":"Mikaeloff","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.braindev.2019.02.011_b0065","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1055\/s-2003-42208","article-title":"Acute disseminated encephalomyelitis in children: outcome and prognosis","volume":"34","author":"Anlar","year":"2003","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.braindev.2019.02.011_b0070","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1212\/WNL.56.10.1313","article-title":"Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients","volume":"56","author":"Schwarz","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2019.02.011_b0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/1817-1745.111418","article-title":"Acute demyelinating encephalomyelitis: clinical characteristics and outcome","volume":"8","author":"Elhassanien","year":"2013","journal-title":"J Pediatr Neurosci"},{"key":"10.1016\/j.braindev.2019.02.011_b0080","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1212\/WNL.0000000000002825","article-title":"Acute disseminated encephalomyelitis: updates on an inflammatory CNS syndrome","volume":"87","author":"Pohl","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2019.02.011_b0085","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ejpn.2016.01.008","article-title":"Long-term motor, cognitive and behavioral outcome of acute disseminated encephalomyelitis","volume":"20","author":"Shilo","year":"2016","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.braindev.2019.02.011_b0090","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00431-006-0249-2","article-title":"Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey","volume":"166","author":"Pohl","year":"2007","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.braindev.2019.02.011_b0095","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrneurol.2009.158","article-title":"Pediatric multiple sclerosis","volume":"5","author":"Yeh","year":"2009","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.braindev.2019.02.011_b0100","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1212\/WNL.0b013e31826aac4e","article-title":"Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype","volume":"79","author":"Kitley","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2019.02.011_b0105","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1136\/jnnp-2014-308346","article-title":"Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein","volume":"86","author":"Baumann","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.braindev.2019.02.011_b0110","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00415-012-6441-6","article-title":"Incidence of acquired demyelinating syndromes of the CNS in Dutch children: a nationwide study","volume":"259","author":"Ketelslegers","year":"2012","journal-title":"J Neurol"},{"key":"10.1016\/j.braindev.2019.02.011_b0115","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1212\/01.wnl.0000316193.89691.e1","article-title":"Prognostic factors after a first attack of inflammatory CNS demyelination in children","volume":"71","author":"Neuteboom","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2019.02.011_b0120","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pediatrneurol.2016.01.003","article-title":"Long-term neurocognitive, psychosocial, and magnetic resonance imaging outcomes in pediatric-onset acute disseminated encephalomyelitis","volume":"57","author":"Beatty","year":"2016","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.braindev.2019.02.011_b0125","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s11065-017-9343-7","article-title":"Long-term neuropsychological outcomes of childhood onset acute disseminated encephalomyelitis (ADEM): a meta-analysis","volume":"27","author":"Burton","year":"2017","journal-title":"Neuropsychol Rev"},{"issue":"Pt 12","key":"10.1016\/j.braindev.2019.02.011_b0130","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1093\/brain\/123.12.2407","article-title":"Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children","volume":"123","author":"Dale","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.braindev.2019.02.011_b0135","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.autrev.2015.12.004","article-title":"Anti-MOG antibody: the history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination","volume":"15","author":"Ramanathan","year":"2016","journal-title":"Autoimmun Rev"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760418306466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760418306466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:48:01Z","timestamp":1759952881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760418306466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0387760418306466"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2019.02.011","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical time course of pediatric acute disseminated encephalomyelitis","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2019.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}