{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:09:50Z","timestamp":1772172590299,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.brainres.2005.10.011","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T23:08:02Z","timestamp":1135292882000},"page":"95-102","source":"Crossref","is-referenced-by-count":45,"title":["Neonatal pinealectomy induces Purkinje cell loss in the cerebellum of the chick: A stereological study"],"prefix":"10.1016","volume":"1067","author":[{"given":"Ayten T\u00fcrkkani","family":"Tun\u00e7","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fcnyamin","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine Ertem","family":"Yurtseven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fcleyman","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2005.10.011_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1034\/j.1600-079X.2001.300201.x","article-title":"Melatonin, mitochondria, and cellular bioenergetics","volume":"30","author":"Acuna-Castroviejo","year":"2001","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.brainres.2005.10.011_bib2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/cne.901360303","article-title":"Autoradiographic and histological studies of postnatal neurogenesis: III. Dating the time of production and onset of differentiation of cerebellar microneurons in rats","volume":"136","author":"Altman","year":"1969","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/cne.901450402","article-title":"Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layers","volume":"145","author":"Altman","year":"1972","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1034\/j.1600-079X.2000.290303.x","article-title":"Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical","volume":"29","author":"Bandyopadhyay","year":"2000","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.brainres.2005.10.011_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00315453","article-title":"Process of differentiation of cerebellar Purkinje neurons in the chick embryo","volume":"175","author":"Bertossi","year":"1986","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.brainres.2005.10.011_bib6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00007632-200102010-00007","article-title":"The critical stage of pinealectomy surgery after which scoliosis is produced in young chickens","volume":"26","author":"Beuerlein","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.brainres.2005.10.011_bib7","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1046\/j.1460-9568.2003.02647.x","article-title":"Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis","volume":"17","author":"Brown","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2005.10.011_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0232-1513(11)80067-8","article-title":"Brain changes in experimental chronic hypoxia","volume":"42","author":"Cervos-Navarro","year":"1991","journal-title":"Exp. Pathol."},{"key":"10.1016\/j.brainres.2005.10.011_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000139083","article-title":"Melatonin decreases brain serotonin release, arterial pressure and heart rate in rats","volume":"47","author":"Chuang","year":"1993","journal-title":"Pharmacology"},{"key":"10.1016\/j.brainres.2005.10.011_bib10","series-title":"Alcohol and Brain Development","first-page":"158","article-title":"Neuropathology in fetal alcohol syndrome","author":"Clarren","year":"1986"},{"key":"10.1016\/j.brainres.2005.10.011_bib11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0306-9877(79)90107-5","article-title":"The pineal and regulation of fibrosis: pinealectomy as a model of primary biliary cirrhosis: roles of melatonin and prostaglandins in fibrosis and regulation of T lymphocytes","volume":"5","author":"Cunnane","year":"1979","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.brainres.2005.10.011_bib12","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1046\/j.1460-9568.2002.02177.x","article-title":"Passive avoidance training enhances neuron proliferation in day old chicks","volume":"16","author":"Dermon","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2005.10.011_bib13","first-page":"51","article-title":"Melatonin suppresses the pinealectomy-induced elevation of collagen content in a wound","volume":"85","author":"Drobnik","year":"1996","journal-title":"Cytobios"},{"key":"10.1016\/j.brainres.2005.10.011_bib14","first-page":"23","article-title":"Collagen accumulation in the wound of a rat is controlled by the pineal gland","volume":"51","author":"Drobnik","year":"1995","journal-title":"Biomed. Lett."},{"key":"10.1016\/j.brainres.2005.10.011_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1083\/jcb.32.2.277","article-title":"Quantitative analysis of cell proliferation and differentiation in the cortex of the postnatal mouse cerebellum","volume":"32","author":"Fujita","year":"1967","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainres.2005.10.011_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-0270(02)00363-1","article-title":"Differential tissue shrinkage and compression in the z-axis: implications for optical counting in vibratome-, plastic- and cryosections","volume":"124","author":"Gardella","year":"2003","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2005.10.011_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10221","article-title":"On counting and counting errors","volume":"447","author":"Guillery","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2818.1986.tb02764.x","article-title":"Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones in memory of William R Thomson","volume":"143","author":"Gundersen","year":"1986","journal-title":"J. Microsc."