{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:27:01Z","timestamp":1793194021625,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.brainres.2005.03.013","type":"journal-article","created":{"date-parts":[[2005,4,30]],"date-time":"2005-04-30T11:22:07Z","timestamp":1114860127000},"page":"22-30","source":"Crossref","is-referenced-by-count":78,"title":["Erythropoietin prevents long-term sensorimotor deficits and brain injury following neonatal hypoxia\u2013ischemia in rats"],"prefix":"10.1016","volume":"1045","author":[{"given":"Evangelia","family":"Spandou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoi","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki","family":"Soubasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Karkavelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantina","family":"Simeonidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Pazaiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olympia","family":"Guiba-Tziampiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2005.03.013_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0014-2999(00)00691-9","article-title":"Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage","volume":"406","author":"Alafaci","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2005.03.013_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0006-8993(03)02436-3","article-title":"Neonatal cerebral hypoxia\u2013ischemia causes lateralized memory impairments in the adult rat","volume":"973","author":"Arteni","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0387-7604(03)00039-1","article-title":"Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic\u2013ischemic brain injury","volume":"25","author":"Aydin","year":"2003","journal-title":"Brain Dev."},{"key":"10.1016\/j.brainres.2005.03.013_bib4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0006-8993(00)01997-1","article-title":"Long-lasting behavioral alterations following a hypoxic\u2013ischemic brain injury in neonatal rats","volume":"859","author":"Balduini","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/00004647-199906000-00007","article-title":"A potential role for erythropoietin in focal permanent cerebral ischemia in mice","volume":"19","author":"Bernaudin","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2005.03.013_bib6","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1203\/00006450-199711000-00021","article-title":"Sensorimotor function and neuropathology five to six weeks after hypoxia\u2013ischemia in seven-day-old rats","volume":"42","author":"Bona","year":"1997","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib7","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1203\/00006450-199806000-00005","article-title":"Protective effects of moderate hypothermia after hypoxia\u2013ischemia: short- and long-term outcome","volume":"43","author":"Bona","year":"1998","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib8","doi-asserted-by":"crossref","first-page":"10526","DOI":"10.1073\/pnas.97.19.10526","article-title":"Erythropoietin crosses the blood\u2013brain barrier to protect against experimental brain injury","volume":"97","author":"Brines","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2005.03.013_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/000155502762064520","article-title":"Recombinant human erythropoietin influences revascularization and healing in a random model of ischemic flaps in rat","volume":"82","author":"Buemi","year":"2002","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.brainres.2005.03.013_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0014-4886(91)90147-5","article-title":"The effect of neonatal hypoxia\u2013ischemia on striatal cholinergic neuropil: a quantitative morphological analysis","volume":"113","author":"Burke","year":"1991","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2005.03.013_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0014-2999(00)00466-0","article-title":"Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation","volume":"401","author":"Calapai","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2005.03.013_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-2999(02)01292-X","article-title":"Erythropoietin prevents cognition impairment induced by transient brain ischemia in gerbils","volume":"427","author":"Catania","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2005.03.013_bib13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00004647-200205000-00001","article-title":"Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades","volume":"22","author":"Chong","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2005.03.013_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.clp.2004.03.007","article-title":"Nuclear mechanisms of hypoxic cerebral injury in the newborn","volume":"31","author":"Delivoria-Papadopoulos","year":"2004","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.brainres.2005.03.013_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejphar.2003.09.016","article-title":"Inhibiting caspase-8 after injury reduces hypoxic\u2013ischemic brain injury in the newborn rat","volume":"481","author":"Feng","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2005.03.013_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2003.12.037","article-title":"Erythropoietin and the nervous system","volume":"1000","author":"Genc","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib17","doi-asserted-by":"crossref","first-page":"9450","DOI":"10.1073\/pnas.142287899","article-title":"Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma","volume":"99","author":"Gorio","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2005.03.013_bib18","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.1523\/JNEUROSCI.20-15-05775.2000","article-title":"BDNF