{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:13:59Z","timestamp":1789391639659,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1016\/j.brainres.2005.08.032","type":"journal-article","created":{"date-parts":[[2005,9,22]],"date-time":"2005-09-22T07:21:12Z","timestamp":1127373672000},"page":"108-117","source":"Crossref","is-referenced-by-count":50,"title":["Roles of brain angiotensins II and III in thirst and sodium appetite"],"prefix":"10.1016","volume":"1060","author":[{"given":"Wendy L.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard P.","family":"Roques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Llorens-Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Speth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2005.08.032_bib1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0928-4257(99)80154-5","article-title":"Effects of peptide and non-peptide antagonist of angiotensin II receptors on drinking behavior in rats","volume":"93","author":"Alova","year":"1999","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.brainres.2005.08.032_bib2","first-page":"349","article-title":"Increased sodium appetite in the rat induced by intracranial administration components of the renin","volume":"301","author":"Avrith","year":"1980","journal-title":"J. Angiotensin Syst. Physiol. (Paris)"},{"key":"10.1016\/j.brainres.2005.08.032_bib3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1210\/jcem-32-4-575","article-title":"The effect of the heptapeptide (2\u20138) and hexapeptide (3\u20138) fragments of angiotensin II on aldosterone secretion","volume":"32","author":"Blair-West","year":"1971","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.brainres.2005.08.032_bib4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1677\/joe.0.0870409","article-title":"A dose-response comparison of the actions of angiotensin II and angiotensin III in sheep","volume":"87","author":"Blair-West","year":"1980","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.brainres.2005.08.032_bib5","first-page":"R1940","article-title":"Central infusion of the AT1 receptor antagonist losartan inhibits thirst but not sodium appetite in cattle","volume":"272","author":"Blair-West","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib6","first-page":"R1633","article-title":"Possible contribution of brain angiotensin III to ingestive behaviors in baboons","volume":"281","author":"Blair-West","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib7","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.184.4140.994","article-title":"Angiotensin II- and angiotensin III-induced aldosterone release vivo in the rat","volume":"184","author":"Campbell","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.brainres.2005.08.032_bib8","first-page":"R382","article-title":"Angiotensin-related intakes of water and NaCl in Fischer 344 and Sprague\u2013Dawley rats","volume":"262","author":"Caputo","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib9","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1021\/jm00044a016","article-title":"Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols","volume":"37","author":"Chauvel","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.brainres.2005.08.032_bib10","first-page":"446","article-title":"Anterior third ventricle (A3V) lesions and homeostasis regulation","volume":"79","author":"Chiaraviglio","year":"1984","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.brainres.2005.08.032_bib11","first-page":"415","article-title":"International union of pharmacology: XXIII. The angiotensin II receptors","volume":"52","author":"DeGasparo","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainres.2005.08.032_bib12","article-title":"Effects of area postrema lesion and right atrial stretch on sodium appetite","volume":"923.20","author":"DeGobbi","year":"2003","journal-title":"Abstr. - Soc. Neurosci."},{"key":"10.1016\/j.brainres.2005.08.032_bib13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0006-8993(88)91279-6","article-title":"Effects of aminopeptidase inhibition on the half-lives of [125I] angiotensins in the cerebroventricles of the rat","volume":"448","author":"Dewey","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.08.032_bib14","first-page":"496","article-title":"The dependence of the salt appetite of the rat on the hormonal consequences of sodium deficiency","volume":"79","author":"Epstein","year":"1984","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.brainres.2005.08.032_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0014-2999(80)90419-7","article-title":"Captopril given intracerebroventricularly, subcutaneously or by gavage inhibits angiotensin-converting enzyme activity in the rat brain","volume":"68","author":"Evered","year":"1980","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2005.08.032_bib16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/0735-7044.104.4.643","article-title":"Preoptic angiotensin and salt appetite","volume":"104","author":"Fitts","year":"1990","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2005.08.032_bib17","first-page":"R2277","article-title":"Circumventricular organ and AngII-induced salt appetite: blood pressure and connectivity","volume":"279","author":"Fitts","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib18","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.1998.78.3.583","article-title":"Angiotensin, thirst, and sodium appetite","volume":"78","author":"Fitzsimons","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainres.2005.08.032_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.physbeh.2003.08.010","article-title":"Hypovolemia stimulates intraoral intake of water and NaCl solution in intact rats but not in chronic decerebrate rats","volume":"80","author":"Flynn","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainres.2005.08.032_bib20","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1021\/jm00085a013","article-title":"Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation","volume":"35","author":"Fournie-Zaluski","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.brainres.2005.08.032_bib21","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0006-8993(87)80033-1","article-title":"Angiotensin-sensitive neurons in the rat paraventricular nucleus: relative potencies of angiotensin II and angiotensin III","volume":"410","author":"Harding","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.08.032_bib22","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1471-4159.1986.tb00652.x","article-title":"Cerebroventricular and intravascular metabolism of [125I]angiotensins in rat","volume":"46","author":"Harding","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2005.08.032_bib23","first-page":"F17","article-title":"Release of angiotensins in paraventricular nucleus of rat in response to physiological and chemical stimuli","volume":"262","author":"Harding","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1113\/jphysiol.1984.sp015258","article-title":"Reversal by angiotensins II and III of the effects of converting enzyme inhibition on renal electrolyte excretion in rats","volume":"351","author":"Harris","year":"1984","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/frne.1997.0153","article-title":"The neuroendocrinology of thirst and salt appetite: visceral sensory signals and mechanisms of central integration","volume":"18","author":"Johnson","year":"1997","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.brainres.2005.08.032_bib26","first-page":"R356","article-title":"Sodium appetite during captopril blockade of