{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:52:30Z","timestamp":1784386350846,"version":"3.55.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","brainanddevelopment.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.braindev.2019.05.006","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T08:55:18Z","timestamp":1559811318000},"page":"803-807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Transition from Leigh syndrome to MELAS syndrome in a patient with heteroplasmic MT-ND3 m.10158T&gt;C"],"prefix":"10.1016","volume":"41","author":[{"given":"Atsuko","family":"Kori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsushi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2019.05.006_b0005","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1203\/01.PDR.0000117844.73436.68","article-title":"A new mitochondrial DNA mutation in ND3 gene causing severe Leigh syndrome with early lethality","volume":"55","author":"Crimi","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.braindev.2019.05.006_b0010","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/jmg.40.12.896","article-title":"Recurrent de novo mitochondrial DNA mutations in respiratory chain deficiency","volume":"40","author":"Lebon","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.braindev.2019.05.006_b0015","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/ana.10787","article-title":"De novo mutations in the mitochondrial ND3 gene as a cause of infantile mitochondrial encephalopathy and complex I deficiency","volume":"55","author":"McFarland","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.braindev.2019.05.006_b0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.braindev.2017.08.005","article-title":"Japanese Leigh syndrome case treated with EPI-743","volume":"40","author":"Kouga","year":"2018","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2019.05.006_b0025","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s11427-017-9080-y","article-title":"The clinical and genetic characteristics in children with mitochondrial disease in China","volume":"60","author":"Fang","year":"2017","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.braindev.2019.05.006_b0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/NRL.0000000000000084","article-title":"Mitochondrial encephalopathy and optic neuropathy due to m.10158 MT-ND3 complex I mutation presenting in an adult patient: case report and review of the literature","volume":"21","author":"Vodopivec","year":"2016","journal-title":"Neurologist"},{"key":"10.1016\/j.braindev.2019.05.006_b0035","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.braindev.2016.09.013","article-title":"Complex I deficiency related to T10158C mutation ND3 gene: a further definition of the clinical spectrum","volume":"39","author":"Grosso","year":"2017","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2019.05.006_b0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pediatrneurol.2009.02.010","article-title":"Rolandic mitochondrial encephalomyelopathy and MT-ND3 mutations","volume":"41","author":"Werner","year":"2009","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.braindev.2019.05.006_b0045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2169\/internalmedicine.56.7301","article-title":"Adult-onset mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke (MELAS)-like encephalopathy diagnosed based on the complete sequencing of mitochondrial DNA extracted from biopsied muscle without any myopathic changes","volume":"56","author":"Mukai","year":"2017","journal-title":"Intern Med"},{"key":"10.1016\/j.braindev.2019.05.006_b0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/jmg.2010.079624","article-title":"A common pattern of brain MRI imaging in mitochondrial diseases with complex I deficiency","volume":"48","author":"Lebre","year":"2011","journal-title":"J Med Genet"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760419301172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760419301172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T17:10:15Z","timestamp":1566925815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760419301172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0387760419301172"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2019.05.006","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transition from Leigh syndrome to MELAS syndrome in a patient with heteroplasmic MT-ND3 m.10158T>C","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2019.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}