},{"key":"10.1016\/j.brainres.2005.10.011_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2818.1987.tb02837.x","article-title":"The efficacy of systematic sampling in stereology and its prediction","volume":"147","author":"Gundersen","year":"1987","journal-title":"J. Microsc."},{"key":"10.1016\/j.brainres.2005.10.011_bib20","series-title":"Fundamental Neuroscience","first-page":"379","article-title":"The cerebellum","author":"Haines","year":"1997"},{"key":"10.1016\/j.brainres.2005.10.011_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.901310102","article-title":"Formation and differentiation of the external granular layer of the chick cerebellum","volume":"131","author":"Hanaway","year":"1967","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1096-9861(19990628)409:2<169::AID-CNE1>3.0.CO;2-O","article-title":"Analysis of cell death in the trochlear nucleus of the chick embryo: calibration of the optical disector counting method reveals systematic bias","volume":"409","author":"Hatton","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib23","series-title":"Unbiased Stereology: Three Dimensional Measurement in Microscopy","first-page":"1","author":"Howard","year":"1998"},{"key":"10.1016\/j.brainres.2005.10.011_bib24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/jcem-55-1-27","article-title":"Age-dependent reduction in serum melatonin concentrations in healthy human subjects","volume":"55","author":"Iguchi","year":"1982","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.brainres.2005.10.011_bib25","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/00005072-199806000-00003","article-title":"Expression of two glutamate transporters, GLAST and EAAT4, in the human cerebellum: their correlation in development and neonatal hypoxic\u2013ischemic damage","volume":"57","author":"Inage","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib26","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1073\/pnas.081011098","article-title":"Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat","volume":"98","author":"Jin","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainres.2005.10.011_bib27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-079X.2004.00162.x","article-title":"Prophylactic use of melatonin protects against focal cerebral ischemia in mice: role of endothelin converting enzyme-1","volume":"37","author":"Kilic","year":"2004","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.brainres.2005.10.011_bib28","series-title":"Birds: Their Structure and Function","first-page":"210","author":"King","year":"1984"},{"key":"10.1016\/j.brainres.2005.10.011_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000146237","article-title":"Ectopic Purkinje cells in the cerebellar white matter of normal adult rodents: a Golgi study","volume":"127","author":"Lafarga","year":"1986","journal-title":"Acta Anat."},{"key":"10.1016\/j.brainres.2005.10.011_bib30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0006-8993(01)02362-9","article-title":"Cerebellar alterations induced by chronic hypoxia: an immunohistochemical study using a chick embryonic model","volume":"901","author":"Lee","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.10.011_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/sj.npp.1300565","article-title":"Electroconvulsive seizure treatment increases cell proliferation in rat frontal cortex","volume":"30","author":"Madsen","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainres.2005.10.011_bib32","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1177\/074873049701200626","article-title":"Melatonin modulates vascular smooth muscle tone","volume":"12","author":"Mahle","year":"1997","journal-title":"J. Biol. Rhytms"},{"key":"10.1016\/j.brainres.2005.10.011_bib33","first-page":"79","article-title":"Differentiation of cerebellar Purkinje neurons of the normal and chronically hypoxic chick embryo","volume":"61","author":"Mancini","year":"1985","journal-title":"Boll. Soc. Ital. Sper."},{"key":"10.1016\/j.brainres.2005.10.011_bib34","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jcb.240530415","article-title":"Nuclear localization of melatonin in different mammalian tissues: immunocytochemical and radioimmunoassay evidence","volume":"53","author":"Menendez-Pelaez","year":"1993","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.brainres.2005.10.011_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(98)00790-3","article-title":"Anticonvulsant effects of melatonin in amygdala-kindled rats","volume":"257","author":"Mevissen","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2005.10.011_bib36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0014-4886(61)90055-3","article-title":"An autoradiographic analysis on histogenesis in the mouse cerebellum","volume":"4","author":"Miale","year":"1961","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/(SICI)1096-9861(19980525)395:1<112::AID-CNE8>3.0.CO;2-3","article-title":"Cytological compartmentalization in the staggerer cerebellum, as revealed by calbindin immunohistochemistry for Purkinje cells","volume":"395","author":"Nakagawa","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0304-3940(01)02503-4","article-title":"Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat","volume":"318","author":"Pei","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2005.10.011_bib39","first-page":"211","article-title":"Structure of the fetal sheep brain in experimental growth retardation","volume":"10","author":"Rees","year":"1988","journal-title":"J. Dev. Physiol."