{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:09:27Z","timestamp":1791580167793,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.brainres.2006.04.030","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T17:13:22Z","timestamp":1149700402000},"page":"113-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["The systemic application of diazepam facilitates the reacquisition of a well-balanced vestibular function in a unilateral vestibular re-input model with intracochlear tetrodotoxin infusion using an osmotic pump"],"prefix":"10.1016","volume":"1096","author":[{"given":"Kenji","family":"Takeno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimogori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyoshi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takefumi","family":"Mikuriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Orita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.04.030_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3233\/VES-1999-9208","article-title":"Recovery of vestibulo-ocular reflex-function in subjects with an acute unilateral peripheral vestibular deficit","volume":"9","author":"Allum","year":"1999","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/00129492-200109000-00018","article-title":"Recovery from vestibular ototoxicity","volume":"22","author":"Black","year":"2001","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.brainres.2006.04.030_bib3","series-title":"Vertigo: Its Multisensory Syndromes","author":"Brandt","year":"1999"},{"key":"10.1016\/j.brainres.2006.04.030_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0378-5955(93)90155-T","article-title":"Osmotic pump implant for chronic infusion of drugs into the inner ear","volume":"70","author":"Brown","year":"1993","journal-title":"Hear. Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s10072-004-0213-8","article-title":"The treatment of acute vertigo","volume":"24","author":"Cesarani","year":"2004","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.brainres.2006.04.030_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3233\/VES-1995-5201","article-title":"Vestibular compensation: a review of the oculomotor, neural, and clinical consequences of unilateral vestibular loss","volume":"5","author":"Curthoys","year":"1995","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib8","first-page":"97","article-title":"\u201dVestibular compensation\u201d: neural plasticity and its relations to functional recovery after labyrinthine lesions in frogs and other vertebrates","volume":"46","author":"Dieringer","year":"1995","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainres.2006.04.030_bib9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s00221-004-1997-8","article-title":"An in situ hybridization and immunofluorescence study of GABAA and GABAB receptors in the vestibular nuclei of the intact and unilaterally labyrinthectomized rat","volume":"160","author":"Eleore","year":"2005","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/VES-2003-132-306","article-title":"A comparison of the monothermal and bithermal caloric tests","volume":"13","author":"Enticott","year":"2003","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00129492-200503000-00024","article-title":"Effects of vestibulo-ocular reflex exercises on vestibular compensation after vestibular schwannoma surgery","volume":"26","author":"Enticott","year":"2005","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.brainres.2006.04.030_bib12","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1152\/jn.1988.59.2.370","article-title":"Recovery from unilateral labyrinthectomy in rhesus monkey","volume":"59","author":"Fetter","year":"1988","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2006.04.030_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00221-005-2344-4","article-title":"GABAA receptor subunit expression in the guinea pig vestibular nucleus complex during the development of vestibular compensation","volume":"166","author":"Gliddon","year":"2005","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1365-2273.2002.00545.x","article-title":"Head-shaking nystagmus in the follow-up of patients with vestibular diseases","volume":"27","author":"Guidetti","year":"2002","journal-title":"Clin. Otolaryngol."},{"key":"10.1016\/j.brainres.2006.04.030_bib37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0196-0709(87)80017-0","article-title":"Head-shaking nystagmus in patients with unilateral peripheral vestibular lesions","volume":"8","author":"Hain","year":"1987","journal-title":"Am. J. Otolaryngol."},{"key":"10.1016\/j.brainres.2006.04.030_bib14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0306-4522(99)00142-6","article-title":"Ultrastructure of vestibular commissural neurons related to velocity storage in the monkey","volume":"93","author":"Holstein","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2006.04.030_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-2999(03)01367-0","article-title":"Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig","volume":"464","author":"Horiike","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2006.04.030_bib16","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0091-3057(94)00339-4","article-title":"The effects of long-term, low-dose diazepam treatment on the guinea pig righting reflex and medial vestibular nucleus neuronal activity","volume":"50","author":"Hutchinson","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2006.04.030_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/000164800750000865","article-title":"Head-shaking nystagmus(HSN): the theoretical explanation and the experimental proof","volume":"120","author":"Katsarkas","year":"2000","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.brainres.2006.04.030_bib17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0006-8993(95)00950-U","article-title":"Effect of MK801 on Fos expression in the rat brainstem after unilateral labyrinthectomy","volume":"700","author":"Kitahara","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0306-4522(96)00374-0","article-title":"Role of the flocculus in the development of vestibular compensation: immunohistochemical studies with retrograde tracing and flocculectomy using fos expression as a maker in the rat brainstem","volume":"76","author":"Kitahara","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainres.2006.04.030_bib19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF00230906","article-title":"ON the role of vestibulo-ocular reflex plasticity in recovery after unilateral peripheral vestibular lesions","volume":"59","author":"Maioli","year":"1985","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3233\/VES-1996-6208","article-title":"Early diazepam treatment following unilateral labyrinthectomy does not impair vestibular compensation of spontaneous nystagmus in guinea pig","volume":"6","author":"Martin","year":"1996","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3109\/00016489509121900","article-title":"Stage-assessment of the progress of continuous vertigo of peripheral origin by means of spontaneous and head-shaking nystagmus findings","volume":"519","author":"Matsuzaki","year":"1995","journal-title":"Acta Oto-Laryngol., Suppl."