protects the neonatal brain from hypoxic\u2013ischemic injury in vivo via the ERK pathway","volume":"20","author":"Han","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2005.03.013_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-4328(00)00287-4","article-title":"Selective and long-term learning impairment following neonatal hypoxic\u2013ischemic brain insult in rats","volume":"118","author":"Ikeda","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0166-4328(95)00248-0","article-title":"Long-term effects of neonatal ischemic\u2013hypoxic brain injury on sensorimotor and locomotor tasks in rats","volume":"78","author":"Jansen","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1152\/physrev.1992.72.2.449","article-title":"Erythropoietin: structure, control of production, and function","volume":"72","author":"Jelkmann","year":"1992","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2005.03.013_bib22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ana.410130507","article-title":"Neurotransmitter alterations in a model of perinatal hypoxic\u2013ischemic brain injury","volume":"13","author":"Johnston","year":"1983","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2005.03.013_bib23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0095-5108(05)70037-3","article-title":"Nonerythropoietic roles of erythropoietin in the fetus and neonate","volume":"27","author":"Juul","year":"2000","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.brainres.2005.03.013_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.clp.2004.03.004","article-title":"Recombinant erythropoietin as a neuroprotective treatment: in vitro and in vivo models","volume":"31","author":"Juul","year":"2004","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.brainres.2005.03.013_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1203\/00006450-199801000-00007","article-title":"Erythropoietin and erythropoietin receptor in the developing human central nervous system","volume":"43","author":"Juul","year":"1998","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s100249900103","article-title":"Imunohistochemical localization of erythropoietin and its receptor in the developing human brain","volume":"2","author":"Juul","year":"1999","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.brainres.2005.03.013_bib27","doi-asserted-by":"crossref","first-page":"39469","DOI":"10.1074\/jbc.M105832200","article-title":"Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia","volume":"276","author":"Kawakami","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2005.03.013_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0006-8993(93)90850-M","article-title":"Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo","volume":"609","author":"Konishi","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000068926","article-title":"Neuroprotective effect of erythropoietin on hypoxic\u2013ischemic brain injury in neonatal rats","volume":"83","author":"Kumral","year":"2003","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.brainres.2005.03.013_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000074958","article-title":"Selective inhibition of nitric oxide in hypoxic\u2013ischemic brain model in newborn rats: is it an explanation for the protective role of erythropoietin?","volume":"85","author":"Kumral","year":"2004","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.brainres.2005.03.013_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbr.2003.11.002","article-title":"Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia\u2013ischemia in rats","volume":"153","author":"Kumral","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib32","first-page":"1","article-title":"Anoxic\u2013ischemic encephalopathy in rats","volume":"36","author":"Levine","year":"1960","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2005.03.013_bib33","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1097\/00001756-200011090-00017","article-title":"Survival of hippocampal neurons in culture upon hypoxia: effect of erythropoietin","volume":"11","author":"Lewczuk","year":"2000","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2005.03.013_bib34","first-page":"225","article-title":"Neuroprotection and angiogenesis: dual role of erythropoietin in brain ischemia","volume":"15","author":"Marti","year":"2000","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.brainres.2005.03.013_bib35","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1097\/00001756-200309150-00020","article-title":"Protective effect of erythropoietin in neonatal hypoxic ischemia in mice","volume":"14","author":"Matushita","year":"2003","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2005.03.013_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0306-4522(96)00306-5","article-title":"Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons and erythropoietin prevents in vitro glutamate-induced neuronal death","volume":"76","author":"Morishita","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2005.03.013_bib37","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1161\/01.STR.29.12.2622","article-title":"Apoptosis, in a neonatal rat model of cerebral hypoxia\u2013ischemia","volume":"29","author":"Pulera","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2005.03.013_bib38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic\u2013ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2005.03.013_bib39","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0095-5108(18)30405-6","article-title":"Long-term