},{"key":"10.1016\/j.brainres.2005.10.011_bib40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0165-3806(97)81787-7","article-title":"The vulnerability of the fetal sheep brain to hypoxemia at mid-gestation","volume":"103","author":"Rees","year":"1997","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainres.2005.10.011_bib41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0301-0082(98)00052-5","article-title":"Oxidative damage in the central nervous system: protection by melatonin","volume":"56","author":"Reiter","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2005.10.011_bib42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1749-6632.2001.tb03627.x","article-title":"Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system","volume":"939","author":"Reiter","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainres.2005.10.011_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/153537020523000205","article-title":"When melatonin gets on your nerves: its beneficial actions in experimental models of stroke","volume":"230","author":"Reiter","year":"2005","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.brainres.2005.10.011_bib44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1469-8749.1980.tb04363.x","article-title":"Chronology of neuron development: animal studies and their clinical implications","volume":"22","author":"Rodier","year":"1980","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib45","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0720-048X(02)00152-3","article-title":"Unbiased estimation of the liver volume by the Cavalieri principle using magnetic resonance images","volume":"47","author":"Sahin","year":"2003","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.brainres.2005.10.011_bib46","series-title":"Motor Hierarchies in Neurobiology","first-page":"452","author":"Shepherd","year":"1994"},{"key":"10.1016\/j.brainres.2005.10.011_bib47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/cne.20066","article-title":"Late granule cell genesis in quail cerebellum","volume":"474","author":"Stamatakis","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2005.10.011_bib48","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1471-4159.1985.tb04088.x","article-title":"Alteration in the postnatal ontogeny of cerebellar norepinephrine content following chronic prenatal carbon monoxide","volume":"45","author":"Storm","year":"1985","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2005.10.011_bib49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000014635","article-title":"Significance of melatonin in antioxidative defense system: reactions and products","volume":"9","author":"Tan","year":"2000","journal-title":"Biol. Signals Recept."},{"key":"10.1016\/j.brainres.2005.10.011_bib50","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1568026023394443","article-title":"Chemical and physical properties and potential mechanism: melatonin as a broad spectrum antioxidant and free radical scavenger","volume":"2","author":"Tan","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.brainres.2005.10.011_bib51","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00586-003-0528-9","article-title":"The effects of pineal gland transplantation on the production of spinal deformity and serum melatonin level following pinealectomy in the chicken","volume":"12","author":"Turgut","year":"2003","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.brainres.2005.10.011_bib52","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1600-079X.2004.00205.x","article-title":"Pinealectomy exaggerates and melatonin treatment suppresses neuroma formation of transected sciatic nerve in rats: gross morphological, histological and stereological analysis","volume":"38","author":"Turgut","year":"2005","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.brainres.2005.10.011_bib53","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00701-004-0426-x","article-title":"Assessment of effects of pinealectomy and exogenous melatonin administration on rat sciatic nerve suture repair: an electrophysiological, electron microscopic, and immunohistochemical study","volume":"147","author":"Turgut","year":"2005","journal-title":"Acta Neurochir. (Wien)"},{"key":"10.1016\/j.brainres.2005.10.011_bib54","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/ar.1092310411","article-title":"Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator","volume":"231","author":"West","year":"1991","journal-title":"Anat. Rec."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305014137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305014137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T06:16:37Z","timestamp":1555049797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899305014137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0006899305014137"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2005.10.011","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}