{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:22:16Z","timestamp":1783106536967,"version":"3.54.6"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe University","doi-asserted-by":"publisher","award":["THD-2018-16135"],"award-info":[{"award-number":["THD-2018-16135"]}],"id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["brainanddevelopment.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.braindev.2026.104538","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:33:35Z","timestamp":1776875615000},"page":"104538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening for serum antineuronal antibodies in pediatric epilepsy"],"prefix":"10.1016","volume":"48","author":[{"given":"Hatice","family":"Bektas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anar","family":"Tagiyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceren","family":"Gunbey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahadir","family":"Konuskan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcin","family":"Sener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Yalnizoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Anlar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2026.104538_bb0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.seizure.2016.07.002","article-title":"Antibody-associated epilepsies: clinical features, evidence for immunotherapies and future research questions","volume":"41","author":"Bakpa","year":"2016","journal-title":"Seizure"},{"key":"10.1016\/j.braindev.2026.104538_bb0010","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1684\/epd.2017.0946","article-title":"Refractory chronic epilepsy associated with neuronal auto-antibodies: could perisylvian semiology be a clue?","volume":"19","author":"Gillinder","year":"2017","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.braindev.2026.104538_bb0015","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/epi.16571","article-title":"Acute symptomatic seizures secondary to autoimmune encephalitis and autoimmune-associated epilepsy: conceptual definitions","volume":"61","author":"Steriade","year":"2020","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2026.104538_bb0020","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000663","article-title":"Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient","volume":"7","author":"Cellucci","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.braindev.2026.104538_bb0025","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/B978-0-444-63432-0.00011-6","article-title":"Voltage-gated potassium channel-complex autoimmunity and associated clinical syndromes","volume":"133","author":"Irani","year":"2016","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.braindev.2026.104538_bb0030","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1111\/epi.12405","article-title":"Autoantibodies to neuronal antigens in children with new-onset seizures classified according to the revised ILAE organization of seizures and epilepsies","volume":"54","author":"Suleiman","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2026.104538_bb0035","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/epi.13797","article-title":"Predictive models in the diagnosis and treatment of autoimmune epilepsy","volume":"58","author":"Dubey","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2026.104538_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184529","article-title":"Relevance of surface neuronal protein autoantibodies as biomarkers in seizure-associated disorders","volume":"20","author":"Stanciu","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.braindev.2026.104538_bb0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ejpn.2016.03.005","article-title":"Autoantibodies to neuronal antigens in children with focal epilepsy and no prima facie signs of encephalitis","volume":"20","author":"Borusiak","year":"2016","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.braindev.2026.104538_bb0050","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jamaneurol.2016.5429","article-title":"Neurological autoantibody prevalence in epilepsy of unknown etiology","volume":"74","author":"Dubey","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.braindev.2026.104538_bb0055","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/epi.14649","article-title":"Antibody prevalence in epilepsy and encephalopathy score: increased specificity and applicability","volume":"60","author":"Dubey","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2026.104538_bb0060","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1007\/s10072-022-06044-5","article-title":"Do the neurologists recognize autoimmune epilepsy well enough? What is the effect of the pandemic on this matter?","volume":"43","author":"Yavuz","year":"2022","journal-title":"Neurol Sci"},{"key":"10.1016\/j.braindev.2026.104538_bb0065","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/dmcn.15927","article-title":"Paediatric antibody prevalence in seizure score to predict autoimmune aetiology in seizure disorders","volume":"66","author":"Mori","year":"2024","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.braindev.2026.104538_bb0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.seizure.2022.10.005","article-title":"Performance of a pediatric adaptation of the RITE(2) and APE2 scores in children with autoimmune epilepsy: P-RITE(2) and P-APE(2) scores","volume":"103","author":"Panda","year":"2022","journal-title":"Seizure"},{"key":"10.1016\/j.braindev.2026.104538_bb0075","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE commission for classification and terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2026.104538_bb0080","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2026.104538_bb0085","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3389\/fimmu.2017.00442","article-title":"Hello from the other side: how autoantibodies circumvent the blood-brain barrier in autoimmune encephalitis","volume":"8","author":"Platt","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.braindev.2026.104538_bb0090","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1093\/brain\/awn183","article-title":"Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association","volume":"131","author":"Saiz","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.braindev.2026.104538_bb0095","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.yebeh.2018.01.021","article-title":"Antiglutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy","volume":"80","author":"Daif","year":"2018","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.braindev.2026.104538_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103701","article-title":"Neurological