{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:46:02Z","timestamp":1778658362244,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.brainres.2005.06.024","type":"journal-article","created":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T20:39:53Z","timestamp":1121978393000},"page":"108-115","source":"Crossref","is-referenced-by-count":18,"title":["Glutamate and GABA immunocytochemical electron microscopy in the hippocampal dentate gyrus of normal and genetic absence epilepsy rats"],"prefix":"10.1016","volume":"1053","author":[{"given":"Serap","family":"Sirvanci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles K.","family":"Meshul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiz","family":"Onat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tangul","family":"San","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2005.06.024_bib1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/cne.901820508","article-title":"A Golgi study of cell types in the hilar region of the hippocampus in the rat","volume":"182","author":"Amaral","year":"1978","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.06.024_bib2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1046\/j.1460-9568.2003.02828.x","article-title":"GABA and GABAA receptors at hippocampal mossy fiber synapses","volume":"18","author":"Bergersen","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2005.06.024_bib3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/hipo.450020403","article-title":"Mossy cell axonal projection to the dentate gyrus molecular layer in the rat hippocampal slice","volume":"2","author":"Buckmaster","year":"1992","journal-title":"Hippocampus"},{"key":"10.1016\/j.brainres.2005.06.024_bib4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/(SICI)1096-9861(19960304)366:2<270::AID-CNE7>3.0.CO;2-2","article-title":"Axon arbors and synaptic connections of hippocampal mossy cells in the rat in vivo","volume":"366","author":"Buckmaster","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.06.024_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-8993(98)00507-1","article-title":"Changes in extracellular glutamate and GABA levels in the hippocampal areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainic acid","volume":"800","author":"Ding","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.06.024_bib6","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1046\/j.0022-3042.2002.00768.x","article-title":"Decreased expression of glutamate transporters in genetic absence epilepsy rats before seizure occurrence","volume":"80","author":"Dutuit","year":"2002","journal-title":"J. Neurochem."},{"issue":"10","key":"10.1016\/j.brainres.2005.06.024_bib7","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1046\/j.1528-1157.2002.35601.x","article-title":"Resistance to propagation of amygdaloid kindling seizures in rats with genetic absence epilepsy","volume":"43","author":"Eskazan","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2005.06.024_bib8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/BF00237484","article-title":"Implantation of d-[3H] aspartate loaded gel particles permits restricted uptake sites for transmitter-selective axonal transport","volume":"63","author":"Fischer","year":"1986","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainres.2005.06.024_bib9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/cne.902150306","article-title":"Lesion-induced mossy fibers to the molecular layer of the rat fascia dentata: identification of postsynaptic granule cells by the Golgi-EM technique","volume":"215","author":"Frotscher","year":"1983","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.06.024_bib10","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1152\/jn.2000.84.6.3088","article-title":"Seizures induce simultaneous GABAergic and glutamatergic transmission in the dentate gyrus-CA3 system","volume":"84","author":"Guti\u00e9rrez","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2005.06.024_bib11","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1152\/jn.2002.87.5.2562","article-title":"Activity-dependent expression of simultaneous glutamatergic and GABAergic neurotransmission from the mossy fibers in vitro","volume":"87","author":"Guti\u00e9rrez","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2005.06.024_bib12","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1046\/j.0953-816x.2001.01508.x","article-title":"Kindling induces transient fast inhibition in the dentate gyrus-CA3 projection","volume":"13","author":"Guti\u00e9rrez","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2005.06.024_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/36.1.2891743","article-title":"Characterization of antisera to glutamate and aspartate","volume":"36","author":"Hepler","year":"1988","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.brainres.2005.06.024_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0304-3940(96)12777-4","article-title":"Immunocytochemical localization of GABA immunoreactivity in dentate granule cells of normal and kindled rats","volume":"212","author":"Lehmann","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2005.06.024_bib15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF00227262","article-title":"Distribution of calretinin immunoreactivity in the mouse dentate gyrus. General description","volume":"108","author":"Liu","year":"1996","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainres.2005.06.024_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/exnr.1999.7138","article-title":"Excitatory granule cells of the dentate gyrus exhibit a double neurochemical content after intrahippocampal administration of kainate in adult mice","volume":"159","author":"Makiura","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2005.06.024_bib17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0920-1211(99)00051-0","article-title":"Glutamate receptors and transporters in genetic and acquired models of epilepsy","volume":"36","author":"Meldrum","year":"1999","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2005.06.024_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(94)91117-7","article-title":"Haloperidol-induced synaptic changes in striatum are associated with glutamate synapses","volume":"648","author":"Meshul","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.06.024_bib19","first-page":"141","article-title":"Mapping of cerebral energy metabolism in rats with genetic generalized nonconvulsive epilepsy","volume":"35","author":"Nehlig","year":"1992","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.brainres.2005.06.024_bib20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0920-1211(98)00052-7","article-title":"Local cerebral glucose utilization in adult and immature GAERS","volume":"32","author":"Nehlig","year":"1998","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainres.2005.06.024_bib21","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0165-6147(90)90129-V","article-title":"The release and uptake of excitatory amino acids","volume":"11","author":"Nicholls","year":"1990","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainres.2005.06.024_bib22","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/cne.902290308","article-title":"Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique","volume":"229","author":"Ottersen","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.06.024_bib23","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1016\/S0028-3908(00)00065-4","article-title":"Hippocampal extracellular amino acids and EEG spectral analysis in a genetic rat model of absence epilepsy","volume":"39","author":"Richards","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2005.06.024_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cne.903030202","article-title":"Coexistence of GABA and glutamate in mossy fiber terminals of the primate hippocampus: an ultrastructural study","volume":"303","author":"Sandler","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.06.024_bib25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0006-8993(03)03349-3","article-title":"Immunocytochemical analysis of glutamate and GABA in hippocampus of genetic absence epilepsy rats (GAERS)","volume":"988","author":"Sirvanci","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.06.024_bib26","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/ana.410350604","article-title":"The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy","volume":"35","author":"Sloviter","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2005.06.024_bib27","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/(SICI)1096-9861(19960930)373:4<593::AID-CNE8>3.0.CO;2-X","article-title":"Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus","volume":"373","author":"Sloviter","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.06.024_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/hipo.450040108","article-title":"Mossy cells of the rat fascia dentata are glutamate-immunoreactive","volume":"4","author":"Soriano","year":"1994","journal-title":"Hippocampus"},{"issue":"3","key":"10.1016\/j.brainres.2005.06.024_bib29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1528-1157.2002.26901.x","article-title":"Neural networks in human epilepsy: evidence of and implications for treatment","volume":"43","author":"Spencer","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainres.2005.06.024_bib30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/301517a0","article-title":"First visualization of glutamate and GABA in neurons by immunochemistry","volume":"301","author":"Storm-Mathisen","year":"1983","journal-title":"Nature"},{"issue":"Suppl. 5","key":"10.1016\/j.brainres.2005.06.024_bib31","first-page":"96","article-title":"Do mossy fibers release GABA?","volume":"43","author":"Walker","year":"2002","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.brainres.2005.06.024_bib32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/(SICI)1098-1063(1997)7:5<559::AID-HIPO11>3.0.CO;2-#","article-title":"Ultrastructural localization of neurotransmitter immunoreactivity in mossy cell axons and their synaptic targets in the rat dentate gyrus","volume":"7","author":"Wenzel","year":"1997","journal-title":"Hippocampus"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305008929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305008929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T13:22:30Z","timestamp":1551964950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899305008929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":32,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0006899305008929"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2005.06.024","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}