{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:19:22Z","timestamp":1783091962537,"version":"3.54.6"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.brainres.2006.07.061","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T08:39:36Z","timestamp":1157013576000},"page":"194-199","source":"Crossref","is-referenced-by-count":25,"title":["Biperiden-induced delirium model in rats: A behavioral and electroencephalographic study"],"prefix":"10.1016","volume":"1115","author":[{"given":"Yoshiyuki","family":"Tamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Takasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ishimaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainres.2006.07.061_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1479-8301.2002.tb00080.x","article-title":"The prognosis of delirium","volume":"2","author":"Bhat","year":"2002","journal-title":"Psychogeriatrics"},{"key":"10.1016\/j.brainres.2006.07.061_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1017\/S1041610291000686","article-title":"Utility of EEG in delirium: past views and current practice","volume":"3","author":"Brenner","year":"1991","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.brainres.2006.07.061_bib3","series-title":"Delirium: Acute Confusional States in Palliative Medicine","author":"Caraceni","year":"2003"},{"key":"10.1016\/j.brainres.2006.07.061_bib4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0168-8278(87)80538-X","article-title":"Correlation between electroencephalographic and biochemical indices in acute hepatic encephalopathy in rats","volume":"4","author":"Chamuleau","year":"1987","journal-title":"J. Hepatol."},{"key":"10.1016\/j.brainres.2006.07.061_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1152\/jn.1991.65.3.393","article-title":"Short-lasting nicotinic and long-lasting muscarinic depolarizing responses of thalamocortical neurons to stimulation of mesopontine cholinergic nuclei","volume":"65","author":"Curro Dossi","year":"1991","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainres.2006.07.061_bib6","first-page":"33","article-title":"Neurochemical, electroencephalographic and behavioral correlates of ethanol withdrawal in the rat","volume":"4","author":"Edmonds","year":"1982","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"10.1016\/j.brainres.2006.07.061_bib7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0021-9681(59)90165-1","article-title":"Delirium, a syndrome of cerebral insufficiency","volume":"9","author":"Engel","year":"1959","journal-title":"J. Chronic. Dis."},{"key":"10.1016\/j.brainres.2006.07.061_bib8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00004714-200102000-00026","article-title":"Successful treatment of nonanticholinergic delirium with a cholinesterase inhibitor","volume":"21","author":"Fischer","year":"2001","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.brainres.2006.07.061_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/archinte.161.8.1099","article-title":"Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients","volume":"161","author":"Han","year":"2001","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.brainres.2006.07.061_bib10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1055\/s-2007-1001778","article-title":"Delirium syndrome in biperiden poisoning","volume":"56","author":"Hewer","year":"1988","journal-title":"Fortschr. Neurol. Psychiatr."},{"key":"10.1016\/j.brainres.2006.07.061_bib11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1017\/S1041610291000844","article-title":"Disturbance of neural systems in delirium","volume":"3","author":"Hishikawa","year":"1991","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.brainres.2006.07.061_bib12","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1176\/ajp.134.12.1335","article-title":"The brain as a dream state generator: an activation-synthesis hypothesis of the dream process","volume":"134","author":"Hobson","year":"1977","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainres.2006.07.061_bib13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJM199903043400901","article-title":"A multicomponent intervention to prevent delirium in hospitalized older patients","volume":"340","author":"Inouye","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainres.2006.07.061_bib14","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/00005053-196612000-00005","article-title":"Anticholinergic drug-induced delirium: experimental modification, quantitative EEG and behavioral correlations","volume":"143","author":"Itil","year":"1966","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.brainres.2006.07.061_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0079-6123(08)64549-5","article-title":"EEG and behavioral aspects of the interaction of anticholinergic hallucinogens with centrally active compounds","volume":"28","author":"Itil","year":"1968","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainres.2006.07.061_bib16","first-page":"86","article-title":"EEG in delirium. Semin","volume":"5","author":"Jacobson","year":"2000","journal-title":"Clin. Neuropsychiatry"},{"key":"10.1016\/j.brainres.2006.07.061_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/jnnp.56.2.153","article-title":"Conventional and quantitative EEG in the diagnosis of delirium among the elderly","volume":"56","author":"Jacobson","year":"1993","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainres.2006.07.061_bib18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0166-2236(79)90110-3","article-title":"What dose a cat dream about?","volume":"2","author":"Jouvet","year":"1979","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.brainres.2006.07.061_bib19","series-title":"Eyes and The Mind","author":"Kojima","year":"2000"},{"key":"10.1016\/j.brainres.2006.07.061_bib20","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1136\/jnnp.52.8.980","article-title":"EEG spectral analysis in delirium","volume":"52","author":"Koponen","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.brainres.2006.07.061_bib21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1176\/jnp.6.3.279","article-title":"Rat model of delirium: atropine dose\u2013response