{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:25:46Z","timestamp":1791307546397,"version":"4.3.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.brainres.2004.07.090","type":"journal-article","created":{"date-parts":[[2004,9,18]],"date-time":"2004-09-18T11:06:59Z","timestamp":1095505619000},"page":"23-32","source":"Crossref","is-referenced-by-count":103,"title":["Effect of systemic LPS injection on cortical NF-\u03baB activity and inflammatory response following traumatic brain injury in rats"],"prefix":"10.1016","volume":"1026","author":[{"given":"Chun-hua","family":"Hang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-xin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-shou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-xia","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2004.07.090_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-065X.1992.tb01409.x","article-title":"Bacterial toxin-induced cytokine production studied at the single-cell level","volume":"127","author":"Andersson","year":"1992","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.brainres.2004.07.090_bib2","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.4049\/jimmunol.155.8.3994","volume":"155","author":"Arditi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainres.2004.07.090_bib3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1749-6632.1995.tb16561.x","article-title":"Brain injury and inflammation: a putative role of TNF alpha","volume":"765","author":"Arvin","year":"1995","journal-title":"Ann. N. Y. Acad of Sci."},{"key":"10.1016\/j.brainres.2004.07.090_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0092-8674(00)81318-5","article-title":"NF-\u03baB: ten years after","volume":"87","author":"Baeuerle","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2004.07.090_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-B in the immune system","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.brainres.2004.07.090_bib6","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.18-09-03251.1998","article-title":"Traumatic spinal cord injury induces nuclear factor-\u03baB activation","volume":"18","author":"Bethea","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2004.07.090_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/exnr.2001.7764","article-title":"Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency","volume":"172","author":"Bohatschek","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2004.07.090_bib8","doi-asserted-by":"crossref","first-page":"11393","DOI":"10.1073\/pnas.91.24.11393","article-title":"Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration","volume":"91","author":"Breder","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2004.07.090_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(03)02545-9","article-title":"Differential roles of tumor necrosis factor-\u03b1 and interleukin-1\u03b2 in lipopolysaccharide-induced brain injury in the neonatal rat","volume":"975","author":"Cai","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jlb.61.3.279","article-title":"Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats","volume":"61","author":"Carlos","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.brainres.2004.07.090_bib11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-8993(96)00824-4","article-title":"Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits","volume":"739","author":"Colicos","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0165-5728(95)00148-4","article-title":"The influence of cytokines on the integrity of the blood-brain barrier in vitro","volume":"64","author":"de Vries","year":"1996","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2004.07.090_bib13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0169-328X(95)00274-V","article-title":"Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS","volume":"36","author":"Fan","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0006-8993(81)90067-6","article-title":"Responses to cortical injury: I. Methodology and local effects of contusions in the rat","volume":"211","author":"Feeney","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib15","first-page":"341","article-title":"Cytokines, inflammation and brain injury: role of tumor necrosis factor","volume":"6","author":"Feuerstein","year":"1994","journal-title":"Cerebrovasc. Brain Metab. Rev."},{"key":"10.1016\/j.brainres.2004.07.090_bib16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/1074-7613(95)90112-4","article-title":"Mechanistic aspects of NF-kappa B regulation: the emerging role of phosphorylation and proteolysis","volume":"3","author":"Finco","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.brainres.2004.07.090_bib17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0165-5728(89)90030-1","article-title":"The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor alpha, lymphotoxin, and interleukin-1","volume":"23","author":"Frohman","year":"1989","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2004.07.090_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0169-328X(98)00330-1","article-title":"Activation of nuclear factor kappa B in the rat brain after transient focal ischemia","volume":"65","author":"Gabriel","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-8993(93)90090-A","article-title":"Induction of tumor necrosis factor- mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6","volume":"624","author":"Gatti","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation","volume":"119","author":"Gavrieli","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2004.07.090_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-2952(98)00214-7","article-title":"Nuclear factor-\u03baB\/Rel proteins: a point of convergence of signaling pathways relevant in neuronal function and dysfunction","volume":"57","author":"Grilli","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2004.07.090_bib22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00004647-199902000-00010","article-title":"Experimental axonal injury triggers interleukin-6 mRNA, protein synthesis and release into cerebrospinal fluid","volume":"19","author":"Hans","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2004.07.090_bib23","first-page":"101","article-title":"Adhesion to human neurons and astrocytes of monocytes: the role of interaction of CR3 and ICAM-1 and modulation by cytokines","volume":"57","author":"Hery","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainres.2004.07.090_bib24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF01404857","article-title":"Intracerebral