follow-up of term neonates with perinatal asphyxia","volume":"20","author":"Robertson","year":"1993","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.brainres.2005.03.013_bib40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/bbrc.1998.9748","article-title":"Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery","volume":"253","author":"Sadamoto","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainres.2005.03.013_bib41","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1073\/pnas.95.8.4635","article-title":"In vivo evidence that erythropoietin protects neurons from ischemic damage","volume":"95","author":"Sakanaka","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.brainres.2005.03.013_bib42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0304-3940(00)00878-8","article-title":"The neuroprotective effect of deferoxamine in the hypoxic\u2013ischemic immature mouse brain","volume":"252","author":"Sarco","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2005.03.013_bib43","doi-asserted-by":"crossref","first-page":"9733","DOI":"10.1523\/JNEUROSCI.21-24-09733.2001","article-title":"Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells","volume":"21","author":"Shingo","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2005.03.013_bib44","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.051606598","article-title":"Erythropoietin prevents neuronal apoptosis after cerebral ischemia and in metabolically stressed neurons","volume":"98","author":"Siren","year":"2001","journal-title":"Proc. Natl. Acad. U.S.A."},{"key":"10.1016\/j.brainres.2005.03.013_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00381-002-0680-2","article-title":"Erythropoietin prevents ischemia\u2013reperfusion from inducing oxidative damage in fetal rat brain","volume":"19","author":"Solaroglu","year":"2000","journal-title":"Child Nerv. Syst."},{"key":"10.1016\/j.brainres.2005.03.013_bib46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neulet.2004.05.032","article-title":"Erythropoietin prevents hypoxia\/ischemia-induced DNA fragmentation in an experimental model pf perinatal asphyxia","volume":"366","author":"Spandou","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2005.03.013_bib47","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/01.WCB.0000110049.43905.AC","article-title":"Mechanisms of erythropoietin-induced brain protection in neonatal hypoxia\u2013ischemia rat model","volume":"24","author":"Sun","year":"2004","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2005.03.013_bib48","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0736-5748(94)00020-4","article-title":"Neurotrophic effect of hematopoietic cytokines on cholinergic and other neurons in vitro","volume":"13","author":"Tabira","year":"1995","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.brainres.2005.03.013_bib49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-4328(03)00146-3","article-title":"Brain injury and neurofunctional deficit in neonatal mice with hypoxic\u2013ischemic encephalopathy","volume":"145","author":"Ten","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib50","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1749-6632.1997.tb48634.x","article-title":"A model of perinatal hypoxic\u2013ischemic brain damage","volume":"835","author":"Vannucci","year":"1997","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2005.03.013_bib51","series-title":"Neurology of the Newborn","author":"Volpe","year":"2001"},{"key":"10.1016\/j.brainres.2005.03.013_bib52","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/01.STR.0000132196.49028.a4","article-title":"Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats","volume":"35","author":"Wang","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2005.03.013_bib53","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0006-8993(02)03604-1","article-title":"Erythropoeitin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures","volume":"958","author":"Weber","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib54","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/jnr.10166","article-title":"Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up-regulating Bcl-xL expression","volume":"67","author":"Wen","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib55","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1203\/00006450-199310000-00029","article-title":"Influence of mild hypothermia on hypoxic\u2013ischemic brain damage in the immature rat","volume":"34","author":"Yager","year":"1993","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.brainres.2005.03.013_bib56","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/dev.129.2.505","article-title":"Erythropoietin receptor signaling is required for normal brain development","volume":"129","author":"Yu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.brainres.2005.03.013_bib57","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1471-4159.2003.01832.x","article-title":"Involvement of apoptosis-inducing factor in neuronal death after hypoxia\u2013ischemia in the neonatal rat brain","volume":"86","author":"Zhu","year":"2003","journal-title":"J. Neurochem."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305003719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305003719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T07:48:19Z","timestamp":1625903299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899305003719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":57,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0006899305003719"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2005.03.013","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}