endogenous angiotensin II formation","volume":"247","author":"Moe","year":"1984","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0006-8993(02)02963-3","article-title":"Forebrain circumventricular organs mediate salt appetite induced by intravenous angiotensin II in rats","volume":"949","author":"Morris","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.08.032_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0361-9230(87)90178-X","article-title":"Amastatin and bestatin-induced dipsogenicity in the Sprague\u2013Dawley rat","volume":"19","author":"Quirk","year":"1987","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainres.2005.08.032_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000054439","article-title":"PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain angiotensin III","volume":"69","author":"Reaux","year":"1999","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainres.2005.08.032_bib30","doi-asserted-by":"crossref","first-page":"13415","DOI":"10.1073\/pnas.96.23.13415","article-title":"Aminopeptidase A inhibitors as potential central antihypertensive agents","volume":"96","author":"Reaux","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2005.08.032_bib31","doi-asserted-by":"crossref","first-page":"13415","DOI":"10.1073\/pnas.96.23.13415","article-title":"Aminopeptidase A inhibitors as potential central antihypertensive agents","volume":"96","author":"Reaux","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2005.08.032_bib32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1043-2760(01)00381-2","article-title":"Angiotensin III: a central regulator of vasopressin release and blood pressure","volume":"12","author":"Reaux","year":"2001","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.brainres.2005.08.032_bib33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-8993(96)01016-5","article-title":"Losartan inhibition of angiotensin-related drinking and Fos inmmunoreactivity in hypertensive and hypotensive contexts","volume":"742","author":"Rowland","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.08.032_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1037\/0735-7044.104.1.167","article-title":"Dependence of adrenalectomy-induced sodium appetite on the action of angiotensin II in the brain of the rat","volume":"104","author":"Sakai","year":"1990","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2005.08.032_bib35","first-page":"R723","article-title":"Circulating angiotensin II mediates sodium appetite in adrenalectomized rats","volume":"281","author":"Schoorlemmer","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(96)00952-3","article-title":"Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses","volume":"744","author":"Song","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.08.032_bib37","first-page":"11","article-title":"Brain angiotensinergic activity: the state of our current knowledge","volume":"46","author":"Speth","year":"2003","journal-title":"Proc. West. Pharmacol. Soc."},{"key":"10.1016\/j.brainres.2005.08.032_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0006-8993(88)90224-7","article-title":"Differential effects of aminopeptidase inhibitors on angiotensin-induced pressor responses","volume":"456","author":"Sullivan","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.08.032_bib39","first-page":"R458","article-title":"Renin\u2013angiotensin, arterial blood pressure, and salt appetite in rats","volume":"266","author":"Thunhorst","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib40","first-page":"R1726","article-title":"Effects of hypotension and fluid depletion on central angiotensin-induced thirst and salt appetite","volume":"281","author":"Thunhorst","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib41","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1037\/0735-7044.104.4.637","article-title":"Subfornical organ participates in salt appetite","volume":"104","author":"Thunhorst","year":"1990","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainres.2005.08.032_bib42","first-page":"R1043","article-title":"Effects of sinoaortic baroreceptor denervation on depletion-induced salt appetite","volume":"267","author":"Thunhorst","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib43","first-page":"R925","article-title":"Cardiac control of salt appetite","volume":"252","author":"Toth","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib44","first-page":"R971","article-title":"Effects of different angiotensins during acute, double blockade of the renin system in conscious dogs","volume":"285","author":"Wamberg","year":"2003","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib45","first-page":"R250","article-title":"Interference with central actions of angiotensin II suppresses sodium appetite","volume":"250","author":"Weiss","year":"1986","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib46","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0166-4328(02)00193-6","article-title":"Salt appetite of adrenalectomized rats after a lesion of the SFO","volume":"136","author":"Wilson","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainres.2005.08.032_bib47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0165-0173(97)00019-2","article-title":"Important roles of angiotensin III and IV in the brain renin\u2013angiotesin system","volume":"25","author":"Wright","year":"1997","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainres.2005.08.032_bib48","first-page":"R514","article-title":"Pressor action and dipsogenicity induced by angiotensin II and III in rats","volume":"249","author":"Wright","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(88)91401-1","article-title":"Influence of aminopeptidase inhibitors on brain angiotensin metabolism and drinking in rats","volume":"441","author":"Wright","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.08.032_bib50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0006-8993(90)90428-E","article-title":"Intracerebroventricularly infused [D-Arg1] angiotensin III, is superior to [D-Asp1] angiotensin II, as a pressor agent in rats","volume":"514","author":"Wright","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.08.032_bib51","series-title":"Cell-surface Aminopeptidases: Basic and Clinical Aspects","first-page":"39","article-title":"Physiological significance of conversion of angiotensin II to III by aminopeptidase A","author":"Wright","year":"2001"},{"key":"10.1016\/j.brainres.2005.08.032_bib52","first-page":"R725","article-title":"Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats","volume":"284","author":"Wright","year":"2003","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib53","first-page":"R725","article-title":"Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats","volume":"284","author":"Wright","year":"2003","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainres.2005.08.032_bib54","doi-asserted-by":"crossref","first-page":"11968","DOI":"10.1073\/pnas.93.21.11968","article-title":"Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release","volume":"93","author":"Zini","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305012138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305012138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T12:33:37Z","timestamp":1549629217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899305012138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":54,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0006899305012138"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2005.08.032","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}