{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:48:25Z","timestamp":1791121705135,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA014392"],"award-info":[{"award-number":["DA014392"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA10756"],"award-info":[{"award-number":["DA10756"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32 DA07310"],"award-info":[{"award-number":["T32 DA07310"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR00166"],"award-info":[{"award-number":["RR00166"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.brainres.2006.02.047","type":"journal-article","created":{"date-parts":[[2006,4,12]],"date-time":"2006-04-12T15:28:28Z","timestamp":1144855708000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":127,"title":["Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies"],"prefix":"10.1016","volume":"1085","author":[{"given":"Stacey A.","family":"Sakowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Geddes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edi","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Hatfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.02.047_bib1","first-page":"688","article-title":"Ecstasy (MDMA)-induced alterations in tryptophan hydroxylase protein and mRNA expression in the dorsal and median raphe nuclei","volume":"689","author":"Austin","year":"2004","journal-title":"Abstr.-Soc. Neurosci."},{"key":"10.1016\/j.brainres.2006.02.047_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1017\/S1092852900002339","article-title":"New trends in the treatment of anxiety disorders","volume":"9","author":"Brawman-Mintzer","year":"2004","journal-title":"CNS Spectr."},{"key":"10.1016\/j.brainres.2006.02.047_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3940(99)00340-7","article-title":"Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland","volume":"267","author":"Chamas","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2006.02.047_bib4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0006-3223(03)00788-1","article-title":"Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei","volume":"55","author":"Chamas","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2006.02.047_bib5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0169-328X(97)00106-X","article-title":"Tissue-specific glucocorticoid regulation of tryptophan hydroxylase mRNA levels","volume":"48","author":"Clark","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2006.02.047_bib6","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.biopsych.2005.01.013","article-title":"Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus","volume":"57","author":"Clark","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2006.02.047_bib7","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1046\/j.1471-4159.1996.67030917.x","article-title":"Expression and deletion mutagenesis of tryptophan hydroxylase fusion proteins: delineation of the enzyme catalytic core","volume":"67","author":"D'Sa","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.02.047_bib8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00213-005-0191-4","article-title":"Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia","volume":"183","author":"De Luca","year":"2005","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.brainres.2006.02.047_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jnr.490240412","article-title":"Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: evidence for a role of translation efficiency","volume":"24","author":"Dumas","year":"1989","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2006.02.047_bib10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.coph.2003.07.005","article-title":"Plasticity in serotonin control mechanisms in the gut","volume":"3","author":"Gershon","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"issue":"Suppl. 7","key":"10.1016\/j.brainres.2006.02.047_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2036.2004.02180.x","article-title":"Review article: serotonin receptors and transporters\u2014roles in normal and abnormal gastrointestinal motility","volume":"20","author":"Gershon","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.brainres.2006.02.047_bib12","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1097\/01.mcg.0000156403.37240.30","article-title":"Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome","volume":"39","author":"Gershon","year":"2005","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.brainres.2006.02.047_bib13","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1073\/pnas.84.16.5530","article-title":"Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases","volume":"84","author":"Grenett","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.02.047_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0006-8993(87)90420-3","article-title":"Identification of serotonergic neurons in human brain by a monoclonal antibody binding to all three aromatic amino acid hydroxylases","volume":"426","author":"Haan","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.02.047_bib15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1042\/bj2480501","article-title":"Demonstration of non-neural tryptophan 5-mono-oxygenase in mouse intestinal mucosa","volume":"248","author":"Hasegawa","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainres.2006.02.047_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0165-0270(01)00530-1","article-title":"A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope","volume":"114","author":"Haycock","year":"2002","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2006.02.047_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0169-328X(94)90126-0","article-title":"A 6.1 kb 5\u2032 upstream region of the mouse tryptophan hydroxylase gene directs expression of E. coli lacZ to major serotonergic brain regions and pineal gland in transgenic mice","volume":"24","author":"Huh","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2006.02.047_bib18","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1046\/j.1471-4159.1996.66020817.x","article-title":"Phosphorylation and activation of tryptophan hydroxylase by exogenous protein kinase A","volume":"66","author":"Johansen","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.02.047_bib19","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2165\/00023210-200418150-00005","article-title":"Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment","volume":"18","author":"Johnson","year":"2004","journal-title":"CNS