{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T22:57:24Z","timestamp":1774393044400,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.brainres.2006.06.065","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T09:13:33Z","timestamp":1153905213000},"page":"193-200","source":"Crossref","is-referenced-by-count":65,"title":["Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia\u2013reperfusion injury"],"prefix":"10.1016","volume":"1110","author":[{"given":"Yufang","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisha","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.06.065_bib1","first-page":"126","article-title":"Protective effects of polydatin, an active compound from polygonum cuspidatum, on cerebral ischemic damage in rats","volume":"12","author":"Z.m.","year":"1996","journal-title":"Chin. Pharmacol. Bull."},{"key":"10.1016\/j.brainres.2006.06.065_bib2","first-page":"H2555","article-title":"Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion","volume":"287","author":"Arumugam","year":"2004","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"10.1016\/j.brainres.2006.06.065_bib3","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/01.STR.17.6.1304","article-title":"Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats","volume":"17","author":"Bederson","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2006.06.065_bib4","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1097\/00004647-200209000-00004","article-title":"Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia\u2013reperfusion brain injury","volume":"22","author":"Berti","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2006.06.065_bib5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/00004647-199607000-00007","article-title":"Antibodies against adhesion molecules reduce apoptosis after transient middle cerebral artery occlusion in rat brain","volume":"16","author":"Chopp","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2006.06.065_bib6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.addr.2003.10.029","article-title":"Selectins\u2014An emerging target for drug delivery","volume":"56","author":"Ehrhardt","year":"2004","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.brainres.2006.06.065_bib7","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1161\/01.STR.0000021902.33129.69","article-title":"Inflammatory cell adhesion molecules in ischemic cerebrovascular disease","volume":"33","author":"Frijns","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2006.06.065_bib8","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1172\/JCI23445","article-title":"Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation","volume":"115","author":"Garmy-Susini","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainres.2006.06.065_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0022-510X(98)00262-7","article-title":"P-selectin antibody reduces hemorrhage and infarct volume resulting from MCA occlusion in the rat","volume":"161","author":"Goussev","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainres.2006.06.065_bib10","first-page":"1253","article-title":"Effect of polydatin on lipopolysaccharide-induced leucocyte chemotaxis","volume":"23","author":"Huang","year":"2003","journal-title":"Di Yi Junyi Daxue Xuebao"},{"key":"10.1016\/j.brainres.2006.06.065_bib11","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0002-9440(10)64280-0","article-title":"Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts","volume":"162","author":"Jakubzick","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainres.2006.06.065_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0165-5728(96)00109-9","article-title":"Vascular cell adhesion molecule-1 mRNA is expressed in immune-mediated and ischemic injury of the rat nervous system","volume":"70","author":"Jander","year":"1996","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2006.06.065_bib13","first-page":"1382","article-title":"Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon","volume":"43","author":"Jean","year":"1998","journal-title":"Neurosurgery"},{"key":"10.1016\/j.brainres.2006.06.065_bib14","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1097\/00004647-199812000-00008","article-title":"Deficiency of intercellular adhesion molecule 1 attenuates microcirculatory disturbance and infarction size in focal cerebral ischemia","volume":"18","author":"Kitagawa","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainres.2006.06.065_bib15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0165-5728(03)00031-6","article-title":"Regional and temporal expression patterns of interleukin-10, interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE","volume":"136","author":"Ledeboer","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainres.2006.06.065_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00024382-200404000-00004","article-title":"Cell adhesion molecules as a marker reflecting the reduction of endothelial activation induced by glucocorticoids","volume":"21","author":"Leone","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.brainres.2006.06.065_bib17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2006.06.065_bib18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0006-8993(94)91478-8","article-title":"Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat","volume":"656","author":"Matsuo","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.06.065_bib19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1365-2125.1992.tb05634.x","article-title":"New models of focal cerebral ischaemia","volume":"34","author":"Mhairi Macrae","year":"1992","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.brainres.2006.06.065_bib20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/labinvest.3700256","article-title":"Prolactin stimulates integrin-mediated adhesion of circulating mononuclear cells to endothelial cells","volume":"85","author":"Montes de Oca","year":"2005","journal-title":"Lab. Invest."