},{"key":"10.1016\/j.brainres.2006.04.030_bib22","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1097\/00005537-200406000-00023","article-title":"Functional significance of peripheral head-shaking nystagmus","volume":"114","author":"P\u00e9rez Vazquez","year":"2004","journal-title":"Laryngoscope"},{"key":"10.1016\/j.brainres.2006.04.030_bib23","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000046130","article-title":"A novel microperfusion system for the long-term local supply of drugs to the inner ear: implantation and function in the rat model","volume":"6","author":"Praetorius","year":"2001","journal-title":"Audiol. Neuro-Otol."},{"key":"10.1016\/j.brainres.2006.04.030_bib24","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0006-8993(73)90631-8","article-title":"Removal of vestibular commissural inhibition by antagonists of GABA and glycine","volume":"62","author":"Prechet","year":"1973","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF00236613","article-title":"Velocity storage in the vestibulo-ocular reflex arc (VOR)","volume":"35","author":"Raphan","year":"1979","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib26","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1152\/jn.1998.80.5.2352","article-title":"Neuronal activity in the vestibular nuclei after contralateral or bilateral labyrinthectomy in the alert guinea pig","volume":"80","author":"Ris","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2006.04.030_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0194-5998(95)70109-5","article-title":"Comparison of vestibular autorotation and caloric testing","volume":"113","author":"Saadat","year":"1995","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"10.1016\/j.brainres.2006.04.030_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3940(02)01426-X","article-title":"Asymmetric Fos labeling in lobule X of the cerebellum following transtympanic tetrodotoxin (TTX) in the rat","volume":"339","author":"Saxon","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2006.04.030_bib28","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000027718","article-title":"Effectiveness and utility of chemical labyrinthectomy with streptomycin using osmotic pump","volume":"62","author":"Shimogori","year":"2000","journal-title":"ORL, J. Oto-Rhino-Laryngol. Relate Spec."},{"key":"10.1016\/j.brainres.2006.04.030_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-3940(00)01534-2","article-title":"Efficacy of intracochlear administration of betamethasone on peripheral vestibular disorder in the guinea pig","volume":"294","author":"Shimogori","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2006.04.030_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3940(01)02329-1","article-title":"Rapid correction of vestibular imbalance by intracochlear administration of ATP in a guinea pig model of unilateral peripheral vestibular disorder","volume":"315","author":"Shimogori","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2006.04.030_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neulet.2004.08.047","article-title":"Peripheral vestibular disorder induced by (\u00b1)-\u03b1-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA)","volume":"371","author":"Shimogori","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainres.2006.04.030_bib40","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0006-8993(99)02141-1","article-title":"A role of glucocorticoid receptors in the guinea pig vestibular system","volume":"851","author":"Shimogori","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0165-0173(91)90001-O","article-title":"Neurochemical mechanisms of recovery from peripheral vestibular lesions (vestibular compensation)","volume":"16","author":"Smith","year":"1991","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.brainres.2006.04.030_bib32","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0091-3057(94)90566-5","article-title":"Rapid tolerance to the depressive effects of diazepam on guinea pig motor control using divided doses","volume":"48","author":"Smith","year":"1994","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainres.2006.04.030_bib42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/VES-1994-4606","article-title":"Comparison of different exercise programs in the rehabilitation of patients with chronic peripheral vestibular dysfunction","volume":"4","author":"Szturm","year":"1994","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.brainres.2006.04.030_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3109\/00016489009107409","article-title":"The clinical significance of head-shaking nystagmus in the dizzy patient","volume":"109","author":"Takahashi","year":"1990","journal-title":"Acta Oto-Laryngol."},{"key":"10.1016\/j.brainres.2006.04.030_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1469-7793.2000.t01-1-00413.x","article-title":"Rapid compensatory changes in GABA receptor efficacy in rat vestibular neurons after unilateral labyrinthectomy","volume":"523","author":"Yamanaka","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainres.2006.04.030_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0378-5955(90)90156-J","article-title":"Reversible blockade of vestibular evoked activity in the chick","volume":"47","author":"Weisleder","year":"1990","journal-title":"Hear. Res."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306011012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306011012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:31:46Z","timestamp":1757784706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899306011012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0006899306011012"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.04.030","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The systemic application of diazepam facilitates the reacquisition of a well-balanced vestibular function in a unilateral vestibular re-input model with intracochlear tetrodotoxin infusion using an osmotic pump","name":"articletitle","label":"Article Title"},{"value":"Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainres.2006.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}