{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:49:37Z","timestamp":1762177777463,"version":"3.40.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ40356","2023JJ40358","2023JJ40354"],"award-info":[{"award-number":["2023JJ40356","2023JJ40358","2023JJ40354"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","brainanddevelopment.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.braindev.2025.104321","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T01:06:12Z","timestamp":1739495172000},"page":"104321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis"],"prefix":"10.1016","volume":"47","author":[{"given":"Jialing","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aojie","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2025.104321_bb0005","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0140-6736(18)31129-2","article-title":"Autism spectrum disorder","volume":"392","author":"Lord","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.braindev.2025.104321_bb0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pharmthera.2018.05.007","article-title":"Autism Spectrum disorder: classification, diagnosis and therapy","volume":"190","author":"Sharma","year":"2018","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.braindev.2025.104321_bb0015","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/aur.239","article-title":"Global prevalence of autism and other pervasive developmental disorders","volume":"5","author":"Elsabbagh","year":"2012","journal-title":"Autism Res"},{"key":"10.1016\/j.braindev.2025.104321_bb0020","doi-asserted-by":"crossref","first-page":"e520","DOI":"10.1542\/peds.2013-0763","article-title":"Economic burden of childhood autism spectrum disorders","volume":"133","author":"Lavelle","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.braindev.2025.104321_bb0025","series-title":"Autism Lancet","first-page":"896","volume":"383","author":"Lai","year":"2014"},{"key":"10.1016\/j.braindev.2025.104321_bb0030","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/HRP.0000000000000030","article-title":"Psychopharmacological interventions in autism spectrum disorder","volume":"22","author":"Politte","year":"2014","journal-title":"Harv Rev Psychiatry"},{"key":"10.1016\/j.braindev.2025.104321_bb0035","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.chc.2022.08.004","article-title":"Autism Spectrum disorder and complementary-integrative medicine","volume":"32","author":"Vandana","year":"2023","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"10.1016\/j.braindev.2025.104321_bb0040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40265-013-0021-7","article-title":"Pharmacotherapy for the core symptoms in autistic disorder: current status of the research","volume":"73","author":"Farmer","year":"2013","journal-title":"Drugs"},{"key":"10.1016\/j.braindev.2025.104321_bb0045","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/258589","article-title":"Complementary and alternative therapies for autism Spectrum disorder","volume":"2015","author":"Brondino","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.braindev.2025.104321_bb0050","first-page":"892","article-title":"Sulforaphane treatment for autism spectrum disorder: a systematic review","volume":"19","author":"McGuinness","year":"2020","journal-title":"EXCLI J"},{"key":"10.1016\/j.braindev.2025.104321_bb0055","doi-asserted-by":"crossref","first-page":"10367","DOI":"10.1073\/pnas.94.19.10367","article-title":"Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens","volume":"94","author":"Fahey","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.braindev.2025.104321_bb0060","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.3390\/ijms21228637","article-title":"Efficacy of Sulforaphane in neurodegenerative diseases","volume":"21","author":"Schepici","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.braindev.2025.104321_bb0065","first-page":"571","article-title":"Current potential health benefits of sulforaphane","volume":"15","author":"Kim","year":"2016","journal-title":"EXCLI J"},{"key":"10.1016\/j.braindev.2025.104321_bb0070","doi-asserted-by":"crossref","first-page":"602","DOI":"10.2174\/1871527315666160413120414","article-title":"Biomarker-guided strategy for treatment of autism Spectrum disorder (ASD)","volume":"15","author":"Liu","year":"2016","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.braindev.2025.104321_bb0075","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.1038\/s41598-020-62714-4","article-title":"Biomarker exploration in human peripheral blood mononuclear cells for monitoring Sulforaphane treatment responses in autism Spectrum disorder","volume":"10","author":"Liu","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.braindev.2025.104321_bb0080","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3390\/nu15030718","article-title":"Sulforaphane treatment in children with autism: a prospective randomized double-blind study","volume":"15","author":"Magner","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.braindev.2025.104321_bb0085","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/pcn.13016","article-title":"Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: a randomized, double-blind, placebo-controlled clinical trial","volume":"74","author":"Momtazmanesh","year":"2020","journal-title":"Psychiatry Clin Neurosci"},{"author":"Politte","key":"10.1016\/j.braindev.2025.104321_bb0090"},{"key":"10.1016\/j.braindev.2025.104321_bb0095","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s10803-022-05784-9","article-title":"Efficacy of Sulforaphane in treatment of children with autism Spectrum disorder: a randomized double-blind placebo-controlled multi-center