{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:15:57Z","timestamp":1762658157362},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.brainres.2004.08.065","type":"journal-article","created":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T11:04:01Z","timestamp":1097147041000},"page":"66-74","source":"Crossref","is-referenced-by-count":12,"title":["In the adult CNS, ethanol prevents rather than produces NMDA antagonist-induced neurotoxicity"],"prefix":"10.1016","volume":"1028","author":[{"given":"Nuri B.","family":"Farber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey","family":"Heinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Dribben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Nemmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2004.08.065_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1126\/science.2403696","article-title":"Phencyclidine, dizocilpine, and cerebrocortical neurons","volume":"247","author":"Allen","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.brainres.2004.08.065_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1530-0277.1996.tb01641.x","article-title":"Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic \u201cbinge\u201d intoxication with ethanol: possible explanation for olfactory deficits in alcoholics","volume":"20","author":"Collins","year":"1996","journal-title":"Alcohol., Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2004.08.065_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0014-2999(89)90153-2","article-title":"Ro 15-4513, a partial inverse agonist for benzodiazepine recognition sites, has proconflict and proconvulsant effects in the rat","volume":"159","author":"Corda","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2004.08.065_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(96)01347-9","article-title":"Multifocal brain damage induced by phencyclidine is augmented by pilocarpine","volume":"752","author":"Corso","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.08.065_bib5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0161-813X(02)00009-8","article-title":"Inhibition of muscarinic receptor-induced proliferation of astroglial cells by ethanol: mechanisms and implications for the fetal alcohol syndrome","volume":"23","author":"Costa","year":"2002","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.brainres.2004.08.065_bib6","first-page":"263","article-title":"The role of GABAA receptors in mediating the effects of alcohol in the central nervous system","volume":"28","author":"Davies","year":"2003","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.brainres.2004.08.065_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/nbdi.2001.0411","article-title":"Apoptosis in the in vivo mammalian forebrain","volume":"8","author":"Dikranian","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2004.08.065_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.brainres.2004.08.065_bib9","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1097\/00001756-199412000-00070","article-title":"Competitive and non-competitive NMDA antagonists induce similar limbic degeneration","volume":"5","author":"Ellison","year":"1994","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2004.08.065_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00001756-199310000-00004","article-title":"Dissimilar patterns of degeneration in brain following four different addictive stimulants","volume":"5","author":"Ellison","year":"1993","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2004.08.065_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1196\/annals.1300.008","article-title":"The NMDA receptor hypofunction model of psychosis","volume":"1003","author":"Farber","year":"2003","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2004.08.065_bib12","first-page":"494.18","article-title":"Sensitivity of neurons in the retrosplenial cortex of rats to the irreversible cell killing effect of NMDA antagonists is highly age dependent","volume":"28","author":"Farber","year":"2002","journal-title":"Abstr.-Soc. Neurosci."},{"key":"10.1016\/j.brainres.2004.08.065_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.devbrainres.2003.09.009","article-title":"Drugs of abuse that cause developing neurons to commit suicide","volume":"147","author":"Farber","year":"2003","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2004.08.065_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0006-3223(93)90265-F","article-title":"Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity","volume":"34","author":"Farber","year":"1993","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2004.08.065_bib15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0893-133X(95)00048-I","article-title":"\u03b12 adrenergic agonists prevent MK-801 neurotoxicity","volume":"12","author":"Farber","year":"1995","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2004.08.065_bib16","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/0006-3223(95)00046-1","article-title":"Age specific neurotoxicity in the rat associated with NMDA receptor blockade: potential relevance to schizophrenia?","volume":"38","author":"Farber","year":"1995","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2004.08.065_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0893-133X(97)00127-9","article-title":"Serotonergic agents that activate 5HT2A receptors prevent NMDA antagonist neurotoxicity","volume":"18","author":"Farber","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2004.08.065_bib18","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/sj.mp.4001087","article-title":"Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity","volume":"7","author":"Farber","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2004.08.065_bib19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/sj.mp.4000912","article-title":"Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity","volume":"7","author":"Farber","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainres.2004.08.065_bib20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2003.09.002","article-title":"Muscimol prevents NMDA antagonist neurotoxicity by activating GABAA receptors in several brain regions","volume":"993","author":"Farber","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.08.065_bib21","first-page":"951.7","article-title":"Bromocriptine and N,N\u2013propylnorapomorphine (NPA) prevent NMDA antagonist neurotoxicity","volume":"29","author":"Farber","year":"2003","journal-title":"Abstr.-Soc. Neurosci."