{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:01:09Z","timestamp":1786114869048,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,7,11]],"date-time":"2027-07-11T00:00:00Z","timestamp":1815264000000},"content-version":"am","delay-in-days":344,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["brainanddevelopment.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Development"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.braindev.2026.104573","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:00:21Z","timestamp":1783792821000},"page":"104573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical practices in prehospital rescue medication use for pediatric status epilepticus in Japan: a nationwide questionnaire survey"],"prefix":"10.1016","volume":"48","author":[{"given":"Masahiro","family":"Nishiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuki","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Shiohama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Motobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotaro","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Torio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Maegaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.braindev.2026.104573_bb0005","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1474-4422(15)00042-3","article-title":"Status epilepticus in adults","volume":"14","author":"Betjemann","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.braindev.2026.104573_bb0010","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/jamaneurol.2017.4382","article-title":"Association of time to treatment with short-term outcomes for pediatric patients with refractory convulsive status epilepticus","volume":"75","author":"Ga\u00ednza-Lein","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.braindev.2026.104573_bb0015","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/ana.1018","article-title":"How long do new-onset seizures in children last?","volume":"49","author":"Shinnar","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.braindev.2026.104573_bb0020","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/epi.13121","article-title":"A definition and classification of status epilepticus: report of the ILAE task force on classification of status epilepticus","volume":"56","author":"Trinka","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.braindev.2026.104573_bb0025","series-title":"Epilepsies in children, young people and adults","author":"National Institute for Health and Care Excellence (NICE)","year":"2022"},{"key":"10.1016\/j.braindev.2026.104573_bb0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12028-012-9695-z","article-title":"Guidelines for the evaluation and management of status epilepticus","volume":"17","author":"Brophy","year":"2012","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.braindev.2026.104573_bb0035","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5698\/1535-7597-16.1.48","article-title":"Evidence-based guideline: treatment of convulsive status epilepticus in children and adults","volume":"16","author":"Glauser","year":"2016","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.braindev.2026.104573_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.braindev.2024.104306","article-title":"Japanese guidelines for treatment of pediatric status epilepticus \u2013 2023","volume":"47","author":"Kikuchi","year":"2025","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2026.104573_bb0045","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S1474-4422(08)70141-8","article-title":"Treatment of community-onset childhood convulsive status epilepticus: a prospective population-based study","volume":"7","author":"Chin","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.braindev.2026.104573_bb0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpeds.2019.05.034","article-title":"Seizure rescue medication use among US pediatric epilepsy providers: a survey of the pediatric epilepsy research consortium","volume":"212","author":"Wallace","year":"2019","journal-title":"J Pediatr"},{"key":"10.1016\/j.braindev.2026.104573_bb0055","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s13311-023-01359-3","article-title":"Seizure rescue therapies: comparing approved and commonly used benzodiazepine formulations","volume":"20","author":"Krauss","year":"2023","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.braindev.2026.104573_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.110038","article-title":"Transition from rectal to intranasal route among pediatric patients with repeated prescriptions of rescue benzodiazepines","volume":"161","author":"Sanchez Fernandez","year":"2024","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.braindev.2026.104573_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0140-6736(05)66909-7","article-title":"Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomized controlled trial","volume":"366","author":"McIntyre","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.braindev.2026.104573_bb0070","article-title":"Management of pediatric status epilepticus after hospital arrival in Japan: a nationwide questionnaire survey","volume":"48","author":"Nishiyama","year":"2026","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2026.104573_bb0075","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.braindev.2026.104573_bb0080","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1474-4422(06)70546-4","article-title":"Outcome of paediatric convulsive