trial","volume":"54","author":"Ou","year":"2024","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.braindev.2025.104321_bb0100","doi-asserted-by":"crossref","first-page":"15550","DOI":"10.1073\/pnas.1416940111","article-title":"Sulforaphane treatment of autism spectrum disorder (ASD)","volume":"111","author":"Singh","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.braindev.2025.104321_bb0105","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13229-021-00447-5","article-title":"Randomized controlled trial of sulforaphane and metabolite discovery in children with autism Spectrum disorder","volume":"12","author":"Zimmerman","year":"2021","journal-title":"Mol Autism"},{"key":"10.1016\/j.braindev.2025.104321_bb0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13229-018-0218-4","article-title":"Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli","volume":"9","author":"Bent","year":"2018","journal-title":"Mol Autism"},{"key":"10.1016\/j.braindev.2025.104321_bb0115","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.3390\/ijms24086979","article-title":"Sulforaphane and its protective role in prostate Cancer: a mechanistic approach","volume":"24","author":"Mordecai","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.braindev.2025.104321_bb0120","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.ridd.2013.01.002","article-title":"An evaluation of the aberrant behavior checklist for children under age 5","volume":"34","author":"Schmidt","year":"2013","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.braindev.2025.104321_bb0125","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/aur.1813","article-title":"Validating the social responsiveness scale for adults with autism","volume":"10","author":"Chan","year":"2017","journal-title":"Autism Res"},{"key":"10.1016\/j.braindev.2025.104321_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.braindev.2025.104321_bb0135","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.braindev.2025.104321_bb0140","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.3390\/molecules24193593","article-title":"Broccoli or Sulforaphane: is it the source or dose that matters?","volume":"24","author":"Yagishita","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.braindev.2025.104321_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2012.61","article-title":"Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain","volume":"2","author":"Rose","year":"2012","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.braindev.2025.104321_bb0150","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s11064-012-0775-4","article-title":"Brain region-specific glutathione redox imbalance in autism","volume":"37","author":"Chauhan","year":"2012","journal-title":"Neurochem Res"},{"key":"10.1016\/j.braindev.2025.104321_bb0155","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2040-2392-4-2","article-title":"Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism","volume":"4","author":"Napoli","year":"2013","journal-title":"Mol Autism"},{"key":"10.1016\/j.braindev.2025.104321_bb0160","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/415078","article-title":"Sulforaphane as a potential protective phytochemical against neurodegenerative diseases","volume":"2013","author":"Tarozzi","year":"2013","journal-title":"Oxidative Med Cell Longev"},{"key":"10.1016\/j.braindev.2025.104321_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104554","article-title":"Differential regulation of Nrf2 is linked to elevated inflammation and nitrative stress in monocytes of children with autism","volume":"113","author":"Nadeem","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.braindev.2025.104321_bb0170","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1007\/s12035-015-9230-2","article-title":"Sulforaphane ameliorates 3-Nitropropionic acid-induced striatal toxicity by activating the Keap1-Nrf2-ARE pathway and inhibiting the MAPKs and NF-kappaB pathways","volume":"53","author":"Jang","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.braindev.2025.104321_bb0175","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41386-022-01374-6","article-title":"Adaptive control of synaptic plasticity integrates micro- and macroscopic network function","volume":"48","author":"Scott","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.braindev.2025.104321_bb0180","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.3390\/molecules28041889","article-title":"mTOR signaling disruption and its association with the development of autism Spectrum disorder","volume":"28","author":"Thomas","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.braindev.2025.104321_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1448130","article-title":"The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update","volume":"11","author":"Ramakrishnan","year":"2024","journal-title":"Front Nutr"},{"key":"10.1016\/j.braindev.2025.104321_bb0190","article-title":"Biological mechanisms and clinical efficacy of sulforaphane for mental disorders","volume":"35","author":"Zheng","year":"2022","journal-title":"Gen Psychiatr"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760425000026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760425000026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T20:06:35Z","timestamp":1742328395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760425000026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0387760425000026"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2025.104321","relation":{},"ISSN":["0387-7604"],"issn-type":[{"type":"print","value":"0387-7604"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2025.104321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Japanese Society of Child Neurology. Elsevier B.V. CC BY 4.0","name":"copyright","label":"Copyright"}],"article-number":"104321"}}