{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:06:26Z","timestamp":1776204386151,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.brainres.2006.04.013","type":"journal-article","created":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T14:33:59Z","timestamp":1148308439000},"page":"167-177","source":"Crossref","is-referenced-by-count":41,"title":["Aspirin protects striatal dopaminergic neurons from neurotoxin-induced degeneration: An in vivo microdialysis study"],"prefix":"10.1016","volume":"1095","author":[{"given":"Vincenzo","family":"Di Matteo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Pierucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Di Giovanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Di Santo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreina","family":"Poggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arcangelo","family":"Benigno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ennio","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.04.013_bib1","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1046\/j.1471-4159.1998.71041635.x","article-title":"Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice","volume":"71","author":"Aubin","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.04.013_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/34651","article-title":"Prostaglandins stimulate calcium-dependent glutamate release in astrocytes","volume":"39","author":"Bezzi","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2006.04.013_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease","volume":"65","author":"Blum","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2006.04.013_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/jnr.20541","article-title":"Dopaminergic neurotoxicity by 6-OHDA and MPP+: differential requirement for neuronal cyclooxygenase activity","volume":"81","author":"Carrasco","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainres.2006.04.013_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1353-8020(02)00022-6","article-title":"Selective destruction of dopaminergic neurons by low concentrations of 6-OHDA and MPP+: protection by acetylsalicylic acid (aspirin)","volume":"8","author":"Carrasco","year":"2002","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.brainres.2006.04.013_bib7","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/archneur.60.8.1059","article-title":"Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease","volume":"60","author":"Chen","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainres.2006.04.013_bib8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0891-5849(92)90151-6","article-title":"Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation through dopamine autooxidation in the caudate nucleus: effects of MPP+","volume":"13","author":"Chiueh","year":"1992","journal-title":"Free Rad. Biol. & Med."},{"key":"10.1016\/j.brainres.2006.04.013_bib9","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/114.4.1953","article-title":"Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia","volume":"114","author":"Dexter","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2006.04.013_bib10","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0197-4580(02)00078-7","article-title":"A review of specific antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes","volume":"23","author":"Esposito","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainres.2006.04.013_bib11","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","article-title":"Ageing and Parkinson's disease: SNc regional selectivity","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.brainres.2006.04.013_bib12","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1097\/00001756-200310270-00009","article-title":"COX-2-deficient mice are less prone to MPTP-neurotoxicity than wild-type mice","volume":"14","author":"Feng","year":"2003","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainres.2006.04.013_bib13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0304-3940(02)00704-8","article-title":"Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra","volume":"329","author":"Feng","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2006.04.013_bib14","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s002109900079","article-title":"Salicylate protects against MPTP-induced impairments in dopaminergic neurotransmission at the striatal and nigral level in mice","volume":"360","author":"Ferger","year":"1999","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.brainres.2006.04.013_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-7091-6842-4_7","article-title":"Mechanism of 6-hydroxydopamine neurotoxicity","volume":"50","author":"Glinka","year":"1997","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.brainres.2006.04.013_bib16","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.274.5291.1383","article-title":"Neuroprotection by aspirin and sodium salicylate through blockade of NF-\u03baB activation","volume":"274","author":"Grilli","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.04.013_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0278-5846(89)90121-8","article-title":"Ageing and neurotoxins as causative factors in idiopathic Parkinson's disease\u2014a critical analysis of the neurochemical evidence","volume":"13","author":"Hornykiewicz","year":"1989","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainres.2006.04.013_bib18","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S1566-2772(01)00022-6","article-title":"The inflammatory response in the Parkinson's brain","volume":"1","author":"Hunott","year":"2001","journal-title":"Clin. Neurosci. Res."},{"key":"10.1016\/j.brainres.2006.04.013_bib19","first-page":"47","article-title":"Pathology of Parkinson's disease","volume":"vol. 8","author":"Jellinger","year":"1989"},{"key":"10.1016\/j.brainres.2006.04.013_bib20","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1002\/ana.410320714","article-title":"Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group","volume":"32","author":"Jenner","year":"1992","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.brainres.2006.04.013_bib21","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.8052854","article-title":"Inhibition of NF-kB by sodium salicylate and aspirin","volume":"265","author":"Kopp","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.04.013_bib22","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1056\/NEJM199810083391506","article-title":"Parkinson's disease first of two parts","volume":"339","author":"Lang","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2006.04.013_bib23","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.04.013_bib24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1023\/A:1015998732066","article-title":"On the application of 4-hydroxybenzoic acid as a trapping agent to study hydroxyl radical generation