Drugs"},{"key":"10.1016\/j.brainres.2006.02.047_bib20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.psych.56.091103.070320","article-title":"The psychology and neurobiology of suicidal behavior","volume":"56","author":"Joiner","year":"2005","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.brainres.2006.02.047_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0169-328X(91)90073-7","article-title":"Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons","volume":"9","author":"Kim","year":"1991","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2006.02.047_bib22","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1046\/j.1471-4159.1996.67031072.x","article-title":"Inactivation of brain tryptophan hydroxylase by nitric oxide","volume":"67","author":"Kuhn","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.02.047_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1471-4159.1979.tb11700.x","article-title":"Determination of some molecular parameters of tryptophan hydroxylase from rat midbrain and murine mast cell","volume":"33","author":"Kuhn","year":"1979","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.02.047_bib24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0003-9861(80)90291-X","article-title":"Comparisons of tryptophan hydroxylase from a malignant murine mast cell tumor and rat mesencephalic tegmentum","volume":"199","author":"Kuhn","year":"1980","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.brainres.2006.02.047_bib25","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1046\/j.1471-4159.1999.0731309.x","article-title":"Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease","volume":"73","author":"Kuhn","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.02.047_bib26","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1097\/01.wnr.0000131007.59315.66","article-title":"Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina","volume":"15","author":"Liang","year":"2004","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2006.02.047_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0006-3223(98)00139-5","article-title":"The spectrum of behaviors influenced by serotonin","volume":"44","author":"Lucki","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2006.02.047_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0167-0115(95)00102-H","article-title":"Antisense oligonucleotide inhibition of tryptophan hydroxylase activity in mouse brain","volume":"59","author":"McCarthy","year":"1995","journal-title":"Regul. Pept."},{"key":"10.1016\/j.brainres.2006.02.047_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF00494064","article-title":"Subcellular localization of serotonin immunoreactivity in rat enterochromaffin cells","volume":"82","author":"Nilsson","year":"1985","journal-title":"Histochemistry"},{"key":"10.1016\/j.brainres.2006.02.047_bib30","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.biopsych.2003.09.002","article-title":"Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland","volume":"55","author":"Patel","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2006.02.047_bib31","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1471-4159.2005.03604.x","article-title":"Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function","volume":"96","author":"Sakowski","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.02.047_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.expneurol.2004.04.015","article-title":"Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons","volume":"188","author":"Salli","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainres.2006.02.047_bib33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molbrainres.2004.12.011","article-title":"A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques","volume":"135","author":"Sanchez","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2006.02.047_bib34","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1016\/S0021-9258(19)86484-0","article-title":"A simple purification of phenylalanine hydroxylase by substrate-induced hydrophobic chromatography","volume":"254","author":"Shiman","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.02.047_bib35","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0306-4522(81)90146-9","article-title":"Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals","volume":"6","author":"Steinbusch","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2006.02.047_bib36","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1046\/j.1471-4159.2003.01959.x","article-title":"Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real-time PCR","volume":"86","author":"Sugden","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.02.047_bib37","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0006-2952(03)00556-2","article-title":"A unique central tryptophan hydroxylase isoform","volume":"66","author":"Walther","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainres.2006.02.047_bib38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","article-title":"Synthesis of serotonin by a second tryptophan hydroxylase isoform","volume":"299","author":"Walther","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.02.047_bib39","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/(SICI)1096-9861(19990906)411:4<654::AID-CNE9>3.0.CO;2-H","article-title":"Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts","volume":"411","author":"Yu","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainres.2006.02.047_bib40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1097540","article-title":"Caron Tryptophan hydroxylase-2 controls brain serotonin synthesis","volume":"305","author":"Zhang","year":"2004","journal-title":"Science"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306004550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306004550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:47:17Z","timestamp":1778629637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899306004550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0006899306004550"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.02.047","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2006.02.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}