{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:54:04Z","timestamp":1791100444730,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001697","name":"Keio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.brainres.2006.03.068","type":"journal-article","created":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T01:51:57Z","timestamp":1146793917000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Ho15J\u2014A new hotfoot allele in a hot spot in the gene encoding the \u03b42 glutamate receptor"],"prefix":"10.1016","volume":"1140","author":[{"given":"Junko","family":"Motohashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Kakegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michisuke","family":"Yuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.03.068_bib1","series-title":"Development of the Cerebellar System: In Relation to its Evolution, Structure, and Functions","author":"Altman","year":"1997"},{"key":"10.1016\/j.brainres.2006.03.068_bib2","doi-asserted-by":"crossref","first-page":"15053","DOI":"10.1074\/jbc.M408413200","article-title":"Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subtype-specific receptor assembly","volume":"280","author":"Ayalon","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.03.068_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.neuro.20.1.157","article-title":"Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain","volume":"20","author":"Chen","year":"1997","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2006.03.068_bib4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/neu.480070609","article-title":"Evidence for a multiple innervation of Purkinje cells by climbing fibers in the immature rat cerebellum","volume":"7","author":"Crepel","year":"1976","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.brainres.2006.03.068_bib5","first-page":"30","article-title":"New mutations","volume":"34","author":"Dickie","year":"1966","journal-title":"Mouse News Lett."},{"key":"10.1016\/j.brainres.2006.03.068_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0006-8993(90)91488-3","article-title":"Hot-foot murine mutation: behavioral effects and neuroanatomical alterations","volume":"523","author":"Guastavino","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.03.068_bib7","doi-asserted-by":"crossref","first-page":"9701","DOI":"10.1523\/JNEUROSCI.21-24-09701.2001","article-title":"Roles of glutamate receptor delta 2 subunit (GluRdelta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development","volume":"21","author":"Hashimoto","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2006.03.068_bib8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/sj.embor.7400312","article-title":"Rescue of abnormal phenotypes of the delta2 glutamate receptor-null mice by mutant delta2 transgenes","volume":"6","author":"Hirai","year":"2005","journal-title":"EMBO Rep."},{"key":"10.1016\/j.brainres.2006.03.068_bib9","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nn1576","article-title":"Cbln1 is essential for synaptic integrity and plasticity in the cerebellum","volume":"8","author":"Hirai","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainres.2006.03.068_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev.ne.12.030189.000505","article-title":"Long-term depression","volume":"12","author":"Ito","year":"1989","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainres.2006.03.068_bib11","doi-asserted-by":"crossref","first-page":"17846","DOI":"10.1073\/pnas.0508910102","article-title":"A mechanism underlying AMPA receptor trafficking during cerebellar long-term potentiation","volume":"102","author":"Kakegawa","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.03.068_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(95)90334-8","article-title":"Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice","volume":"81","author":"Kashiwabuchi","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2006.03.068_bib13","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/j.1460-9568.2005.03946.x","article-title":"Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells","volume":"21","author":"Katoh","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2006.03.068_bib14","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1046\/j.0953-816x.2001.01488.x","article-title":"Classical eyeblink conditioning in glutamate receptor subunit delta 2 mutant mice is impaired in the delay paradigm but not in the trace paradigm","volume":"13","author":"Kishimoto","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2006.03.068_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/geno.1998.5314","article-title":"Hotfoot mouse mutations affect the delta 2 glutamate receptor gene and are allelic to lurcher","volume":"50","author":"Lalouette","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.brainres.2006.03.068_bib16","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0306-4522(01)00193-2","article-title":"Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor","volume":"105","author":"Lalouette","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2006.03.068_bib17","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1046\/j.1460-9568.2002.02219.x","article-title":"Mutation in hotfoot-4J mice results in retention of delta2 glutamate receptors in ER","volume":"16","author":"Matsuda","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2006.03.068_bib18","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1093\/emboj\/19.12.2765","article-title":"Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons","volume":"19","author":"Matsuda","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2006.03.068_bib32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0169-328X(02)00173-0","article-title":"Cloning and characterization of a novel NMDA receptor subunit NR3B: a dominant subunit that reduces calcium permeability","volume":"100","author":"Matsuda","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2006.03.068_bib19","doi-asserted-by":"crossref","first-page":"20021","DOI":"10.1074\/jbc.M410513200","article-title":"Roles of the N-terminal domain on the function and quaternary structure of the ionotropic glutamate receptor","volume":"280","author":"Matsuda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.03.068_bib20","doi-asserted-by":"crossref","first-page":"49662","DOI":"10.1074\/jbc.M208349200","article-title":"Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain","volume":"277","author":"Pasternack","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.03.068_bib21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00335-004-2423-z","article-title":"Two reciprocal translocations provide new clues to the high mutability of the Grid2 locus","volume":"16","author":"Robinson","year":"2005","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.brainres.2006.03.068_bib22","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.neuron.2004.05.012","article-title":"Long-term synaptic changes induced in the cerebellar cortex by fear conditioning","volume":"42","author":"Sacchetti","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2006.03.068_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/1073858405276428","article-title":"The cerebellum: synaptic changes and fear conditioning","volume":"11","author":"Sacchetti","year":"2005","journal-title":"Neuroscientist"},{"key":"10.1016\/j.brainres.2006.03.068_bib24","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1523\/JNEUROSCI.4740-04.2005","article-title":"Control of synaptic connection by glutamate receptor delta2 in the adult cerebellum","volume":"25","author":"Takeuchi","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2006.03.068_bib25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2144\/00291bm09","article-title":"Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT)","volume":"29","author":"Truett","year":"2000","journal-title":"Biotechniques"},{"key":"10.1016\/j.brainres.2006.03.068_bib26","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0896-6273(00)81066-1","article-title":"Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis","volume":"25","author":"Wang","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.brainres.2006.03.068_bib27","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1046\/j.1460-9568.2003.02595.x","article-title":"A hot spot for hotfoot mutations in the gene encoding the delta2 glutamate receptor","volume":"17","author":"Wang","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainres.2006.03.068_bib28","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1126\/science.286.5446.1888","article-title":"Posttranslational quality control: folding, refolding, and degrading proteins","volume":"286","author":"Wickner","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.03.068_bib29","doi-asserted-by":"crossref","first-page":"47765","DOI":"10.1074\/jbc.M207122200","article-title":"A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors","volume":"277","author":"Xia","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.03.068_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0168-0102(03)00036-1","article-title":"The delta2 glutamate receptor: 10\u00a0years later","volume":"46","author":"Yuzaki","year":"2003","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.brainres.2006.03.068_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/14734220410028921","article-title":"The delta2 glutamate receptor: a key molecule controlling synaptic plasticity and structure in Purkinje cells","volume":"3","author":"Yuzaki","year":"2004","journal-title":"Cerebellum"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306008584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306008584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:53:25Z","timestamp":1762102405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899306008584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":32,"alternative-id":["S0006899306008584"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.03.068","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ho15J\u2014A new hotfoot allele in a hot spot in the gene encoding the \u03b42 glutamate receptor","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2006.03.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}