relationships","volume":"6","author":"Leavitt","year":"1994","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.brainres.2006.07.061_bib22","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/archinte.165.14.1657","article-title":"Premature death associated with delirium at 1-year follow-up","volume":"165","author":"Leslie","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.brainres.2006.07.061_bib23","series-title":"Delirium: Acute Confusional States","author":"Lipowski","year":"1990"},{"key":"10.1016\/j.brainres.2006.07.061_bib24","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1192\/bjp.161.6.843","article-title":"An empirical study of delirium subtypes","volume":"161","author":"Liptzin","year":"1992","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.brainres.2006.07.061_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1176\/jnp.7.2.251","article-title":"Brain stem reticular formation and activation of the EEG. 1949","volume":"7","author":"Moruzzi","year":"1995","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.brainres.2006.07.061_bib26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0013-4694(88)90017-X","article-title":"Phasic EEG activities associated with rapid eye movements during REM sleep in man","volume":"70","author":"Niiyama","year":"1988","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.brainres.2006.07.061_bib27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000017174","article-title":"Clinical subtypes of delirium in the elderly","volume":"10","author":"O'Keeffe","year":"1999","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainres.2006.07.061_bib28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0166-2236(98)01361-7","article-title":"Acetylcholine in mind: a neurotransmitter correlate of consciousness?","volume":"22","author":"Perry","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainres.2006.07.061_bib29","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/j.1532-5415.1999.tb07429.x","article-title":"Clinical profile of delirium in older patients","volume":"47","author":"Sandberg","year":"1999","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.brainres.2006.07.061_bib30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0006-8993(90)91140-C","article-title":"Inhibition by carbachol microinjections of presumptive cholinergic PGO\u2212 on neurons in freely moving cats","volume":"527","author":"Sakai","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.brainres.2006.07.061_bib31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0014-2999(81)90082-0","article-title":"Quantification of slow-wave EEG induced by atropine: effects of physostigmine, amphetamine and haloperidol","volume":"73","author":"Santucci","year":"1981","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainres.2006.07.061_bib32","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1053\/ejvs.2000.1130","article-title":"Postoperative delirium in patients with lower limb ischemia: what are the specific markers?","volume":"20","author":"Sasajima","year":"2000","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.brainres.2006.07.061_bib33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/sleep\/9.2.293","article-title":"Chronic behavioral disorders of human REM sleep: a new category of parasomnia","volume":"9","author":"Schenck","year":"1986","journal-title":"Sleep"},{"key":"10.1016\/j.brainres.2006.07.061_bib34","first-page":"177","article-title":"A sleep study of acute psychotic states due to alcohol and meprobamate addiction","volume":"vol. 2","author":"Tachibana","year":"1975"},{"key":"10.1016\/j.brainres.2006.07.061_bib35","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1001\/archpsyc.1988.01800340065009","article-title":"A prospective study of delirium and prolonged hospital stay","volume":"45","author":"Thomas","year":"1988","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainres.2006.07.061_bib36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0193-953X(05)70299-9","article-title":"Delirium. Advances in diagnosis, pathophysiology, and treatment","volume":"19","author":"Trzepacz","year":"1996","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.brainres.2006.07.061_bib37","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1159\/000017164","article-title":"Update on the neuropathogenesis of delirium","volume":"10","author":"Trzepacz","year":"1999","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.brainres.2006.07.061_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0163-8343(85)90018-0","article-title":"Delirium and other organic mental disorders in a general hospital","volume":"7","author":"Trzepacz","year":"1985","journal-title":"Gen. Hosp. Psych."},{"key":"10.1016\/j.brainres.2006.07.061_bib39","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0033-3182(92)71945-8","article-title":"An animal model for delirium","volume":"33","author":"Trzepacz","year":"1992","journal-title":"Psychosomatics"},{"key":"10.1016\/j.brainres.2006.07.061_bib40","series-title":"Biology of Cholinergic Function","first-page":"603","article-title":"Cholinergic involvement in neuropsychiatric syndromes","author":"Weiss","year":"1976"},{"key":"10.1016\/j.brainres.2006.07.061_bib41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/089198879801100308","article-title":"Donepezil improves symptoms of delirium in dementia: implications for future research","volume":"11","author":"Wengel","year":"1998","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.brainres.2006.07.061_bib42","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1532-5415.1999.tb03015.x","article-title":"Donepezil for postoperative delirium associated with Alzheimer's disease","volume":"47","author":"Wengel","year":"1999","journal-title":"J. Am. Geriatr. Soc."}],"container-title":["Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306022050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006899306022050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T20:36:05Z","timestamp":1555792565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006899306022050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0006899306022050"],"URL":"https:\/\/doi.org\/10.1016\/j.brainres.2006.07.061","relation":{},"ISSN":["0006-8993"],"issn-type":[{"value":"0006-8993","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}