{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:30:35Z","timestamp":1778830235404,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.brainres.2004.04.004","type":"journal-article","created":{"date-parts":[[2004,6,3]],"date-time":"2004-06-03T08:31:05Z","timestamp":1086251465000},"page":"71-79","source":"Crossref","is-referenced-by-count":27,"title":["Progesterone treatment reduces NADPH-diaphorase\/nitric oxide synthase in Wobbler mouse motoneuron disease"],"prefix":"10.1016","volume":"1014","author":[{"given":"Mar\u0131\u0301a Claudia","family":"Gonz\u00e1lez Deniselle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Garay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"L\u00f3pez-Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anal\u0131\u0301a","family":"Mougel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachida","family":"Guennoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro F","family":"De Nicola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2004.04.004_BIB1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/(SICI)1097-4547(19970401)48:1<63::AID-JNR6>3.0.CO;2-C","article-title":"Protective effect of a novel free-radical scavenger, OPC-14117, on Wobbler mouse motor neuron disease","volume":"48","author":"Abe","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2004.04.004_BIB2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0197-4580(02)00234-8","article-title":"Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats","volume":"24","author":"Azcoitia","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2004.04.004_BIB3","first-page":"217","article-title":"Mitochondrial dysfunction in neurodegenerative diseases","volume":"1366","author":"Beal","year":"1998","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.brainres.2004.04.004_BIB4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1385\/MN:28:1:65","article-title":"The Wobbler mouse: a neurodegeneration jigsaw puzzle","volume":"28","author":"Boill\u00e9e","year":"2003","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00174615","article-title":"Developmental cell death: morphological diversity and multiple mechanisms","volume":"181","author":"Clarke","year":"1990","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0304-3940(96)12971-2","article-title":"Expression of nitric oxide synthase by motor neurons in the spinal cord of the mutant mouse Wobbler","volume":"215","author":"Clowry","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2004.04.004_BIB7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1023\/A:1022345720852","article-title":"S100B protein and 4-hydroxynonenal in the spinal cord of Wobbler mice","volume":"28","author":"Corvino","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2004.04.004_BIB8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0014-4886(03)00091-8","article-title":"Early mitochondrial dysfunction occurs in motor cortex and spinal cord at the onset of disease in the Wobbler mouse","volume":"182","author":"Dave","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB9","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1046\/j.1471-4159.1998.71041765.x","article-title":"Progesterone stimulates the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells","volume":"71","author":"Desarnaud","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2004.04.004_BIB10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0006-8993(99)01783-7","article-title":"Evidence for down-regulation of GAP-43 mRNA in Wobbler mouse spinal motoneurons by corticosterone and a 21-aminosteroid","volume":"841","author":"Gonz\u00e1lez Deniselle","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.04.004_BIB11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1020918310281","article-title":"The 21-aminosteroid U-74389F attenuates hyperexpression of GAP-43 and NADPHDiaphorase in the spinal cord of Wobbler mouse, a model for Amyotrophic Lateral Sclerosis","volume":"24","author":"Gonz\u00e1lez Deniselle","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainres.2004.04.004_BIB12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1023\/A:1010943104315","article-title":"Cellular basis of steroid neuroprotection in the Wobbler mouse, a model for motoneuron disease","volume":"21","author":"Gonz\u00e1lez Deniselle","year":"2001","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/nbdi.2002.0564","article-title":"Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease","volume":"11","author":"Gonz\u00e1lez Deniselle","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2004.04.004_BIB14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0960-0760(02)00262-5","article-title":"Basis of progesterone protection in spinal cord neurodegeneration","volume":"83","author":"Gonz\u00e1lez Deniselle","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0304-3940(01)01575-0","article-title":"Dysfunctional mitochondrial respiration in the Wobbler mouse brain","volume":"300","author":"Guang-Ping","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2004.04.004_BIB16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/(SICI)1521-1878(200003)22:3<297::AID-BIES12>3.0.CO;2-I","article-title":"What transgenic mice tell us about neurodegenerative disease","volume":"22","author":"Gurney","year":"2000","journal-title":"BioEssays"},{"key":"10.1016\/j.brainres.2004.04.004_BIB17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF00711581","article-title":"Neuroprotective actions of glucocorticoid and nonglucocorticoid steroids in acute neuronal injury","volume":"13","author":"Hall","year":"1993","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB18","first-page":"563","article-title":"Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and (Na, K)-ATPase activity. Dose response analysis during 1st hour after contusion injury in the cat","volume":"49","author":"Hall","year":"1982","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2004.04.004_BIB19","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1523\/JNEUROSCI.16-23-07574.1996","article-title":"Reduction of lower motor neuron degeneration in wobbler mice by n-acetyl-l-cysteine","volume":"16","author":"Henderson","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2004.04.004_BIB20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-510X(98)00224-X","article-title":"Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the Wobbler mouse","volume":"160","author":"Ikeda","year":"1988","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2004.04.004_BIB21","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1126\/science.7770777","article-title":"Progesterone synthesis and myelin formation by Schwann