during cerebral ischemia and reperfusion","volume":"234\/235","author":"Liu","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.brainres.2006.04.013_bib25","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1523\/JNEUROSCI.19-04-01284.1999","article-title":"Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons","volume":"19","author":"Lotharius","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainres.2006.04.013_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0197-0186(03)00170-0","article-title":"Acetaminophen and aspirin inhibit superoxide anion generation and lipid peroxidation, and protect against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats","volume":"44","author":"Maharaj","year":"2004","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainres.2006.04.013_bib27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1471-4159.1997.68010255.x","article-title":"A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide","volume":"68","author":"Mark","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainres.2006.04.013_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0006-8993(00)02189-2","article-title":"Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity","volume":"864","author":"Mohanakumar","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.04.013_bib29","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0028-3908(99)00226-9","article-title":"Mechanisms of the neuroprotective effect of aspirin after oxygen and glucose deprivation in rat forebrain slices","volume":"39","author":"Moro","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainres.2006.04.013_bib30","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/0024-3205(85)90146-8","article-title":"Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine","volume":"36","author":"Nicklas","year":"1985","journal-title":"Life Sci."},{"key":"10.1016\/j.brainres.2006.04.013_bib31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0006-8993(99)01329-3","article-title":"Reserpine prevents hydroxyl radical formation by MPP+ in rat striatum","volume":"828","author":"Obata","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.04.013_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(01)01966-8","article-title":"Protective effect of tamoxifen on 1-methyl-4-phenylpyridine-induced hydroxyl radical generation in the rat striatum","volume":"308","author":"Obata","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2006.04.013_bib33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0301-0082(02)00127-2","article-title":"An inflammatory review of Parkinson's disease","volume":"68","author":"Orr","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2006.04.013_bib34","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJM199405053301808","article-title":"Aspirin as an antiplatelet drug","volume":"330","author":"Patrono","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2006.04.013_bib35","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.brainres.2006.04.013_bib36","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1566-2772(01)00019-6","article-title":"MPTP: a review of its mechanisms of neurotoxicity","volume":"1","author":"Przedborski","year":"2001","journal-title":"Clin. Neurosci. Res."},{"key":"10.1016\/j.brainres.2006.04.013_bib37","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.brainres.2004.05.095","article-title":"Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse","volume":"1019","author":"Przybylkowski","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.04.013_bib38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0014-2999(86)90071-3","article-title":"Brain dialysis in conscious rats reveals an instantaneous massive release of striatal dopamine in response to MPP+","volume":"126","author":"Rollema","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2006.04.013_bib39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0006-8993(02)04174-4","article-title":"Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats","volume":"966","author":"Sairam","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.04.013_bib40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-2094-1-6","article-title":"Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease","volume":"1","author":"S\u00e1nchez-Pernaute","year":"2004","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainres.2006.04.013_bib41","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0165-0270(01)00390-9","article-title":"Validity of a quantitative technique to study striatal dopaminergic neurodegeneration by in vivo microdialysis","volume":"108","author":"Santiago","year":"2001","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainres.2006.04.013_bib42","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/ana.410260409","article-title":"Striatal dopamine deficiency in Parkinson's disease: role of aging","volume":"26","author":"Scherman","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainres.2006.04.013_bib43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.pa.36.040196.000503","article-title":"Oxidative stress in neurodegenerative diseases","volume":"36","author":"Simonian","year":"1996","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.brainres.2006.04.013_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/abio.1996.0379","article-title":"Evaluation of sodium 4-hydroxybenzoate as an hydroxyl radical trap using gas chromatography-mass spectrometry and high-performance liquid chromatography with electrochemical detection","volume":"241","author":"Ste-Marie","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.brainres.2006.04.013_bib45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/1098-2396(200102)39:2<167::AID-SYN8>3.0.CO;2-U","article-title":"Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease","volume":"39","author":"Teismann","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.brainres.2006.04.013_bib46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pneurobio.2004.05.002","article-title":"Genes, proteins, and neurotoxins involved in Parkinson's disease","volume":"73","author":"von Bohlen und Halbach","year":"2004","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2006.04.013_bib47","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1353-8020(02)00019-6","article-title":"Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity?","volume":"8","author":"Zigmond","year":"2002","journal-title":"Parkinsonism Relat. Disord."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306010365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306010365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T23:47:33Z","timestamp":1555631253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899306010365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0006899306010365"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.04.013","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}