syndromes associated with anti-GAD antibodies","volume":"21","author":"Dade","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.braindev.2026.104538_bb0105","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s13311-019-00750-3","article-title":"Autoimmune epilepsy","volume":"16","author":"Husari","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.braindev.2026.104538_bb0110","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41390-021-01818-7","article-title":"Peripheral immune cells and perinatal brain injury: a double-edged sword?","volume":"91","author":"Herz","year":"2022","journal-title":"Pediatr Res"},{"key":"10.1016\/j.braindev.2026.104538_bb0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s40141-017-0146-9","article-title":"Autoimmunity and traumatic brain injury","volume":"5","author":"Yang","year":"2017","journal-title":"Curr Phys Med Rehabil Rep"},{"key":"10.1016\/j.braindev.2026.104538_bb0120","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.0305-1846.2001.00314.x","article-title":"Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy","volume":"27","author":"Aronica","year":"2001","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.braindev.2026.104538_bb0125","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/00207454.2017.1389928","article-title":"Immunopathology in drug resistant mesial temporal lobe epilepsy with different types of hippocampal sclerosis","volume":"128","author":"Tezer","year":"2018","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.braindev.2026.104538_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-63541-7","article-title":"Altered immune pathways in patients of temporal lobe epilepsy with and without hippocampal sclerosis","volume":"14","author":"Che","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.braindev.2026.104538_bb0135","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/NEN.0b013e31826809a6","article-title":"IgG leakage may contribute to neuronal dysfunction in drug-refractory epilepsies with blood-brain barrier disruption","volume":"71","author":"Michalak","year":"2012","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.braindev.2026.104538_bb0140","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1212\/01.WNL.0000086819.53078.70","article-title":"Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua","volume":"61","author":"Takahashi","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2026.104538_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2025.578671","article-title":"Evolution and significance of neuronal surface autoantibodies after japanese encephalitis","volume":"406","author":"Nibber","year":"2025","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.braindev.2026.104538_bb0150","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.braindev.2018.06.002","article-title":"Investigation of neuronal auto-antibodies in children diagnosed with epileptic encephalopathy of unknown cause","volume":"40","author":"Tekturk","year":"2018","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2026.104538_bb0155","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/epi.13356","article-title":"Neuronal antibodies in pediatric epilepsy: clinical features and long-term outcomes of a historical cohort not treated with immunotherapy","volume":"57","author":"Wright","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2026.104538_bb0160","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ejpn.2017.12.007","article-title":"Circulating neural antibodies in unselected children with new-onset seizures","volume":"22","author":"Garcia-Tarodo","year":"2018","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.braindev.2026.104538_bb0165","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/jnnp-2020-325275","article-title":"Clinical spectrum of high-titre GAD65 antibodies","volume":"92","author":"Budhram","year":"2021","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.braindev.2026.104538_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1043723","article-title":"The study of neural antibodies in neurology: a practical summary","volume":"13","author":"Fern\u00e1ndez-Fournier","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.braindev.2026.104538_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.691536","article-title":"Limitations of a commercial assay as diagnostic test of autoimmune encephalitis","volume":"12","author":"Ruiz-Garc\u00eda","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.braindev.2026.104538_bb0180","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jalm\/jfab133","article-title":"Utility of live cell-based assays for autoimmune neurology diagnostics","volume":"7","author":"Woodhall","year":"2022","journal-title":"J Appl Lab Med"},{"key":"10.1016\/j.braindev.2026.104538_bb0185","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1212\/WNL.0000000000001922","article-title":"Clinical relevance of voltage-gated potassium channel\u2013complex antibodies in children","volume":"85","author":"Hacohen","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2026.104538_bb0190","first-page":"13","article-title":"Epilepsy and autoimmunity in pediatric patients","volume":"46","author":"Bekta\u015f","year":"2015","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.braindev.2026.104538_bb0195","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/practneurol-2019-002494","article-title":"Stop testing for autoantibodies to the VGKC-complex: only request LGI1 and CASPR2","volume":"20","author":"Michael","year":"2020","journal-title":"Pract Neurol"},{"key":"10.1016\/j.braindev.2026.104538_bb0200","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1212\/WNL.0000000000002637","article-title":"The relevance of VGKC positivity in the absence of LGI1 and caspr2 antibodies","volume":"86","author":"van Sonderen","year":"2016","journal-title":"Neurology"}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760426000392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760426000392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:58:03Z","timestamp":1783105083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760426000392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0387760426000392"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2026.104538","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Screening for serum antineuronal antibodies in pediatric epilepsy","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2026.104538","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Japanese Society of Child Neurology. Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104538"}}