inflammatory response to experimental brain contusion","volume":"132","author":"Holmin","year":"1995","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.brainres.2004.07.090_bib25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3171\/jns.1997.86.3.0493","article-title":"Delayed cytokine expression in rat brain following experimental contusion","volume":"86","author":"Holmin","year":"1997","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.brainres.2004.07.090_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00006123-199802000-00047","article-title":"Intracerebral inflammation after human brain contusion","volume":"42","author":"Holmin","year":"1998","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2004.07.090_bib27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s004010050666","article-title":"Up-regulation of intercellular adhesion molecule 1 in cerebral microvessels after cortical contusion trauma in a rat model","volume":"94","author":"Isaksson","year":"1997","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainres.2004.07.090_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-5728(98)00273-2","article-title":"Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment","volume":"95","author":"Knoblach","year":"1999","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2004.07.090_bib29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0006-8993(96)00081-9","article-title":"Changes in microtubule-associated protein 2 and amyloid precursor protein immunoreactivity following traumatic brain injury in rat: influence of MK-801 treatment","volume":"719","author":"Lew\u00e9n","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1471-4159.2000.740443.x","article-title":"Roles of nuclear factor kappa B in neuronal survival plasticity","volume":"74","author":"Mattson","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2004.07.090_bib31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0166-2236(96)10047-3","article-title":"Cytokines in inflammatory brain lesions: helpful and harmful","volume":"19","author":"Merrill","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2004.07.090_bib32","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1523\/JNEUROSCI.20-09-03456.2000","article-title":"Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor \u03baB activity in the brain during endotoxemia","volume":"20","author":"Nadeau","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2004.07.090_bib33","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm0996-998","article-title":"Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice","volume":"2","author":"Neurath","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainres.2004.07.090_bib34","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1089\/neu.1999.16.1023","article-title":"Prolonged activation of NF-\u03baB following traumatic brain injury in rats","volume":"16","author":"Nonaka","year":"1999","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainres.2004.07.090_bib35","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0166-2236(96)01035-1","article-title":"NF-\u03baB: a crucial transcription factor for glial and neuronal cell function","volume":"20","author":"O'Neill","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2004.07.090_bib36","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/1097-4547(20010301)63:5<438::AID-JNR1039>3.0.CO;2-P","article-title":"Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats","volume":"63","author":"Rancan","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib37","first-page":"1575","article-title":"Evidence of apoptotic cell death after experimental traumatic brain injury in the rat","volume":"147","author":"Rink","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2004.07.090_bib38","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/jcbfm.1994.76","article-title":"Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue","volume":"14","author":"Shohami","year":"1994","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2004.07.090_bib39","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/00004647-199605000-00004","article-title":"Inhibition of tumor necrosis factor alpha (TNF-a) activity in rat brain is associated with cerebroprotection after closed head injury","volume":"16","author":"Shohami","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2004.07.090_bib40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0304-3940(00)01187-3","article-title":"Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-alpha in relation to brain edema and contusion following controlled cortical impact injury in rats","volume":"288","author":"Stover","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2004.07.090_bib41","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0006-8993(94)01343-G","article-title":"Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat","volume":"671","author":"Toulmond","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0006-8993(94)91964-X","article-title":"Increased expression of c-fos mRNA and AP-1 transcription factor after cortical impact injury in rats","volume":"664","author":"Yang","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.07.090_bib43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0304-3940(95)11919-N","article-title":"Increased cortical nuclear factor-\u03baB (NF-\u03baB) DNA binding activity after traumatic brain injury in rats","volume":"197","author":"Yang","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2004.07.090_bib44","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1161\/01.STR.26.8.1438","article-title":"Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat","volume":"26","author":"Zhang","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2004.07.090_bib45","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1046\/j.1471-4159.2001.00080.x","article-title":"Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide","volume":"76","author":"Zhang","year":"2001","journal-title":"J. Neurochem."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899304012491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899304012491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T06:03:36Z","timestamp":1682748216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899304012491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0006899304012491"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2004.07.090","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}