{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T12:41:55Z","timestamp":1775824915825,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.brainres.2006.05.013","type":"journal-article","created":{"date-parts":[[2006,6,14]],"date-time":"2006-06-14T13:17:20Z","timestamp":1150291040000},"page":"32-41","source":"Crossref","is-referenced-by-count":19,"title":["S6k1 is not required for Pten-deficient neuronal hypertrophy"],"prefix":"10.1016","volume":"1100","author":[{"given":"Nader","family":"Chalhoub","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara C.","family":"Kozma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne J.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.05.013_bib1","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1093\/jnci\/91.22.1922","article-title":"Mutational spectra of PTEN\/MMAC1 gene: a tumor suppressor with lipid phosphatase activity","volume":"91","author":"Ali","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.brainres.2006.05.013_bib2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ng782","article-title":"Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte\u2013Duclos disease","volume":"29","author":"Backman","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2006.05.013_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2005.11.042","article-title":"PTEN function in normal and neoplastic growth","author":"Chow","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.brainres.2006.05.013_bib4","doi-asserted-by":"crossref","first-page":"12333","DOI":"10.1073\/pnas.172376399","article-title":"Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice","volume":"99","author":"Condorelli","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.05.013_bib5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(02)00969-8","article-title":"Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways","volume":"110","author":"Crackower","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2006.05.013_bib6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/1235","article-title":"Pten is essential for embryonic development and tumour suppression","volume":"19","author":"Di Cristofano","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2006.05.013_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/humu.10257","article-title":"PTEN: one gene, many syndromes","volume":"22","author":"Eng","year":"2003","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.brainres.2006.05.013_bib8","doi-asserted-by":"crossref","first-page":"7773","DOI":"10.1158\/0008-5472.CAN-04-2487","article-title":"Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo","volume":"64","author":"Fraser","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainres.2006.05.013_bib9","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1006\/dbio.2000.9680","article-title":"Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways","volume":"221","author":"Gao","year":"2000","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.brainres.2006.05.013_bib10","doi-asserted-by":"crossref","first-page":"R239","DOI":"10.1093\/hmg\/ddg288","article-title":"PTEN: tumour suppressor, multifunctional growth regulator and more","volume":"12","author":"Goberdhan","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainres.2006.05.013_bib11","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1101\/gad.13.24.3244","article-title":"Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico\/PI3-kinase signaling pathway","volume":"13","author":"Goberdhan","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2006.05.013_bib12","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1126\/science.1065518","article-title":"Negative regulation of neural stem\/progenitor cell proliferation by the Pten tumor suppressor gene in vivo","volume":"294","author":"Groszer","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.05.013_bib13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.molmed.2005.06.007","article-title":"An expanding role for mTOR in cancer","volume":"11","author":"Guertin","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.brainres.2006.05.013_bib14","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2006.05.013_bib15","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1242\/dev.126.23.5365","article-title":"PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development","volume":"126","author":"Huang","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.brainres.2006.05.013_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1475-4924-2-20","article-title":"The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling","volume":"2","author":"Junger","year":"2003","journal-title":"J. Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1247\/csf.28.11","article-title":"Physiological functions of Pten in mouse tissues","volume":"28","author":"Kishimoto","year":"2003","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.brainres.2006.05.013_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/bies.10031","article-title":"Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K","volume":"24","author":"Kozma","year":"2002","journal-title":"BioEssays"},{"key":"10.1016\/j.brainres.2006.05.013_bib19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng781","article-title":"Pten regulates neuronal soma size: a mouse model of Lhermitte\u2013Duclos disease","volume":"29","author":"Kwon","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainres.2006.05.013_bib20","doi-asserted-by":"crossref","first-page":"12923","DOI":"10.1073\/pnas.2132711100","article-title":"mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo","volume":"100","author":"Kwon","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.05.013_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/mcne.2002.1115","article-title":"PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation","volume":"20","author":"Li","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainres.2006.05.013_bib22","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.1074\/jbc.273.22.13375","article-title":"The tumor suppressor, PTEN\/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate","volume":"273","author":"Maehama","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.05.013_bib23","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1242\/dev.129.14.3513","article-title":"PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum","volume":"129","author":"Marino","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.brainres.2006.05.013_bib24","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1074\/jbc.M310405200","article-title":"The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway","volume":"279","author":"McMullen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainres.2006.05.013_bib25","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1128\/MCB.24.14.6231-6240.2004","article-title":"Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy","volume":"24","author":"McMullen","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib26","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1126\/science.285.5436.2126","article-title":"Drosophila