status epilepticus: a systematic review","volume":"5","author":"Raspall-Chaure","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.braindev.2026.104573_bb0085","doi-asserted-by":"crossref","first-page":"e1393","DOI":"10.1212\/WNL.0000000000200912","article-title":"Mortality, disability, and prognostic factors of status epilepticus: a nationwide population-based retrospective cohort study","volume":"99","author":"Choi","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.braindev.2026.104573_bb0090","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.braindev.2024.09.005","article-title":"Efficacy and safety of buccal midazolam for seizures outside the hospital: real-world clinical experience","volume":"46","author":"Ueda","year":"2024","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2026.104573_bb0095","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.seizure.2024.08.018","article-title":"Prescription patterns of home rescue benzodiazepines for febrile seizures","volume":"121","author":"Sanchez Fernandez","year":"2024","journal-title":"Seizure"},{"key":"10.1016\/j.braindev.2026.104573_bb0100","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/brain\/awu042","article-title":"Seizure burden is independently associated with short-term outcome in critically ill children","volume":"137","author":"Payne","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.braindev.2026.104573_bb0105","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.pediatrneurol.2015.02.001","article-title":"Demographics and outcomes of pediatric febrile convulsive status epilepticus","volume":"52","author":"Nishiyama","year":"2015","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.braindev.2026.104573_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.braindev.2025.104456","article-title":"Impact of the coronavirus disease pandemic on emergency transport times for pediatric febrile seizures: a retrospective study","volume":"47","author":"Matsumoto","year":"2025","journal-title":"Brain Dev"},{"key":"10.1016\/j.braindev.2026.104573_bb0115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.seizure.2023.07.010","article-title":"Pediatric status epilepticus management by emergency medical services (pSERG cohort)","volume":"111","author":"Amengual-Gual","year":"2023","journal-title":"Seizure"},{"key":"10.1016\/j.braindev.2026.104573_bb0120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pediatrneurol.2023.07.015","article-title":"Risk factors of prehospital emergency care for acute encephalopathy in children with febrile status epilepticus","volume":"147","author":"Arai","year":"2023","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.braindev.2026.104573_bb0125","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1056\/NEJMoa1107494","article-title":"Intramuscular versus intravenous therapy for prehospital status epilepticus","volume":"366","author":"Silbergleit","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.braindev.2026.104573_bb0130","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12883-025-04200-w","article-title":"Time to treatment in pediatric patients with repeated episodes of status epilepticus","volume":"25","author":"Gettings","year":"2025","journal-title":"BMC Neurol"},{"key":"10.1016\/j.braindev.2026.104573_bb0135","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1542\/peds.2007-0930","article-title":"Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in children: a randomized clinical trial","volume":"121","author":"Mpimbaza","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.braindev.2026.104573_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.eplepsyres.2021.106651","article-title":"A phase 3 open-label study of the efficacy, safety and pharmacokinetics of buccally administered midazolam hydrochloride for treatment of status epilepticus in pediatric Japanese subjects","volume":"174","author":"Yoshinaga","year":"2021","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.braindev.2026.104573_bb0145","series-title":"Buccolam (midazolam) oromucosal solution: EPAR \u2013 product information","author":"European Medicines Agency","year":"2023"},{"key":"10.1016\/j.braindev.2026.104573_bb0150","unstructured":"Clinigen Healthcare Japan Buccolam (midazolam) oromucosal solution: interview form. Clinigen Healthcare Japan; 2025. updated Oct 2025. Available at: https:\/\/clinigen.co.jp\/medical\/.assets\/BUC251002_\u30d6\u30b3\u30e9\u30e0\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u30d5\u30a9\u30fc\u30e0.pdf (Japanese)."}],"container-title":["Brain and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760426000744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0387760426000744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:34:05Z","timestamp":1785969245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0387760426000744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0387760426000744"],"URL":"https:\/\/doi.org\/10.1016\/j.braindev.2026.104573","relation":{},"ISSN":["0387-7604"],"issn-type":[{"value":"0387-7604","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical practices in prehospital rescue medication use for pediatric status epilepticus in Japan: a nationwide questionnaire survey","name":"articletitle","label":"Article Title"},{"value":"Brain and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.braindev.2026.104573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Japanese Society of Child Neurology. Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104573"}}