},{"key":"10.1016\/j.brainres.2004.08.065_bib22","first-page":"1563","article-title":"Ethanol actions on multiple ion channels: which are important?","volume":"23","author":"Harris","year":"1999","journal-title":"Alcohol., Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2004.08.065_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0006-8993(96)01290-5","article-title":"MK-801-induced neuronal damage in rats","volume":"753","author":"Horvath","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2004.08.065_bib24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.283.5398.70","article-title":"Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain","volume":"283","author":"Ikonomidou","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.brainres.2004.08.065_bib25","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1126\/science.287.5455.1056","article-title":"Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome","volume":"287","author":"Ikonomidou","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.brainres.2004.08.065_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/(SICI)1096-9861(19990614)408:4<461::AID-CNE2>3.0.CO;2-9","article-title":"Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain","volume":"408","author":"Ishimaru","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2004.08.065_bib27","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/00004647-199702000-00006","article-title":"Isoflurane and propofol block neurotoxicity caused by MK-801 in the rat posterior cingulate\/retrosplenial cortex","volume":"17","author":"Jevtovic-Todorovic","year":"1997","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2004.08.065_bib28","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neubiorev.2003.11.010","article-title":"Neurochemical and behavioral studies on ethanol and nicotine interactions","volume":"27","author":"Larsson","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.brainres.2004.08.065_bib29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0163-7258(99)00040-6","article-title":"The contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol","volume":"84","author":"Little","year":"1999","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainres.2004.08.065_bib30","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.2467382","article-title":"Ethanol inhibits NMDA-activated ion current in hippocampal neurons","volume":"243","author":"Lovinger","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.brainres.2004.08.065_bib31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pharmthera.2003.10.002","article-title":"Recent advances in the neurobiology of alcoholism: the role of adenosine","volume":"101","author":"Mailliard","year":"2004","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainres.2004.08.065_bib32","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/0006-2952(70)90298-4","article-title":"Kinetics of ethanol metabolism in the intact rat and monkey","volume":"19","author":"Makar","year":"1970","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2004.08.065_bib33","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.281.5381.1349","article-title":"Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats","volume":"281","author":"Moghaddam","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.brainres.2004.08.065_bib34","doi-asserted-by":"crossref","first-page":"182S","DOI":"10.1111\/j.1530-0277.2001.tb02394.x","article-title":"Neuroreceptors and ion channels as targets of alcohol","volume":"25","author":"Narahashi","year":"2001","journal-title":"Alcohol., Clin. Exp. Res."},{"key":"10.1016\/j.brainres.2004.08.065_bib35","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1523\/JNEUROSCI.09-05-01701.1989","article-title":"MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain","volume":"9","author":"Olney","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2004.08.065_bib36","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1126\/science.2660263","article-title":"Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs","volume":"244","author":"Olney","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.brainres.2004.08.065_bib37","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1289\/ehp.00108s3383","article-title":"Environmental agents that have the potential to trigger massive apoptotic neurodegeneration in the developing brain","volume":"108","author":"Olney","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.brainres.2004.08.065_bib38","first-page":"1880","article-title":"Perinatal hypoxia\/ischemia kills neurons directly by excitotoxic necrosis and indirectly by deafferentation apoptosis","volume":"26","author":"Olney","year":"2000","journal-title":"Abstr.-Soc. Neurosci."},{"key":"10.1016\/j.brainres.2004.08.065_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/nbdi.2001.0475","article-title":"Ethanol-induced caspase-3 activation in the in vivo developing mouse brain","volume":"9","author":"Olney","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2004.08.065_bib40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-3806(02)00279-1","article-title":"Ethanol-induced apoptotic neurodegeneration in the developing C57BL\/6 mouse brain","volume":"133","author":"Olney","year":"2002","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainres.2004.08.065_bib41","first-page":"120.1","article-title":"Threshold conditions for triggering alcohol-induced apoptotic neurodegeneration in infant mouse brain","volume":"28","author":"Olney","year":"2002","journal-title":"Abstr.-Soc. Neurosci."},{"key":"10.1016\/j.brainres.2004.08.065_bib42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/1029842021000010875","article-title":"Glutamate and GABA receptor dysfunction in the fetal alcohol syndrome","volume":"4","author":"Olney","year":"2002","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainres.2004.08.065_bib43","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.brainres.2004.08.065_bib44","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1167\/iovs.02-0982","article-title":"Ethanol-induced apoptosis in the developing visual system during synaptogenesis","volume":"44","author":"Tenkova","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.brainres.2004.08.065_bib45","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0091-3057(88)90487-X","article-title":"Molecular interactions of ethanol with GABAergic system and potential of RO15-4513 as an ethanol antagonist","volume":"30","author":"Ticku","year":"1988","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2004.08.065_bib46","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1523\/JNEUROSCI.20-05-01982.2000","article-title":"Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol","volume":"20","author":"VanDoren","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2004.08.065_bib47","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1073\/pnas.93.10.5049","article-title":"Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors","volume":"93","author":"Wan","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2004.08.065_bib48","first-page":"335","article-title":"GABA- and glutamate-gated ion channels as molecular sites of alcohol and anesthetic action","volume":"47","author":"Weight","year":"1992","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"10.1016\/j.brainres.2004.08.065_bib49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1124\/mol.56.1.85","article-title":"Ethanol inhibition of synaptically evoked kainate responses in rat hippocampal CA3 pyramidal neurons","volume":"56","author":"Weiner","year":"1999","journal-title":"Mol. Pharmacol."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899304014763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899304014763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T01:27:23Z","timestamp":1549157243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899304014763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0006899304014763"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2004.08.065","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}