S6 kinase: a regulator of cell size","volume":"285","author":"Montagne","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.05.013_bib27","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/ncb1231","article-title":"Atrophy of S6K1(\u2212\/\u2212) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control","volume":"7","author":"Ohanna","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib28","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/35050135","article-title":"Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice","volume":"408","author":"Pende","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainres.2006.05.013_bib29","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/MCB.24.8.3112-3124.2004","article-title":"S6K1(\u2212\/\u2212)\/S6K2(\u2212\/\u2212) mice exhibit perinatal lethality and rapamycin-sensitive 5\u2032-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway","volume":"24","author":"Pende","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib30","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1073\/pnas.96.4.1563","article-title":"Mutation of Pten\/Mmac1 in mice causes neoplasia in multiple organ systems","volume":"96","author":"Podsypanina","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainres.2006.05.013_bib31","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1101\/gad.1098703","article-title":"Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway","volume":"17","author":"Puig","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2006.05.013_bib32","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1126\/science.1092089","article-title":"Regulation of cell migration by the C2 domain of the tumor suppressor PTEN","volume":"303","author":"Raftopoulou","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.05.013_bib33","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.cub.2004.08.061","article-title":"SKAR is a specific target of S6 kinase 1 in cell growth control","volume":"14","author":"Richardson","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.semcdb.2003.12.023","article-title":"PI3-kinase and TOR: PIKTORing cell growth","volume":"15","author":"Richardson","year":"2004","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib35","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1101\/gad.351605","article-title":"Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis","volume":"19","author":"Ruvinsky","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.brainres.2006.05.013_bib36","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ceb.2005.09.009","article-title":"Growing roles for the mTOR pathway","volume":"17","author":"Sarbassov dos","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib37","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1038\/sj.onc.1203739","article-title":"The conserved PI3\u2032K\/PTEN\/Akt signaling pathway regulates both cell size and survival in Drosophila","volume":"19","author":"Scanga","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.brainres.2006.05.013_bib38","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1093\/emboj\/17.22.6649","article-title":"Disruption of the p70(s6k)\/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase","volume":"17","author":"Shima","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2006.05.013_bib39","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1093\/emboj\/19.11.2537","article-title":"The conserved phosphoinositide 3-kinase pathway determines heart size in mice","volume":"19","author":"Shioi","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.brainres.2006.05.013_bib40","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1128\/MCB.22.8.2799-2809.2002","article-title":"Akt\/protein kinase B promotes organ growth in transgenic mice","volume":"22","author":"Shioi","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0092-8674(00)81780-8","article-title":"Negative regulation of PKB\/Akt-dependent cell survival by the tumor suppressor PTEN","volume":"95","author":"Stambolic","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.brainres.2006.05.013_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ydbio.2004.06.008","article-title":"PTENless means more","volume":"273","author":"Stiles","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib43","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0959-437X(00)00123-4","article-title":"Genetic control of cell size","volume":"10","author":"Stocker","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.brainres.2006.05.013_bib44","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0962-8924(03)00175-2","article-title":"PTEN: from pathology to biology","volume":"13","author":"Sulis","year":"2003","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib45","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0960-9822(07)00488-5","article-title":"High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice","volume":"8","author":"Suzuki","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.brainres.2006.05.013_bib46","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1126\/science.280.5369.1614","article-title":"Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN","volume":"280","author":"Tamura","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.brainres.2006.05.013_bib47","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc839","article-title":"The phosphatidylinositol 3-kinase AKT pathway in human cancer","volume":"2","author":"Vivanco","year":"2002","journal-title":"Nat. Rev., Cancer"},{"key":"10.1016\/j.brainres.2006.05.013_bib48","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1242\/dev.01891","article-title":"PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization","volume":"132","author":"Yue","year":"2005","journal-title":"Development"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306013850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306013850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T09:30:57Z","timestamp":1627464657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899306013850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0006899306013850"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.05.013","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}