{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:11:53Z","timestamp":1790759513377,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.brainres.2005.12.035","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T07:39:07Z","timestamp":1138693147000},"page":"224-226","source":"Crossref","is-referenced-by-count":23,"title":["Brain penetration of the novel free radical trapping neuroprotectant NXY-059 in rats subjected to permanent focal ischemia"],"prefix":"10.1016","volume":"1072","author":[{"given":"A. Richard","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Lanbeck-Vall\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Ashwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lundquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Lindstr\u00f6m B\u00f6\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallgrimur","family":"Jonasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2005.12.035_bib1","first-page":"301","article-title":"Alterations in cerebral endothelial cell function in ischaemia","volume":"71","author":"Betz","year":"1996","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.brainres.2005.12.035_bib2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0006-8993(02)03469-8","article-title":"In vitro blood\u2013brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischaemic conditions","volume":"955","author":"Dehouck","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2005.12.035_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10571-004-1377-8","article-title":"Permeability studies on in vitro blood\u2013brain barrier models: physiology, pathology and pharmacology","volume":"25","author":"Deli","year":"2005","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainres.2005.12.035_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/1568007053544156","article-title":"Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers","volume":"4","author":"Green","year":"2005","journal-title":"Curr. Drug Targets. CNS Neurol. Disord."},{"key":"10.1016\/j.brainres.2005.12.035_bib5","first-page":"281","article-title":"Inflammatory reactions at the blood\u2013endothelial interface in acute stroke","volume":"71","author":"Hallenbeck","year":"1996","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.brainres.2005.12.035_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0022-510X(99)00121-5","article-title":"Dynamics of cerebral injury, perfusion, and blood\u2013brain barrier changes after temporary and permanent middle cerebral artery occlusion in the rat","volume":"166","author":"Kastrup","year":"1999","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2005.12.035_bib7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/00004647-199907000-00008","article-title":"Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischaemia in the rat","volume":"19","author":"Kuroda","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2005.12.035_bib8","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.STR.0000053032.14223.81","article-title":"Tolerability of NXY-059 at higher target concentrations in patients with acute stroke","volume":"34","author":"Lees","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2005.12.035_bib9","article-title":"Preliminary results of SAINT-1 trial","author":"Lees","year":"2005"},{"key":"10.1016\/j.brainres.2005.12.035_bib10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2005.12.035_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/10715760100300351","article-title":"Comparison of the radical trapping ability of PBN, S-PBN and NXY-059","volume":"34","author":"Maples","year":"2001","journal-title":"Free Radical Res."},{"key":"10.1016\/j.brainres.2005.12.035_bib12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1161\/01.STR.32.1.190","article-title":"NXY-059, a free radical trapping agent, substantially attenuates the functional disability induced by stroke in a primate species","volume":"32","author":"Marshall","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2005.12.035_bib13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1161\/01.STR.0000087790.79851.A8","article-title":"Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion","volume":"34","author":"Marshall","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2005.12.035_bib14","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/jcbfm.1995.119","article-title":"Role of neutrophils in radical production during ischaemia and reperfusion of the rat brain: effect of neutrophil depletion on extracellular ascorbyl radical formation","volume":"15","author":"Matsuo","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2005.12.035_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-2236(98)01261-2","article-title":"Extracellular space revealed by diffusion analysis","volume":"21","author":"Nicholson","year":"1998","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2005.12.035_bib16","first-page":"631","article-title":"Molecules mediating adhesion of T and B cells, monocytes and granulocytes to vascular endothelial cells","volume":"63","author":"Prieto","year":"1988","journal-title":"Immunology"},{"key":"10.1016\/j.brainres.2005.12.035_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/sj.bjp.0704449","article-title":"Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat: studies on dose, plasma concentration and therapeutic time window","volume":"135","author":"Sydserff","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainres.2005.12.035_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0022-510X(94)90234-8","article-title":"Temporal profile of ischaemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2 h) middle cerebral artery occlusion in the rat","volume":"125","author":"Zhang","year":"1994","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2005.12.035_bib19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0006-8993(01)02618-X","article-title":"NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischaemia in the rat","volume":"909","author":"Zhao","year":"2001","journal-title":"Brain Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305017373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899305017373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T12:36:09Z","timestamp":1549629369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899305017373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0006899305017373"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2005.12.035","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}