cells","volume":"268","author":"Koenig","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.brainres.2004.04.004_BIB22","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1523\/JNEUROSCI.18-09-03241.1998","article-title":"Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1","volume":"18","author":"Kong","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2004.04.004_BIB23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0960-0760(00)00064-9","article-title":"Modulation of NADPHDiaphorase and glial fibrillary acidic protein by progesterone in astrocytes from normal and injured spinal cord","volume":"73","author":"Labombarda","year":"2000","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB24","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1089\/089771502753594918","article-title":"Cellular basis for progesterone neuroprotection in the injured spinal cord","volume":"19","author":"Labombarda","year":"2002","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2004.04.004_BIB25","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1046\/j.1471-4159.2003.02055.x","article-title":"Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25 Dx in the rat spinal cord","volume":"87","author":"Labombarda","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2004.04.004_BIB26","series-title":"Atlas Stereotaxique du Cerveau de la Souris","author":"Lehmann","year":"1974"},{"key":"10.1016\/j.brainres.2004.04.004_BIB27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0301-0082(99)00028-3","article-title":"Aging in peripheral nerves: regulation of myelin protein genes by steroid hormones","volume":"60","author":"Melcangi","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB28","first-page":"811","article-title":"Murine motor neuron disease (the Wobbler mouse): degeneration and regeneration of the lower motor neuron","volume":"105","author":"Mitsumoto","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.04.004_BIB29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/14660820050515089","article-title":"Expression of nitric oxide synthase isoforms in spinal cord in amyotrophic lateral sclerosis","volume":"4","author":"Phul","year":"2000","journal-title":"Amyotroph. Lateral Scler. Other Mot. Neuron Disord."},{"key":"10.1016\/j.brainres.2004.04.004_BIB30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0003-9861(91)90224-7","article-title":"Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide","volume":"288","author":"Radi","year":"1991","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.brainres.2004.04.004_BIB31","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/neu.2000.17.367","article-title":"Gender differences in acute CNS trauma and stroke: neuroprotective effects and progesterone","volume":"17","author":"Roof","year":"2000","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2004.04.004_BIB32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/exnr.1994.1147","article-title":"Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats","volume":"129","author":"Roof","year":"1994","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02815156","article-title":"Progesterone protects against lipid peroxidation following traumatic brain injury in rats","volume":"31","author":"Roof","year":"1997","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB34","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0896-6273(93)90156-L","article-title":"Progesterone receptor-mediated effects of neuroactive steroids","volume":"11","author":"Rupprecht","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2004.04.004_BIB35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1007165127420","article-title":"Diabetes increases the expression of hypothalamic neuropeptides in a spontaneous model of type I diabetes, the nonobese diabetic (NOD) mouse","volume":"21","author":"Saravia","year":"2001","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00401-001-0484-6","article-title":"Neuronal nitric oxide synthase (nNos) immunoreactivity in the spinal cord of transgenic mice with G93A mutant SOD1 gene","volume":"103","author":"Sasaki","year":"2002","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1023\/A:1007152904926","article-title":"Steroid synthesis and metabolism in the nervous system: trophic and protective effects","volume":"29","author":"Schumacher","year":"2000","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.brainres.2004.04.004_BIB38","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/107385849800400615","article-title":"Progesterone and recovery after traumatic brain injury: an overview","volume":"4","author":"Stein","year":"1998","journal-title":"Neuroscientist"},{"key":"10.1016\/j.brainres.2004.04.004_BIB39","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1046\/j.0953-816x.2001.01878.x","article-title":"Nitric-oxide dependent damage to neuronal mitochondria involves the NMDA receptor","volume":"15","author":"Stewart","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2004.04.004_BIB40","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1097\/00007632-199910150-00013","article-title":"Progesterone is neuroprotective after acute experimental spinal cord trauma in rats","volume":"24","author":"Thomas","year":"1999","journal-title":"Spine"},{"key":"10.1016\/j.brainres.2004.04.004_BIB41","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/mus.1029","article-title":"Role of brain-derived neurotrophic factor in Wobbler mouse motor neuron disease","volume":"24","author":"Tsuzaka","year":"2001","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.brainres.2004.04.004_BIB42","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0306-4522(92)90184-4","article-title":"Histochemical mapping of nitric oxide synthase in the rat brain","volume":"46","author":"Vincent","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2004.04.004_BIB43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0306-4522(92)90393-G","article-title":"Changes of neuropeptides in spinal cord and brain stem of Wobbler mouse at different stages of motoneuron disease","volume":"50","author":"Yung","year":"1992","journal-title":"Neuroscience"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899304005566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899304005566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T08:24:57Z","timestamp":1549527897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899304005566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":43,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0006899304005566"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2004.04.004","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}