},{"key":"10.1016\/j.brainres.2006.06.065_bib21","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1939-1676.2001.tb01586.x","article-title":"Cell adhesion molecules, leukocyte trafficking, and strategies to reduce leukocyte infiltration","volume":"15","author":"Radi","year":"2001","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.brainres.2006.06.065_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0300-9572(01)00444-0","article-title":"L-selectin in health and disease","volume":"52","author":"Rainer","year":"2002","journal-title":"Resuscitation"},{"key":"10.1016\/j.brainres.2006.06.065_bib23","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1161\/01.STR.31.5.1153","article-title":"Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke","volume":"31","author":"Ritter","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2006.06.065_bib24","first-page":"394","article-title":"Effects of polydatin on platelet aggregation in rabbits","volume":"23","author":"Shan","year":"1988","journal-title":"Yaoxue Xuebao"},{"key":"10.1016\/j.brainres.2006.06.065_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.abb.2003.06.001","article-title":"Age-related changes of cardiac gene expression following myocardial ischemia\/reperfusion","volume":"420","author":"Simkhovich","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.brainres.2006.06.065_bib26","first-page":"86","article-title":"Soluble adhesion molecules in acute ischemic stroke","volume":"27","author":"Simundic","year":"2004","journal-title":"Clin. Invest. Med."},{"key":"10.1016\/j.brainres.2006.06.065_bib27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0006-8993(97)01298-5","article-title":"ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia","volume":"780","author":"Soriano","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.06.065_bib28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/01.STR.30.1.134","article-title":"Mice deficient in Mac-1 (CD11b\/CD18) are less susceptible to cerebral ischemia\/reperfusion injury","volume":"30","author":"Soriano","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2006.06.065_bib29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.nbd.2004.11.001","article-title":"C1-inhibitor protects against brain ischemia\u2013reperfusion injury via inhibition of cell recruitment and inflammation","volume":"19","author":"Storini","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainres.2006.06.065_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/01.STR.0000106479.53235.3E","article-title":"Inhibition of intercellular adhesion molecule-1 protein expression by antisense oligonucleotides is neuroprotective after transient middle cerebral artery occlusion in rat","volume":"35","author":"Vemuganti","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.brainres.2006.06.065_bib31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0169-328X(94)90074-4","article-title":"Upregulation of intercellular adhesion molecule 1 (ICAM-1) on brain microvascular endothelial cells in rat ischemic cortex","volume":"26","author":"Wang","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2006.06.065_bib32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/dvdy.20120","article-title":"Expression and function of integrin alpha4beta1 and vascular cell adhesion molecule-1 (VCAM-1) during sympathetic innervation of the heart","volume":"231","author":"Wingerd","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.brainres.2006.06.065_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0169-328X(98)00335-0","article-title":"Expression of intercellular adhesion molecule 1 (ICAM-1) is reduced in permanent focal cerebral ischemic mouse brain using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist","volume":"65","author":"Yang","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainres.2006.06.065_bib34","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1161\/01.CIR.95.6.1515","article-title":"Inhibition of intimal hyperplasia after balloon injury by antibodies to intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1","volume":"95","author":"Yasukawa","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.brainres.2006.06.065_bib35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0006-8993(95)00346-R","article-title":"The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat","volume":"682","author":"Zhang","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.06.065_bib36","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0006-8993(97)01343-7","article-title":"The expression of P- and E-selectins in three models of middle cerebral artery occlusion","volume":"785","author":"Zhang","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.06.065_bib37","first-page":"211","article-title":"The mechanism of polydatin in shock treatment","volume":"29","author":"Zhao","year":"2003","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.brainres.2006.06.065_bib38","first-page":"364","article-title":"Protective effect of polydatin against lipopolysaccharide-induced myocardial injury","volume":"23","author":"Zhao","year":"2003","journal-title":"Di Yi Junyi Daxue Xuebao"}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306018701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306018701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T23:00:35Z","timestamp":1549666835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899306018701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0006899306018701"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.06.065","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}